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1. 发明申请

US20220339626A1 MICROFLUIDIC DEVICE 有权
公开(公告)号：US20220339626A1
公开(公告)日：2022-10-27
申请号：US17358021
申请日：2021-06-25
申请人： NATIONAL CHUNG CHENG UNIVERSITY
发明人： Shau-Chun WANG , Lai-Kwan CHAU , Yuan-Yu CHEN
IPC分类号： B01L3/00
摘要： The present disclosure provides a microfluidic device, including a bottom substrate, an electrowetting-on-dielectric (EWOD) chip, a circuit board, a dielectric film, and a motor. The EWOD chip is disposed on the bottom substrate, and the circuit board is arranged on the EWOD chip. The circuit board includes a circuit area that is electrically connected to the EWOD chip, and the empty area is adjacent to the circuit area and the EWOD chip is exposed. The dielectric film is disposed on the empty area of the circuit board and covers the exposed EWOD chip. The motor is disposed under the bottom substrate, and one end of the motor has a magnetic structure, so that the magnetic structure can move closer to or away from the bottom substrate.

2. 发明申请

US20160264602A1 MANUFACTURING METHOD OF SILATRANE WITH THIOL GROUP AND PRESERVATION METHOD THEREOF 审中-公开
标题翻译：具有硫醇基的硅烷的制备方法及其保存方法
公开(公告)号：US20160264602A1
公开(公告)日：2016-09-15
申请号：US14856145
申请日：2015-09-16
申请人： NATIONAL CHUNG CHENG UNIVERSITY
发明人： Wen-Hao CHEN , Lai-Kwan CHAU , Yen-Ta TSENG , Chao-Wen CHEN
IPC分类号： C07F7/18
CPC分类号： C07F7/1804
摘要： A manufacturing method of silatrane with thiol group and a preservation method thereof are disclosed. (3-Mercaptopropyl)trimethoxysilane and triethanolamine are reacted for a pre-determined time at a pre-determined temperature under nitrogen atmosphere in presence or absence of catalyst, and then a recrystallization process is performed with a solvent to obtain silatrane with thiol group of formula (1). Silatrane with thiol group is dissolved in an organic solvent to preserve the silatrane with thiol group.

3. 发明公开

US20230341411A1 METHOD AND KIT OF MEASURING CONCENTRATION OF ANALYTE 审中-公开
公开(公告)号：US20230341411A1
公开(公告)日：2023-10-26
申请号：US18214988
申请日：2023-06-27
申请人： NATIONAL CHUNG CHENG UNIVERSITY
发明人： Lai-Kwan CHAU , Chang-Yue CHIANG
IPC分类号： G01N33/68 , G01N33/543 , G01N33/74 , G01N33/53 , G01N21/77
CPC分类号： G01N33/6848 , G01N33/54346 , G01N33/6887 , G01N33/74 , G01N33/5308 , G01N21/7703 , G01N2333/585 , G01N2333/4712 , G01N2470/04
摘要： A method of measuring a concentration of an analyte is provided, including: reacting a test solution including an analyte with a nanoparticle solution including a plurality of nanoparticles and an optical waveguide element to form a sandwich-like structure; and measuring evanescent wave energy of the optical waveguide element absorbed and/or scattered by the plurality of nanoparticles after the plurality of nanoparticles forming the sandwich-like structure by using a photodetector to obtain a first signal, and calculating the concentration of the analyte based on the first signal. Wherein, a detection recognition element is conjugated on a surface of each of the plurality of nanoparticles, and a capture recognition element is conjugated on a waveguide surface of the optical waveguide element.

4. 发明申请

US20160169797A1 Self-Referencing Localized Plasmon Resonance Sensing Device and System Thereof 审中-公开
标题翻译：自引用本地等离子体共振感测装置及其系统
公开(公告)号：US20160169797A1
公开(公告)日：2016-06-16
申请号：US15048828
申请日：2016-02-19
申请人： National Chung Cheng University
发明人： Lai-Kwan CHAU , Chin-Wei WU , Chang-Yue CHIANG , Chien-Hsing CHEN
IPC分类号： G01N21/552
CPC分类号： G01N21/554 , G01N2201/088
摘要： A self-referencing localized plasmon resonance sensing device and a system thereof are disclosed. The reference optical waveguide element is modified with a noble metal nanoparticle layer. The sensing optical waveguide element is modified with a noble metal nanoparticle layer, which is further modified with a recognition unit. The incident light is guided into the reference and the sensing optical waveguide elements to respectively generate localized plasmon resonance sensor signals. The reference and the sensing optical waveguide elements respectively have a calibration slope. The processor utilizes the calibration slopes to regulate the second difference generated by detecting with the sensing optical waveguide element. The processor utilizes a difference between the first difference, which is generated by detecting with the reference optical waveguide element, and the regulated second difference to obtain a sensor response.
摘要翻译：公开了一种自参考的局部等离子体共振感测装置及其系统。参考光波导元件用贵金属纳米颗粒层进行改性。传感光波导元件用贵金属纳米粒子层进行改性，该金属纳米粒子层被识别单元进一步修饰。入射光被引导到参考和感测光波导元件中以分别产生局部等离子体共振传感器信号。参考和感测光波导元件分别具有校准斜率。处理器利用校准斜率来调节由感测光波导元件检测产生的第二差异。处理器利用通过与参考光波导元件检测而产生的第一差异和调节的第二差值之间的差异来获得传感器响应。

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