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1. 发明申请

US20120294829A1 LIQUID FORMULATIONS FOR LONG-ACTING G-CSF CONJUGATE 有权
标题翻译：用于长时间运动G-CSF凝血液的液体制剂
公开(公告)号：US20120294829A1
公开(公告)日：2012-11-22
申请号：US13574039
申请日：2011-01-18
申请人： Mi Ji Lee , Jae Min Lee , Byung Sun Lee , Sung Min Bae , Se Chang Kwon
发明人： Mi Ji Lee , Jae Min Lee , Byung Sun Lee , Sung Min Bae , Se Chang Kwon
IPC分类号： A61K38/19
CPC分类号： A61K9/0019 , A61K38/193 , A61K47/12 , A61K47/26 , A61K47/6813 , A61K47/6835 , C07K14/535
摘要： Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.
摘要翻译：本发明公开了一种允许长效G-CSF缀合物的液体制剂，其具有改善的体内持续时间和稳定性，在长时间储存时是稳定的。它包括以缓冲液和甘露醇为特征的稳定剂组合物。没有人体血清白蛋白和其他对身体有害的潜在因素，液体制剂没有对病毒感染的担忧，并保证了对长效G-CSF缀合物的极好的储存稳定性。

2. 发明授权

US09867777B2 Liquid formulations for long-acting G-CSF conjugate 有权
公开(公告)号：US09867777B2
公开(公告)日：2018-01-16
申请号：US13574039
申请日：2011-01-18
申请人： Mi Ji Lee , Jae Min Lee , Byung Sun Lee , Sung Min Bae , Se Chang Kwon
发明人： Mi Ji Lee , Jae Min Lee , Byung Sun Lee , Sung Min Bae , Se Chang Kwon
IPC分类号： A61K9/00 , A61K38/19 , A61K47/12 , A61K47/26 , A61K47/48 , C07K14/535 , A61K47/68
CPC分类号： A61K9/0019 , A61K38/193 , A61K47/12 , A61K47/26 , A61K47/6813 , A61K47/6835 , C07K14/535
摘要： Disclosed is a liquid formulation which allows long-acting G-CSF conjugates, that have improved in vivo duration and stability, to be stable when stored for a long period of time. It comprises a stabilizer composition characterized by buffer and mannitol. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting G-CSF conjugates.

3. 发明授权

US09061072B2 Liquid formulation of long-acting human growth hormone conjugate 有权
标题翻译：长效人生长激素结合物的液体制剂
公开(公告)号：US09061072B2
公开(公告)日：2015-06-23
申请号：US13809783
申请日：2011-07-14
申请人： Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
发明人： Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
IPC分类号： C07K17/06 , A61K39/00 , A61K47/48 , A61K9/00 , A61K9/08 , A61K38/27 , A61K47/26 , A61K47/12
CPC分类号： A61K47/48415 , A61K9/0019 , A61K9/08 , A61K38/27 , A61K47/12 , A61K47/26 , A61K47/60 , A61K47/68 , C07K2319/30
摘要： Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
摘要翻译：公开了长效人生长激素（hGH）缀合物的液体制剂，其不含白蛋白，其可以长期保存长效hGH缀合物的稳定性，其中长效人生长激素缀合物包括与免疫球蛋白Fc区连接的人生长激素，并且与天然形式相比具有延长的体内稳定性。包含pH 5.0〜6.0缓冲液，糖醇，盐和非离子表面活性剂的hGH缀合物的液体制剂不含人血清白蛋白和潜在的病毒污染的其他有害因素，可提供优良的储存稳定性对于由hGH多肽和具有较高分子量和体内耐久性的免疫球蛋白Fc区组成的长效hGH缀合物，与天然产物相比。

