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1. 发明申请

US20060114448A1 Multiple optical channels 有权
标题翻译：多个光通道
公开(公告)号：US20060114448A1
公开(公告)日：2006-06-01
申请号：US10518088
申请日：2003-06-18
申请人： Leif Andersson , Mikael Herzman , Christian Grasser , Rolf Richter
发明人： Leif Andersson , Mikael Herzman , Christian Grasser , Rolf Richter
IPC分类号： G01C3/08
CPC分类号： G01C3/18 , G01C3/08
摘要： The invention relates to an electronic distance measuring apparatus for surveying, e.g. for measuring the distance from the apparatus to an object. The apparatus comprises: a) an objective lens (101), defining an optical axis (OA), b) at least two sources (111, 112) of structured light for transmitting beams (λ1, λ2) of separate wavelengths towards said object, said beams on reflection from said object received by the objective lens (101), (c) at least two receivers (141, 142) arranged outside a beam path (109) as defined by the objective lens (101), and adapted to receive said received beams (λ1, λ2) of structured light. Optical means comprising at least two dichroic surfaces (121a, 122a) are each arranged at a tilt angle (α1, α2) with respect to said axis (OA), said optical axis (OA) passing through said surfaces, at least one of said dichroic surfaces arranged on a plate (121, 122), said at least two dichroic surfaces (121a, 122a) adapted to reflect at least one of said received structured light beams (λ1, λ2), respectively, towards said receivers (141, 142).
摘要翻译：电子测距装置技术领域本发明涉及一种电子测距装置，用于测量从设备到物体的距离。该装置包括：a）限定光轴（OA）的物镜（101），b）至少两个用于传输光束（λλ1，λ 分离的波长朝向所述物体的所述光束，所述光束从物镜（101）接收的所述物体反射，（c）至少两个接收器（141,142），布置在光束路径外 109），并且适于接收结构光的所述接收光束（λ1，λ2，λ2）。包括至少两个二向色表面（121a，122a）的光学装置各自以相对于所述轴线（OA）的倾斜角（α1，α2 2）），所述光轴（OA）穿过所述表面，布置在板（121,122）上的至少一个所述二向色表面，所述至少两个二向色表面（121a，122a）适于反映至少一个所述接收的结构化光束（λ1，λ2，λ2）分别朝向所述接收器（141,142）。

2. 发明授权

US07382444B2 Multiple optical channels 有权
标题翻译：多个光通道
公开(公告)号：US07382444B2
公开(公告)日：2008-06-03
申请号：US10518088
申请日：2003-06-18
申请人： Leif Andersson , Mikael Herzman , Christian Grässer , Rolf Richter
发明人： Leif Andersson , Mikael Herzman , Christian Grässer , Rolf Richter
IPC分类号： G01C3/08
CPC分类号： G01C3/18 , G01C3/08
摘要： The invention relates to an electronic distance measuring apparatus for surveying, e.g. for measuring the distance from the apparatus to an object. The apparatus comprises: a) an objective lens (101), defining an optical axis (OA), b) at least two sources (111, 112) of structured light for transmitting beams (λ1, λ2) of separate wavelengths towards said object, said beams on reflection from said object received by the objective lens (101), (c) at least two receivers (141, 142) arranged outside a beam path (109) as defined by the objective lens (101), and adapted to receive said received beams (λ1, λ2) of structured light. Optical means comprising at least two dichroic surfaces (121a, 122a) are each arranged at a tilt angle (α1, α2) with respect to said axis (OA), said optical axis (OA) passing through said surfaces, at least one of said dichroic surfaces arranged on a plate (121, 122), said at least two dichroic surfaces (121a, 122a) adapted to reflect at least one of said received structured light beams (λ1, λ2), respectivly, towards said receivers (141, 142).
摘要翻译：电子测距装置技术领域本发明涉及一种电子测距装置，用于测量从设备到物体的距离。该装置包括：a）限定光轴（OA）的物镜（101），b）至少两个用于传输光束（λλ1，λ 分离的波长朝向所述物体的所述光束，所述光束从物镜（101）接收的所述物体反射，（c）至少两个接收器（141,142），布置在光束路径外 109），并且适于接收结构光的所述接收光束（λ1，λ2，λ2）。包括至少两个二向色表面（121a，122a）的光学装置各自以相对于所述轴线（OA）的倾斜角（α1，α2 2）），所述光轴（OA）穿过所述表面，布置在板（121,122）上的至少一个所述二向色表面，所述至少两个二向色表面（121a，122a）适于反映至少一个所述接收的结构化光束（λ1，λ2，λ2）相应地朝向所述接收器（141,142）。

