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1. 发明申请

US20090192118A1 TAK1-D MEDIATED INDUCTION OF CELL DEATH IN HUMAN CANCER CELLS BY SPECIFIC SEQUENCE SHORT DOUBLE-STRANDED RNAS 有权
标题翻译： TAK1-D介导诱导人类癌细胞死亡细胞的特异性序列短双链RNA
公开(公告)号：US20090192118A1
公开(公告)日：2009-07-30
申请号：US12361311
申请日：2009-01-28
申请人： Reinhard Kodym , Michael Story
发明人： Reinhard Kodym , Michael Story
IPC分类号： A61K31/7105 , C12N5/06
CPC分类号： A61K31/7105 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The splicing variant D of the TAK1 gene is activated by short double-stranded RNAs in a sequence specific manner. Activation of TAK1-D leads to the downstream activation of the p38 MAPK and of SAPK/JNK but not the NFκB pathway. The current invention therefore provides a method of inducing apoptosis and/or cell cycle arrest in a cancer cell comprising contacting said cell with an agonist of Tak1-D function. The invention further provides a method of modulating inflammation and the treatment of cancer by the administration of an agonist of Tak1-D function or expression. In yet another aspect, the invention provides a method of inducing p38 MAPK and SAPK/JNK signaling in a cell comprising contacting said cell with an agonist of Tak1-D function or expression.
摘要翻译： TAK1基因的剪接变体D以序列特异性方式被短双链RNA激活。 TAK1-D的激活导致p38MAPK和SAPK / JNK的下游激活，而不是NFkappaB途径。因此，本发明提供在癌细胞中诱导凋亡和/或细胞周期阻滞的方法，包括使所述细胞与Tak1-D功能的激动剂接触。本发明还提供了通过施用Tak1-D功能或表达的激动剂调节炎症和治疗癌症的方法。另一方面，本发明提供在细胞中诱导p38MAPK和SAPK / JNK信号传导的方法，包括使所述细胞与Tak1-D功能或表达的激动剂接触。

2. 发明授权

US08163709B2 TAK1-D mediated induction of cell death in human cancer cells by specific sequence short double-stranded RNAS 有权
标题翻译： TAK1-D介导通过特异性序列短双链RNAS诱导人类癌细胞中的细胞死亡
公开(公告)号：US08163709B2
公开(公告)日：2012-04-24
申请号：US12361311
申请日：2009-01-28
申请人： Reinhard Kodym , Michael Story
发明人： Reinhard Kodym , Michael Story
IPC分类号： A61K48/00
CPC分类号： A61K31/7105 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The splicing variant D of the TAK1 gene is activated by short double-stranded RNAs in a sequence specific manner. Activation of TAK1-D leads to the downstream activation of the p38 MAPK and of SAPK/JNK but not the NFκB pathway. The current invention therefore provides a method of inducing apoptosis and/or cell cycle arrest in a cancer cell comprising contacting said cell with an agonist of Tak1-D function. The invention further provides a method of modulating inflammation and the treatment of cancer by the administration of an agonist of Tak1-D function or expression. In yet another aspect, the invention provides a method of inducing p38 MAPK and SAPK/JNK signaling in a cell comprising contacting said cell with an agonist of Tak1-D function or expression.
摘要翻译： TAK1基因的剪接变体D以序列特异性方式被短双链RNA激活。 TAK1-D的激活导致p38MAPK和SAPK / JNK的下游激活，但不导致NF＆kgr B途径的激活。因此，本发明提供在癌细胞中诱导凋亡和/或细胞周期阻滞的方法，包括使所述细胞与Tak1-D功能的激动剂接触。本发明还提供了通过施用Tak1-D功能或表达的激动剂调节炎症和治疗癌症的方法。另一方面，本发明提供在细胞中诱导p38MAPK和SAPK / JNK信号传导的方法，包括使所述细胞与Tak1-D功能或表达的激动剂接触。

3. 发明授权

US10953209B2 Treating tumors using TTFields combined with a PARP inhibitor 有权
公开(公告)号：US10953209B2
公开(公告)日：2021-03-23
申请号：US15938088
申请日：2018-03-28
申请人： Michael Story , Debabrata Saha , Narasimha Kumar Karanam
发明人： Michael Story , Debabrata Saha , Narasimha Kumar Karanam
IPC分类号： A61M37/00 , A61P35/00 , A61K31/502 , A61N5/10
摘要： Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.