4. 发明申请

US20130115231A1 LIQUID FORMULATION OF LONG-ACTING HUMAN GROWTH HORMONE CONJUGATE 有权
标题翻译：长寿命人体生长激素联合液的液体配方
公开(公告)号：US20130115231A1
公开(公告)日：2013-05-09
申请号：US13809783
申请日：2011-07-14
申请人： Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
发明人： Sung Hee Hong , Byung Sun Lee , Dae Seong Im , Jae Min Lee , Sung Min Bae , Se Chang Kwon
IPC分类号： A61K47/48
CPC分类号： A61K47/48415 , A61K9/0019 , A61K9/08 , A61K38/27 , A61K47/12 , A61K47/26 , A61K47/60 , A61K47/68 , C07K2319/30
摘要： Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
摘要翻译：公开了长效人生长激素（hGH）缀合物的液体制剂，其不含白蛋白，其可以长期保存长效hGH缀合物的稳定性，其中长效人生长激素缀合物包括与免疫球蛋白Fc区连接的人生长激素，并且与天然形式相比具有延长的体内稳定性。包含pH 5.0〜6.0缓冲液，糖醇，盐和非离子表面活性剂的hGH缀合物的液体制剂不含人血清白蛋白和其他可能被病毒污染的危险因素，可以提供优良的储存稳定性对于由hGH多肽和具有较高分子量和体内耐久性的免疫球蛋白Fc区组成的长效hGH缀合物，与天然产物相比。

5. 发明申请

US20130022626A1 LONG-ACTING HUMAN FOLLICLE-STIMULATING HORMONE FORMULATION USING IMMUNOGLOBULIN FRAGMENT 有权
标题翻译：使用免疫抑制蛋白片段长效人体激素激素配方
公开(公告)号：US20130022626A1
公开(公告)日：2013-01-24
申请号：US13638860
申请日：2011-04-04
申请人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
发明人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
IPC分类号： C07K19/00 , A61P15/00 , A61P15/08 , C07K1/107 , A61K39/395
CPC分类号： A61K47/48215 , A61K47/60 , A61K47/68
摘要： The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的长效促卵泡激素制剂，其包含人促卵泡激素缀合物，其通过非激素共价连接人卵泡刺激激素与免疫球蛋白Fc区而制备 - 肽基聚合物及其制备方法。本发明的长效人促卵泡激素制剂在较高水平维持人卵泡刺激激素的体内活性，并且显着增加其血清半衰期。

6. 发明授权

US09186415B2 Long-acting human follicle-stimulating hormone formulation using immunoglobulin fragment 有权
标题翻译：使用免疫球蛋白片段的长效人卵泡刺激素制剂
公开(公告)号：US09186415B2
公开(公告)日：2015-11-17
申请号：US13638860
申请日：2011-04-04
申请人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
发明人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
IPC分类号： A61K38/24 , A61K38/00 , A61K38/16 , C07K16/00 , C07K1/00 , A61K47/48
CPC分类号： A61K47/48215 , A61K47/60 , A61K47/68
摘要： The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的长效促卵泡激素制剂，其包含人促卵泡激素缀合物，其通过非激素共价连接人卵泡刺激激素与免疫球蛋白Fc区而制备 - 肽基聚合物及其制备方法。本发明的长效人促卵泡激素制剂在较高水平维持人卵泡刺激激素的体内活性，并且显着增加其血清半衰期。

