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1. 发明授权

US08788047B2 Systems and methods for the treatment of pain through neural fiber stimulation 有权
标题翻译：通过神经纤维刺激治疗疼痛的系统和方法
公开(公告)号：US08788047B2
公开(公告)日：2014-07-22
申请号：US13309107
申请日：2011-12-01
申请人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021 , A61N1/36057
摘要： Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.
摘要翻译：本发明的实施方案提供了通过激活选择性神经纤维来治疗疼痛的系统和方法。神经纤维可以包含一个或多个传入神经纤维和/或一个或多个传出神经纤维。如果传入纤维被单独或与传出纤维组合刺激，则施用治疗有效量的电刺激以以接近自然传入活性的方式激活传入途径。传入纤维可能与肌肉锭，高尔基体腱器官，肌肉锭子的次要受体，关节受体，触觉受体和其他类型的机械感受器和/或本体感受器的主要受体相关联。如果传出纤维被单独或与传入纤维组合刺激，则施加治疗有效量的电刺激以激活内部和/或外部肌肉纤维，这导致与其相关联的传入纤维的间接活化。

2. 发明授权

US08788048B2 Systems and methods for the treatment of pain through neural fiber stimulation 有权
公开(公告)号：US08788048B2
公开(公告)日：2014-07-22
申请号：US13309152
申请日：2011-12-01
申请人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/36003 , A61N1/36017 , A61N1/36021 , A61N1/36057 , A61N1/36139
摘要： Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

3. 发明申请

US20120310302A1 SYSTEMS AND METHODS FOR THE TREATMENT OF PAIN THROUGH NEURAL FIBER STIMULATION 有权
公开(公告)号：US20120310302A1
公开(公告)日：2012-12-06
申请号：US13309152
申请日：2011-12-01
申请人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/36071 , A61N1/36003 , A61N1/36017 , A61N1/36021 , A61N1/36057 , A61N1/36139
摘要： Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

4. 发明授权

US08788046B2 Systems and methods for the treatment of pain through neural fiber stimulation 有权
公开(公告)号：US08788046B2
公开(公告)日：2014-07-22
申请号：US13309024
申请日：2011-12-01
申请人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/36003 , A61N1/36017 , A61N1/36021 , A61N1/36057
摘要： Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

5. 发明申请

US20140046416A1 SYSTEM AND METHOD FOR TREATING SHOULDER PAIN RELATED TO SUBACROMIAL IMPINGEMENT SYNDROME 有权
标题翻译：用于治疗与亚型侵袭综合症相关的肩痛疼痛的系统和方法
公开(公告)号：US20140046416A1
公开(公告)日：2014-02-13
申请号：US13991033
申请日：2011-12-05
申请人： Maria E. Bennett , Joseph W. Boggs, II , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , John Chae
IPC分类号： A61N1/05
CPC分类号： A61N1/0504 , A61N1/025 , A61N1/0456 , A61N1/0502 , A61N1/0551 , A61N1/08 , A61N1/36071
摘要： Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and/or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.
摘要翻译：提供的系统和方法用于治疗二次发生在人体内的肩峰下冲击综合征的慢性疼痛。提供一种系统，用于通过至少一个电极将经皮电刺激递送到后三和三分之一肌肉的神经运动点，以调解这种疼痛。根据本发明的治疗方法的一次性，持续和/或定期给药可能导致中枢神经系统适应不良的神经可塑性的变化。

6. 发明授权

US08886337B2 System and method for treating shoulder pain related to subacromial impingement syndrome 有权
标题翻译：治疗肩峰疼痛与肩峰下冲击综合征相关的系统和方法
公开(公告)号：US08886337B2
公开(公告)日：2014-11-11
申请号：US13991033
申请日：2011-12-05
申请人： Maria E. Bennett , Joseph W. Boggs, II , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , John Chae
IPC分类号： A61N1/00 , A61B18/04 , A61B18/18 , A61N1/36 , A61N1/04 , A61N1/05
CPC分类号： A61N1/0504 , A61N1/025 , A61N1/0456 , A61N1/0502 , A61N1/0551 , A61N1/08 , A61N1/36071
摘要： Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and/or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.
摘要翻译：提供的系统和方法用于治疗二次发生在人体内的肩峰下冲击综合征的慢性疼痛。提供一种系统，用于通过至少一个电极将经皮电刺激递送到后三和三分之一肌肉的神经运动点，以调解这种疼痛。根据本发明的治疗方法的一次性，持续和/或定期给药可能导致中枢神经系统适应不良的神经可塑性的变化。

