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1. 发明授权

US08496964B2 Controlled release micro-capsule for osteogenic action 有权
标题翻译：用于成骨作用的控释微胶囊
公开(公告)号：US08496964B2
公开(公告)日：2013-07-30
申请号：US13203603
申请日：2010-02-26
申请人： Prabhat Ranjan Mishra , Ritu Trivedi , Girish Kumar Gupta , Avinash Kumar , Varsha Gupta , Srikanta Kumar Rath , Kamini Srivastava , Naibedya Chattopadhyay , Anil Kumar Dwivedi
发明人： Prabhat Ranjan Mishra , Ritu Trivedi , Girish Kumar Gupta , Avinash Kumar , Varsha Gupta , Srikanta Kumar Rath , Kamini Srivastava , Naibedya Chattopadhyay , Anil Kumar Dwivedi
IPC分类号： A61K9/52 , A61K9/50 , A61K31/70 , B01J13/00 , B05D3/00 , A01N43/04
CPC分类号： A61K9/1641 , A61K9/1611 , A61K9/1652 , A61K9/1658 , A61K9/5031 , A61K9/5052 , A61K9/5073
摘要： The present invention relates to a microcapsule for controlled release of flavanoid compound and a process for preparation thereof. The microcapsule comprising a core particle consisting of a calcium salt, Pluronic F68 [poly (ethylene oxide-co-polypropylene oxide), block poly oxyethylene-polypropylene block copolymer], loaded with a flavanoid compound, the resulting core particle having a plurality of alternate layers of cationic and anionic polyelectrolytes adsorbed thereon and an outer layer formed by a bile salt, wherein the flavanoid is ranging between 10 to 96% by weight.
摘要翻译：本发明涉及一种用于控制释放类黄酮化合物的微胶囊及其制备方法。所述微胶囊包含由钙盐，Pluronic F68 [聚（环氧乙烷 - 共聚 - 丙烯氧化物），嵌段聚氧乙烯 - 聚丙烯嵌段共聚物]组成的核心颗粒，负载有类黄酮化合物，所得核心颗粒具有多个交替吸附在其上的阳离子和阴离子聚电解质层以及由胆汁盐形成的外层，其中类黄酮的范围在10至96重量％之间。

2. 发明申请

US20110305754A1 CONTROLLED RELEASE MICRO-CAPSULE FOR OSTEOGENIC ACTION 有权
标题翻译：控制释放微胶囊用于卵泡作用
公开(公告)号：US20110305754A1
公开(公告)日：2011-12-15
申请号：US13203603
申请日：2010-02-26
申请人： Prabhat Ranjan Mishra , Ritu Trivedi , Girish Kumar Gupta , Avinash Kumar , Varsha Gupta , Srikanta Kumar Rath , Kamini Srivastava , Naibedya Chattopadhyay , Anil Kumar Dwivedi
发明人： Prabhat Ranjan Mishra , Ritu Trivedi , Girish Kumar Gupta , Avinash Kumar , Varsha Gupta , Srikanta Kumar Rath , Kamini Srivastava , Naibedya Chattopadhyay , Anil Kumar Dwivedi
IPC分类号： A61K9/52 , A61K9/50 , A61P19/10 , A61P19/00 , A61K31/352 , A61K31/7048
CPC分类号： A61K9/1641 , A61K9/1611 , A61K9/1652 , A61K9/1658 , A61K9/5031 , A61K9/5052 , A61K9/5073
摘要： The present invention relates to a microcapsule for controlled release of flavanoid compound and a process for preparation thereof. The microcapsule comprising a core particle consisting of a calcium salt, Pluronic F68 [poly (ethylene oxide-co-polypropylene co-polypropylene oxide), block poly oxyethylene-polypropylene block copolymer], loaded with a flavanoid compound, the resulting core particle having a plurality of alternate layers of cationic and anionic polyelectrolytes adsorbed thereon and an outer layer formed by a bile salt, wherein the flavanoid is ranging between 10 to 96% by weight.
摘要翻译：本发明涉及一种用于控制释放类黄酮化合物的微胶囊及其制备方法。该微胶囊包含由钙盐，Pluronic F68 [聚（环氧乙烷 - 共聚 - 丙烯共聚 - 丙烯氧化物），嵌段聚氧乙烯 - 聚丙烯嵌段共聚物]组成的核心颗粒，负载有类黄酮化合物，所得核心颗粒具有吸附在其上的多个阳离子和阴离子聚电解质的交替层和由胆汁盐形成的外层，其中所述类黄酮的范围在10至96重量％之间。

