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1. 发明授权

US09229212B2 Image-acquisition device 有权
标题翻译：图像采集装置
公开(公告)号：US09229212B2
公开(公告)日：2016-01-05
申请号：US13395175
申请日：2010-07-12
申请人： Masafumi Oshiro , Yuichi Toyoda , Yoshinori Hashimoto
发明人： Masafumi Oshiro , Yuichi Toyoda , Yoshinori Hashimoto
IPC分类号： H04N7/18 , G02B21/36 , G02B21/00 , G02B27/00
CPC分类号： G02B21/367 , G02B21/002 , G02B27/0075
摘要： An image acquisition apparatus 1A includes a sample stage 10 for placing a sample S thereon, an image pickup device 20 capable of acquiring a two-dimensional image and TDI driving, an image pickup optical system 30 including an objective lens 32, a scanning unit for acquiring an observation image while scanning the sample S by the image pickup device 20 and the image pickup optical system 30, and a focus oscillation control device 40 for controlling oscillation of a focus in the sample S so that an image pickup focus in the sample S oscillates at an oscillation frequency fs in an optical axis direction. The focus oscillation control device 40 sets the oscillation frequency fs so that the oscillation frequency fs substantially coincides with Ns times (Ns is an integer not less than 1) the basic frequency, which is a reciprocal 1/Ti of an image pickup period Ti of TDI driving in the image pickup device 20. Thus, an image acquisition apparatus capable of efficiently acquiring an observation image with focus extended can be realized.
摘要翻译：图像获取装置1A包括用于放置样品S的样本台10，能够获取二维图像和TDI驱动的图像拾取装置20，包括物镜32的图像拾取光学系统30，用于在通过图像拾取装置20和摄像光学系统30扫描样本S的同时获取观察图像，以及用于控制样本S中的焦点的振荡的聚焦振荡控制装置40，使得样本S中的图像拾取聚焦以光轴方向的振荡频率fs振荡。焦点振荡控制装置40将振荡频率fs设定为使得振荡频率fs基本上与Ns次（Ns为1以上的整数）基本一致，基本频率为基本频率，其为摄像周期Ti的倒数1 / TDI驱动在图像拾取装置20中。因此，可以实现能够有效地获取具有聚焦延伸的观察图像的图像获取装置。

2. 发明申请

US20120176489A1 IMAGE-ACQUISITION DEVICE 有权
标题翻译：图像采集设备
公开(公告)号：US20120176489A1
公开(公告)日：2012-07-12
申请号：US13395175
申请日：2010-07-12
申请人： Masafumi Oshiro , Yuichi Toyoda , Yoshinori Hashimoto
发明人： Masafumi Oshiro , Yuichi Toyoda , Yoshinori Hashimoto
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B27/0075
摘要： An image acquisition apparatus 1A includes a sample stage 10 for placing a sample S thereon, an image pickup device 20 capable of acquiring a two-dimensional image and TDI driving, an image pickup optical system 30 including an objective lens 32, a scanning unit for acquiring an observation image while scanning the sample S by the image pickup device 20 and the image pickup optical system 30, and a focus oscillation control device 40 for controlling oscillation of a focus in the sample S so that an image pickup focus in the sample S oscillates at an oscillation frequency fs in an optical axis direction. The focus oscillation control device 40 sets the oscillation frequency fs so that the oscillation frequency fs substantially coincides with Ns times (Ns is an integer not less than 1) the basic frequency, which is a reciprocal 1/Ti of an image pickup period Ti of TDI driving in the image pickup device 20. Thus, an image acquisition apparatus capable of efficiently acquiring an observation image with focus extended can be realized.
摘要翻译：图像获取装置1A包括用于放置样品S的样本台10，能够获取二维图像和TDI驱动的图像拾取装置20，包括物镜32的图像拾取光学系统30，用于在通过图像拾取装置20和摄像光学系统30扫描样本S的同时获取观察图像，以及用于控制样本S中的焦点的振荡的聚焦振荡控制装置40，使得样本S中的图像拾取聚焦以光轴方向的振荡频率fs振荡。焦点振荡控制装置40将振荡频率fs设定为使得振荡频率fs基本上与Ns次（Ns为1以上的整数）基本一致，基本频率为基本频率，其为摄像周期Ti的倒数1 / TDI驱动在图像拾取装置20中。因此，可以实现能够有效地获取具有聚焦延伸的观察图像的图像获取装置。

