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1. 发明授权

US11613748B2 Method for producing nucleic acid molecule, biomaterial, and method for producing biomaterial 有权
公开(公告)号：US11613748B2
公开(公告)日：2023-03-28
申请号：US16668717
申请日：2019-10-30
申请人： NEC Solution Innovators, Ltd. , MOSAIC BIOSCIENCES, INC.
发明人： Tomoko Fujita , Iwao Waga , Katsunori Horii , Martin Stanton , Andrew Dalby
IPC分类号： C12N15/113 , C12N15/115 , C07K14/705 , C12N15/62
摘要： The present invention provides a method for producing a nucleic acid molecule that can obtain a nucleic acid molecule that binds to a target and does not inhibit a function of the target. The production method for a nucleic acid molecule of the present invention is a method for producing a nucleic acid molecule that binds to a first biological molecule and does not inhibit a function of the first biological molecule, the method including the steps of:
(A) bringing a candidate nucleic acid molecule into contact with the first biological molecule to select a nucleic acid molecule that has bound to the first biological molecule as a first selected nucleic acid molecule; and
(B) selecting the first selected nucleic acid molecule as an intended nucleic acid molecule.

2. 发明授权

US10662216B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US10662216B2
公开(公告)日：2020-05-26
申请号：US16333333
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/02 , C07H19/04 , C07H19/14 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/115 , C07K16/00
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

3. 发明授权

US10611791B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US10611791B2
公开(公告)日：2020-04-07
申请号：US16333325
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/10 , C07H19/067 , C07H19/073 , C07K16/00 , C12N15/115 , C07H21/00
CPC分类号： C07H19/10 , C07H19/073 , C07H21/00 , C07K16/00 , C12N15/115 , Y02P20/55
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule.
The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1):

where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

4. 发明授权

US09797888B2 Nucleic acid element candidate molecule and screening method for screening for nucleic acid element for target analysis using the same 有权
公开(公告)号：US09797888B2
公开(公告)日：2017-10-24
申请号：US14770520
申请日：2014-02-17
申请人： NEC Solution Innovators, Ltd.
发明人： Jou Akitomi , Naoto Kaneko , Katsunori Horii
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/5308 , C12Q1/6816 , C12Q2521/337 , C12Q2521/345
摘要： The present invention provides a novel nucleic acid element candidate molecule for use in screening for a nucleic acid element for target analysis and a novel screening method for screening for a nucleic acid element for target analysis using the same. The candidate molecule according to the present invention is a molecule for screening for a nucleic acid element for target analysis, being the following single-stranded nucleic acid (I): (I) a single-stranded nucleic acid comprising a catalyst sequence (D), a blocking sequence (B), and a binding sequence (A) that binds to a target, linked in this order. The blocking sequence (B) is complementary to a partial region (Dp) in the catalyst sequence (D). A terminal region (Ab) on the blocking sequence (B) side in the binding sequence (A) is complementary to a flanking region (Df) of the partial region (Dp) in the catalyst sequence (D) and is complementary to a terminal region (Af) on the side opposite to the blocking sequence (B) side in the binding sequence (A).

5. 发明申请

US20150167106A1 NUCLEIC ACID MOLECULE THAT BINDS TO INFLUENZA VIRUSES AND USE THEREOF 审中-公开
标题翻译：含有流感病毒的核酸分子及其用途
公开(公告)号：US20150167106A1
公开(公告)日：2015-06-18
申请号：US14405026
申请日：2013-04-25
申请人： NEC Solution Innovators, Ltd.
发明人： Ikuo Shiratori , Jou Akitomi , Katsunori Horii , Makio Furuichi , Iwao Waga
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , C12N15/115 , C12N2310/16 , C12Q2600/112
摘要： The present invention provides a nucleic acid molecule applicable to detection of influenza virus. The nucleic acid molecule according to the present invention is a nucleic acid molecule that binds to an influenza virus, including at least one polynucleotide selected from the group consisting of the following polynucleotides (a) to (d): (a) a polynucleotide that has any of base sequences of SEQ ID NOs: 1 to 30; (b) a polynucleotide that has a base sequence obtained by deletion, substitution, insertion, and/or addition of one or more bases in any of the base sequences of the polynucleotide (a) and binds to the influenza virus; (c) a polynucleotide that has a base sequence with an identity of at least 80% to any of the base sequences of the polynucleotide (a) and binds to the influenza virus; and (d) a polynucleotide that has a base sequence complementary to a polynucleotide hybridizing to any of the base sequences of the polynucleotide (a) under stringent conditions and binds to the influenza virus.
摘要翻译：本发明提供了适用于检测流感病毒的核酸分子。根据本发明的核酸分子是结合流感病毒的核酸分子，包括至少一种选自以下多核苷酸的多核苷酸（a）至（d）：（a）具有 SEQ ID NO：1至30的任何碱基序列; （b）具有通过在多核苷酸（a）的任何碱基序列中缺失，取代，插入和/或添加一个或多个碱基并与流感病毒结合而获得的碱基序列的多核苷酸; （c）具有与多核苷酸（a）的任何碱基序列具有至少80％同一性的碱基序列并与流感病毒结合的多核苷酸; 和（d）具有与在严格条件下与多核苷酸（a）的任何碱基序列杂交的多核苷酸互补的碱基序列并与流感病毒结合的多核苷酸。

6. 发明授权

US10900045B2 Protein, novel gene, expression vector, transformant, method for producing transformant, and method for screening for novel fluorescent protein 有权
公开(公告)号：US10900045B2
公开(公告)日：2021-01-26
申请号：US15737517
申请日：2016-06-13
申请人： NEC Solution Innovators, Ltd.
发明人： Ikuo Shiratori , Akihisa Shimizu , Katsunori Horii , Hiroshi Mishima , Iwao Waga
IPC分类号： C12N15/82 , C12N15/09 , C12N5/10 , C07K14/435 , A01H1/04
摘要： The present invention provides a novel fluorescent protein.
A novel protein includes the following protein (F1): (F1) a protein consisting of an amino acid sequence of SEQ ID NO: 1, wherein in the amino acid sequence of SEQ ID NO: 1, a 52nd amino acid Xaa52 is an arbitrary amino acid, a 133rd amino acid Xaa133 is an arbitrary amino acid, and a 154th amino acid Xaa154 is an arbitrary amino acid.

