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1. 发明申请

US20190176415A1 METHOD FOR PRODUCING MPS-COMPATIBLE WATER GRADIENT CONTACT LENSES 审中-公开
公开(公告)号：US20190176415A1
公开(公告)日：2019-06-13
申请号：US16204664
申请日：2018-11-29
申请人： Novartis AG
发明人： Yongxing Qiu , John Dallas Pruitt , Newton T. Samuel
IPC分类号： B29D11/00 , G02C7/04 , B65B55/22 , G02B1/04 , G02B1/18
摘要： The invention is related to a process for producing contact lenses that not only comprise a water gradient structural configurations, but also have a minimized uptakes of polyquaternium-1 and a long-lasting surface hydrophilicity and wettability even after being undergone a 30-days lens care regime.

2. 发明授权

US09507173B2 Silicone hydrogel lens with a crosslinked hydrophilic coating 有权
公开(公告)号：US09507173B2
公开(公告)日：2016-11-29
申请号：US14962354
申请日：2015-12-08
申请人： Novartis AG
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： G02C7/00 , G02C7/04 , G02B1/04 , G02B1/10 , G02B1/18 , C08J7/04
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

3. 发明授权

US10920102B2 Silicone hydrogel lens with a crosslinked hydrophilic coating 有权
公开(公告)号：US10920102B2
公开(公告)日：2021-02-16
申请号：US16720932
申请日：2019-12-19
申请人： Novartis AG
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： C09D177/06 , B29D11/00 , G02B1/18 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

4. 发明申请

US20170306178A1 SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 审中-公开
公开(公告)号：US20170306178A1
公开(公告)日：2017-10-26
申请号：US15646291
申请日：2017-07-11
申请人： Novartis AG
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： C09D177/06 , B29D11/00 , C08G77/388 , C08J5/00 , C08J7/04 , C08L83/04 , G02B1/18 , G02C7/04 , G02B1/10 , G02B1/04 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

5. 发明申请

US20150099822A1 SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 有权
标题翻译：硅胶水晶镜片，带有交联胶粘剂
公开(公告)号：US20150099822A1
公开(公告)日：2015-04-09
申请号：US14571350
申请日：2014-12-16
申请人： Novartis AG
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： G02B1/10 , G02B1/04
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译：本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成，和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

6. 发明授权

US08784867B2 Contact lenses containing carotenoid and method for making same 有权
标题翻译：含有类胡萝卜素的隐形眼镜及其制作方法
公开(公告)号：US08784867B2
公开(公告)日：2014-07-22
申请号：US13716496
申请日：2012-12-17
申请人： Novartis AG
发明人： Newton T. Samuel , Nirupama Kenkare , Peter D. Lackey , Jessie Chen
IPC分类号： A61K9/00 , G02B1/04 , A61K31/355 , C07C403/24 , A61F9/00 , C09B61/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K31/355 , C07C403/24 , C09B61/00 , G02B1/043
摘要： The instant invention pertains to a method for producing contact lenses with improved oxidative stability of Carotenoids in the contact lens. The method of the invention involves adding a vitamin E material into a contact lens in an amount sufficient to reduce oxidative degradation of Carotenoids in the lens by at least about 30% in comparison with an identical contact lens without the vitamin E material.
摘要翻译：本发明涉及一种具有改善隐形眼镜中类胡萝卜素的氧化稳定性的隐形眼镜的方法。本发明的方法涉及将隐形眼镜中的维生素E添加到相对于没有维生素E材料的相同隐形眼镜相比，其量足以减少透镜中类胡萝卜素的氧化降解至少约30％。

7. 发明申请

US20190179055A1 WEEKLY AND MONTHLY DISPOSABLE WATER GRADIENT CONTACT LENSES 审中-公开
公开(公告)号：US20190179055A1
公开(公告)日：2019-06-13
申请号：US16204641
申请日：2018-11-29
申请人： Novartis AG
发明人： Yongxing Qiu , John Dallas Pruitt , Newton T. Samuel , Chung-Yuan Chiang , Robert Carey Tucker , Yuan Chang , Ethan Leveillee
IPC分类号： G02B1/04 , C08L83/04 , C08L33/02 , C09D133/02 , C08L79/04
摘要： The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

8. 发明申请

US20170037276A1 SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 有权
标题翻译：硅胶水晶镜片，带有交联胶粘剂
公开(公告)号：US20170037276A1
公开(公告)日：2017-02-09
申请号：US15298298
申请日：2016-10-20
申请人： Novartis AG
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： C09D177/06 , G02B1/04 , G02B1/10 , C09D5/16 , B29D11/00 , C08J5/00 , C09D133/26 , C09D133/14 , C09D133/02 , C09D171/02 , G02C7/04 , C08G77/388
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译：本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成，和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

9. 发明申请

US20160091734A1 SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 有权
公开(公告)号：US20160091734A1
公开(公告)日：2016-03-31
申请号：US14962354
申请日：2015-12-08
申请人： Novartis AG
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： G02C7/04 , G02B1/18 , C08J7/04
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

10. 发明授权

US09261626B2 Contact lenses with enzymatically degradable coatings thereon 有权
标题翻译：具有可降解酶层的隐形眼镜
公开(公告)号：US09261626B2
公开(公告)日：2016-02-16
申请号：US13706737
申请日：2012-12-06
申请人： Novartis AG
发明人： Newton T. Samuel , Nirupama Kenkare
IPC分类号： G02B1/04
CPC分类号： G02B1/043
摘要： The invention is related to a disposable contact lens comprising a top coating which is made of a hydrophilic polymeric material including dangling hydrophilic polymer chains covalently linked to the hydrophilic polymeric material through oligo-caprolactone linkages susceptible to enzymatic degradation in the eyes. The top coating is stable to lens processing/storage and confers lubricity to the lens. However, it slowly is degraded during the lens wear due to the action of enzymes (e.g., Lipase) in tear film. The loss in lubricity will be experienced as a drop in comfort for the lens wearer and thereby serves as the built-in compliance features of the disposable contact lens.
摘要翻译：本发明涉及一次性隐形眼镜，其包括由亲水性聚合材料制成的顶部涂层，其包括通过易于在眼睛中酶促降解的低聚己内酯键与亲水性聚合物材料共价连接的悬浮的亲水性聚合物链。顶部涂层对透镜加工/储存稳定，并赋予透镜润滑性。然而，由于在泪液膜中的酶（例如脂肪酶）的作用，它在镜片佩戴期间缓慢地降解。润滑性的损失将作为镜片佩戴者的舒适度降低，从而用作一次性隐形眼镜的内置柔顺特征。

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