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1. 发明授权

US06972510B2 Array of ultrasound transducers 有权
标题翻译：超声换能器阵列
公开(公告)号：US06972510B2
公开(公告)日：2005-12-06
申请号：US10306599
申请日：2002-11-27
申请人： Mareike Klee , Tilman Schlenker , Olaf Dannappel , Hans-Peter Loebl , Georg Schmitz , John Fraser
发明人： Mareike Klee , Tilman Schlenker , Olaf Dannappel , Hans-Peter Loebl , Georg Schmitz , John Fraser
IPC分类号： H04R17/00 , B06B1/06 , H01L41/08 , H01L41/09 , H01L41/187 , H01L41/22 , H02N2/00
CPC分类号： B06B1/0622 , H01L41/0973 , H01L41/1875 , H01L41/1876 , H01L41/319
摘要： The invention relates to an array of ultrasound transducers which each comprise a substrate (1), a membrane (2), a first electrode (4), a piezoelectric layer (5), and a second electrode (6), wherein the substrate (1) comprises at least one opening (3) which adjoins the membrane (2) at one side, while the piezoelectric layer (5) has a high piezoelectric coupling coefficient k and is textured. The invention further relates to an ultrasound transducer and to a method of manufacturing an array of ultrasound transducers.
摘要翻译：本发明涉及一种超声波换能器阵列，每个超声换能器包括基底（1），膜（2），第一电极（4），压电层（5）和第二电极（6） 1）包括在一侧与膜（2）相邻的至少一个开口（3），而压电层（5）具有高压电耦合系数k并具有纹理。本发明还涉及超声换能器和制造超声换能器阵列的方法。

2. 发明授权

US06515402B2 Array of ultrasound transducers 有权
公开(公告)号：US06515402B2
公开(公告)日：2003-02-04
申请号：US09768564
申请日：2001-01-24
申请人： Mareike Klee , Tilman Schlenker , Olaf Dannappel , Hans-Peter Loebl , Georg Schmitz , John Fraser
发明人： Mareike Klee , Tilman Schlenker , Olaf Dannappel , Hans-Peter Loebl , Georg Schmitz , John Fraser
IPC分类号： H01L4108
CPC分类号： B06B1/0622 , H01L41/0973 , H01L41/1875 , H01L41/1876 , H01L41/319
摘要： The invention relates to an array of ultrasound transducers which each comprise a substrate (1), a membrane (2), a first electrode (4), a piezoelectric layer (5), and a second electrode (6), wherein the substrate (1) comprises at least one opening (3) which adjoins the membrane (2) at one side, while the piezoelectric layer (5) has a high piezoelectric coupling coefficient k and is textured. The invention further relates to an ultrasound transducer and to a method of manufacturing an array of ultrasound transducers.

3. 发明申请

US20080249409A1 Method of Using a Combination Imaging and Therapy transducer to Dissolve Blood Clots 有权
标题翻译：使用组合成像和治疗传感器溶解血液凝块的方法
公开(公告)号：US20080249409A1
公开(公告)日：2008-10-09
申请号：US12065343
申请日：2006-08-25
申请人： John Fraser , Jeffry E. Powers , Michalakis Averkiou
发明人： John Fraser , Jeffry E. Powers , Michalakis Averkiou
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/0833 , A61B8/14 , A61B8/4405 , A61B8/481 , A61B2017/22008 , A61B2090/378 , A61N2007/0078
摘要： A combined ultrasound imaging and therapy transducer includes a linear array of imaging transducer elements. First and second linear arrays of therapy transducer elements extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.
摘要翻译：组合的超声成像和治疗换能器包括成像换能器元件的线性阵列。治疗换能器元件的第一和第二线性阵列沿着成像换能器元件的相应第一和第二侧纵向延伸并且向内朝向彼此倾斜。成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中的微泡再灌注，或继续存在的凝块。

4. 发明申请

US20070036768A1 Systems and methods for treating patients with processed lipoaspirate cells 有权
标题翻译：用于治疗患有脂溢性胃炎细胞的患者的系统和方法
公开(公告)号：US20070036768A1
公开(公告)日：2007-02-15
申请号：US11584202
申请日：2006-10-20
申请人： John Fraser , Marc Hedrick
发明人： John Fraser , Marc Hedrick
IPC分类号： A61K35/12 , C12N5/08 , C12M3/00
CPC分类号： A61K35/28 , A61B10/0283 , A61K9/0019 , A61K35/35 , A61M1/0039 , A61M2202/08 , C12M47/04 , C12N5/0667 , C12N5/069 , C12N2506/1384 , G06F19/00
摘要： Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.
摘要翻译：存在于加工的lipoaspirate组织中的细胞用于治疗患者。治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。施用于患者的组合物包括脂肪组织和干细胞的混合物，使得组合物具有比从患者中除去脂肪组织时更高浓度的干细胞。