7. 发明授权

US10760084B2 α-amylase-binding nucleic acid molecule and use thereof 有权
公开(公告)号：US10760084B2
公开(公告)日：2020-09-01
申请号：US15775797
申请日：2016-09-12
申请人： NEC Solution Innovators, Ltd. , Gunma University
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Ikuo Shiratori , Iwao Waga , Masayasu Kuwahara
IPC分类号： C12N15/11 , C12N15/115 , C12Q1/40 , C12Q1/68 , G01N33/53 , C12N15/10
摘要： The present invention provides a novel nucleic acid molecule that can be used for detection of α-amylase. The α-amylase-binding nucleic acid molecule of the present invention is characterized in that it binds to α-amylase with a dissociation constant of 17 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 22, for example. According to the nucleic acid molecule of the present invention, it is possible to detect α-amylase in saliva.

8. 发明申请

US20160169875A1 NUCLEIC ACID SENSOR FOR MELAMINE ANALYSIS, DEVICE FOR MELAMINE ANALYSIS, AND METHOD FOR MELAMINE ANALYSIS 审中-公开
标题翻译：用于梅毒分析的核酸传感器，甲酚分析装置和甲酰胺分析方法
公开(公告)号：US20160169875A1
公开(公告)日：2016-06-16
申请号：US14417333
申请日：2013-07-23
申请人： NEC Solution Innovators, Ltd.
发明人： Katsunori Horii , Naoto Kaneko , Jou Akitomi , Shintarou Katou , Makio Furuichi , Iwao Waga
IPC分类号： G01N33/53 , G01N33/58 , G01N21/76 , G01N21/25 , C12N15/115 , C12N15/113
CPC分类号： G01N33/5308 , C12N15/111 , C12N15/113 , C12N15/115 , C12N2310/127 , C12N2310/16 , C12N2310/3519 , C12N2320/10 , C12Q1/6825 , G01N21/251 , G01N21/76 , G01N33/581 , G01N2333/9005 , C12Q2521/345 , C12Q2525/205
摘要： The present invention is to provide a new sensor for melamine detection. The nucleic acid sensor for melamine analysis of the present invention includes a polynucleotide (x1) that includes a catalytic nucleic acid molecule (D) that activates a catalytic function and a binding nucleic acid molecule (A) that binds to melamine. The polynucleotide (x1) has any one of the base sequences of SEQ ID NOs: 1 to 14, and n and m are positive integers. In the nucleic acid sensor, since the catalytic function of the catalytic nucleic acid molecule (D) is inhibited in the absence of melamine and the catalytic function of the catalytic nucleic acid molecule (D) is activated in the presence of melamine, melamine can be analyzed by detecting the catalytic function.
摘要翻译：本发明提供一种用于三聚氰胺检测的新型传感器。用于本发明的三聚氰胺分析的核酸传感器包括包含活化催化功能的催化核酸分子（D）和结合三聚氰胺的结合核酸分子（A）的多核苷酸（x1）。多核苷酸（x1）具有SEQ ID NO：1〜14的碱基序列中的任一个，n和m是正整数。在核酸传感器中，由于催化性核酸分子（D）的催化功能在没有三聚氰胺的情况下被抑制，催化性核酸分子（D）的催化功能在三聚氰胺的存在下被活化，所以三聚氰胺可以通过检测催化功能进行分析。

9. 发明授权

US10934548B2 Wheat allergen-binding nucleic acid molecule and use thereof 有权
公开(公告)号：US10934548B2
公开(公告)日：2021-03-02
申请号：US15776142
申请日：2015-11-16
申请人： NEC Solution Innovators, Ltd.
发明人： Tomoko Shiratori , Naoto Kaneko , Ikuo Shiratori , Katsunori Horii , Hirotaka Minagawa , Jou Akitomi , Yoshihito Yoshida , Iwao Waga
IPC分类号： C12N15/11 , C12N15/115 , C07K14/415 , C12Q1/6883
摘要： The present invention provides a novel nucleic acid molecule that can be used for detection of a wheat allergen. The wheat allergen-binding nucleic acid according to the present invention is characterized in that it binds to a wheat allergen with a dissociation constant of 20 nM or less, and preferably includes a polynucleotide consisting of either of base sequences of SEQ ID NOs: 1 and 2, for example.

10. 发明授权

US10781230B2 Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule 有权
公开(公告)号：US10781230B2
公开(公告)日：2020-09-22
申请号：US16333333
申请日：2017-09-14
申请人： NEC Solution Innovators, Ltd. , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
发明人： Hirotaka Minagawa , Katsunori Horii , Jou Akitomi , Naoto Kaneko , Iwao Waga , Masayasu Kuwahara
IPC分类号： C07H19/02 , C07H19/04 , C07H19/14 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/115 , C07K16/00
摘要： The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

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