专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08133738B2 Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
标题翻译：利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的血细胞比容的方法和装置
公开(公告)号：US08133738B2
公开(公告)日：2012-03-13
申请号：US13116837
申请日：2011-05-26
申请人： Robert A. Levine , Stephen C. Wardlaw , Darryn Unfricht , Niten V. Lalpuria
发明人： Robert A. Levine , Stephen C. Wardlaw , Darryn Unfricht , Niten V. Lalpuria
IPC分类号： G01N33/48 , G01N33/86
CPC分类号： G01N33/80 , A61B5/145 , G01N15/1463 , G01N15/1475 , G01N33/48 , G01N33/49 , G01N33/721 , G01N33/86
摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.
摘要翻译：提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，由第一和第二面板的内表面限定的腔室和高度在其间延伸，其中两个面板是透明的，并且高度使得样品中的至少一些红细胞接触面板的两个内表面，并且静止样品内的一个或多个空隙在内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对齐的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。

2. 发明授权

US08361799B2 Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
标题翻译：利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的血细胞比容的方法和装置
公开(公告)号：US08361799B2
公开(公告)日：2013-01-29
申请号：US13418007
申请日：2012-03-12
申请人： Robert A. Levine , Stephen C. Wardlaw , Darryn Unfricht , Niten V. Lalpuria
发明人： Robert A. Levine , Stephen C. Wardlaw , Darryn Unfricht , Niten V. Lalpuria
IPC分类号： G01N33/48 , G01N33/86
CPC分类号： G01N33/80 , A61B5/145 , G01N15/1463 , G01N15/1475 , G01N33/48 , G01N33/49 , G01N33/721 , G01N33/86
摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting optical density values of the image units aligned with the red blood cells; 4) selecting optical density values of the image units aligned with the one or more lacunae; and 5) determining the hematocrit of the sample using the selected optical density values of the image units aligned with the red blood cells and the lacunae.
摘要翻译：提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品用于分析的分析室中; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择与红细胞对准的图像单元的光密度值; 4）选择与一个或多个空隙对准的图像单元的光密度值; 以及5）使用所选择的与红细胞和空隙对准的图像单元的光密度值来确定样品的血细胞比容。

3. 发明授权

US09873118B2 Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion 有权
公开(公告)号：US09873118B2
公开(公告)日：2018-01-23
申请号：US13341618
申请日：2011-12-30
申请人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
发明人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
IPC分类号： A61J1/06 , B01L3/00
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0861
摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.

4. 发明申请

US20130029373A1 METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING 有权
标题翻译：使用荧光猝灭和/或漂白分析个体细胞或颗粒物的方法和装置
公开(公告)号：US20130029373A1
公开(公告)日：2013-01-31
申请号：US13645075
申请日：2012-10-04
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：提供具有每个第一和第二成分中的一个或多个的血液样品; 将着色剂与样品混合，该着色剂可操作以使第一组分和第二组分发光和吸收光; 照亮样品的至少一部分; e）对样品的一部分进行成像; 确定每个第一组分和第二组分的荧光值; 确定每个第一组分和第二组分的光密度值; 以及使用所确定的荧光和光密度值来识别第一成分和第二成分。

5. 发明申请

US20110230740A1 METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 有权
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的HEMATOCRIT的方法和装置
公开(公告)号：US20110230740A1
公开(公告)日：2011-09-22
申请号：US13116837
申请日：2011-05-26
申请人： Robert A. Levine , Stephen C. Wardlaw , Darryn W. Unfricht , Niten V. Lalpuria
发明人： Robert A. Levine , Stephen C. Wardlaw , Darryn W. Unfricht , Niten V. Lalpuria
IPC分类号： A61B5/1455
CPC分类号： G01N33/80 , A61B5/145 , G01N15/1463 , G01N15/1475 , G01N33/48 , G01N33/49 , G01N33/721 , G01N33/86
摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.
摘要翻译：提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，由第一和第二面板的内表面限定的腔室和高度在其间延伸，其中两个面板是透明的，并且高度使得样品中的至少一些红细胞接触面板的两个内表面，并且静止样品内的一个或多个空隙在内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对齐的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。

