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1. 发明申请

US20220097058A1 Platform and Method For Multi-Variable Screening 有权
公开(公告)号：US20220097058A1
公开(公告)日：2022-03-31
申请号：US17496409
申请日：2021-10-07
申请人： Wisconsin Alumni Research Foundation
发明人： David J. Beebe , Duane S. Juang , Jiaquan Yu , Jo Handelsman
IPC分类号： B01L3/00 , C12Q1/20 , C40B60/12
摘要： A platform and method for conducting multi-variable combinational interactions are provided. An array of multiplexing chambers in formed in a body. The body also includes a common well communicating with each multiplexing chamber of the array of multiplexing chambers and a plurality of variable wells. Each of variable wells communicates with at least one multiplexing chamber of the array of multiplexing chambers. The common well is loaded with a first variable and different variables are loaded in each of the plurality of variable wells. The interaction of the first variable with at least one of the different variables in each multiplexing chamber of the array of multiplexing chambers is observed.

2. 发明授权

US11016053B2 Devices and methods for sample analysis 有权
公开(公告)号：US11016053B2
公开(公告)日：2021-05-25
申请号：US15726298
申请日：2017-10-05
申请人： Abbott Laboratories
发明人： Jeffrey B. Huff , Mark A. Hayden , Graham Davis , Sergey Gershtein
IPC分类号： G01N27/327 , C12Q1/00 , G01N33/543 , C40B60/12 , B01L3/00 , C12Q1/6869 , G01N33/487 , G01N21/78 , B82Y15/00 , G01N21/64 , G01N21/82
摘要： Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided. Also provided herein are instruments that are programmed to operate a cartridge that includes an array of electrodes for actuating a droplet and further includes an electrochemical species sensing region. The instrument may be used to analyse a sample in a cartridge that includes an array of electrodes for actuating a droplet and further includes a nanopore layer for detecting translocation of a tag/second binding member through nanopore. An instrument configured to operate a first cartridge that includes an array of electrodes for actuating a droplet and further includes an electrochemical species sensing region and a second cartridge that includes an array of electrodes for actuating a droplet and further includes a nanopore layer for detecting translocation of a tag/second binding member through nanopore is disclosed. An instrument configured to operate a cartridge that includes an array of electrodes for actuating a droplet, an electrochemical species sensing region, and a nanopore layer for detecting translocation of a tag/second binding member through nanopore is disclosed.

3. 发明授权

US10739366B2 System and method for screening a library of samples 有权
公开(公告)号：US10739366B2
公开(公告)日：2020-08-11
申请号：US16251744
申请日：2019-01-18
申请人： The Johns Hopkins University , Pioneer Hi-Bred International, Inc.
发明人： Tza-huei J. Wang , Tushar Dnyandeo Rane , Helena Claire Zec , Wen-Chy Chu
IPC分类号： G01N35/08 , B01L3/02 , C40B60/14 , G01N1/28 , B01L3/00 , B01J19/00 , G01N35/00 , C40B60/12
摘要： A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.

4. 发明授权

US10670592B2 Detection of analytes using metal nanoparticle probes and dynamic light scattering 审中-公开
公开(公告)号：US10670592B2
公开(公告)日：2020-06-02
申请号：US16244628
申请日：2019-01-10
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： Qun Huo , Xiong Liu , Qiu Dai
IPC分类号： G01N33/543 , G01N15/02 , C12Q1/682 , G01N33/542 , G01N33/58 , G01J3/44 , C40B60/12
摘要： Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.

5. 发明授权

US10422793B2 Compound arrays for sample profiling 有权
公开(公告)号：US10422793B2
公开(公告)日：2019-09-24
申请号：US13624332
申请日：2012-09-21
申请人： The Arizona Board of Regents, A body Corporate of the State of Arizona for and on behalf of Arizona
发明人： Stephen Albert Johnston , Phillip Stafford
IPC分类号： C40B40/10 , C40B60/12 , G01N33/543 , G01N33/68 , G01N33/53
摘要： The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to components of the samples can be increased by forming arrays such that multivalent components of the samples (e.g., antibodies or cells) can bind to more than one molecule of a compound at the same time. When a sample is applied to an array under such conditions, the compounds of the array bind to component(s) of the sample with significantly different avidities generating a profile characteristic of the sample.

