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1. 发明申请

US20080208274A1 Method for treating myocardial infarction 有权
标题翻译：心肌梗死的治疗方法
公开(公告)号：US20080208274A1
公开(公告)日：2008-08-28
申请号：US12150296
申请日：2008-04-25
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.
摘要翻译：公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

2. 发明授权

US07366567B2 Method for treating myocardial infarction 有权
公开(公告)号：US07366567B2
公开(公告)日：2008-04-29
申请号：US11088231
申请日：2005-03-23
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

3. 发明授权

US06829506B2 Linear stimulation of the heart for improved hemodynamic benefit 有权
标题翻译：心脏的线性刺激改善血液动力学效益
公开(公告)号：US06829506B2
公开(公告)日：2004-12-07
申请号：US09915088
申请日：2001-07-25
申请人： Joseph M. Pastore , Qingsheng Zhu , Rodney W. Salo
发明人： Joseph M. Pastore , Qingsheng Zhu , Rodney W. Salo
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.
摘要翻译：用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

4. 发明申请

US20120041506A1 METHOD FOR TREATING MYOCARDIAL INFARCTION 有权
标题翻译：治疗心肌梗死的方法
公开(公告)号：US20120041506A1
公开(公告)日：2012-02-16
申请号：US13281096
申请日：2011-10-25
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.
摘要翻译：公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

5. 发明授权

US08050761B2 Method for treating myocardial infarction 有权
标题翻译：心肌梗死的治疗方法
公开(公告)号：US08050761B2
公开(公告)日：2011-11-01
申请号：US12150296
申请日：2008-04-25
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365 , A61N1/08
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.
摘要翻译：公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

6. 发明授权

US08406878B2 Method for treating myocardial infarction 有权
标题翻译：心肌梗死的治疗方法
公开(公告)号：US08406878B2
公开(公告)日：2013-03-26
申请号：US13281096
申请日：2011-10-25
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.
摘要翻译：公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

7. 发明授权

US07039462B2 Method and apparatus for detecting oscillations in cardiac rhythm 有权
公开(公告)号：US07039462B2
公开(公告)日：2006-05-02
申请号：US10172825
申请日：2002-06-14
申请人： Joseph M. Pastore , Rodney W. Salo , Quan Ni , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Rodney W. Salo , Quan Ni , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/39 , A61B5/05
CPC分类号： A61N1/3925 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/36521 , A61N1/36542
摘要： A cardiac rhythm management device is configured to detect mechanical oscillations in cardiac rhythm. Upon detection of such oscillations, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

8. 发明授权

US08731677B2 Myocardium conditioning using myocardial and parasympathetic stimulation 有权
标题翻译：心肌调理使用心肌和副交感神经刺激
公开(公告)号：US08731677B2
公开(公告)日：2014-05-20
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

9. 发明授权

US08046069B2 Method and apparatus for control of cardiac therapy using non-invasive hemodynamic sensor 有权
标题翻译：使用非侵入性血液动力学传感器控制心脏治疗的方法和装置
公开(公告)号：US08046069B2
公开(公告)日：2011-10-25
申请号：US11315032
申请日：2005-12-22
申请人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
发明人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61N1/36114 , A61N1/36564
摘要： A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.
摘要翻译：心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。

10. 发明授权

US07914452B2 Method and apparatus for controlling cardiac therapy using ultrasound transducer 有权
标题翻译：使用超声波换能器控制心脏治疗的方法和装置
公开(公告)号：US07914452B2
公开(公告)日：2011-03-29
申请号：US11539939
申请日：2006-10-10
申请人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
发明人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
IPC分类号： A61B8/00 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/36528
摘要： A cardiac rhythm management (CRM) system provides for post-myocardial infarction (MI) therapy with closed-loop control using one or more ultrasound transducers sensing one or more ultrasound signals indicative of cardiac dimensions. Cardiac size parameters are produced using the one or more ultrasound signals to represent, for example, cardiac chamber diameter, cardiac chamber volume, cardiac wall thickness, infarct size, and degree of change in any of these parameters over time or between measurements. In various embodiments, such cardiac size parameters provide for titration, safety check, and acute optimization of the post-MI therapy.
摘要翻译：心律控制（CRM）系统通过使用一个或多个超声换能器感测一个或多个指示心脏尺寸的超声信号，通过闭环控制提供心肌梗死后心肌梗死（MI）治疗。使用一个或多个超声信号产生心脏尺寸参数，以表示例如心脏室直径，心室容积，心壁厚度，梗塞面积以及随时间或测量之间的任何这些参数的变化程度。在各种实施方案中，这种心脏尺寸参数提供滴定，安全性检查和MI后治疗的急性优化。

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