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1. 发明授权

US07728105B2 Peptides impairing PBX dependent gene regulation 失效
标题翻译：损害PBX依赖性基因调控的肽
公开(公告)号：US07728105B2
公开(公告)日：2010-06-01
申请号：US10538723
申请日：2003-12-12
申请人： Richard George Leonard Morgan , Ruth Pettengell , Nicolas Pierre Benoît Forraz , Colin Patrick McGuckin
发明人： Richard George Leonard Morgan , Ruth Pettengell , Nicolas Pierre Benoît Forraz , Colin Patrick McGuckin
IPC分类号： C07K14/00
CPC分类号： C07K14/4702 , A61K38/08
摘要： The present invention relates to peptides which impair PBX-dependent regulation of gene transcription. In particular, the invention provides the use of a peptide comprising the amino acid sequence X1 X2 X3 W M X4 X5 X6 X7, wherein the sequence X1 to X7 is an amino acid sequence comprising at least 9 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein; X1 is selected from W, T, PE, KQI, VV, PQT, H, RI and absent; X2 is an amino acid with an aromatic side chain; X3 is P or D; X4 is an amino acid with a basic side chain; X5 is an amino acid with a charged side chain; X6 is an amino acid with a charged side chain; and X7 is an amino acid with a basic side chain or Serine; in the manufacture of a medicament for treating or preventing a disorder in which aberrant cell division occurs.
摘要翻译：本发明涉及削弱基因转录的PBX依赖性调节的肽。特别地，本发明提供了包含氨基酸序列X1 X2 X3 WM X4 X5 X6 X7的肽的用途，其中序列X1至X7是包含至少9个氨基酸的氨基酸序列，其可任选地被一个或在本文定义的9个氨基酸位置中的一个或多个之间的两个氨基酸残基; X1选自W，T，PE，KQI，VV，PQT，H，RI和不存在; X2是具有芳香侧链的氨基酸; X3是P或D; X4是具有碱性侧链的氨基酸; X5是具有带电侧链的氨基酸; X6是具有带电侧链的氨基酸; X7是具有碱性侧链或丝氨酸的氨基酸; 在制备用于治疗或预防发生异常细胞分裂的病症的药物中。

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