4. 发明申请

US20190298982A1 Treating Tumors Using TTFields Combined with a PARP Inhibitor 审中-公开
公开(公告)号：US20190298982A1
公开(公告)日：2019-10-03
申请号：US15938088
申请日：2018-03-28
申请人： Michael Story , Debabrata Saha , Narasimha Kumar Karanam
发明人： Michael Story , Debabrata Saha , Narasimha Kumar Karanam
IPC分类号： A61M37/00 , A61P35/00 , A61K31/502 , A61N5/10
摘要： Tumor-Treating Fields elicit a conditional vulnerability to PARP inhibitors (e.g., Olaparib) in certain cancer cells such as non-small cell lung cancer (NSCLC) cell lines. This conditional vulnerability is exploited in a method of killing cancer cells that comprises delivering a PARP inhibitor to the cancer cells and applying an alternating 80-300 kHz electric field to the cancer cells. At least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some embodiments, an additional step of treating the cancer cells with a radiation therapy is added to the method. In some embodiments, the frequency of the alternating electric field is between 100 and 200 kHz.

5. 发明申请

US20110238231A1 ALTERNATIVE POWER OPERATION OF LOADING DOCKS AND LOADING DOCK EQUIPMENT 有权
标题翻译：装载锁和装载装置的替代动力运行
公开(公告)号：US20110238231A1
公开(公告)日：2011-09-29
申请号：US13130989
申请日：2009-12-16
申请人： Benjamin I. Blackwell , Brett A. Walford , L. B. Whitley , Michael Story , Allan Thomson
发明人： Benjamin I. Blackwell , Brett A. Walford , L. B. Whitley , Michael Story , Allan Thomson
IPC分类号： G05B19/05 , H02J4/00
CPC分类号： B65G69/2882 , H02J9/06 , Y10T307/696
摘要： Technology generally directed to operation of loading dock equipment such as vehicle restraints, dock levelers, overhead doors/openers, barrier gates, lights, and linked or unlinked control systems is disclosed herein. The disclosed technology may be employed to power electrical loading dock systems from batteries and/or alternative power sources, including “green” power sources. For example, the technology may be employed at new, temporary, and/or mobile facilities having any number of loading docks where reliable commercial power may not be readily available. Further, the technology may also be employed at warehouses in remote and/or developing areas where electrical infrastructure is not available and/or reasonably priced. The technology may be embodied as methods, apparatuses, manufactures (e.g., computer- and/or processor-readable storage and/or other mediums), and/or the like.
摘要翻译：本文公开了一般涉及装卸码头设备如车辆限制器，码头调平器，架空门/开启器，障碍门，灯和连接或非连接控制系统的操作的技术。可以使用所公开的技术来从包括“绿色”电源的电池和/或替代电源为电力装载坞系统供电。例如，该技术可以用于具有任何数量的装载码头的新的，临时的和/或移动的设施，其中可能的商业功率可能不容易获得。此外，该技术还可以用于远程和/或开发区域的仓库，其中电气基础设施不可用和/或价格合理。技术可以体现为方法，装置，制造（例如，计算机和/或处理器可读存储和/或其他介质）和/或类似物。

6. 发明申请

US20110047725A1 DOCK LEVELERS AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译： DOCK LEVELERS及相关系统和方法
公开(公告)号：US20110047725A1
公开(公告)日：2011-03-03
申请号：US12862638
申请日：2010-08-24
申请人： Michael Story , Jeff Limbaugh , Richard K. Hoofard
发明人： Michael Story , Jeff Limbaugh , Richard K. Hoofard
IPC分类号： B65G69/28 , E01D1/00
CPC分类号： B65G69/2841
摘要： Dock levelers, such as mechanical dock levelers, are described herein. In one embodiment, a mechanical dock leveler includes a ramp having a lip pivotally attached to a forward edge. A ramp lifting system is configured to assist upward rotation of the ramp as it is manually raised. In this embodiment, a lip lifting system is operably coupled to the ramp lifting system so that the ramp is initially “downward biased” prior to being raised, and then becomes at least partially supported in a raised position by the lip lifting mechanism, once the lip lifting mechanism is engaged.
摘要翻译：这里描述了底座调平器，例如机械底座调平器。在一个实施例中，机械平台矫直机包括具有枢转地附接到前边缘的唇缘的斜面。坡道升降系统配置成在手动升高时辅助斜坡的向上旋转。在该实施例中，唇部提升系统可操作地联接到斜坡提升系统，使得斜坡在升起之前最初被“向下偏置”，然后由唇部提升机构至少部分地支撑在升高位置，一旦唇部提升机构接合。

