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    • 6. 发明申请
    • METHOD AND SYSTEM FOR DETERMINING AN OPTIMAL DILUTION OF A REAGENT
    • 用于确定试剂的最佳稀释度的方法和系统
    • US20090074266A1
    • 2009-03-19
    • US12188133
    • 2008-08-07
    • Robert PinardGregory R. TedeschiMark Gustavson
    • Robert PinardGregory R. TedeschiMark Gustavson
    • G06K9/00
    • G01N33/53
    • A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay.
    • 提供了用于自动和定量地确定试剂的最佳稀释度的系统和方法。 在所要求保护的方法的一个实施方案中,接收多个稀释组,其中每个稀释组由不同的相应稀释值和相应的多个免疫测定染色强度值组成。 相应的动态范围度量是相对于相应的多个免疫测定染色强度值确定多个稀释组中的每一个。 已经找到相应的动态范围度量,选择具有数值最优动态范围度量的稀释组,并且选择该稀释组的稀释值代表用于定量免疫测定的试剂的最佳稀释水平。 在一个实施例中,提供了具有显微镜,图像传感器和配置的处理器模块的系统,以确定用于定量免疫测定中的试剂的最佳稀释度。
    • 7. 发明授权
    • Automatic exposure time selection for imaging tissue
    • 成像组织的自动曝光时间选择
    • US08878983B2
    • 2014-11-04
    • US13117789
    • 2011-05-27
    • Jason ChristiansenDylan M. ReillyBrian Bourke-MartinMark Gustavson
    • Jason ChristiansenDylan M. ReillyBrian Bourke-MartinMark Gustavson
    • H04N5/238H04N5/235
    • H04N5/2353
    • The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.
    • 本发明涉及一种用于自动调节曝光时间以改善或以其它方式优化数字图像的动态范围的系统。 该系统包括被配置为在第一曝光时间内在视野内拍摄被摄体的图像的照相机。 拍摄的图像由多个像素组成,每个像素具有相应的强度值。 该系统还包括配置为控制相机的曝光时间的快门或适当的控制。 一种控制器,被配置为执行以下步骤,包括:(a)查询像素强度值的频率分布; (b)确定这种分布或直方图的有效“质心”以确定经调整的曝光时间; 和(c)在经调整的曝光时间捕获被摄体的第二图像,从而获得具有改善或最佳动态范围的图像。
    • 9. 发明授权
    • Method and system for determining an optimal dilution of a reagent
    • 用于确定试剂的最佳稀释度的方法和系统
    • US08605971B2
    • 2013-12-10
    • US13366081
    • 2012-02-03
    • Robert PinardGregory R. TedeschiMark Gustavson
    • Robert PinardGregory R. TedeschiMark Gustavson
    • G06K9/00
    • G01N33/53
    • A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay.
    • 提供了用于自动和定量地确定试剂的最佳稀释度的系统和方法。 在一个实施方案中,接收多个稀释组,其中每个稀释组由不同的相应稀释值和相应的多个免疫测定染色强度值组成。 相应的动态范围度量是相对于相应的多个免疫测定染色强度值确定多个稀释组中的每一个。 已经找到相应的动态范围度量,选择具有数值最优动态范围度量的稀释组,并且选择该稀释组的稀释值代表用于定量免疫测定的试剂的最佳稀释水平。 在一个实施例中,提供了具有显微镜,图像传感器和配置的处理器模块的系统,以确定用于定量免疫测定中的试剂的最佳稀释度。
    • 10. 发明申请
    • AUTOMATIC EXPOSURE TIME SELECTION FOR IMAGING TISSUE
    • 自动曝光时间选择用于成像组织
    • US20110228993A1
    • 2011-09-22
    • US13117789
    • 2011-05-27
    • Dylan M. ReillyBrian Bourke-MartinMark GustavsonJason Christiansen
    • Dylan M. ReillyBrian Bourke-MartinMark GustavsonJason Christiansen
    • G06K9/00
    • H04N5/2353
    • The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.
    • 本发明涉及一种用于自动调节曝光时间以改善或以其它方式优化数字图像的动态范围的系统。 该系统包括被配置为在第一曝光时间内在视野内拍摄被摄体的图像的照相机。 拍摄的图像由多个像素组成,每个像素具有相应的强度值。 该系统还包括配置为控制相机的曝光时间的快门或适当的控制。 一种控制器,被配置为执行以下步骤,包括:(a)查询像素强度值的频率分布; (b)确定这种分布或直方图的有效“质心”以确定经调整的曝光时间; 和(c)在经调整的曝光时间捕获被摄体的第二图像,从而获得具有改善或最佳动态范围的图像。