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1. 发明授权

US09612197B2 Reflection-based tubular waveguide particle plasmon resonance sensing system and sensing device thereof 有权
公开(公告)号：US09612197B2
公开(公告)日：2017-04-04
申请号：US14806321
申请日：2015-07-22
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Yu-Chung Huang , Chih-To Wang , Chien-Hsing Chen , Chang-Yue Chiang
IPC分类号： G01N21/552
CPC分类号： G01N21/554 , G01N2201/08
摘要： A reflection-based tubular waveguide particle plasmon resonance sensing system and a sensing device thereof are provided. The sensing device includes a hollow tubular waveguide element having wall, a reflection layer disposed on one end of the wall (distal end), and a noble metal nanoparticle layer distributed on the surface of the wall. An incident light enters the wall through another end of the tubular waveguide element (proximal end) and being total internal reflected many times along the wall, then is reflected by the reflection layer and being total internal reflected many times along the wall again, and finally, the incident light exits the proximal end. Wherein, when the sample contacts the noble metal nanoparticle layer of the tubular waveguide element, the particle plasmon resonance condition is altered and hence the signal intensity of the light exiting the tubular waveguide element changes.

2. 发明授权

US09096620B2 Mercaptoalkylsilatrane derivative having protecting group and method of manufacturing the same 有权
标题翻译：具有保护基的巯基烷基硅烷衍生物及其制造方法
公开(公告)号：US09096620B2
公开(公告)日：2015-08-04
申请号：US14195367
申请日：2014-03-03
申请人： National Chung Cheng University
发明人： Wen-Hao Chen , Lai-Kwan Chau , Chao-Wen Chen , Yen-Ta Tseng
IPC分类号： C07F7/02 , C07F7/18
CPC分类号： C07F7/1804 , Y02P20/55
摘要： A mercaptoalkylsilatrane derivative having protecting group and a method of manufacturing the same. The mercaptoalkylsilatrane derivative includes: mercaptoalkylsilatrane compound having a mercapto group; a protecting group bonding to sulfur of the mercapto group, wherein the protecting group is used to avoid the chemical reaction of the mercapto group with reactive chemical species, e.g., oxygen, ketone, and aldehyde, etc. Besides, the manufacturing method thereof includes the steps of: providing silane compound having the mercapto group; bonding the protecting group to the mercapto group of the silane compound; performing the chemical reaction of triethanolamine with the silane compound having the protecting group for manufacturing the mercaptoalkylsilatrane derivative having the protecting group.
摘要翻译：具有保护基的巯基烷基硅烷衍生物及其制造方法。巯基烷基硅烷衍生物包括：具有巯基的巯基烷基硅烷化合物; 与巯基结合硫的保护基团，其中保护基团用于避免巯基与活性化学物质例如氧，酮和醛等的化学反应。此外，其制造方法包括步骤：提供具有巯基的硅烷化合物; 将保护基键合到硅烷化合物的巯基上; 进行三乙醇胺与具有保护基的硅烷化合物的化学反应，制造具有保护基的巯基烷基硅烷衍生物。

3. 发明申请

US20140296552A1 Mercaptoalkylsilatrane Derivative Having Protecting Group and Method of Manufacturing the Same 有权
标题翻译：具有保护基的巯基烷基硅烷衍生物及其制造方法
公开(公告)号：US20140296552A1
公开(公告)日：2014-10-02
申请号：US14195367
申请日：2014-03-03
申请人： National Chung Cheng University
发明人： Wen-Hao Chen , Lai-Kwan Chau , Chao-Wen Chen , Yen-Ta Tseng
IPC分类号： C07F7/18
CPC分类号： C07F7/1804 , Y02P20/55
摘要： A mercaptoalkylsilatrane derivative having protecting group and a method of manufacturing the same. The mercaptoalkylsilatrane derivative includes: mercaptoalkylsilatrane compound having a mercapto group; a protecting group bonding to sulfur of the mercapto group, wherein the protecting group is used to avoid the chemical reaction of the mercapto group with reactive chemical species, e.g., oxygen, ketone, and aldehyde, etc. Besides, the manufacturing method thereof includes the steps of: providing silane compound having the mercapto group; bonding the protecting group to the mercapto group of the silane compound; performing the chemical reaction of triethanolamine with the silane compound having the protecting group for manufacturing the mercaptoalkylsilatrane derivative having the protecting group.
摘要翻译：具有保护基的巯基烷基硅烷衍生物及其制造方法。巯基烷基硅烷衍生物包括：具有巯基的巯基烷基硅烷化合物; 与巯基结合硫的保护基团，其中保护基团用于避免巯基与活性化学物质例如氧，酮和醛等的化学反应。此外，其制造方法包括步骤：提供具有巯基的硅烷化合物; 将保护基键合到硅烷化合物的巯基上; 进行三乙醇胺与具有保护基的硅烷化合物的化学反应，制造具有保护基的巯基烷基硅烷衍生物。