6. 发明申请

US20140248647A1 METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING 有权
标题翻译：使用荧光猝灭和/或漂白分析个体细胞或颗粒物的方法和装置
公开(公告)号：US20140248647A1
公开(公告)日：2014-09-04
申请号：US13959294
申请日：2013-08-05
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N33/50
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：提供具有每个第一和第二成分中的一个或多个的血液样品; 将着色剂与样品混合，该着色剂可操作以使第一组分和第二组分发光和吸收光; 照亮样品的至少一部分; e）对样品的一部分进行成像; 确定每个第一组分和第二组分的荧光值; 确定每个第一组分和第二组分的光密度值; 以及使用所确定的荧光和光密度值来识别第一成分和第二成分。

7. 发明授权

US08284384B2 Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching 有权
标题翻译：使用荧光猝灭和/或漂白分析单个细胞或微粒的方法和装置
公开(公告)号：US08284384B2
公开(公告)日：2012-10-09
申请号：US13330236
申请日：2011-12-19
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N33/48
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：提供具有每个第一和第二成分中的一个或多个的血液样品; 将着色剂与样品混合，该着色剂可操作以使第一组分和第二组分发光和吸收光; 照亮样品的至少一部分; e）对样品的一部分进行成像; 确定每个第一组分和第二组分的荧光值; 确定每个第一组分和第二组分的光密度值; 以及使用所确定的荧光和光密度值来识别第一成分和第二成分。

8. 发明授权

US08269954B2 Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching 有权
标题翻译：使用荧光猝灭和/或漂白分析单个细胞或微粒的方法和装置
公开(公告)号：US08269954B2
公开(公告)日：2012-09-18
申请号：US13330253
申请日：2011-12-19
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N33/48
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample residing within an analysis chamber, which sample has one or more first and second constituents, which constituents are different from one another. The method includes the steps of: a) imaging the sample containing the first and second constituents, which sample is mixed with a colorant that causes the first and second constituents to fluoresce upon exposure to light, and which colorant is also operative to absorb light, the imaging produces image signals representative of fluorescent emissions from the sample and optical density of the sample; b) determining one or more values representative of fluorescent emission from the first and second constituents; c) determining one or more values representative of optical density for the first and second constituents; and d) distinguishing the first constituents from the second constituents using the fluorescent emission representative values and the optical density representative values.
摘要翻译：一种用于分析驻留在分析室内的血液样本的方法，该样品具有一个或多个第一和第二组分，该组分彼此不同。该方法包括以下步骤：a）对包含第一和第二成分的样品进行成像，该样品与着色剂混合，使得第一和第二组分在暴露于光时发荧光，并且哪种着色剂也可操作地吸收光，成像产生代表样品的荧光发射和样品的光密度的图像信号; b）确定代表来自第一和第二组分的荧光发射的一个或多个值; c）确定表示第一和第二组分的光密度的一个或多个值; 以及d）使用荧光发射代表值和光密度代表值来区分第一组分与第二组分。

9. 发明申请

US20120219457A1 BIOLOGIC FLUID ANALYSIS CARTRIDGE WITH SAMPLE HANDLING PORTION AND ANALYSIS CHAMBER PORTION 有权
标题翻译：生物流体分析盒与样品处理部分和分析室部分
公开(公告)号：US20120219457A1
公开(公告)日：2012-08-30
申请号：US13341618
申请日：2011-12-30
申请人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
发明人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
IPC分类号： B01L3/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0861
摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.
摘要翻译：提供生物流体分析盒。在某些实施例中，盒包括在样品处理部分和分析室部分之间延伸的基板。处理上面板附接到样品处理部分中的基板。收集口至少部分地形成有处理上面板。在处理上板和基板之间形成初始通道和次通道。收集口和初始和次要通道彼此流体连通。腔室上面板在分析室部分内连接到基板。在室上板和基板之间形成至少一个分析室。第二通道和分析室彼此流体连通。

10. 发明授权

US07929122B2 Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
标题翻译：利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的红细胞指数的方法和装置
公开(公告)号：US07929122B2
公开(公告)日：2011-04-19
申请号：US12946503
申请日：2010-11-15
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： G01N33/48
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
摘要翻译：用于确定红细胞指数的方法，包括体积和各个红细胞的血红蛋白含量和浓度，以及包括样品中存在的红细胞总数的红细胞群统计，以及平均值提供了基本上未稀释的血液样品中的每个上述指标。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式