3. 发明申请

US20180282812A1 Diagnostic test for skeletal atavism in horses 审中-公开
公开(公告)号：US20180282812A1
公开(公告)日：2018-10-04
申请号：US16004537
申请日：2018-06-11
申请人： Sofia Mikko , Leif Andersson , Gabriella Lindgren , Carl-Johan Rubin , Bhanu Chowdhary , Terje Raudsepp , Evan E. Eichler , John Huddleston , Maika Malig
发明人： Sofia Mikko , Leif Andersson , Gabriella Lindgren , Carl-Johan Rubin , Bhanu Chowdhary , Terje Raudsepp , Evan E. Eichler , John Huddleston , Maika Malig
IPC分类号： C12Q1/6883
摘要： The present invention relates to methods for detecting a genetic deletion at the SHOX locus of a horse, where the presence of such a genetic deletion indicates that the horse is a carrier of disease-causing mutation that can lead to skeletal atavism. The invention further provides nucleic acid primers and probes for use in methods for detecting the presence or absence of disease-causing genetic deletion at the SHOX locus of a horse.

4. 发明授权

US09096901B2 Methods and materials related to hair pigmentation and cancer 有权
标题翻译：与头发色素沉着和癌症相关的方法和材料
公开(公告)号：US09096901B2
公开(公告)日：2015-08-04
申请号：US13603109
申请日：2012-09-04
申请人： Leif Andersson , Gerli Rosengren Pielberg , Anna Olegovna Golovko , Kjell Robert Johan Lennartsson , Carl-Henrik Heldin
发明人： Leif Andersson , Gerli Rosengren Pielberg , Anna Olegovna Golovko , Kjell Robert Johan Lennartsson , Carl-Henrik Heldin
IPC分类号： C12N15/11 , C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6886 , C12Q2600/124 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： This document relates to methods and materials for determining whether or not a horse contains a Grey allele. For example, diagnostic methods such as nucleic acid-based detection methods and materials such as nucleic acid probes and primer pairs that can be used to determine whether or not a horse contains a duplication in intron 6 of STX17 nucleic acid are provided. This document also relates to methods and materials for treating a mammal having or being likely to develop cancer (e.g., benign, malignant, or metastatic cancer). For example, methods and materials for treating cancer in a mammal by administering an agent having the ability to reduce expression of an STX17 polypeptide and/or an NR4A polypeptide (e.g., an NR4A1, NR4A2, or NR4A3 polypeptide) in the mammal are provided.
摘要翻译：本文件涉及用于确定马是否包含Gray等位基因的方法和材料。例如，提供诊断方法，例如基于核酸的检测方法和诸如核酸探针和引物对的材料，其可用于确定马是否含有STX17核酸的内含子6中的重复。本文件还涉及用于治疗具有或可能发展为癌症（例如良性，恶性或转移性癌症）的哺乳动物的方法和材料。例如，提供了通过在哺乳动物中施用具有降低STX17多肽和/或NR4A多肽（例如NR4A1，NR4A2或NR4A3多肽）的表达能力的药剂来治疗哺乳动物癌症的方法和材料。

5. 发明申请

US20150044681A1 METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES 审中-公开
标题翻译：预测马氏体位置图的方法
公开(公告)号：US20150044681A1
公开(公告)日：2015-02-12
申请号：US14467594
申请日：2014-08-25
申请人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
发明人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A01K29/00 , C12Q1/6876 , C12Q1/6881 , C12Q2600/124 , C12Q2600/156 , G01N33/6872 , G01N33/6875 , G01N2333/4703
摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.
摘要翻译：本发明提供了一种用于预测马中运动模式的方法，其中包括马匹使用不同步态的能力和快速跑步的能力。所述方法包括在样品中确定从马获得的DNA是否存在至少一种遗传标记，其中所述至少一种遗传标记位于马染色体23上，所述标记与使用不同步态的能力相关联。本发明还提供了扩增与使用不同步态和杂交探针的能力相关联的标记的引物，以检测与使用不同步态的能力相关联的标记和以快速速度跑步的能力。

