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1. 发明授权

US08494643B2 Systems and methods for implantable leadless nerve stimulation 有权
标题翻译：用于植入式无引导神经刺激的系统和方法
公开(公告)号：US08494643B2
公开(公告)日：2013-07-23
申请号：US13008433
申请日：2011-01-18
申请人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/08
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/37217
摘要： Systems and methods are disclosed to stimulate nerves to treat medical conditions such as pain, and other conditions, such as, CHF, obesity, incontinence, etc., that could be controlled by the stimulation of the vagal nerves. The invention uses electrical stimulation of the nerve, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined nerve site. The vibrational energy is generated by a controller-transmitter, which could be implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located in the various regions on or around the nerve that needs to be stimulated. The implantable receiver-stimulator stimulates different nerves and regions of a nerve to provide therapeutic benefit.
摘要翻译：公开了系统和方法以刺激神经来治疗可以通过迷走神经的刺激来控制的医学状况，例如疼痛和其它病症，例如CHF，肥胖症，失禁等。本发明使用神经的电刺激，其中来自源的振动能量被植入的装置接收并转换成电能，并且转换的电能被植入的电极用于刺激预定的神经部位。振动能量由控制器 - 发射器产生，其可被植入或位于外部。接收器刺激器接收振动能，其可以位于需要被刺激的神经上或周围的各个区域中。可植入接收器刺激器刺激神经的不同神经和区域以提供治疗益处。

2. 发明申请

US20110166621A1 SYSTEMS AND METHODS FOR IMPLANTABLE LEADLESS SPINE STIMULATION 有权
标题翻译：可植入无脊椎刺激的系统与方法
公开(公告)号：US20110166621A1
公开(公告)日：2011-07-07
申请号：US13007419
申请日：2011-01-14
申请人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/36
CPC分类号： A61N1/37217 , A61N1/36071 , A61N1/37288 , A61N1/3756
摘要： Systems and methods are disclosed to stimulate spine tissue to treat medical conditions such as pain and spinal injury. The invention uses electrical stimulation of the spine, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined brain site. The vibrational energy is generated by a controller-transmitter, which could be located either externally or implanted. The vibrational energy is received by a receiver-stimulator, which could be located in the various regions on around the spine. The implantable receiver-stimulator stimulates different locations in the spine region to provide therapeutic benefit.
摘要翻译：公开了系统和方法来刺激脊柱组织来治疗诸如疼痛和脊柱损伤的医学病症。本发明使用脊柱的电刺激，其中来自源的振动能量被植入装置接收并转换成电能，并且所转换的电能被植入电极用于刺激预定的脑部位。振动能量由控制器 - 发射器产生，其可以位于外部或植入。振动能量由接收器刺激器接收，其可以位于脊柱周围的各个区域中。可植入接收器刺激器刺激脊柱区域中的不同位置以提供治疗益处。

3. 发明申请

US20110118810A1 SYSTEMS AND METHODS FOR IMPLANTABLE LEADLESS NERVE STIMULATION 有权
标题翻译：无侵袭性神经刺激的系统和方法
公开(公告)号：US20110118810A1
公开(公告)日：2011-05-19
申请号：US13008433
申请日：2011-01-18
申请人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/08
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/37217
摘要： Systems and methods are disclosed to stimulate nerves to treat medical conditions such as pain, and other conditions, such as, CHF, obesity, incontinence, etc., that could be controlled by the stimulation of the vagal nerves. The invention uses electrical stimulation of the nerve, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined nerve site. The vibrational energy is generated by a controller-transmitter, which could be implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located in the various regions on or around the nerve that needs to be stimulated. The implantable receiver-stimulator stimulates different nerves and regions of a nerve to provide therapeutic benefit.
摘要翻译：公开了系统和方法以刺激神经来治疗可以通过迷走神经的刺激来控制的医学状况，例如疼痛和其它病症，例如CHF，肥胖症，失禁等。本发明使用神经的电刺激，其中来自源的振动能量被植入的装置接收并转换成电能，并且转换的电能被植入的电极用于刺激预定的神经部位。振动能量由控制器 - 发射器产生，其可被植入或位于外部。接收器刺激器接收振动能，其可以位于需要被刺激的神经上或周围的各个区域中。可植入接收器刺激器刺激神经的不同神经和区域以提供治疗益处。