7. 发明授权

US08626302B2 Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain 有权
标题翻译：将一个或多个引线放置在肌肉中以提供电刺激以治疗疼痛的系统和方法
公开(公告)号：US08626302B2
公开(公告)日：2014-01-07
申请号：US12462371
申请日：2009-08-03
申请人： Maria E. Bennett , Geoffrey B. Thrope , Joseph W. Boggs, II , Andreas Inmann , John Chae
发明人： Maria E. Bennett , Geoffrey B. Thrope , Joseph W. Boggs, II , Andreas Inmann , John Chae
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/36003 , A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： Systems and methods are adapted to provide the relief of pain. The systems and methods make possible the percutaneous placement of one or more intramuscular leads, without the need for fluoroscopy, for providing electrical stimulation to activate a motor point innervating the muscle, to provide the therapeutic relief of pain. The one or more intramuscular leads may be placed in muscle(s) to resist migration. The target nerves and their motor points innervate the muscles in which the one or more leads are placed. The systems and methods can include a two-stage solution. The first stage may include temporary systems and methods, including the use of an external pulse generator. The second stage may include more permanent systems and methods, including the use of an implanted pulse generator.
摘要翻译：系统和方法适应于缓解疼痛。系统和方法使得一个或多个肌内引线的经皮放置成为可能，而不需要荧光透视，用于提供电刺激以激活支配肌肉的运动点，以提供疼痛的治疗缓解。一个或多个肌内引线可以放置在肌肉中以抵抗迁移。目标神经及其运动点支配放置一根或多根引线的肌肉。系统和方法可以包括两阶段解决方案。第一阶段可以包括临时系统和方法，包括使用外部脉冲发生器。第二阶段可以包括更永久的系统和方法，包括使用植入式脉冲发生器。

8. 发明授权

US07047078B2 Methods for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于刺激阴部神经或其分支中，上或附近的组分以实现选择性生理反应的方法
公开(公告)号：US07047078B2
公开(公告)日：2006-05-16
申请号：US10662055
申请日：2003-09-12
申请人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
发明人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
IPC分类号： A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Systems and methods control physiological functions of the urinary tract using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve. The systems and methods apply an electrical signal to the electrode at a selected frequency to stimulate the targeted component. The selected frequency is a first frequency or range of frequencies for achieving a first physiologic response (e.g., controlling urinary continence) and a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).
摘要翻译：系统和方法使用至少一个电极来控制泌尿道的生理功能，所述至少一个电极的尺寸和构型设置成位于阴部神经的目标成分中，附近或其附近。系统和方法以选定的频率将电信号施加到电极以刺激目标成分。所选择的频率是用于实现与第一生理学不同的第一生理反应（例如，控制尿路）和频率不同于第一频率的第二频率或频率范围的第一频率或频率范围反应（例如控制排尿）。

9. 发明授权

US08396555B2 Apparatus for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于刺激阴部神经或其分支中，上或附近的组分以实现选择性生理反应的装置
公开(公告)号：US08396555B2
公开(公告)日：2013-03-12
申请号：US12490611
申请日：2009-06-24
申请人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
发明人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
IPC分类号： A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Apparatus to control physiological functions, including urinary track physiological functions are described. The apparatus includes an electrode(s) configured to be placed on or in a targeted component of a pudendal nerve and to stimulate the targeted pudendal nerve pudendal. The targeted component of the pudendal nerve includes a pudendal nerve urethral afferent, and afferent nerve fibers in the deep perineal nerve. The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude and a selected frequency chosen to stimulate the targeted component. The controller operates in a first mode to apply a first frequency without substantially changing the amplitude for achieving a first physiologic response and the controller operates in a second mode to apply a second frequency, different than the first frequency, for achieving a second physiologic response different than the first physiologic response.
摘要翻译：描述了用于控制生理功能的装置，包括尿道生理功能。该装置包括构造成放置在阴部神经的目标部件上或其中的电极，并刺激目标阴部神经阴部。阴部神经的目标成分包括阴部神经尿道传入和深会阴神经中的传入神经纤维。该装置包括耦合到电极的控制器，以施加具有选择的振幅和选定频率的电信号，以刺激目标成分。控制器以第一模式操作以施加第一频率而基本上不改变幅度以实现第一生理响应，并且控制器以第二模式操作以施加与第一频率不同的第二频率，以实现不同于第二频率的第二生理响应比第一次生理反应。

10. 发明授权

US07571000B2 Apparatus for stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于刺激阴部神经或其分支中，上或附近的组分以实现选择性生理反应的装置
公开(公告)号：US07571000B2
公开(公告)日：2009-08-04
申请号：US11402036
申请日：2006-04-11
申请人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
发明人： Joseph W. Boggs, II , Brian J. Wenzel , Kenneth J. Gustafson , Warren M. Grill
IPC分类号： A61N1/36
CPC分类号： A61N1/36196 , A61N1/36007 , A61N1/37247
摘要： Apparatus for control of physiological functions, including physiological functions of the urinary tract, using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve, and/or its branch(es), and/or its spinal root(s). The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude to the electrode at a selected frequency to stimulate the targeted component. The controller operates in a first mode to apply a first frequency or range of frequencies without substantially changing the amplitude for achieving a first physiologic response (e.g., controlling urinary continence) and the controller operates in a second mode to apply a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).
摘要翻译：用于控制生理功能的装置，包括尿道的生理功能，使用至少一个尺寸和构造为位于阴部神经和/或其分支的目标组分中，附近或附近的电极和/或其分支，以及 /或其脊髓根部。该装置包括耦合到该电极的控制器，以一选定频率将具有振幅的电信号施加到该电极上以刺激该目标部件。控制器以第一模式操作以施加第一频率或频率范围，而基本上不改变振幅以实现第一生理响应（例如，控制尿路），并且控制器以第二模式操作以施加第二频率或范围频率，不同于第一频率，用于实现与第一生理反应不同的第二生理反应（例如，控制排尿）。

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