6. 发明授权

US10369569B2 Method of identifying droplets in a stack and an associated sequencer 有权
公开(公告)号：US10369569B2
公开(公告)日：2019-08-06
申请号：US15574005
申请日：2017-07-14
申请人： BASE4 INNOVATION LTD
发明人： Cameron Alexander Frayling , Thomas Henry Isaac
IPC分类号： B01L3/00 , G01N21/64 , C12Q1/6869 , B01L3/02 , B01J19/00 , C40B60/12
摘要： Disclosed is a method of identifying the contents of individual droplets in a droplet stream each droplet containing fluorophores in an initial non-fluorescing state characterized by the steps of introducing the droplets one-by-one into at least one open-ended tube to create a stack of droplets therein; activating the fluorophores within the droplets to cause them to fluoresce; releasing each droplet in the droplet stack in turn from the tube and detecting along the major axis of the tube fluorescence associated with each droplet as it emerges. Also disclosed is a method suitable for sequencing a biopolymer characterized by the steps of (1) progressively digesting the biopolymer into an ordered stream of its constituent monomers; (2) converting the stream of monomers into a corresponding stream of monomer-containing aqueous droplets each droplet additionally containing a probe capable of (a) capturing the monomer and (b) thereafter being digested to release an unqueched fluorophore characteristic of the captured monomer; (3) introducing the stream of droplets created in step (2) into an inlet end of at least one open-ended tube to create a stack of droplets therein and (4) releasing each droplet in turn from an outlet end of the tube(s) and detecting fluorophores in each droplet as each droplet emerges. The method may be used in a corresponding apparatus for sequencing a biopolymer such as a nucleic acid or protein.

7. 发明申请

US20180355350A1 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 审中-公开
公开(公告)号：US20180355350A1
公开(公告)日：2018-12-13
申请号：US15996222
申请日：2018-06-01
申请人： Raindance Technologies, Inc.
发明人： Darren Roy Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC分类号： C12N15/10 , G01N33/68 , B01F13/00 , G01N33/543 , G01N33/536 , C40B70/00 , C40B60/12 , C40B60/08 , C40B50/08 , C40B40/04 , C40B30/04 , C12Q1/6876 , C12Q1/6874 , C12Q1/686 , C07K1/04 , B82Y30/00 , B82Y5/00 , B01L3/00 , B01J19/00 , G01N33/542 , G01N21/64 , C12Q1/6869 , C12Q1/6834 , C12Q1/6825 , C12Q1/6816 , C12Q1/6804 , B01L7/00 , B01F3/08
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.

8. 发明授权

US10132821B2 Automated method for determining the presence of a mucoid strand 有权
公开(公告)号：US10132821B2
公开(公告)日：2018-11-20
申请号：US15054943
申请日：2016-02-26
申请人： GEN-PROBE INCORPORATED
发明人： Rolf Silbert , David Opalsky , David Aaron Buse , Robert J. Rosati , Olev Tammer , Richard Capella , Matthias Merten
IPC分类号： G01N35/00 , G01N35/10 , G01F23/26 , G01N1/28 , C40B60/12 , G01N35/04
摘要： The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.

9. 发明授权

US09829485B2 Biosensor device and method of manufacturing the same 有权
公开(公告)号：US09829485B2
公开(公告)日：2017-11-28
申请号：US12743026
申请日：2008-11-12
申请人： Pablo Garcia Tello , Freddy Roozeboom
发明人： Pablo Garcia Tello , Freddy Roozeboom
IPC分类号： G01N33/543 , G01N21/17 , G01N21/41 , G01N21/59 , G01N21/62 , C40B60/12
CPC分类号： G01N33/54373 , C40B60/12 , G01N21/17 , G01N21/41 , G01N21/59 , G01N21/62 , G01N33/54326
摘要： A biosensor device for detecting biological particles, the biosensor device comprising a substrate, a regular pattern of pores formed in the substrate, and a plurality of sensor active structures each of which being arranged on a surface of a corresponding one of the pores, wherein each of the plurality of sensor active structures is sensitive to specific biological particles and is adapted to modify electromagnetic radiation interaction properties in the event of the presence of the respective biological particles.

10. 发明授权

US09528995B2 Systems and methods for high-throughput detection of an analyte in a sample 有权
公开(公告)号：US09528995B2
公开(公告)日：2016-12-27
申请号：US14846499
申请日：2015-09-04
申请人： MagArray, Inc.
发明人： Sebastian J. Osterfeld , Shan Xiang Wang
IPC分类号： B01L3/00 , G01N33/58 , C40B60/12 , B82Y15/00 , B82Y30/00 , G01N27/327 , G01R33/12 , G01N27/74 , G01N35/00 , G01R33/00 , B01L9/00 , B82Y10/00 , G01N35/02
CPC分类号： G01N33/585 , B01J2219/00317 , B01J2219/00655 , B01J2219/00662 , B01L3/5085 , B01L9/523 , B01L2300/0829 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C40B60/12 , G01N27/3276 , G01N27/745 , G01N33/587 , G01N35/0098 , G01N35/026 , G01R33/0094 , G01R33/1269 , Y10S977/773 , Y10S977/92
摘要： Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.

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