7. 发明申请

US20130273634A1 METHOD FOR MASS PRODUCTION OF FACTOR VII/VIIA 有权
标题翻译：大量生产VII / VIIA因子的方法
公开(公告)号：US20130273634A1
公开(公告)日：2013-10-17
申请号：US13881974
申请日：2011-10-26
申请人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Sung Hwan Hong , Se Chang Kwon
发明人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Sung Hwan Hong , Se Chang Kwon
IPC分类号： C12N9/64
CPC分类号： C12N9/6437 , C07K14/745 , C12N15/85 , C12N2830/85
摘要： A method for the mass production of human coagulation factor VII. The method includes a) providing an expression vector carrying i) a dihydrofolate reductase promoter devoid of one or more CCGCC repeat sequences from the GC-rich region thereof and a dihydrofolate reductase (DHFR) gene operably linked thereto and ii) a cytomegalovirus (CMV) promoter and a human coagulation factor VII gene operably linked thereto; b) obtaining a transformed a host cell line containing the expression vector; and c) culturing the transfected host cell in the presence of a dihydrofolate reductase inhibitor to select cells which express human coagulation factor VII with high efficiency; and d) adding sodium butyrate to the selected host cells.
摘要翻译：大量生产人凝血因子VII的方法。所述方法包括：a）提供表达载体，其携带i）没有来自其富含GC的区域的一个或多个CCGCC重复序列的二氢叶酸还原酶启动子和与其可操作地连接的二氢叶酸还原酶（DHFR）基因，和ii）巨细胞病毒（CMV）启动子和与之有效连接的人凝血因子VII基因; b）获得含有表达载体的转化的宿主细胞系; 和c）在二氢叶酸还原酶抑制剂存在下培养转染的宿主细胞以选择以高效率表达人凝血因子VII的细胞; 和d）向所选择的宿主细胞中加入丁酸钠。

8. 发明授权

US09243237B2 Method for mass production of factor VII/VIIA 有权
标题翻译：大量生产因子VII / VIIA的方法
公开(公告)号：US09243237B2
公开(公告)日：2016-01-26
申请号：US13881974
申请日：2011-10-26
申请人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Sung Hwan Hong , Se Chang Kwon
发明人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Sung Hwan Hong , Se Chang Kwon
IPC分类号： A61K38/00 , C12N9/64 , C07K14/745
CPC分类号： C12N9/6437 , C07K14/745 , C12N15/85 , C12N2830/85
摘要： A method for the mass production of human coagulation Factor VII. The method includes a) providing an expression vector carrying i) a dihydrofolate reductase promoter devoid of one or more CCGCC repeat sequences from the GC-rich region thereof and a dihydrofolate reductase (DHFR) gene operably linked thereto and ii) a cytomegalovirus (CMV) promoter and a human coagulation Factor VII gene operably linked thereto; b) obtaining a transformed host cell line containing the expression vector; and c) culturing the transfected host cell in the presence of a dihydrofolate reductase inhibitor to select cells which express human coagulation Factor VII with high efficiency; and d) adding sodium butyrate to the selected host cells.
摘要翻译：大量生产人凝血因子VII的方法。所述方法包括：a）提供表达载体，其携带i）没有来自其富含GC的区域的一个或多个CCGCC重复序列的二氢叶酸还原酶启动子和与其可操作地连接的二氢叶酸还原酶（DHFR）基因，和ii）巨细胞病毒（CMV）启动子和与之有效连接的人凝血因子VII基因; b）获得含有表达载体的转化的宿主细胞系; 和c）在二氢叶酸还原酶抑制剂存在下培养转染的宿主细胞以选择以高效率表达人凝血因子VII的细胞; 和d）向所选择的宿主细胞中加入丁酸钠。