4. 发明授权

US07894910B2 Systems and methods for implantable leadless cochlear stimulation 有权
标题翻译：用于植入式无引线耳蜗刺激的系统和方法
公开(公告)号：US07894910B2
公开(公告)日：2011-02-22
申请号：US11764611
申请日：2007-06-18
申请人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/36
CPC分类号： A61N1/36036 , A61N1/0541 , A61N1/37217 , A61N1/3756
摘要： Systems and methods are disclosed to enable hearing in the deaf by stimulating sites in the cochlea. The invention uses electrical stimulation in the cochlea, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the cochlear nerve. The vibrational energy is generated by a controller-transmitter, which could be located either externally or implanted. The vibrational energy is received by a receiver-stimulator, which contains multiple electrodes to stimulate along selected sites in the cochlea.
摘要翻译：公开了系统和方法，以通过刺激耳蜗中的部位来在聋人中进行听觉。本发明在耳蜗中使用电刺激，其中来自源的振动能量被注入的装置接收并转换成电能，并且转换的电能被注入的电极用于刺激耳蜗神经。振动能量由控制器 - 发射器产生，其可以位于外部或植入。接收器刺激器接收振动能量，该接收器刺激器包含多个电极以沿着耳蜗中的选定部位刺激。

5. 发明授权

US07894907B2 Systems and methods for implantable leadless nerve stimulation 有权
标题翻译：用于植入式无引导神经刺激的系统和方法
公开(公告)号：US07894907B2
公开(公告)日：2011-02-22
申请号：US11764592
申请日：2007-06-18
申请人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/08
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/37217
摘要： Systems and methods are disclosed to stimulate nerves to treat medical conditions such as pain, and other conditions, such as, CHF, obesity, incontinence, etc., that could be controlled by the stimulation of the vagal nerves. The invention uses electrical stimulation of the nerve, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined nerve site. The vibrational energy is generated by a controller-transmitter, which could be implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located in the various regions on or around the nerve that needs to be stimulated. The implantable receiver-stimulator stimulates different nerves and regions of a nerve to provide therapeutic benefit.
摘要翻译：公开了系统和方法以刺激神经来治疗可以通过迷走神经的刺激来控制的医学状况，例如疼痛和其它病症，例如CHF，肥胖症，失禁等。本发明使用神经的电刺激，其中来自源的振动能量被植入的装置接收并转换成电能，并且转换的电能被植入的电极用于刺激预定的神经部位。振动能量由控制器 - 发射器产生，其可被植入或位于外部。接收器刺激器接收振动能，其可以位于需要被刺激的神经上或周围的各个区域中。可植入接收器刺激器刺激神经的不同神经和区域以提供治疗益处。

6. 发明授权

US08494642B2 Systems and methods for implantable leadless spine stimulation 有权
标题翻译：用于植入式无铅脊柱刺激的系统和方法
公开(公告)号：US08494642B2
公开(公告)日：2013-07-23
申请号：US13007419
申请日：2011-01-14
申请人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/372
CPC分类号： A61N1/37217 , A61N1/36071 , A61N1/37288 , A61N1/3756
摘要： Systems and methods are disclosed to stimulate spine tissue to treat medical conditions such as pain and spinal injury. The invention uses electrical stimulation of the spine, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined brain site. The vibrational energy is generated by a controller-transmitter, which could be located either externally or implanted. The vibrational energy is received by a receiver-stimulator, which could be located in the various regions on around the spine. The implantable receiver-stimulator stimulates different locations in the spine region to provide therapeutic benefit.
摘要翻译：公开了系统和方法来刺激脊柱组织来治疗诸如疼痛和脊柱损伤的医学病症。本发明使用脊柱的电刺激，其中来自源的振动能量被植入装置接收并转换成电能，并且所转换的电能被植入电极用于刺激预定的脑部位。振动能量由控制器 - 发射器产生，其可以位于外部或植入。振动能量由接收器刺激器接收，其可以位于脊柱周围的各个区域中。可植入接收器刺激器刺激脊柱区域中的不同位置以提供治疗益处。

