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1. 发明授权

US11455719B2 Image based analysis of samples 有权
公开(公告)号：US11455719B2
公开(公告)日：2022-09-27
申请号：US16310125
申请日：2017-06-15
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： G06K9/00 , G06T7/00 , G06T7/70 , G02B21/36 , G06T5/50 , H04N5/232
摘要： A method of image-based analysis of multiple samples includes using a sample holder having multiple locations of interest and multiple focal structures that are each associated, one or more, with the multiple locations of interest, wherein the multiple samples are dispersed across the multiple locations of interest and obtaining image areas of the multiple locations of interest. Multiple digital image areas are thus obtained for use in an analysis of the multiple samples with each of the image areas including at least one of the locations of interest and at least one of the focal structures. An image processing algorithm is used to analyse each of the digital image areas and check if the focal structure indicates that the image area is in clear focus. An indication is provided and/or remedial action is taken if the image processing algorithm indicates that any digital image areas are out of focus.

2. 发明授权

US10995311B2 Medical sample transportation container 有权
公开(公告)号：US10995311B2
公开(公告)日：2021-05-04
申请号：US15569036
申请日：2016-04-21
申请人： Q-LINEA AB
发明人： Jonas Jarvius , Anders Lind , Henrik Soderstrom , Jan Grawe , Ian Fitzpatrick , Jurg Bartholdi
IPC分类号： C12M3/00 , C12M1/00 , B01L3/00 , A01N1/02 , C12M3/06 , C12M1/02 , C12Q1/04
摘要： A portable apparatus for transport and incubation of a medical sample in a blood culture flask includes a sealable container having a thermally insulated compartment for receiving the blood culture flask and a heater for heating the medical sample to a temperature suitable for pre-culturing of the sample. An agitator is provided for agitating the sample in the blood culture flask.

3. 发明申请

US20210224978A1 IMAGE BASED ANALYSIS OF SAMPLES 有权
公开(公告)号：US20210224978A1
公开(公告)日：2021-07-22
申请号：US16310125
申请日：2017-06-15
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： G06T7/00 , G06T5/50 , G06T7/70 , H04N5/232 , G02B21/36
摘要： A method of image-based analysis of multiple samples includes using a sample holder having multiple locations of interest and multiple focal structures that are each associated, one or more, with the multiple locations of interest, wherein the multiple samples are dispersed across the multiple locations of interest and obtaining image areas of the multiple locations of interest. Multiple digital image areas are thus obtained for use in an analysis of the multiple samples with each of the image areas including at least one of the locations of interest and at least one of the focal structures. An image processing algorithm is used to analyse each of the digital image areas and check if the focal structure indicates that the image area is in clear focus. An indication is provided and/or remedial action is taken if the image processing algorithm indicates that any digital image areas are out of focus.

4. 发明授权

US10829797B2 Method for determining antimicrobial susceptibility of a microorganism 有权
公开(公告)号：US10829797B2
公开(公告)日：2020-11-10
申请号：US15737208
申请日：2016-06-16
申请人： Q-LINEA AB
发明人： Jonas Jarvius , Jan Grawe , Ylva Molin , Markus Klintstedt , Mats Gullberg
IPC分类号： C12Q1/18 , C12M1/26 , C12M1/34
摘要： A method for determining the antimicrobial susceptibility of a microorganism in a clinical sample includes removing a test aliquot from a clinical sample culture before the culture reaches 0.5 McFarland units and isolating the microbial cells. The cells are transferred into a suitable culture medium for microbial growth and an AST assay is performed using the isolated microbes. The concentration of microbial cells in the microbial cells used to set up the AST assay is measured before measuring the degree of microbial growth in different conditions of the AST assay. Devices for determining the anti-microbial susceptibility of a microorganism in a clinical sample are also disclosed.

5. 发明授权

US10227632B2 Rolling circle amplification method 有权
公开(公告)号：US10227632B2
公开(公告)日：2019-03-12
申请号：US15037022
申请日：2014-11-28
申请人： Q-LINEA AB
发明人： Jonas Jarvius
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/6844 , C12Q1/682 , C12Q1/6853
摘要： A method for performing a rolling circle amplification (RCA) reaction includes at least two rounds of RCA. The method includes providing a concatemeric first RCA product having a multiplicity of monomer repeats, each repeat representing a complementary copy of a first RCA template, wherein the nucleic acid molecule to be detected and/or analyzed, or its compliment, is contained in the first RCA template. The first RCA product is cleaved into monomer units which are reduced in size compared to the monomer repeat of the first RCA template. Monomer units resulting from the cleavage are circularized to form second RCA templates, which are smaller than the first RCA template. A second RCA reaction is performed on the second RCA template and a primer for the second RCA to form a second RCA product. The second RCA product, or a monomer unit derived from it, is detected or analyzed.

6. 发明申请

US20190331906A1 SAMPLE HOLDER FOR IMAGE BASED ANALYSIS OF SAMPLES 审中-公开
公开(公告)号：US20190331906A1
公开(公告)日：2019-10-31
申请号：US16310187
申请日：2017-06-15
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： G02B21/34 , G01N21/64 , G02B27/40 , G02B21/24 , B01L3/00
摘要： A sample holder 100 for use in a device for image-based analysis of multiple samples, the sample holder comprising: an optically flat surface 10; multiple locations of interest 16, 18 dispersed across the optically flat surface 10 that each, in use, correspond to locations of a sample of the multiple samples; and multiple focal structures 12 associated with the multiple locations of interest 16, 18; wherein the focal structures 12 each comprise at least one pyramid shaped indentation 30 in the optically flat surface 10.