6. 发明申请

US20140057253A1 METHOD TO PREDICT THE PATTERN OF LOCOMOTION IN HORSES 审中-公开
标题翻译：预测马氏体位置图的方法
公开(公告)号：US20140057253A1
公开(公告)日：2014-02-27
申请号：US13696128
申请日：2012-05-04
申请人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
发明人： Lisa S. Andersson , Leif Andersson , Gabriella Lindgren
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A01K29/00 , C12Q1/6876 , C12Q1/6881 , C12Q2600/124 , C12Q2600/156 , G01N33/6872 , G01N33/6875 , G01N2333/4703
摘要： The present invention provides methods for predicting the pattern of locomotion in a horse including the ability of a horse to use different gaits and the ability to trot at a fast speed. The methods comprise determining in a sample of DNA obtained from a horse the presence or absence of at least one genetic marker, wherein said at least one genetic marker is located on horse chromosome 23, said marker being associated with the ability to use different gaits. The invention further provides primers that amplify markers being associated with the ability to use different gaits and hybridization probes to detect markers being associated with the ability to use different gaits and the ability to trot at a fast speed.
摘要翻译：本发明提供了一种用于预测马中运动模式的方法，其中包括马匹使用不同步态的能力和快速跑步的能力。所述方法包括在样品中确定从马获得的DNA是否存在至少一种遗传标记，其中所述至少一种遗传标记位于马染色体23上，所述标记与使用不同步态的能力相关联。本发明还提供了扩增与使用不同步态和杂交探针的能力相关联的标记的引物，以检测与使用不同步态的能力相关联的标记和以快速速度跑步的能力。

7. 发明授权

US08278043B2 Methods and materials related to grey alleles 有权
标题翻译：与灰色等位基因相关的方法和材料
公开(公告)号：US08278043B2
公开(公告)日：2012-10-02
申请号：US12663138
申请日：2008-06-05
申请人： Leif Andersson , Gerli Rosengren Pielberg , Anna Olegovna Golovko , Kjell Robert Johan Lennartsson , Carl-Henrik Heldin
发明人： Leif Andersson , Gerli Rosengren Pielberg , Anna Olegovna Golovko , Kjell Robert Johan Lennartsson , Carl-Henrik Heldin
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6886 , C12Q2600/124 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： This document relates to methods and materials for determining whether or not a horse contains a Grey allele. For example, diagnostic methods such as nucleic acid-based detection methods and materials such as nucleic acid probes and primer pairs that can be used to determine whether or not a horse contains a duplication in intron 6 of STX17 nucleic acid are provided. This document also relates to methods and materials for treating a mammal having or being likely to develop cancer (e.g., benign, malignant, or metastatic cancer). For example, methods and materials for treating cancer in a mammal by administering an agent having the ability to reduce expression of an STX17 polypeptide and/or an NR4A polypeptide (e.g., an NR4A1, NR4A2, or NR4A3 polypeptide) in the mammal are provided.
摘要翻译：本文件涉及用于确定马是否包含Gray等位基因的方法和材料。例如，提供诊断方法，例如基于核酸的检测方法和诸如核酸探针和引物对的材料，其可用于确定马是否含有STX17核酸的内含子6中的重复。本文件还涉及用于治疗具有或可能发展为癌症（例如良性，恶性或转移性癌症）的哺乳动物的方法和材料。例如，提供了通过在哺乳动物中施用具有降低STX17多肽和/或NR4A多肽（例如NR4A1，NR4A2或NR4A3多肽）的表达能力的药剂来治疗哺乳动物癌症的方法和材料。

8. 发明授权

US07732137B2 Selecting animals for desired genotypic or potential phenotypic properties 有权
标题翻译：选择动物以获得所需的基因型或潜在的表型性质
公开(公告)号：US07732137B2
公开(公告)日：2010-06-08
申请号：US11357718
申请日：2006-02-17
申请人： Leif Andersson , Goran Andersson , Michel Georges , Nadine Buys
发明人： Leif Andersson , Goran Andersson , Michel Georges , Nadine Buys
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/124 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention relates to methods to select animals, such as mammals, particularly domestic animals, such as breeding animals or animals destined for slaughter, for having desired genotypic or potential phenotypic properties, in particular, related to muscle mass and/or fat deposition lean meat, lean back fat, sow prolificacy and/or sow longevity. Provided is a method for selecting an animal for having desired genotypic or potential phenotypic properties comprising testing the animal, a parent of the animal or its progeny for the presence of a nucleic acid modification affecting the activity of an evolutionary conserved CpG island, located in intron 3 of an IGF2 gene and/or for the presence of a nucleic acid modification affecting binding of a nuclear factor to an IGF2 gene.
摘要翻译：本发明涉及选择动物的方法，例如哺乳动物，特别是家畜，如驯化的屠宰动物或动物，具有所需的基因型或潜在的表型性质，特别是涉及肌肉质量和/或脂肪沉积瘦肉，瘦背脂，母猪繁殖和/或播种寿命。提供了选择具有所需基因型或潜在表型性质的动物的方法，包括测试动物，动物的亲本或其后代以存在影响位于内含子中的进化性保守CpG岛的活性的核酸修饰 3的IGF2基因和/或影响核因子与IGF2基因结合的核酸修饰的存在。

