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1. 发明申请

US20090221438A1 METHODS AND SYSTEMS FOR UNIFORM ENRICHMENT OF GENOMIC REGIONS 有权
标题翻译：统一区域均匀增长的方法与系统
公开(公告)号：US20090221438A1
公开(公告)日：2009-09-03
申请号：US12391001
申请日：2009-02-23
申请人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
发明人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
IPC分类号： C40B30/04 , C40B40/08
CPC分类号： C12Q1/6834 , C12N15/1093
摘要： The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
摘要翻译：本发明提供了用于在微阵列系统中富集靶核酸的方法和组合物。特别地，本发明提供了以微阵列形式均匀富集靶核酸分子的方法和组合物。本发明还提供靶核酸分子之间有意的不均匀的富集。

2. 发明申请

US20090105081A1 METHODS AND SYSTEMS FOR SOLUTION BASED SEQUENCE ENRICHMENT 审中-公开
标题翻译：用于解决方案的序列增长的方法和系统
公开(公告)号：US20090105081A1
公开(公告)日：2009-04-23
申请号：US12194574
申请日：2008-08-20
申请人： Matthew Rodesch , Thomas Albert
发明人： Matthew Rodesch , Thomas Albert
IPC分类号： C40B10/00 , C40B60/12
CPC分类号： C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要： The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
摘要翻译：本发明提供用于捕获和富集靶核酸的方法和系统以及富集的靶核酸的分析。特别地，本发明提供了以基于溶液的格式富集目标序列。

3. 发明授权

US08383338B2 Methods and systems for uniform enrichment of genomic regions 有权
标题翻译：用于基因组区域均匀富集的方法和系统
公开(公告)号：US08383338B2
公开(公告)日：2013-02-26
申请号：US12391001
申请日：2009-02-23
申请人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
发明人： Jacob Kitzman , Todd Richmond , Mark D'Ascenzo , Thomas Albert , Matthew Rodesch , Jeffrey Jeddeloh , Christina Middle
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00
CPC分类号： C12Q1/6834 , C12N15/1093
摘要： The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions for uniform enrichment of target nucleic acid molecules in a microarray format. The present invention also provides for intentionally non-uniform enrichment among target nucleic acid molecules.
摘要翻译：本发明提供了用于在微阵列系统中富集靶核酸的方法和组合物。特别地，本发明提供了以微阵列形式均匀富集靶核酸分子的方法和组合物。本发明还提供靶核酸分子之间有意的不均匀的富集。

4. 发明申请

US20120046175A1 METHODS AND SYSTEMS FOR SOLUTION BASED SEQUENCE ENRICHMENT 有权
标题翻译：用于解决方案的序列增长的方法和系统
公开(公告)号：US20120046175A1
公开(公告)日：2012-02-23
申请号：US13239585
申请日：2011-09-22
申请人： Matthew Rodesch , Thomas Albert
发明人： Matthew Rodesch , Thomas Albert
IPC分类号： C40B10/00 , C07H21/00
CPC分类号： C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要： The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
摘要翻译：本发明提供用于捕获和富集靶核酸的方法和系统以及富集的靶核酸的分析。特别地，本发明提供了以基于溶液的格式富集目标序列。

5. 发明申请

US20100331204A1 METHODS AND SYSTEMS FOR ENRICHMENT OF TARGET GENOMIC SEQUENCES 审中-公开
标题翻译：用于扩增目标基因组序列的方法和系统
公开(公告)号：US20100331204A1
公开(公告)日：2010-12-30
申请号：US12695447
申请日：2010-01-28
申请人： Jeff Jeddeloh , Todd Richmond , Matthew Rodesch , Daniel Gerhardt , Paul Marrione , Thomas Albert
发明人： Jeff Jeddeloh , Todd Richmond , Matthew Rodesch , Daniel Gerhardt , Paul Marrione , Thomas Albert
IPC分类号： C40B30/04 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/6837 , C12Q2565/515 , C12Q2539/101 , C12Q2563/131 , C12Q2537/149
摘要： The present invention provides methods and systems for targeted nucleic acid sequence enrichment in a sample. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in hybridization assays by first depleting non-target nucleic acid sequences.
摘要翻译：本发明提供了样品中目标核酸序列富集的方法和系统。特别地，本发明提供了通过首先消耗非靶核酸序列在杂交测定中的杂交期间富集靶向的核酸序列。

6. 发明授权

US09790543B2 Methods and systems for solution based sequence enrichment 有权
公开(公告)号：US09790543B2
公开(公告)日：2017-10-17
申请号：US13239585
申请日：2011-09-22
申请人： Matthew Rodesch , Thomas Albert
发明人： Matthew Rodesch , Thomas Albert
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要： The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.