7. 发明申请

US20180223327A1 METHOD FOR DETERMINING ANTIMICROBIAL SUSCEPTIBILITY OF A MICROORGANISM 审中-公开
公开(公告)号：US20180223327A1
公开(公告)日：2018-08-09
申请号：US15737208
申请日：2016-06-16
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe , Ylva Molin , Markus Klintstedt , Mats Gullberg
IPC分类号： C12Q1/18 , C12M1/26 , C12M1/34
摘要： The present invention provides methods for determining the antimicrobial susceptibility of a microorganism in a clinical sample said method comprising removing a test aliquot from a clinical sample culture before the culture reaches 0.5 McFarland units, isolating the microbial cells and transferring the cells into a suitable culture medium for microbial growth, and performing an AST assay using the isolated microbes, wherein the concentration of microbial cells in the microbial cells used to set up the AST assay is measured before the degree of microbial growth in the different growth conditions of the AST assay is measured. Devices for determining the antimicrobial susceptibility of a microorganism in a clinical sample are also provided.

8. 发明申请

US20160257991A1 ROLLING CIRCLE AMPLIFICATION METHOD 审中-公开
标题翻译：滚动圆放大方法
公开(公告)号：US20160257991A1
公开(公告)日：2016-09-08
申请号：US15037022
申请日：2014-11-28
申请人： Q-LINEA AB
发明人： Jonas Jarvius
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/682 , C12Q1/6844 , C12Q1/6853 , C12Q2525/131 , C12Q2531/125
摘要： A method for performing a rolling circle amplification (RCA) reaction includes at least two rounds of RCA. The method includes providing a concatemeric first RCA product having a multiplicity of monomer repeats, each repeat representing a complementary copy of a first RCA template, wherein the nucleic acid molecule to be detected and/or analyzed, or its compliment, is contained in the first RCA template. The first RCA product is cleaved into monomer units which are reduced in size compared to the monomer repeat of the first RCA template. Monomer units resulting from the cleavage are circularized to form second RCA templates, which are smaller than the first RCA template. A second RCA reaction is performed on the second RCA template and a primer for the second RCA to form a second RCA product. The second RCA product, or a monomer unit derived from it, is detected or analyzed.
摘要翻译：进行滚环放大（RCA）反应的方法包括至少两轮RCA。该方法包括提供具有多个单体重复序列的并行第一RCA产物，每个重复代表第一RCA模板的互补拷贝，其中待检测和/或分析的核酸分子或其补体包含在第一个 RCA模板。第一个RCA产物被切割成与第一个RCA模板的单体重复相比尺寸减小的单体单元。由裂解产生的单体单元被环化以形成小于第一RCA模板的第二RCA模板。对第二个RCA模板和第二个RCA的引物进行第二次RCA反应以形成第二个RCA产物。检测或分析第二个RCA产品或衍生自其的单体单元。

9. 发明授权

US11428917B2 Method and device for microscopy-based imaging of samples 有权
公开(公告)号：US11428917B2
公开(公告)日：2022-08-30
申请号：US16956767
申请日：2018-12-18
申请人： Q-LINEA AB
发明人： Jonas Jarvius , Jan Grawé
IPC分类号： G02B21/00 , G02B21/24 , G02B21/36 , G02B21/26
摘要： A method for performing microscopy-based imaging of samples comprises: loading a sample holder (100) onto a support (50) configured to receive the sample holder (100); moving the sample holder (100) in a first direction, from a starting position on a first strip of the sample holder (100), to move the sample holder (100) relative to an imaging line of a line camera (10), to capture an image of the first strip of the sample holder (100); monitoring a focal plane using an autofocus system (15) as the sample holder (100) is moved in the first direction; in response to a signal from the autofocus system (15), moving an objective lens (25) along the optical axis to adjust the focal plane; and moving the sample holder (100) in a second direction, to align the imaging line of the line camera (10) with a position on a second strip of the sample holder (100).

10. 发明申请

US20200318164A1 METHOD FOR DETECTING AND CHARACTERISING A MICROORGANISM 审中-公开
公开(公告)号：US20200318164A1
公开(公告)日：2020-10-08
申请号：US16844240
申请日：2020-04-09
申请人： Q-linea AB
发明人： Jonas Jarvius , Jan Grawe
IPC分类号： C12Q1/689 , C12Q1/18 , C12Q1/04
摘要： A method for detecting and characterizing a microorganism in a clinical sample includes introducing a clinical sample to a first culture vessel containing the culture medium; removing a test aliquot; separating DNA from the test aliquot; and performing nucleic acid tests on the DNA to identify the microorganism and to detect the presence or absence of one or more genetic antimicrobial resistance markers in the microorganism. If a microorganism is identified, an antimicrobial susceptibility test is performed wherein microbial growth in the antimicrobial susceptibility test is monitored by accessing growth or markers for growth and wherein the type and concentration of antimicrobial agents used in the antimicrobial susceptibility test is determined by the identity of the microorganism and the antimicrobial resistance markers detected. A device for performing the method is also provided.

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