3. 发明授权

US07885447B2 Image acquiring apparatus including macro image acquiring and processing portions, image acquiring method, and image acquiring program 有权
标题翻译：包括宏图像获取和处理部分的图像获取装置，图像获取方法和图像获取程序
公开(公告)号：US07885447B2
公开(公告)日：2011-02-08
申请号：US11477805
申请日：2006-06-30
申请人： Masafumi Oshiro , Yoshinori Hashimoto
发明人： Masafumi Oshiro , Yoshinori Hashimoto
IPC分类号： G06K9/00
CPC分类号： G06K9/00134 , G02B21/365 , G02B21/367 , G06K9/0014
摘要： An image acquiring apparatus for acquiring images of a sample includes a macro image acquiring unit 20 for acquiring a macro image of the sample, a dark field light source 26 to be used for acquiring a dark field macro image of the sample as a macro image, a macro image processing unit 66 which generates a reference macro image by processing image data of the macro image, and an image pickup condition setting unit 65 which sets an image acquiring range corresponding to a range including an object of image acquisition as an image pickup condition of a micro image of the sample by referring to the reference macro image. This realizes an image acquiring apparatus, an image acquiring method, and an image acquiring program by which a macro image of a sample as an object of image acquisition is preferably acquired.
摘要翻译：用于获取样本的图像的图像获取装置包括用于获取样本的宏观图像的宏观图像获取单元20，用于将样本的暗场宏观图像作为宏观图像获取的暗场光源26，通过处理宏观图像的图像数据来生成参考宏图像的宏图像处理单元66以及将包含图像获取对象的范围对应的图像获取范围设定为摄像条件的摄像条件设定部65 通过参考参考宏图像来获取样本的微观图像。这实现了图像获取装置，图像获取方法和图像获取程序，通过该图像获取程序，优选地获取作为图像获取对象的样本的宏图像。

4. 发明申请

US20070269085A1 Image acquiring apparatus, image acquiring method, and image acquiring program 有权
标题翻译：图像获取装置，图像获取方法和图像获取程序
公开(公告)号：US20070269085A1
公开(公告)日：2007-11-22
申请号：US11477805
申请日：2006-06-30
申请人： Masafumi Oshiro , Yoshinori Hashimoto
发明人： Masafumi Oshiro , Yoshinori Hashimoto
IPC分类号： G06K9/00
CPC分类号： G06K9/00134 , G02B21/365 , G02B21/367 , G06K9/0014
摘要： An image acquiring apparatus for acquiring images of a sample includes a macro image acquiring unit 20 for acquiring a macro image of the sample, a dark field light source 26 to be used for acquiring a dark field macro image of the sample as a macro image, a macro image processing unit 66 which generates a reference macro image by processing image data of the macro image, and an image pickup condition setting unit 65 which sets an image acquiring range corresponding to a range including an object of image acquisition as an image pickup condition of a micro image of the sample by referring to the reference macro image. This realizes an image acquiring apparatus, an image acquiring method, and an image acquiring program by which a macro image of a sample as an object of image acquisition is preferably acquired.
摘要翻译：用于获取样本的图像的图像获取装置包括用于获取样本的宏观图像的宏观图像获取单元20，用于获取样本的暗场宏图像作为宏图像的暗场光源26，通过处理宏观图像的图像数据来生成参考宏图像的宏图像处理单元66以及将包含图像获取对象的范围对应的图像获取范围设定为摄像条件的图像摄取条件设定部65 通过参考参考宏图像来获取样本的微观图像。这实现了图像获取装置，图像获取方法和图像获取程序，通过该图像获取程序，优选地获取作为图像获取对象的样本的宏图像。

5. 发明申请

US20100188424A1 IMAGE OUTPUTTING SYSTEM, IMAGE OUTPUTTING METHOD, AND IMAGE OUTPUTTING PROGRAM 审中-公开
标题翻译：图像输出系统，图像输出方法和图像输出方案
公开(公告)号：US20100188424A1
公开(公告)日：2010-07-29
申请号：US12636808
申请日：2009-12-14
申请人： Jeremy COOKE , Shigeru Uchiyama , Masafumi Oshiro
发明人： Jeremy COOKE , Shigeru Uchiyama , Masafumi Oshiro
IPC分类号： G09G5/00
CPC分类号： G02B21/367 , G06T5/50 , G06T2207/10056
摘要： The present invention is aimed at easily providing an image which is in focus at any position in the image to be an observation target of a user and is free from misalignment in the image in a virtual microscope or the like.An image outputting server 10 includes an image storing part 11 for storing a plurality of image data with different focal points taken in an imaging direction which are images of a predetermined imaging target, specified area inputting means 12 for inputting information specifying an area in the image data, focal point information obtaining means 13 for obtaining information indicating the matching degree of a focal point in a specified area of each of the plurality of image data, image selection means 14 for selecting an image data to be output from the plurality of image data on the basis of the matching degree of the focal point, and outputting means 15 for outputting the thus selected image data.
摘要翻译：本发明旨在容易地提供一种在图像中的任何位置处聚焦的图像，以成为用户的观察目标，并且在虚拟显微镜等中的图像中没有偏移。图像输出服务器10包括图像存储部11，用于存储具有作为预定成像对象的图像的成像方向拍摄的具有不同焦点的多个图像数据，用于输入指定图像中的区域的信息的指定区域输入装置12 数据，焦点信息获取装置13，用于获得指示多个图像数据中的每一个的指定区域中的焦点的匹配度的信息;图像选择装置14，用于从多个图像数据中选择要输出的图像数据基于焦点的匹配度，以及用于输出这样选择的图像数据的输出装置15。