4. 发明申请

US20140295075A1 METHOD FOR FIXING METAL ONTO SURFACE OF SUBSTRATE 有权
标题翻译：将金属固定在基材表面上的方法
公开(公告)号：US20140295075A1
公开(公告)日：2014-10-02
申请号：US14215821
申请日：2014-03-17
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Wen-Hao Chen , Yen-Ta Tseng , Chin-Wei Wu , Chao-Wen Chen
IPC分类号： C07F7/18
CPC分类号： C07F7/1804
摘要： A method for fixing metal onto a surface of the substrate. The present method includes steps of: providing a substrate and a mercaptoalkylsilatrane compound; dissolving the mercaptoalkylsilatrane compound in a solvent; performing a condensation reaction of the substrate with and the dissolved mercaptoalkylsilatrane compound to complete the surface modification of the substrate; and performing a covalent bonding process to metal with the mercaptoalkylsilatrane compound already modified onto the surface of the substrate to fix the metal onto the surface of the substrate.
摘要翻译：一种用于将金属固定在基板的表面上的方法。本方法包括以下步骤：提供底物和巯基烷基硅藻土化合物; 将巯基烷基硅藻土化合物溶解在溶剂中; 进行底物与溶解的巯基烷基硅烷化合物的缩合反应，完成底物的表面改性; 并且对已经改性的巯基烷基硅烷化合物对金属进行共价键合处理，以将金属固定在基材的表面上。

5. 发明授权

US11467154B2 Optical nano-biosensing system and method thereof 有权
公开(公告)号：US11467154B2
公开(公告)日：2022-10-11
申请号：US16782745
申请日：2020-02-05
申请人： National Chung Cheng University
发明人： Sung-Nien Yu , Tsung-Heng Tsai , Lai-Kwan Chau
IPC分类号： G01N33/543 , H03M1/12 , B01L3/00
摘要： An optical nano-biosensing system and a method thereof are provided. The optical nano-biosensing system includes a nano-plasmonic sensing device, a high-resolution analog-to-digital converter, a signal acquisition and processing device, and an intelligent electronic device. The nano-plasmonic sensing device further includes a light-source control circuit, a sample receiver, a light detector, and a signal-amplifying circuit. The sample receiver receives a sample. The light-source control circuit generates an incident light from a light source to be projected onto the sample receiver. The light detector detects an emergent light from the sample receiver to generate a detection signal. The signal-amplifying circuit converts the detection signal to generate an amplified signal. The high-resolution analog-to-digital converter digitizes the amplified signal to generate a digital signal. The signal calculator of the signal acquisition and processing device operates the digital signal to generate calculated information.

6. 发明授权

US10722534B2 Magnetic nanoaggregate-embedded bead, manufacturing method thereof and bioparticle detection method using the same 有权
公开(公告)号：US10722534B2
公开(公告)日：2020-07-28
申请号：US15648102
申请日：2017-07-12
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Shih-Ying Yen
IPC分类号： B82Y5/00 , A61K33/38 , A61K47/69 , A61K38/02 , A61K47/52 , G01N33/543 , G01N33/58 , A61K33/00
摘要： A magnetic nanoaggregate-embedded bead (NAEB), a manufacturing method thereof and a bioparticle detection method using the same are disclosed. The magnetic NAEB has a protective nanoshell, noble metal nanoparticles, Raman reporter molecules and at least one magnetic nanoparticle. The protective nanoshell covers the noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle. The noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle form a magnetic nanoaggregate. Preferably, a chemical modification is performed on the magnetic NAEB, such that at least one targeting molecule is formed on an outer wall of the protective nanoshell, wherein a type of the targeting molecule is corresponding to a type of the bioparticle to be detected.

7. 发明申请

US20180200296A1 Magnetic Nanoaggregate-Embedded Bead, Manufacturing Method Thereof and Bioparticle Detection Method Using the Same 审中-公开
公开(公告)号：US20180200296A1
公开(公告)日：2018-07-19
申请号：US15648102
申请日：2017-07-12
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Shih-Ying Yen
IPC分类号： A61K33/38 , A61K47/69 , A61K38/02 , A61K47/52
摘要： A magnetic nanoaggregate-embedded bead (NAEB), a manufacturing method thereof and a bioparticle detection method using the same are disclosed. The magnetic NAEB has a protective nanoshell, noble metal nanoparticles, Raman reporter molecules and at least one magnetic nanoparticle. The protective nanoshell covers the noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle. The noble metal nanoparticles, the Raman reporter molecules and the at least one magnetic nanoparticle form a magnetic nanoaggregate. Preferably, a chemical modification is performed on the magnetic NAEB, such that at least one targeting molecule is formed on an outer wall of the protective nanoshell, wherein a type of the targeting molecule is corresponding to a type of the bioparticle to be detected.