9. 发明授权

US07929430B2 Congestion control access gateway and congestion control method for the same 失效
标题翻译：拥塞控制接入网关和拥塞控制方法相同
公开(公告)号：US07929430B2
公开(公告)日：2011-04-19
申请号：US11607505
申请日：2006-11-30
申请人： Hyun Woo Oh , Kee Seong Cho , Byung Sun Lee
发明人： Hyun Woo Oh , Kee Seong Cho , Byung Sun Lee
IPC分类号： H04L12/26 , G08C15/00
CPC分类号： H04L47/10 , G08G1/0104 , G08G1/096716 , G08G1/096741 , G08G1/096775 , H04L12/66 , H04L47/11 , H04L47/12 , H04L49/90 , H04L49/9078
摘要： A congestion control access gateway and a congestion control method for the same are provided. The congestion control access gateway interfaces between a broadband convergence network and a ubiquitous sensor network including sensors and terminals. The congestion control access gateway receives data from the ubiquitous sensor network. When a congestion situation has occurred, the congestion control access gateway detects the congestion situation based on data received in the congestion situation and broadcasts congestion notification and control messages in response to the congestion situation detection. The congestion control access gateway generates a congestion situation detection profile as a result of the congestion situation detection and performs priority queuing of the received data based on the congestion situation detection profile and service classes. The congestion control access gateway determines destination of the queued data using the congestion situation detection profile and routes the data to a corresponding service.
摘要翻译：提供了一种拥塞控制接入网关及其拥塞控制方法。拥塞控制接入网关在宽带融合网络和包括传感器和终端的普遍存在的传感器网络之间进行接口。拥塞控制接入网关从普遍存在的传感器网络接收数据。当发生拥塞情况时，拥塞控制接入网关根据拥塞情况下接收到的数据检测到拥塞状况，并根据拥塞情况检测广播拥塞通知和控制消息。拥塞控制接入网关作为拥塞情况检测的结果，生成拥塞情况检测配置文件，并根据拥塞情况检测配置文件和服务等级对接收到的数据进行优先级排队。拥塞控制访问网关使用拥塞情况检测简档来确定排队数据的目的地，并将数据路由到相应的服务。

10. 发明授权

US07796522B2 System and method for performing traffic process in integrated network of voice-over internet protocol network and public switched telephone network 失效
标题翻译：在互联网协议网络和公共交换电话网络的综合网络中进行流量处理的系统和方法
公开(公告)号：US07796522B2
公开(公告)日：2010-09-14
申请号：US10912307
申请日：2004-08-04
申请人： Hyun Jeong Lee , Yearn Gui Yi , Byung Sun Lee , Dae Ung Kim
发明人： Hyun Jeong Lee , Yearn Gui Yi , Byung Sun Lee , Dae Ung Kim
IPC分类号： H04L12/26 , G06F15/173 , G06F15/16
CPC分类号： H04L65/104 , H04L29/06027 , H04L65/103 , H04L65/1043 , H04L65/1069
摘要： A system and method for performing a traffic process in an integrated network of a VoIP (Voice over Internet Protocol) network and a PSTN (Public Switched Telephone Network) are provided. The system includes: a softswitch which has a plurality of ASPs (Application Server Processes), transmits a data signal to other nodes through an ASP that is selected from among the ASPs, and transmits a heartbeat request message when a CPU (Central Processing Unit) utilization ratio and an SCTP (System Control Transmission Protocol) level congestion of the ASPs exceed respective reference points according to AS (Application Server)/ASP information; and a signaling gateway which updates the reference points of the CPU utilization ratio and the SCTP level congestion in response to the heartbeat request message and transmits a heartbeat acknowledgement message to the softswitch, and checks the CPU utilization ratio and the SCTP level congestion for a plurality of active ASPs within a predetermined CIC (Circuit Identification Code) or SSN (Sub-System Number) range according to the AS/ASP information, to determine the selected ASP when the signaling gateway receives data signal from outside and traffic is distributed.
摘要翻译：提供了一种用于在VoIP（因特网协议语音）网络和PSTN（公共交换电话网络）的集成网络中执行流量处理的系统和方法。该系统包括：具有多个ASP（应用服务器处理）的软交换机，通过从ASP中选择的ASP向其他节点发送数据信号，并且当CPU（中央处理单元）发送心跳请求消息时，利用率和ASP的SCTP（系统控制传输协议）级拥塞根据AS（应用服务器）/ ASP信息超过相应的参考点; 以及信令网关，其响应于心跳请求消息更新CPU利用率和SCTP级拥塞的参考点，并向软交换机发送心跳确认消息，并且检查多个CPU的CPU利用率和SCTP级拥塞在根据AS / ASP信息的预定CIC（电路识别码）或SSN（子系统号）范围内的活动ASP的活动ASP，以在信令网关从外部接收数据信号并且业务量分布时确定所选择的ASP。

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