6. 发明申请

US20050258335A1 Microscope system 有权
标题翻译：显微镜系统
公开(公告)号：US20050258335A1
公开(公告)日：2005-11-24
申请号：US10967301
申请日：2004-10-19
申请人： Masafumi Oshiro , Koji Ichie
发明人： Masafumi Oshiro , Koji Ichie
IPC分类号： G02B7/04 , G02B7/28 , G02B21/00 , G02B21/24 , G02B21/36
CPC分类号： G02B21/244 , G02B21/245
摘要： A microscope system comprises a light guiding optical system 20 containing an objective lens 21 and a beam splitter 25 for splitting an optical image of a sample S to a first optical path and a second optical path, a photodetector 31 disposed on the first optical path used to acquire an image of the sample S, and a CCD camera 32 disposed on the second optical path for acquiring a two-dimensional image for focus control. The camera 32 is disposed being inclined at an angle of θ with respect to the optical path so that the optical path length in the light guiding optical system 20 varies along the z-axis direction. The image acquired by the camera 32 is analyzed by a focus controller 37, and the focal point for image pickup with respect to the sample S is controlled on the basis of the analysis result. Accordingly, there can be implemented a microscope system in which image acquisition of the sample and focus control for image pickup can be simultaneously performed.
摘要翻译：显微镜系统包括包含物镜21的导光光学系统20和用于将样品S的光学图像分割成第一光路和第二光路的分束器25，设置在所述第一光路上的光电检测器31 以获取样本S的图像，以及设置在第二光路上用于获取用于聚焦控制的二维图像的CCD照相机32。照相机32被设置成相对于光路以角度θ倾斜，使得光导系统20中的光路长度沿z轴方向变化。由照相机32获取的图像由聚焦控制器37分析，并且基于分析结果来控制相对于样本S的用于图像拾取的焦点。因此，可以实现可以同时执行用于图像拾取的样本的图像采集和聚焦控制的显微镜系统。

7. 发明授权

US08027548B2 Microscope system 有权
标题翻译：显微镜系统
公开(公告)号：US08027548B2
公开(公告)日：2011-09-27
申请号：US12873446
申请日：2010-09-01
申请人： Masafumi Oshiro , Koji Ichie
发明人： Masafumi Oshiro , Koji Ichie
IPC分类号： H04N7/18
CPC分类号： G02B21/244 , G02B21/245
摘要： A microscope system is constructed by a light guiding optical system 20 having an objective lens 21 and beam splitters 27a and 27b for splitting an optical image of a sample S, a photodetector 31 for acquiring an image of the sample S, and two CCD cameras 33 and 34 for focus control disposed on optical paths split by the beam splitters 27a and 27b. The cameras 33 and 34 are disposed being inclined with respect to the optical path so that the optical paths thereof in the light guiding optical system 20 vary along a z-axis direction in opposite directions to each other. Images acquired by these cameras 33 and 34 are analyzed in a focus controller 37, and the image pickup focal point to the sample S is controlled on the basis of the analysis result, whereby the focus control when an image of the sample is acquired can be suitably performed.
摘要翻译：显微镜系统由具有物镜21的导光光学系统20和用于分割样品S的光学图像的分束器27a和27b，用于获取样品S的图像的光电检测器31和两个CCD照相机33 和34用于聚焦控制，设置在由分束器27a和27b分开的光路上。照相机33和34被设置成相对于光路倾斜，使得其在光导光学系统20中的光路沿着z轴方向在彼此相反的方向上变化。在聚焦控制器37中分析由这些相机33和34获取的图像，并且基于分析结果来控制对样本S的图像拾取焦点，由此获取样本的图像时的聚焦控制可以是适当地执行。