8. 发明授权

US09506861B2 Method for obtaining binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor 有权
标题翻译：使用光纤粒子等离子体共振（FOPPR）传感器获得结合动力学速率常数的方法
公开(公告)号：US09506861B2
公开(公告)日：2016-11-29
申请号：US14063763
申请日：2013-10-25
申请人： NATIONAL CHUNG CHENG UNIVERSITY
发明人： Shau-Chun Wang , Lai-Kwan Chau , Ting-Chou Chang , Chao-Ching Wu
IPC分类号： G01N21/552 , G01N21/55 , G01N21/27 , G01N21/77
CPC分类号： G01N21/55 , G01N21/272 , G01N21/554 , G01N21/7703
摘要： A method for obtaining the binding kinetic rate constants using fiber optic particle plasmon resonance (FOPPR) sensor, suitable for a test solution with two or more concentrations, which employs the following major steps: providing one FOPPR sensor instrument system, obtaining optical time-resolved signal intensities starting at the initial time to the steady state of the two or more regions, substituting the measured signal intensity values into the formula which is derived by using the pseudo-first order rate equation model. In addition, this method measures the temporal signal intensity evolution under static conditions as the samples are quickly loaded. As a result, unlike the conventional device where the sample is continuously infused, the method is able to measure the association and dissociation rate constants of which the upper bounds are not limited by the sample flow rate.
摘要翻译：一种使用光纤粒子等离子体共振（FOPPR）传感器获得结合动力学速率常数的方法，适用于具有两个或多个浓度的测试溶液，其采用以下主要步骤：提供一个FOPPR传感器仪器系统，获得光学时间分辨信号强度从初始时间开始到两个或更多个区域的稳定状态，将测量的信号强度值代入通过使用伪一阶速率方程模型导出的公式。此外，该方法测量样品快速加载时在静态条件下的时间信号强度演化。结果，与连续输入样品的常规装置不同，该方法能够测量上限的关联和解离速率常数不受样品流速的限制。

9. 发明申请

US20210011011A1 Optical Nano-Biosensing System and Method Thereof 有权
公开(公告)号：US20210011011A1
公开(公告)日：2021-01-14
申请号：US16782745
申请日：2020-02-05
申请人： National Chung Cheng University
发明人： Sung-Nien Yu , Tsung-Heng Tsai , Lai-Kwan Chau
IPC分类号： G01N33/543 , B01L3/00 , H03M1/12
摘要： An optical nano-biosensing system and a method thereof are provided. The optical nano-biosensing system includes a nano-plasmonic sensing device, a high-resolution analog-to-digital converter, a signal acquisition and processing device, and an intelligent electronic device. The nano-plasmonic sensing device further includes a light-source control circuit, a sample receiver, a light detector, and a signal-amplifying circuit. The sample receiver receives a sample. The light-source control circuit generates an incident light from a light source to be projected onto the sample receiver. The light detector detects an emergent light from the sample receiver to generate a detection signal. The signal-amplifying circuit converts the detection signal to generate an amplified signal. The high-resolution analog-to-digital converter digitizes the amplified signal to generate a digital signal. The signal calculator of the signal acquisition and processing device operates the digital signal to generate calculated information.

10. 发明授权

US10324034B2 Self-referencing localized plasmon resonance sensing device and system thereof 有权
公开(公告)号：US10324034B2
公开(公告)日：2019-06-18
申请号：US15048828
申请日：2016-02-19
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Chin-Wei Wu , Chang-Yue Chiang , Chien-Hsing Chen
IPC分类号： G01N21/552
摘要： A self-referencing localized plasmon resonance sensing device and a system thereof are disclosed. The reference optical waveguide element is modified with a noble metal nanoparticle layer. The sensing optical waveguide element is modified with a noble metal nanoparticle layer, which is further modified with a recognition unit. The incident light is guided into the reference and the sensing optical waveguide elements to respectively generate localized plasmon resonance sensor signals. The reference and the sensing optical waveguide elements respectively have a calibration slope. The processor utilizes the calibration slopes to regulate the second difference generated by detecting with the sensing optical waveguide element. The processor utilizes a difference between the first difference, which is generated by detecting with the reference optical waveguide element, and the regulated second difference to obtain a sensor response.

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