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1. 发明授权

US07728105B2 Peptides impairing PBX dependent gene regulation 失效
标题翻译：损害PBX依赖性基因调控的肽
公开(公告)号：US07728105B2
公开(公告)日：2010-06-01
申请号：US10538723
申请日：2003-12-12
申请人： Richard George Leonard Morgan , Ruth Pettengell , Nicolas Pierre Benoît Forraz , Colin Patrick McGuckin
发明人： Richard George Leonard Morgan , Ruth Pettengell , Nicolas Pierre Benoît Forraz , Colin Patrick McGuckin
IPC分类号： C07K14/00
CPC分类号： C07K14/4702 , A61K38/08
摘要： The present invention relates to peptides which impair PBX-dependent regulation of gene transcription. In particular, the invention provides the use of a peptide comprising the amino acid sequence X1 X2 X3 W M X4 X5 X6 X7, wherein the sequence X1 to X7 is an amino acid sequence comprising at least 9 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein; X1 is selected from W, T, PE, KQI, VV, PQT, H, RI and absent; X2 is an amino acid with an aromatic side chain; X3 is P or D; X4 is an amino acid with a basic side chain; X5 is an amino acid with a charged side chain; X6 is an amino acid with a charged side chain; and X7 is an amino acid with a basic side chain or Serine; in the manufacture of a medicament for treating or preventing a disorder in which aberrant cell division occurs.
摘要翻译：本发明涉及削弱基因转录的PBX依赖性调节的肽。特别地，本发明提供了包含氨基酸序列X1 X2 X3 WM X4 X5 X6 X7的肽的用途，其中序列X1至X7是包含至少9个氨基酸的氨基酸序列，其可任选地被一个或在本文定义的9个氨基酸位置中的一个或多个之间的两个氨基酸残基; X1选自W，T，PE，KQI，VV，PQT，H，RI和不存在; X2是具有芳香侧链的氨基酸; X3是P或D; X4是具有碱性侧链的氨基酸; X5是具有带电侧链的氨基酸; X6是具有带电侧链的氨基酸; X7是具有碱性侧链或丝氨酸的氨基酸; 在制备用于治疗或预防发生异常细胞分裂的病症的药物中。

2. 发明申请

US20100093558A1 CANCER BIOMARKERS 有权
标题翻译：癌症生物标志物
公开(公告)号：US20100093558A1
公开(公告)日：2010-04-15
申请号：US12518708
申请日：2007-12-19
申请人： Hardev Pandha , Richard George Leonard Morgan
发明人： Hardev Pandha , Richard George Leonard Morgan
IPC分类号： C40B30/04 , G01N33/53 , C40B40/00
CPC分类号： G01N33/57434 , G01N33/6872
摘要： Provided is a biomarker for detecting cancer, in particular prostate cancer in a male subject, the biomarker comprising at least one homeodomain containing transcription factor, such as a HOX peptide or EN-2 peptide, or a fragment thereof. The use of said biomarker in detecting and/or treating prostate cancer is provided, together with methods and kits therefor.
摘要翻译：提供了用于检测癌症的生物标志物，特别是雄性受试者中的前列腺癌，所述生物标志物包含至少一个含有转录因子的同源结构域，例如HOX肽或EN-2肽或其片段。提供了所述生物标志物在检测和/或治疗前列腺癌中的用途及其方法和试剂盒。

3. 发明授权

US08460882B2 Cancer biomarkers 有权
标题翻译：癌症生物标志物
公开(公告)号：US08460882B2
公开(公告)日：2013-06-11
申请号：US12518708
申请日：2007-12-19
申请人： Hardev Pandha , Richard George Leonard Morgan
发明人： Hardev Pandha , Richard George Leonard Morgan
IPC分类号： G01N33/53 , G01N33/567 , G01N33/574 , C07K14/00 , A61K38/16
CPC分类号： G01N33/57434 , G01N33/6872
摘要： Provided is a biomarker for detecting cancer, in particular prostate cancer in a male subject, the biomarker comprising at least one homeodomain containing transcription factor, such as a HOX peptide or EN-2 peptide, or a fragment thereof. The use of said biomarker in detecting and/or treating prostate cancer is provided, together with methods and kits therefor.
摘要翻译：提供了用于检测癌症的生物标志物，特别是雄性受试者中的前列腺癌，所述生物标志物包含至少一个含有转录因子的同源结构域，例如HOX肽或EN-2肽或其片段。提供了所述生物标志物在检测和/或治疗前列腺癌中的用途及其方法和试剂盒。

4. 发明申请

US20090286738A1 Gene Regulation 审中-公开
公开(公告)号：US20090286738A1
公开(公告)日：2009-11-19
申请号：US11993978
申请日：2006-06-28
申请人： Richard George Leonard Morgan , Jastinder Sohal
发明人： Richard George Leonard Morgan , Jastinder Sohal
IPC分类号： A61K38/03 , A61K38/04 , A61P35/00 , C12N5/00
CPC分类号： A61K38/10 , A61K38/08 , C07K14/47
摘要： The present invention relates to peptides, which impair PBX-dependent regulation of gene transcription and thus have utility in the treatment or prevention of disorders in which aberrant cell division occurs. In particular, the invention provides peptides comprising the amino acid sequence (I), Y1 X1 X2 X3 W X4 X5 X6 X7 X8 Y2 (I) wherein the sequence X1 to X8 is an amino acid sequence comprising at least 8 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein; X1 is selected from W, T, PE, KQI, VV, PQT, H, RI and absent; X2 is an amino acid with an aromatic side chain or cysteine; X3 is P or D; X4 is a hydrophobic amino acid X5 is an amino acid with a charged side chain; X6 is an amino acid with a basic side chain; X7 is a polar hydrophilic amino acid; X8 is one or more amino acids or absent; and Y1 and Y2 are each either absent or a peptide comprising a cationic polymer of basic amino acids, such that at least one Of Y1 and Y2 is present; and peptides comprising the amino acid sequence (II): Y3 X1 X2 X3 W X4 X5 X6 X7 X8 Y4 (II) wherein The sequence X1 to X8 is an amino acid sequence comprising at least 8 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein; X1 is selected from W, T, PE, KQI, VV, PQT, H, RI and absent; X2 is an amino acid with an aromatic side chain; X3 is P or D; X4 is a hydrophobic amino acid X5 is an amino acid with a charged side chain; X6 is an amino acid with a basic side chain; X7 is a polar hydrophilic amino acid; X8 is one or more amino acids or absent; and Y3 and Y4 are each either absent or a peptide comprising a sequence comprising a cell penetration moiety, such that at least one of Y3 and Y4 is present; wherein at least the N-terminal and C-terminal amino acids of said peptide is in the D-conformation.

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