7. 发明授权

US07996087B2 Leadless tissue stimulation systems and methods 有权
标题翻译：无铅组织刺激系统和方法
公开(公告)号：US07996087B2
公开(公告)日：2011-08-09
申请号：US12554234
申请日：2009-09-04
申请人： Mark W. Cowan , Debra S. Echt , Richard E. Riley , Axel F. Brisken
发明人： Mark W. Cowan , Debra S. Echt , Richard E. Riley , Axel F. Brisken
IPC分类号： A61N1/372
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/37205 , A61N1/37217 , A61N1/3756 , A61N1/3787
摘要： Systems including an implantable receiver-stimulator and an implantable controller-transmitter are used for leadless electrical stimulation of body tissues. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external or implantable controller-transmitter. Systems are implanted by testing external or implantable devices at different tissue sites, observing physiologic and device responses, and selecting sites with preferred performance for implanting the systems. In these systems, a controller-transmitter is activated at a remote tissue location to transmit/deliver acoustic energy through the body to a receiver-stimulator at a target tissue location. The receiver-stimulator converts the acoustic energy to electrical energy for electrical stimulation of the body tissue. The tissue locations(s) can be optimized by moving either or both of the controller-transmitter and the receiver-stimulator to determine the best patient and device responses.
摘要翻译：包括可植入接收器刺激器和可植入控制器 - 发射器的系统用于身体组织的无引线电刺激。心脏起搏和心律失常控制由一个或多个可植入接收器刺激器和外部或可植入控制器发射器来实现。通过在不同组织部位测试外部或可植入装置，观察生理和装置反应以及选择具有植入系统的优选性能的部位植入系统。在这些系统中，控制器 - 发射器在远程组织位置处被激活，以将声能通过身体发射/传递到目标组织位置处的接收器 - 刺激器。接收器 - 刺激器将声能转换为电能以对身体组织进行电刺激。可以通过移动控制器 - 发射器和接收器 - 刺激器中的任一者或两者来确定最佳患者和设备响应来优化组织位置。

8. 发明申请

US20110112600A1 SYSTEMS AND METHODS FOR IMPLANTABLE LEADLESS GASTROINTESTINAL TISSUE STIMULATION 有权
标题翻译：无侵袭性胃肠道组织刺激的系统和方法
公开(公告)号：US20110112600A1
公开(公告)日：2011-05-12
申请号：US13008521
申请日：2011-01-18
申请人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
发明人： Mark W. Cowan , Richard E. Riley , Axel F. Brisken , Debra S. Echt
IPC分类号： A61N1/36
CPC分类号： A61N1/05 , A61N1/36007 , A61N1/37217
摘要： Systems and methods are disclosed to stimulate gastrointestinal tissue to treat medical conditions such as eating disorders, gastroparesis, and gastric reflux. The invention uses electrical stimulation of the nerve, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined gastrointestinal tissue site. The vibrational energy is generated by a controller-transmitter, which could be implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located in the various regions on or around the gastrointestinal tissue that needs to be stimulated. The implantable receiver-stimulator stimulates different gastrointestinal tissue to provide the desired therapeutic benefit.
摘要翻译：公开了系统和方法以刺激胃肠组织来治疗诸如进食障碍，胃轻瘫，胃反流等医学病症。本发明使用对神经的电刺激，其中来自源的振动能量被植入装置接收并转换成电能，并且所转换的电能被植入电极用于刺激预定的胃肠道组织部位。振动能量由控制器 - 发射器产生，其可被植入或位于外部。接收器刺激器接收振动能，其可以位于需要刺激的胃肠道组织上或周围的各个区域中。可植入接收器刺激器刺激不同的胃肠道组织以提供所需的治疗益处。

9. 发明授权

US07890173B2 Implantable transducer devices 有权
标题翻译：植入式传感器装置
公开(公告)号：US07890173B2
公开(公告)日：2011-02-15
申请号：US12554181
申请日：2009-09-04
申请人： Axel F. Brisken , Mark W. Cowan , Debra S. Echt , Richard E. Riley
发明人： Axel F. Brisken , Mark W. Cowan , Debra S. Echt , Richard E. Riley
IPC分类号： A61N1/00
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3787
摘要： Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than ½ the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.
摘要翻译：接收器 - 刺激器包括近似各向同性的换能器组件，解调器电路和至少两个组织接触电极。近似各向同性换能器的使用允许植入对于相对于声能源的取向的关注较少。具有相对较小尺寸（通常小于声源的波长的1/2）的传感器或换能器元件增强了各向同性。单晶压电材料的使用提高了灵敏度。

10. 发明授权

US07606621B2 Implantable transducer devices 有权
标题翻译：植入式传感器装置
公开(公告)号：US07606621B2
公开(公告)日：2009-10-20
申请号：US11315524
申请日：2005-12-21
申请人： Axel F. Brisken , Mark W. Cowan , Debra S. Echt , Richard E. Riley
发明人： Axel F. Brisken , Mark W. Cowan , Debra S. Echt , Richard E. Riley
IPC分类号： A61N1/00
CPC分类号： A61N1/37205 , A61N1/362 , A61N1/3787
摘要： Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transducers or transducer elements having relatively small sizes, typically less than ½ the wavelength of the acoustic source, enhance isotropy. The use of single crystal piezoelectric materials enhance sensitivity.
摘要翻译：接收器 - 刺激器包括近似各向同性的换能器组件，解调器电路和至少两个组织接触电极。近似各向同性换能器的使用允许植入对于相对于声能源的取向的关注较少。具有相对较小尺寸（通常小于声源的波长的1/2）的传感器或换能器元件增强了各向同性。单晶压电材料的使用提高了灵敏度。

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