7. 发明授权

US08723607B2 Phase locked loop 有权
标题翻译：锁相环
公开(公告)号：US08723607B2
公开(公告)日：2014-05-13
申请号：US12678106
申请日：2008-08-19
申请人： Michael Story , Nicolas Sornin
发明人： Michael Story , Nicolas Sornin
IPC分类号： H03L7/099 , H03J7/04 , H03L7/02
CPC分类号： H03L7/085 , H03C5/00 , H03L7/091 , H03L2207/50 , H04L27/361
摘要： A phase locked loop comprising: an oscillator for generating an output signal of a frequency that is dependent on an input to the oscillator; sampling means for generating a sequence of digital values representing the output of the oscillator at moments synchronized with a reference frequency; a difference unit for generating a feedback signal representing the difference between successive values in the sequence; and an integrator for integrating the difference between the feedback signal and a signal of a desired output frequency; the signal input to the oscillator being dependent on the output of the integrator.
摘要翻译：一种锁相环，包括：振荡器，用于产生取决于对所述振荡器的输入的频率的输出信号; 采样装置，用于在与参考频率同步的时刻产生表示振荡器的输出的数字值序列; 差分单元，用于产生表示序列中连续值之差的反馈信号; 以及积分器，用于对反馈信号与期望输出频率的信号之间的差进行积分; 输入到振荡器的信号取决于积分器的输出。

8. 发明申请

US20100301961A1 PHASE LOCKED LOOP 有权
标题翻译：相位锁定环
公开(公告)号：US20100301961A1
公开(公告)日：2010-12-02
申请号：US12678106
申请日：2008-08-19
申请人： Michael Story , Nicolas Sornin
发明人： Michael Story , Nicolas Sornin
IPC分类号： H03C1/00 , H03L7/00
CPC分类号： H03L7/085 , H03C5/00 , H03L7/091 , H03L2207/50 , H04L27/361
摘要： A phase locked loop comprising: an oscillator for generating an output signal of a frequency that is dependent on an input to the oscillator; sampling means for generating a sequence of digital values representing the output of the oscillator at moments synchronised with a reference frequency; a difference unit for generating a feedback signal representing the difference between successive values in the sequence; and an integrator for integrating the difference between the feedback signal and a signal of a desired output frequency; the signal input to the oscillator being dependent on the output of the integrator.
摘要翻译：一种锁相环，包括：振荡器，用于产生取决于对所述振荡器的输入的频率的输出信号; 采样装置，用于在与参考频率同步的时刻产生表示振荡器的输出的数字值序列; 差分单元，用于产生表示序列中连续值之差的反馈信号; 以及积分器，用于对反馈信号与期望输出频率的信号之间的差进行积分; 输入到振荡器的信号取决于积分器的输出。

9. 外观设计

USD345958S Flashlight battery recharger system 失效
公开(公告)号：USD345958S
公开(公告)日：1994-04-12
申请号：US6472
申请日：1993-03-30
申请人： Donald A. Keller , W. Clay Reeves , Michael Story
设计人： Donald A. Keller , W. Clay Reeves , Michael Story

10. 发明授权

US08838279B2 Alternative power operation of loading docks and loading dock equipment 有权
标题翻译：装卸码头和装卸码头设备的替代电力运行
公开(公告)号：US08838279B2
公开(公告)日：2014-09-16
申请号：US13130989
申请日：2009-12-16
申请人： Benjamin I. Blackwell , Brett A. Walford , Lowell Blake Whitley , Michael Story , Allan Thomson
发明人： Benjamin I. Blackwell , Brett A. Walford , Lowell Blake Whitley , Michael Story , Allan Thomson
IPC分类号： G06F19/00 , B65G69/28 , H02J9/06
CPC分类号： B65G69/2882 , H02J9/06 , Y10T307/696
摘要： Technology generally directed to operation of loading dock equipment such as vehicle restraints, dock levelers, overhead doors/openers, barrier gates, lights, and linked or unlinked control systems is disclosed herein. The disclosed technology may be employed to power electrical loading dock systems from batteries and/or alternative power sources, including “green” power sources. For example, the technology may be employed at new, temporary, and/or mobile facilities having any number of loading docks where reliable commercial power may not be readily available. Further, the technology may also be employed at warehouses in remote and/or developing areas where electrical infrastructure is not available and/or reasonably priced. The technology may be embodied as methods, apparatuses, manufactures (e.g., computer- and/or processor-readable storage and/or other mediums), and/or the like.
摘要翻译：本文公开了一般涉及装卸码头设备如车辆限制器，码头调平器，架空门/开启器，障碍门，灯和连接或非连接控制系统的操作的技术。可以使用所公开的技术来从包括“绿色”电源的电池和/或替代电源为电力装载坞系统供电。例如，该技术可以用于具有任何数量的装载码头的新的，临时的和/或移动的设施，其中可能的商业功率可能不容易获得。此外，该技术还可以用于远程和/或开发区域的仓库，其中电气基础设施不可用和/或价格合理。技术可以体现为方法，装置，制造（例如，计算机和/或处理器可读存储和/或其它介质）和/或类似物。

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