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1. 发明授权

US09023065B2 Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ 有权
标题翻译：用于支撑中空身体器官内的组织和/或结构的装置，系统和方法
公开(公告)号：US09023065B2
公开(公告)日：2015-05-05
申请号：US13157242
申请日：2011-06-09
申请人： Lee Bolduc , Andrew L. Chiang , Philip R. Houle , Gilbert S. Laroya
发明人： Lee Bolduc , Andrew L. Chiang , Philip R. Houle , Gilbert S. Laroya
IPC分类号： A61B17/10 , A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/12 , A61F2/24
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00783 , A61B2017/0441 , A61B2017/0454 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2017/0646 , A61B2017/0649 , A61F2/2412 , A61F2/2445 , A61F2/2466 , A61F2/2478 , A61F2/2481 , A61F2/2487 , A61F2002/249
摘要： Devices, systems and methods support tissue in a body organ for the purpose of restoring or maintaining native function of the organ. The devices, systems, and methods do not require invasive, open surgical approaches to be implemented, but, instead, lend themselves to catheter-based, intra-vascular and/or percutaneous techniques.
摘要翻译：装置，系统和方法支持身体器官中的组织，以恢复或维持器官的本机功能。装置，系统和方法不需要实施侵入性的开放手术方法，而是适用于基于导管的血管内和/或经皮技术。

2. 发明申请

US20110238088A1 DEVICES, SYSTEMS, AND METHODS FOR SUPPORTING TISSUE AND/OR STRUCTURES WITHIN A HOLLOW BODY ORGAN 有权
标题翻译：用于支持中空身体组织中组织和/或结构的装置，系统和方法
公开(公告)号：US20110238088A1
公开(公告)日：2011-09-29
申请号：US13157242
申请日：2011-06-09
申请人： Lee BOLDUC , Andrew L. Chiang , Philip R. Houle , Gilbert S. Laroya
发明人： Lee BOLDUC , Andrew L. Chiang , Philip R. Houle , Gilbert S. Laroya
IPC分类号： A61B17/00
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/068 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00783 , A61B2017/0441 , A61B2017/0454 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2017/0646 , A61B2017/0649 , A61F2/2412 , A61F2/2445 , A61F2/2466 , A61F2/2478 , A61F2/2481 , A61F2/2487 , A61F2002/249
摘要： Devices, systems and methods support tissue in a body organ for the purpose of restoring or maintaining native function of the organ. The devices, systems, and methods do not require invasive, open surgical approaches to be implemented, but, instead, lend themselves to catheter-based, intra-vascular and/or percutaneous techniques.
摘要翻译：装置，系统和方法支持身体器官中的组织，以恢复或维持器官的本机功能。装置，系统和方法不需要实施侵入性的开放手术方法，而是适用于基于导管的血管内和/或经皮技术。

3. 发明授权

US6125852A Minimally-invasive devices and methods for treatment of congestive heart failure 失效
公开(公告)号：US6125852A
公开(公告)日：2000-10-03
申请号：US685262
申请日：1996-07-23
申请人： John H. Stevens , Lee R. Bolduc , Stephen W. Boyd , Brian S. Donlon , Hanson S. Gifford, III , Philip R. Houle , Daniel C. Rosenman
发明人： John H. Stevens , Lee R. Bolduc , Stephen W. Boyd , Brian S. Donlon , Hanson S. Gifford, III , Philip R. Houle , Daniel C. Rosenman
IPC分类号： A61B17/00 , A61B17/02 , A61B17/04 , A61B17/06 , A61B17/122 , A61B17/28 , A61B17/30 , A61B17/34 , A61B18/00 , A61B18/14 , A61B19/00 , A61F2/24 , A61F2/958 , A61F7/00 , A61F7/10 , A61M1/00 , A61M1/36
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0218 , A61B17/0293 , A61B17/0469 , A61B17/06061 , A61B17/122 , A61B17/29 , A61B17/3421 , A61B18/1492 , A61B90/36 , A61B90/50 , A61F7/10 , A61M39/0247 , A61B17/0467 , A61B17/2909 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2017/00867 , A61B2017/00907 , A61B2017/00946 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , A61B2017/2912 , A61B2017/2926 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00982 , A61B2090/061 , A61B2090/306 , A61F2/2442 , A61F2/2445 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M1/3621 , A61M2025/028 , A61M2039/027 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M25/1011
摘要： A method of treatment of congestive heart failure comprises the steps of introducing an aortic occlusion catheter through a patient's peripheral artery, the aortic occlusion catheter having an occluding member movable from a collapsed position to an expanded position; positioning the occluding member in the patient's ascending aorta; moving the occluding member from the collapsed shape to the expanded shape after the positioning step; introducing cardioplegic fluid into the patient's coronary blood vessels to arrest the patient's heart; maintaining circulation of oxygenated blood through the patient's arterial system; and reshaping an outer wall of the patient's heart while the heart is arrested so as to reduce the transverse dimension of the left ventricle. The ascending aorta may be occluded and cardioplegic fluid delivered by means of an occlusion balloon attached to the distal end of an elongated catheter positioned transluminally in the aorta from a femoral, subclavian, or other appropriate peripheral artery.