7. 发明授权

US08658572B2 Whole proteome tiling microarrays 有权
标题翻译：全蛋白质组织微阵列
公开(公告)号：US08658572B2
公开(公告)日：2014-02-25
申请号：US13419197
申请日：2012-03-13
申请人： Tom Albert , Todd Richmond , Matthew Rodesch , Klaus-Peter Stengele , Jochen Bühler
发明人： Tom Albert , Todd Richmond , Matthew Rodesch , Klaus-Peter Stengele , Jochen Bühler
IPC分类号： C40B40/10
CPC分类号： G01N33/6842 , C07K1/047 , G01N33/6845 , G01N2570/00
摘要： The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.
摘要翻译：本发明涉及包含至少50,000个寡肽特征/ cm 2的微阵列，其中寡肽特征表示至少50％，60％，70％，80％，90％，95％，99％或100％的蛋白质组病毒或有机体。本发明还涉及用于合成这种微阵列的方法和使用每cm 2包含至少50,000个寡肽特征的微阵列的方法。在本发明的一个实施方案中，寡肽特征表示在相同物种中表达的蛋白质，其中寡肽特征呈现代表在物种中表达的至少约5,000至至少约25,000个蛋白质的平铺图案。在一些实施方案中，寡肽微阵列特征表示在相同物种中表达的蛋白质，其中微阵列特征以表示至少约5,000至至少约50,000个表达的蛋白质的平铺图案存在。

8. 发明申请

US20120238477A1 METHODS FOR SYNTHESIS OF AN OLIGOPEPTIDE MICROARRAY 有权
标题翻译：合成寡核苷酸微阵列的方法
公开(公告)号：US20120238477A1
公开(公告)日：2012-09-20
申请号：US13419029
申请日：2012-03-13
申请人： Tom Albert , Todd Richmond , Matthew Rodesch , Klause-Peter Stengele , Jochen Bühler , Markus Ott
发明人： Tom Albert , Todd Richmond , Matthew Rodesch , Klause-Peter Stengele , Jochen Bühler , Markus Ott
IPC分类号： C40B40/10 , C40B50/18
CPC分类号： C07K17/06 , B01J19/0046 , B01J2219/00432 , B01J2219/00439 , B01J2219/00596 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C40B50/18
摘要： An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm2 and preferably at least about 50,000 oligopeptide features per cm2.
摘要翻译：提出了寡肽微阵列及其合成方法。还提出了一种固体支持物上的微阵列，其包含每cm 2至少约10,000个寡肽特征，优选每cm 2至少约50,000个寡肽特征。

9. 发明申请

US20120245057A1 WHOLE PROTEOME TILING MICROARRAYS 有权
标题翻译：全面保护倾斜微波
公开(公告)号：US20120245057A1
公开(公告)日：2012-09-27
申请号：US13419197
申请日：2012-03-13
申请人： Tom Albert , Todd Richmond , Matthew Rodesch , Klaus-Peter Stengele , Jochen Buhler
发明人： Tom Albert , Todd Richmond , Matthew Rodesch , Klaus-Peter Stengele , Jochen Buhler
IPC分类号： C40B40/10 , C40B50/18
CPC分类号： G01N33/6842 , C07K1/047 , G01N33/6845 , G01N2570/00
摘要： The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.
摘要翻译：本发明涉及包含至少50,000个寡肽特征/ cm 2的微阵列，其中寡肽特征表示至少50％，60％，70％，80％，90％，95％，99％或100％的蛋白质组病毒或有机体。本发明还涉及用于合成这种微阵列的方法和使用每cm 2包含至少50,000个寡肽特征的微阵列的方法。在本发明的一个实施方案中，寡肽特征表示在相同物种中表达的蛋白质，其中寡肽特征呈现代表在物种中表达的至少约5,000至至少约25,000个蛋白质的平铺图案。在一些实施方案中，寡肽微阵列特征表示在相同物种中表达的蛋白质，其中微阵列特征以表示至少约5,000至至少约50,000个表达的蛋白质的平铺图案存在。

10. 发明申请

US20100222232A1 ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS 审中-公开
标题翻译：基因组区域的扩充和序列分析
公开(公告)号：US20100222232A1
公开(公告)日：2010-09-02
申请号：US12754308
申请日：2010-04-05
申请人： Thomas J. Albert , Roland Green , Todd Richmond , Michael Molla , Jeffrey Jeddeloh , Jason Patrick Affourtit , Mathreyan Srinivasan , Brian Christopher Godwin , Matthew Rodesch
发明人： Thomas J. Albert , Roland Green , Todd Richmond , Michael Molla , Jeffrey Jeddeloh , Jason Patrick Affourtit , Mathreyan Srinivasan , Brian Christopher Godwin , Matthew Rodesch
IPC分类号： C40B30/04 , C07H21/00 , C12P19/34 , C12Q1/68 , C40B40/06
CPC分类号： C12N15/1093 , C12Q1/6834
摘要： The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules.
摘要翻译：本发明提供了用于降低优选用于进一步分析的基因组样品的复杂性的新方法，例如直接DNA测序，再测序或SNP呼叫。该方法使用预先选择的固定化寡核苷酸探针从含有变性，片段（基因组）核酸的样品中捕获靶核酸分子，以降低核酸分子的原始群体的遗传复杂性。

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