5. 发明申请

US20050095228A1 Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders 审中-公开
标题翻译：使用再生细胞治疗外周血管疾病和相关疾病的方法
公开(公告)号：US20050095228A1
公开(公告)日：2005-05-05
申请号：US10884871
申请日：2004-07-01
申请人： John Fraser , Marc Hedrick , Eric Daniels
发明人： John Fraser , Marc Hedrick , Eric Daniels
IPC分类号： A61K35/28 , A61K35/44 , A61K45/00
CPC分类号： A61K35/28 , A61K9/0019 , A61K35/44 , A61K45/06 , A61L27/3834 , A61L27/3886 , A61L2300/64 , A61L2430/00 , A61L2430/36 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译：存在于脂肪组织中的细胞用于治疗患者，包括患有PVD和相关疾病或病症的患者。治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。

6. 发明申请

US20050025755A1 Methods of using adipose tissue-derived cells in augmenting autologous fat transfer 有权
标题翻译：使用脂肪组织来源的细胞增强自体脂肪转移的方法
公开(公告)号：US20050025755A1
公开(公告)日：2005-02-03
申请号：US10871503
申请日：2004-06-18
申请人： Marc Hedrick , John Fraser
发明人： Marc Hedrick , John Fraser
IPC分类号： A61K35/12 , A61K35/28 , A61K35/36 , A61K35/44 , C12N5/08 , A61K48/00
CPC分类号： A61K35/44 , A61K35/28 , A61L27/3604 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2430/34 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Methods of treating patients for conditions such as breast augmentation, soft tissue defects, and urinary incontinence, are described. The methods include removing adipose tissue from a patient, processing a portion of the adipose tissue to obtain a substantially isolated population of regenerative cells, mixing the regenerative cells with another portion of adipose tissue to form a composition, and administering the composition to the patient from which the adipose tissue was removed.
摘要翻译：描述了治疗患者的症状如隆胸，软组织缺损和尿失禁的方法。所述方法包括从患者中去除脂肪组织，处理脂肪组织的一部分以获得基本上分离的再生细胞群体，将再生细胞与脂肪组织的另一部分混合以形成组合物，并将组合物施用于患者去除脂肪组织。

7. 发明授权

US08461978B2 Wireless ultrasound probe asset tracking 有权
标题翻译：无线超声探头资产跟踪
公开(公告)号：US08461978B2
公开(公告)日：2013-06-11
申请号：US12600895
申请日：2008-05-21
申请人： David Garner , Kevin Appareti , McKee Poland , David Rust , Denise Marie Haley , Martha Wilson , Anthony Gades , Christopher Fleming , Dino Cuscuna , John Fraser
发明人： David Garner , Kevin Appareti , McKee Poland , David Rust , Denise Marie Haley , Martha Wilson , Anthony Gades , Christopher Fleming , Dino Cuscuna , John Fraser
IPC分类号： G08B1/08
CPC分类号： A61B8/00 , A61B8/4405 , A61B8/4427 , A61B8/4438 , A61B8/4472 , A61B8/565 , A61B2560/0209 , G01S7/003 , G01S7/5208 , G01S15/899
摘要： A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds as a function of the range between the wireless probe and a host system. When the probe is within a near field range of the host system, the loudspeaker is silent. But if the probe is moved to an intermediate or a far field range from the host system, the loudspeaker sounds an alert. This audible alert can be used to locate the probe by transmitting a paging signal which, upon reception by the probe, causes the probe to sound its alert. If the probe is moved to an unauthorized location where it is within range of a transmitter or receiver, the reception of a signal by the probe, the transmitter, or receiver will sound an alert signaling the unauthorized presence of the wireless probe.
摘要翻译：无线超声探头具有包围换能器阵列的探针壳，采集电路，收发器和电池。该探头还包括扬声器，其产生作为无线探头和主机系统之间的范围的函数的可听见的声音。当探头位于主机系统的近场范围内时，扬声器静音。但如果探头从主机系统移动到中间或远场范围，则扬声器会发出警报。该可听警报可以用于通过发送寻呼信号来定位探测器，该寻呼信号在探测器接收时使探测器发出警报。如果探头移动到位于发射机或接收机范围内的未授权位置，则由探测器，发射机或接收机接收信号将发出警报，指示无线探测器的未经授权的存在。