4. 发明申请

US20080199830A1 Iontophoresis and Active Dental Appliances 审中-公开
标题翻译：离子电渗疗法和活性牙科器具
公开(公告)号：US20080199830A1
公开(公告)日：2008-08-21
申请号：US12033827
申请日：2008-02-19
申请人： Mark G. Fontenot , Philip R. Houle
发明人： Mark G. Fontenot , Philip R. Houle
IPC分类号： A61C19/06 , H02G3/00 , A46B9/04 , A61C17/00
CPC分类号： A61C19/06 , A46B5/0012 , A46B13/023 , A46B15/0002 , A46B15/0022 , A46B2200/1066 , A61C5/40 , A61N1/30
摘要： Dental trays, toothbrushes, and other devices are provided for the active delivery of medicaments into hard and soft tissues, particularly those of the oral cavity. The devices apply an AC voltage with a DC offset to drive medicaments into the tissues.
摘要翻译：提供牙科托盘，牙刷和其他装置用于将药物主动递送到硬组织和软组织中，特别是口腔中。器件应用具有直流偏移电压的交流电压以将药物驱动到组织中。

5. 发明授权

US07213601B2 Minimally-invasive devices and methods for treatment of congestive heart failure 失效
标题翻译：用于治疗充血性心力衰竭的微创装置和方法
公开(公告)号：US07213601B2
公开(公告)日：2007-05-08
申请号：US10665236
申请日：2003-09-17
申请人： John H. Stevens , Lee R. Bolduc , Stephen W. Boyd , Brian S. Donlon , Hanson S. Gifford, III , Philip R. Houle , Daniel C. Rosenman
发明人： John H. Stevens , Lee R. Bolduc , Stephen W. Boyd , Brian S. Donlon , Hanson S. Gifford, III , Philip R. Houle , Daniel C. Rosenman
IPC分类号： A61B19/00 , A61B5/00 , A61B1/00 , G01B3/10
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0293 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/122 , A61B17/29 , A61B17/2909 , A61B17/3421 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2017/00632 , A61B2017/00867 , A61B2017/00907 , A61B2017/00946 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0496 , A61B2017/2912 , A61B2017/2926 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/3405 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00982 , A61B2090/061 , A61B2090/306 , A61F2/2442 , A61F2/2445 , A61F7/10 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M1/3621 , A61M25/1011 , A61M39/0247 , A61M2025/028 , A61M2039/027 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366
摘要： A method of treatment of congestive heart failure comprises the steps of introducing an aortic occlusion catheter through a patient's peripheral artery, the aortic occlusion catheter having an occluding member movable from a collapsed position to an expanded position; positioning the occluding member in the patient's ascending aorta; moving the occluding member from the collapsed shape to the expanded shape after the positioning step; introducing cardioplegic fluid into the patient's coronary blood vessels to arrest the patient's heart; maintaining circulation of oxygenated blood through the patient's arterial system; and reshaping an outer wall of the patient's heart while the heart is arrested so as to reduce the transverse dimension of the left ventricle. The ascending aorta may be occluded and cardioplegic fluid delivered by means of an occlusion balloon attached to the distal end of an elongated catheter positioned transluminally in the aorta from a femoral, subclavian, or other appropriate peripheral artery.
摘要翻译：治疗充血性心力衰竭的方法包括以下步骤：通过患者的外周动脉引入主动脉闭塞导管，所述主动脉闭塞导管具有可从折叠位置移动到扩张位置的闭塞构件; 将阻塞构件定位在患者升主动脉中; 在定位步骤之后将遮挡构件从折叠形状移动到扩张形状; 将心脏停搏液引入患者的冠状动脉血管以阻止患者的心脏; 维持氧合血液循环通过病人的动脉系统; 并在心脏停止时重塑患者心脏的外壁，以减小左心室的横向尺寸。上升主动脉可能被闭塞，并且通过附接到细长导管的远端的闭塞气囊递送的心脏停跳液体在主动脉中从股骨，锁骨下动脉或其它适当的外周动脉平均放置。