3. 发明申请

US20120003273A1 SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS 有权
标题翻译：用于预防和治疗骨髓相关疾病的替代苯唑西林和相关化合物
公开(公告)号：US20120003273A1
公开(公告)日：2012-01-05
申请号：US13127913
申请日：2009-05-14
申请人： Atul Goel , Amit Kumar , Sumit Chaurasia , Divya Singh , Abnish Kumar Gautam , Rashmi Pandey , Ritu Trivedi , Man Mohan Singh , Naibedya Chattopadhyay , Lakshmi Manickavasagam , Girish Kumar Jain , Anil Kumar Dwivedi
发明人： Atul Goel , Amit Kumar , Sumit Chaurasia , Divya Singh , Abnish Kumar Gautam , Rashmi Pandey , Ritu Trivedi , Man Mohan Singh , Naibedya Chattopadhyay , Lakshmi Manickavasagam , Girish Kumar Jain , Anil Kumar Dwivedi
IPC分类号： A61K31/352 , C07D311/36 , A61P19/08 , A61K31/4453 , A61P19/10 , C07D493/04 , A61K9/00
CPC分类号： C07D493/04 , C07D311/36
摘要： The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C—OH, C-Me, C—OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders.
摘要翻译：本发明涉及具有通式（I）的新型取代的苯并呋喃和其相关化合物，其盐和手性的非手性衍生物; 其中R1，R2，R3，R4，R5，R6，R7，R8独立地选自氢，任选取代的烷基，任选取代的烯基，任选取代的烷氧基，任选取代的芳基，任选取代的杂芳基，任选取代的烷硫基，任选取代的氨基，任选取代的酰基氨基，任选取代的芳基氨基，任选取代的酰基硫基，任选取代的酰基，任选取代的芳酰基，任选取代的酰氧基，任选取代的硫代酰氨基，卤素，腈，酯，羟基，巯基，三氟化碳，硝基，但不限于此 ; 其中R1R2或R2R3或R6R7可以连接并形成五元环或六元环，例如任选取代的呋喃，任选取代的二氢呋喃，任选取代的吡喃; 或可以通过亚甲二氧基部分连接; 其中X选自由任选的酮基，任选的亚甲基，任选取代的亚甲基，任选取代的烯烃组成的单元; 其中Y和Z选自由CH，C-OH，C-Me，C-OMe组成的单元，条件是Y和Z之间的键是单键; 其中Y和Z可以是碳原子，条件是Y和Z之间的键是双键。通式的化合物可用于预防和治疗骨相关疾病。

4. 发明授权

US08686028B2 Substituted benzfurochromenes and related compounds for the prevention and treatment of bone related disorders 有权
标题翻译：用于预防和治疗骨相关疾病的取代苯并呋喃并烯和相关化合物
公开(公告)号：US08686028B2
公开(公告)日：2014-04-01
申请号：US13127913
申请日：2009-05-14
申请人： Atul Goel , Amit Kumar , Sumit Chaurasia , Divya Singh , Abnish Kumar Gautam , Rashmi Pandey , Ritu Trivedi , Man Mohan Singh , Naibedya Chattopadhyay , Lakshmi Manickavasagam , Girish Kumar Jain , Anil Kumar Dwivedi
发明人： Atul Goel , Amit Kumar , Sumit Chaurasia , Divya Singh , Abnish Kumar Gautam , Rashmi Pandey , Ritu Trivedi , Man Mohan Singh , Naibedya Chattopadhyay , Lakshmi Manickavasagam , Girish Kumar Jain , Anil Kumar Dwivedi
IPC分类号： A61K31/352 , A61K31/4453 , C07D311/36 , C07D493/04
CPC分类号： C07D493/04 , C07D311/36
摘要： The present invention relates to novel substituted benzfurochromenes and related compounds having the general formula (I), salts and chiral, achiral derivatives thereof; wherein R1, R2, R3, R4, R5, R6, R7, R8 are independently selected from the groups consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted aroyl, optionally substituted acyloxy, optionally substituted thioamido, halogens, nitriles, esters, hydroxy, mercapto, carbontrifluoride, nitro but not limited to this; wherein R1R2 or R2R3 or R6R7 may be connected and form either a five membered ring or a six membered ring such as optionally substituted furan, optionally substituted dihydrofuran, optionally substituted pyran; or may be connected through a methylenedeoxy moiety; wherein X is selected from the units consisting of optionally a ketone group, optionally a methylene group, optionally substituted methylene group, optionally substituted alkene; wherein Y and Z is selected from the units consisting of CH, C—OH, C-Me, C—OMe with the proviso that bond between Y and Z is a single bond; Wherein Y and Z may be a carbon atom with the proviso that bond between Y and Z is a double bond. The compounds of the general formula is useful for the prevention and treatment of bone related disorders.
摘要翻译：本发明涉及具有通式（I）的新型取代的苯并呋喃和其相关化合物，其盐和手性的非手性衍生物; 其中R1，R2，R3，R4，R5，R6，R7，R8独立地选自氢，任选取代的烷基，任选取代的烯基，任选取代的烷氧基，任选取代的芳基，任选取代的杂芳基，任选取代的烷硫基，任选取代的氨基，任选取代的酰基氨基，任选取代的芳基氨基，任选取代的酰基硫基，任选取代的酰基，任选取代的芳酰基，任选取代的酰氧基，任选取代的硫代酰氨基，卤素，腈，酯，羟基，巯基，三氟化碳，硝基，但不限于此 ; 其中R1R2或R2R3或R6R7可以连接并形成五元环或六元环，例如任选取代的呋喃，任选取代的二氢呋喃，任选取代的吡喃; 或可以通过亚甲二氧基部分连接; 其中X选自由任选的酮基，任选的亚甲基，任选取代的亚甲基，任选取代的烯烃组成的单元; 其中Y和Z选自由CH，C-OH，C-Me，C-OMe组成的单元，条件是Y和Z之间的键是单键; 其中Y和Z可以是碳原子，条件是Y和Z之间的键是双键。通式的化合物可用于预防和治疗骨相关疾病。