8. 发明申请

US20120184854A1 ULTRASONIC VASCULAR FLOW SENSOR WITH TRIANGULAR SENSOR GEOMETRY 审中-公开
标题翻译：超声波流量传感器，具有三角形传感器几何
公开(公告)号：US20120184854A1
公开(公告)日：2012-07-19
申请号：US13203065
申请日：2010-02-10
申请人： Balasundara Raju , Eric Cohen-Solal , Ramon Erkamp , John Fraser
发明人： Balasundara Raju , Eric Cohen-Solal , Ramon Erkamp , John Fraser
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B8/4236 , A61B8/4483 , A61B8/4494 , B06B1/0629
摘要： An ultrasonic blood flow sensor includes a plurality of adjacent triangular shaped transducer elements which transmit ultrasound waves into a blood vessel and receive reflected ultrasound waves from the blood flow in the vessel. Preferably the transducer elements are paired in pairs of transmit and receive elements. The elements are fixed in a matrix which may be attached in acoustic coupling contact with the skin The matrix retains adjacent transducer elements slightly spaced apart so that the matrix of transducer elements may bend and conform to the shape of the skin surface. The spacing between the triangular elements is neither parallel nor orthogonal to the length dimension of the matrix so that a blood vessel will not be aligned with a space between transducer elements when the matrix is affixed across the location of a blood vessel. In addition the geometry of the elements creates a beam pattern that provide more overlap between transmit and receive beam profiles, thereby increasing the area of sensor coverage.
摘要翻译：超声波血流传感器包括多个相邻的三角形换能器元件，其将超声波传输到血管中并从血管中的血流接收反射的超声波。优选地，换能器元件成对地配对成对的发射和接收元件。这些元件被固定在可以与皮肤的声学耦合接触附接的矩阵中。矩阵保持相邻的换能器元件稍微间隔开，使得换能器元件的矩阵可以弯曲并符合皮肤表面的形状。三角形元件之间的间距既不平行也不垂直于矩阵的长度尺寸，使得当基体固定在血管的位置时，血管将不会与换能器元件之间的空间对齐。此外，元件的几何形状产生了在发射和接收波束轮廓之间提供更多重叠的波束图案，从而增加了传感器覆盖面积。

9. 发明申请

US20100277305A1 Wireless Ultrasound Probe Asset Tracking 有权
标题翻译：无线超声探头资产跟踪
公开(公告)号：US20100277305A1
公开(公告)日：2010-11-04
申请号：US12600895
申请日：2008-05-21
申请人： David Garner , Kevin Appareti , McKee Poland , David Rust , Denise Haley , Martha Wilson , Anthony Gades , Christopher Fleming , Dino Cuscuna , John Fraser
发明人： David Garner , Kevin Appareti , McKee Poland , David Rust , Denise Haley , Martha Wilson , Anthony Gades , Christopher Fleming , Dino Cuscuna , John Fraser
IPC分类号： G08B1/08
CPC分类号： A61B8/00 , A61B8/4405 , A61B8/4427 , A61B8/4438 , A61B8/4472 , A61B8/565 , A61B2560/0209 , G01S7/003 , G01S7/5208 , G01S15/899
摘要： A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds as a function of the range between the wireless probe and a host system. When the probe is within a near field range of the host system, the loudspeaker is silent. But if the probe is moved to an intermediate or a far field range from the host system, the loudspeaker sounds an alert. This audible alert can be used to locate the probe by transmitting a paging signal which, upon reception by the probe, causes the probe to sound its alert. If the probe is moved to an unauthorized location where it is within range of a transmitter or receiver, the reception of a signal by the probe, the transmitter, or receiver will sound an alert signaling the unauthorized presence of the wireless probe.
摘要翻译：无线超声探头具有包围换能器阵列的探针壳，采集电路，收发器和电池。该探头还包括扬声器，其产生作为无线探头和主机系统之间的范围的函数的可听见的声音。当探头位于主机系统的近场范围内时，扬声器静音。但如果探头从主机系统移动到中间或远场范围，则扬声器会发出警报。该可听警报可以用于通过发送寻呼信号来定位探测器，该寻呼信号在探测器接收时使探测器发出警报。如果探头移动到位于发射机或接收机范围内的未授权位置，则由探测器，发射机或接收机接收信号将发出警报，指示无线探测器的未经授权的存在。

10. 发明申请

US20100160784A1 Wireless Ultrasound Probe With Audible Indicator 审中-公开
标题翻译：无线超声波探头与声音指示器
公开(公告)号：US20100160784A1
公开(公告)日：2010-06-24
申请号：US12600875
申请日：2008-05-21
申请人： McKee Poland , Dino Cuscuna , Martha Wilson , David Garner , Anthony Gades , Denise Haley , David Rust , John Fraser , Robert Mesaros
发明人： McKee Poland , Dino Cuscuna , Martha Wilson , David Garner , Anthony Gades , Denise Haley , David Rust , John Fraser , Robert Mesaros
IPC分类号： A61B8/14 , A61B8/00
CPC分类号： A61B8/00 , A61B8/4427 , A61B8/4433 , A61B8/4444 , A61B8/4472 , A61B8/565 , G01S7/52079 , G01S7/5208 , G01S15/899
摘要： A wireless ultrasound probe has a probe case enclosing a transducer array, an acquisition circuit, a transceiver and a battery. The probe also includes a loudspeaker which produces audible sounds during use of the probe. The loudspeaker, which may be a piezoelectric loudspeaker, issues an alert when battery power is low or signal strength of the wireless transmission is poor or nonexistent. The loudspeaker can provide user feedback to the actuation of a button or control on the probe. The loudspeaker can provide haptic feedback during use of the probe, and can be used to produce audio Doppler tones or heart sounds during probe use.
摘要翻译：无线超声探头具有包围换能器阵列的探针壳，采集电路，收发器和电池。探头还包括一个扬声器，在探头使用期间产生可听见的声音。可能是压电扬声器的扬声器在电池电量低或无线传输的信号强度差或不存在时发出警报。扬声器可以向使用者提供反馈，以激发探头上的按钮或控制。扬声器可以在使用探头期间提供触觉反馈，并可用于在探头使用期间产生音频多普勒音或心音。

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