6. 发明申请

US20080255498A1 Sensitizer Solutions, Systems, and Methods of Use 审中-公开
标题翻译：敏化剂解决方案，系统和使用方法
公开(公告)号：US20080255498A1
公开(公告)日：2008-10-16
申请号：US12036984
申请日：2008-02-25
申请人： Philip R. Houle
发明人： Philip R. Houle
IPC分类号： A61N1/30 , A61L2/02 , A61L2/08
CPC分类号： A61C19/063 , A61C17/02 , A61C17/0208 , A61C17/0211 , A61C19/06 , A61K41/00 , A61K41/0057 , A61K41/0071 , A61K41/0076 , A61L2/084 , A61L2/085 , A61L2/10 , A61L2/186 , A61L2202/122 , A61L2202/17 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N5/0624 , A61N2005/0604
摘要： A kit cleaning system and method is disclosed. One embodiment of the present invention has a photosensitizer solution supplied by a pressurized nozzle to the target site. Specific application of the solution is to an oral or skin surface target site. The photosensitizer solution is illuminated with sensitizing light creating reactive chemical species. Pressure and a solvent having an elevated concentration of oxygen or oxygen species improve the efficiency of the killing of pathogens. Methods of using the system within an oral cavity are also disclosed.
摘要翻译：公开了一种套件清洁系统和方法。本发明的一个实施方案具有由加压喷嘴提供给目标部位的光敏剂溶液。溶液的具体应用是口服或皮肤表面的靶位。光敏剂溶液用产生反应性化学物质的敏化光照射。压力和具有提高的氧气或氧气浓度的溶剂提高了病原体杀死效率。还公开了在口腔内使用该系统的方法。

7. 发明授权

US06322578B1 Endoscopic microsurgical instruments 失效
标题翻译：内窥镜显微外科器械
公开(公告)号：US06322578B1
公开(公告)日：2001-11-27
申请号：US08892085
申请日：1997-07-14
申请人： Philip R. Houle , Alex T. Roth , Scott H. Miller
发明人： Philip R. Houle , Alex T. Roth , Scott H. Miller
IPC分类号： A61B1700
CPC分类号： A61B17/2909 , A61B2017/2946 , A61B2017/305
摘要： Microsurgical instruments for performing extremely small-scale, minimally-invasive microsurgery such as thoracoscopic coronary artery bypass grafting. The instruments utilize a symmetrical, forcep-like actuator which provides extremely precise actuation and control of the instrument and which mimics the feel of instruments used in conventional open surgical procedures. The instruments generally include a pair of coaxially arranged shafts, an end-effector at the distal ends of the shafts, and an actuator at the proximal ends of the shafts. The actuator includes a pair of arms pivotally coupled to one of the outer and inner shafts, and a pair of links pivotally coupled at one end to the arms, and at a second end to the other of the shafts. The links are coupled to a proximal portion of the arms to maximize mechanical advantage and reduce interference. The actuator may be easily adapted for either pull-type or push-type actuation, and for either outer shaft or inner shaft translation. The actuator is provided with a locking mechanism for fixing the relative position of the shafts to maintain the end-effector in a closed position. The locking mechanism includes rigid catches that are engaged upon actuation of the actuator and are disengaged upon further actuation of the actuator. The end-effectors may have a variety of configurations, including needle drivers, forceps, scissors, and clip appliers.
摘要翻译：显微手术仪器用于进行极小型，微创微创手术，如胸腔镜冠状动脉旁路移植术。仪器采用对称的强力致动器，它提供了非常精确的致动和控制仪器，并且模拟了常规开放式外科手术中使用的仪器的感觉。仪器通常包括一对同轴布置的轴，在轴的远端处的末端执行器和在轴的近端的致动器。致动器包括可枢转地联接到外轴和内轴中的一个的一对臂，以及在一端枢转地连接到臂的一对连杆，并且在另一端处连接到另一个轴。连杆联接到臂的近端部分以最大化机械优点并减少干扰。致动器可以容易地适用于拉式或推式致动，以及用于外轴或内轴平移。致动器设置有用于固定轴的相对位置的锁定机构，以将末端执行器保持在关闭位置。锁定机构包括在致动器致动时接合的刚性卡盘，并且在进一步致动致动器时脱开。末端执行器可以具有各种配置，包括针驱动器，镊子，剪刀和夹具装置。