8. 发明申请

US20050270611A1 Microscope system 有权
标题翻译：显微镜系统
公开(公告)号：US20050270611A1
公开(公告)日：2005-12-08
申请号：US10968261
申请日：2004-10-20
申请人： Masafumi Oshiro , Koji Ichie
发明人： Masafumi Oshiro , Koji Ichie
IPC分类号： G02B7/28 , G02B7/36 , G02B21/24 , H04K1/00
CPC分类号： G02B21/244 , G02B21/245
摘要： A microscope system is constructed by a light guiding optical system 20 having an objective lens 21 and beam splitters 27a and 27b for splitting an optical image of a sample S, a photodetector 31 for acquiring an image of the sample S, and two CCD cameras 33 and 34 for focus control disposed on optical paths split by the beam splitters 27a and 27b. The cameras 33 and 34 are disposed being inclined with respect to the optical path so that the optical paths thereof in the light guiding optical system 20 vary along a z-axis direction in opposite directions to each other. Images acquired by these cameras 33 and 34 are analyzed in a focus controller 37, and the image pickup focal point to the sample S is controlled on the basis of the analysis result, whereby the focus control when an image of the sample is acquired can be suitably performed.
摘要翻译：显微镜系统由具有物镜21的导光光学系统20和用于分割样品S的光学图像的分束器27a和27b，用于获取样品S的图像的光电检测器31和两个CCD 用于聚焦控制的照相机33和34设置在由分束器27a和27b分开的光路上。照相机33和34被设置成相对于光路倾斜，使得其在光导光学系统20中的光路沿着z轴方向在彼此相反的方向上变化。在聚焦控制器37中分析由这些相机33和34获取的图像，并且基于分析结果来控制对样本S的图像拾取焦点，由此获取样本的图像时的聚焦控制可以是适当地执行。

9. 发明授权

US07813579B2 Microscope system 有权
标题翻译：显微镜系统
公开(公告)号：US07813579B2
公开(公告)日：2010-10-12
申请号：US10968261
申请日：2004-10-20
申请人： Masafumi Oshiro , Koji Ichie
发明人： Masafumi Oshiro , Koji Ichie
IPC分类号： H04K1/00
CPC分类号： G02B21/244 , G02B21/245
摘要： A microscope system is constructed by a light guiding optical system 20 having an objective lens 21 and beam splitters 27a and 27b for splitting an optical image of a sample S, a photodetector 31 for acquiring an image of the sample S, and two CCD cameras 33 and 34 for focus control disposed on optical paths split by the beam splitters 27a and 27b. The cameras 33 and 34 are disposed being inclined with respect to the optical path so that the optical paths thereof in the light guiding optical system 20 vary along a z-axis direction in opposite directions to each other. Images acquired by these cameras 33 and 34 are analyzed in a focus controller 37, and the image pickup focal point to the sample S is controlled on the basis of the analysis result, whereby the focus control when an image of the sample is acquired can be suitably performed.
摘要翻译：显微镜系统由具有物镜21的导光光学系统20和用于分割样品S的光学图像的分束器27a和27b，用于获取样品S的图像的光电检测器31和两个CCD照相机33 和34用于聚焦控制，设置在由分束器27a和27b分开的光路上。照相机33和34被设置成相对于光路倾斜，使得其在光导光学系统20中的光路沿着z轴方向在彼此相反的方向上变化。在聚焦控制器37中分析由这些相机33和34获取的图像，并且基于分析结果来控制对样本S的图像拾取焦点，由此获取样本的图像时的聚焦控制可以是适当地执行。

10. 发明授权

US07449151B2 Fluorescence resonance energy transfer analyzer 失效
标题翻译：荧光共振能量转移分析仪
公开(公告)号：US07449151B2
公开(公告)日：2008-11-11
申请号：US10753569
申请日：2004-01-09
申请人： Masahiko Hirano , Masafumi Oshiro , Atsushi Miyawaki
发明人： Masahiko Hirano , Masafumi Oshiro , Atsushi Miyawaki
IPC分类号： G01N33/00
CPC分类号： G01N21/6458 , G01N21/6428 , G01N2021/6417 , G01N2021/6421
摘要： An analyzer for measuring an FRET (fluorescence resonance energy transfer) efficiency of a specimen containing a donor and an acceptor. The analyzer has an illuminator, an optical system, a detector and a calculator. The illuminator emits light for donor excitation and acceptor bleaching. The detector detects fluorescence from the specimen. The calculator calculates the FRET efficiency using the output of the detector. The detector independently detects the fluorescence in wavelength regions. One of the regions has a larger overlap with the fluorescence spectrum of the acceptor than with that of the donor.
摘要翻译：用于测量含有供体和受体的样品的FRET（荧光共振能量转移）效率的分析仪。分析仪具有照明器，光学系统，检测器和计算器。照明器发光，用于供体激发和受主漂白。检测器检测样品的荧光。计算器使用检测器的输出计算FRET效率。检测器独立地检测波长区域中的荧光。其中一个区域与受体的荧光光谱重叠比与供体的荧光光谱重叠。

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