5. 发明申请

US20140079834A1 BIOACTIVE FRACTIONS AND COMPOUNDS FROM DALBERGIA SISSOO FOR THE PREVENTION OR TREATMENT OF OSTEO-HEALTH RELATED DISORDERS 审中-公开
标题翻译：来自DALBERGIA SISSOO的生物活性成分和化合物用于预防或治疗OSTEO-HEALTH相关疾病
公开(公告)号：US20140079834A1
公开(公告)日：2014-03-20
申请号：US14113561
申请日：2012-04-25
申请人： Rakesh Maurya , Preety Dixit , Ritu Trivedi , Vikram Khedgikar , Jyoti Gautam , Avinash Kumar , Divya Singh , Sheelendra Pratap Singh , (none) Wahajuddin , Girish Kumar Jain , Naibedya Chattopadhyay
发明人： Rakesh Maurya , Preety Dixit , Ritu Trivedi , Vikram Khedgikar , Jyoti Gautam , Avinash Kumar , Divya Singh , Sheelendra Pratap Singh , (none) Wahajuddin , Girish Kumar Jain , Naibedya Chattopadhyay
IPC分类号： A61K31/7048 , A61K31/352 , A61K36/48
CPC分类号： A61K31/7048 , A61K31/352 , A61K36/48 , C07D311/36 , C07H17/07
摘要： The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, from Dalbergia sissoo plant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.
摘要翻译：本发明涉及用于预防或治疗与骨骼健康相关的疾病的生物活性级分和来自枸杞子的化合物。本发明涉及药物组合物领域，其提供新的植物提取物，其级分和从天然来源分离的纯化合物，其可用于预防和/或治疗与雌激素依赖性或独立疾病或综合征或病症相关的各种医学适应症优选地在预防或治疗在人和动物中引起的雌激素依赖性或独立性疾病或综合征或障碍，以及在人和动物的骨骼生长和健康期间达到峰值骨量。特别地，本发明还涉及从家蚕豆科的Dalbergia sissoo植物制备生物活性提取物，级分和分离纯化合物的方法，它们的药学上可接受的盐和本发明主要方面的组合物。

6. 发明授权

US10292994B2 Bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders 有权
$Bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders$
公开(公告)号：US10292994B2
公开(公告)日：2019-05-21
申请号：US14113561
申请日：2012-04-25
申请人： Rakesh Maurya , Preety Dixit , Ritu Trivedi , Vikram Khedgikar , Jyoti Gautam , Avinash Kumar , Divya Singh , Shelendra Pratap Singh , Wahajuddin , Girish Kumar Jain , Naibedya Chattopadhyay
发明人： Rakesh Maurya , Preety Dixit , Ritu Trivedi , Vikram Khedgikar , Jyoti Gautam , Avinash Kumar , Divya Singh , Shelendra Pratap Singh , Wahajuddin , Girish Kumar Jain , Naibedya Chattopadhyay
IPC分类号： A61K31/7048 , C07D311/36 , C07H17/07 , A61K31/352 , A61K36/48
摘要： The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, from Dalbergia sissoo plant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.

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