8. 发明授权

US07651510B2 System for performing vascular anastomoses 有权
标题翻译：进行血管吻合的系统
公开(公告)号：US07651510B2
公开(公告)日：2010-01-26
申请号：US09759430
申请日：2001-01-12
申请人： Lee R. Bolduc , James R. Gannoe , Philip R. Houle
发明人： Lee R. Bolduc , James R. Gannoe , Philip R. Houle
IPC分类号： A61B17/08
CPC分类号： A61B17/11 , A61B17/122 , A61B2017/1107 , A61B2017/1135 , A61B2017/1142
摘要： Systems for anastomosing a first hollow tissue structure to a second hollow tissue structure are disclosed. In an exemplary embodiment, such a system comprises at least one tissue securing member adapted to secure the first and second hollow tissue structures together, and a device for applying the tissue securing member to the tissue structures. The tissue securing member is preferably configured to pass through only one of the tissue structures, and is movable from a first configuration to a second configuration which results in a compressive force being applied to the tissue structures. The systems are particularly useful for performing anastomosis of blood vessels in heart surgery.
摘要翻译：公开了将第一中空组织结构吻合到第二中空组织结构的系统。在示例性实施例中，这样的系统包括适于将第一和第二中空组织结构固定在一起的至少一个组织固定构件，以及用于将组织固定构件施加到组织结构的装置。组织固定构件优选地构造成仅穿过组织结构中的一个，并且可以从第一构造移动到第二构造，这导致施加到组织结构的压缩力。该系统对于在心脏手术中进行血管吻合特别有用。

9. 发明授权

US07056326B2 System for performing vascular anastomoses 有权
公开(公告)号：US07056326B2
公开(公告)日：2006-06-06
申请号：US10858640
申请日：2004-06-02
申请人： Lee R. Bolduc , James R. Gannoe , Philip R. Houle
发明人： Lee R. Bolduc , James R. Gannoe , Philip R. Houle
IPC分类号： A61B17/08
CPC分类号： A61B17/11 , A61B17/122 , A61B2017/1107 , A61B2017/1135 , A61B2017/1142
摘要： Systems for anastomosing a first hollow tissue structure to a second hollow tissue structure are disclosed. In an exemplary embodiment, such a system comprises at least one tissue securing member adapted to secure the first and second hollow tissue structures together, and a device for applying the tissue securing member to the tissue structures. The tissue securing member is preferably configured to pass through only one of the tissue structures, and is movable from a first configuration to a second configuration which results in a compressive force being applied to the tissue structures. The systems are particularly useful for performing anastomosis of blood vessels in heart surgery.

10. 发明授权

US06962596B2 System for performing vascular anastomoses 有权
标题翻译：进行血管吻合的系统
公开(公告)号：US06962596B2
公开(公告)日：2005-11-08
申请号：US10389536
申请日：2003-03-14
申请人： Lee R. Bolduc , James R. Gannoe , Philip R. Houle
发明人： Lee R. Bolduc , James R. Gannoe , Philip R. Houle
IPC分类号： A61B17/11 , A61B17/122 , A61B17/08
CPC分类号： A61B17/11 , A61B17/122 , A61B2017/1107 , A61B2017/1135 , A61B2017/1142
摘要： Systems for anastomosing a first hollow tissue structure to a second hollow tissue structure are disclosed. In an exemplary embodiment, such a system comprises at least one tissue securing member adapted to secure the first and second hollow tissue structures together, and a device for applying the tissue securing member to the tissue structures. The tissue securing member is preferably configured to pass through only one of the tissue structures, and is movable from a first configuration to a second configuration which results in a compressive force being applied to the tissue structures. The systems are particularly useful for performing anastomosis of blood vessels in heart surgery.
摘要翻译：公开了将第一中空组织结构吻合到第二中空组织结构的系统。在示例性实施例中，这样的系统包括适于将第一和第二中空组织结构固定在一起的至少一个组织固定构件，以及用于将组织固定构件施加到组织结构的装置。组织固定构件优选地构造成仅穿过组织结构中的一个，并且可以从第一构型移动到第二构造，这导致施加到组织结构的压缩力。该系统对于在心脏手术中进行血管吻合特别有用。

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