9. 发明申请

US20060275763A1 Porcine polymorphisms and methods for detecting them 有权
标题翻译：猪多态性及其检测方法
公开(公告)号：US20060275763A1
公开(公告)日：2006-12-07
申请号：US10536184
申请日：2003-11-25
申请人： Claus Jorgensen , Susanna Cirera , Alan Archibald , Leif Andersson , Merete Fredholm , Inger Edfors-Lilia
发明人： Claus Jorgensen , Susanna Cirera , Alan Archibald , Leif Andersson , Merete Fredholm , Inger Edfors-Lilia
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , A01K2227/108 , C12Q1/6888 , C12Q2600/156 , C12Q2600/172
摘要： Identification of a pig as resistant or non-resistant to enterotoxigenic E. Coli (EIEC). Particularly, there is provided methods, probes and DNA molecules involved in identifying a pig as resistant or non-resistant to ETEC. There is also provided methods for breeding pigs using the information of resistance/non-resistance, mixed boar semen, and methods for developing drugs to compensate for non-resistance to ETEC.
摘要翻译：鉴定猪为抗性或不耐肠毒素大肠杆菌（EIEC）。特别地，提供了鉴定猪对ETEC具有抗性或不耐性的方法，探针和DNA分子。还提供了使用抗性/非抗性信息，混合公猪精液育种猪的方法，以及开发药物以补偿对ETEC的不耐受性的方法。

10. 发明授权

US06183955B2 Methods for determining the coat color genotype of a pig 失效
标题翻译：确定猪的外套颜色基因型的方法
公开(公告)号：US06183955B2
公开(公告)日：2001-02-06
申请号：US09014241
申请日：1998-01-27
申请人： Leif Andersson , Maria Johansson Moller , Richard Wales , Kenneth William Siggens , Graham Stuart Plastow
发明人： Leif Andersson , Maria Johansson Moller , Richard Wales , Kenneth William Siggens , Graham Stuart Plastow
IPC分类号： C12Q168
CPC分类号： C12Q1/6876 , C12Q1/6827 , C12Q2600/124 , C12Q2600/156 , C12Q2600/16 , Y10S435/81
摘要： Coat color is important to the pig breeding industry for a number of reasons. It is therefore desirable to develop populations of pigs which will breed true for coat color. However, establishing such populations would be time-consuming and costly using traditional test mating programs. It is therefore desirable to determine the coat color genotype of individual pigs. The inventors have shown that the KIT gene in pigs is involved with coat color determination. Specifically, the inventors have discovered that the difference between the I, IP, and i alleles of the coat color determining gene is duplication of at least part of the KIT gene in the I and IP alleles. Further, the inventors have discovered that the difference between the I and IP alleles is that, although both I and IP have a duplication in the KIT gene, only I and not IP exhibits a deletion in one of the duplicated regions. These discoveries have allowed the inventors to develop methods for distinguishing between the alleles I, IP, and i, thereby determining the genotype of individual pigs with respect to coat color. In accordance with the present invention, there are provided methods for determining the genotype of individual pigs with respect to coat color and kits for use in carrying out such methods.
摘要翻译：由于种种原因，大衣颜色对养猪业很重要。因此，需要开发出将种植真皮用于外套颜色的猪群。然而，使用传统的测试交配程序，建立这样的人口将是耗时和昂贵的。因此，需要确定个体猪的外套颜色基因型。发明人已经表明，猪中的KIT基因涉及外壳颜色测定。具体地，本发明人已经发现，外层颜色确定基因的I，IP和i等位基因之间的差异是I和IP等位基因中至少部分KIT基因的重复。此外，发明人已经发现，I和IP等位基因之间的区别在于，虽然I和IP在KIT基因中都有重复，但只有I而不是IP在其中一个复制区域中表现出缺失。这些发现允许发明人开发区分等位基因I，IP和i的方法，由此确定单个猪相对于衣服颜色的基因型。根据本发明，提供了确定各种猪相对于外套颜色的基因型的方法和用于实施这些方法的试剂盒。

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