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1. 发明授权

US08780788B2 Systems and methods for decoding automatic identification system signals 有权
标题翻译：用于解码自动识别系统信号的系统和方法
公开(公告)号：US08780788B2
公开(公告)日：2014-07-15
申请号：US12567104
申请日：2009-09-25
申请人： Robert Peach , Weiguo Chen
发明人： Robert Peach , Weiguo Chen
IPC分类号： H04B7/204 , H04H60/32
CPC分类号： G01S13/9307 , G01S1/68 , G01S5/0018 , G08G3/00 , H04B7/18513
摘要： A method of extracting automatic identification system (AIS) message segments from AIS signals received by a satellite. The method includes: (a) receiving AIS signals from satellite antennas; (b) generating multiple versions of the AIS signals; (c) extracting message segments contained within each of the AIS signals using one or more AIS receivers; (d) sorting the message segments by time; and (e) deleting any duplicate message segments. Multiple versions of the AIS signals may be generated by one or more of the following methods: (i) processing the AIS signals multiple times, each time with different AIS receiver parameter settings; (ii) splitting each signal into multiple signals and filtering each of the multiple signals separately; (iii) receiving multiple AIS signals and combining them with different phases and amplitudes to produce a plurality of combined AIS signals; and (iv) removing extracted message segments from the received AIS signals and reprocessing the modified AIS signals.
摘要翻译：一种从卫星接收的AIS信号中提取自动识别系统（AIS）消息段的方法。该方法包括：（a）从卫星天线接收AIS信号; （b）产生AIS信号的多个版本; （c）使用一个或多个AIS接收机提取包含在每个AIS信号内的消息段; （d）按时间对消息片段进行排序; 和（e）删除任何重复的消息段。可以通过以下一种或多种方法产生AIS信号的多个版本：（i）每次使用不同的AIS接收机参数设置多次处理AIS信号; （ii）将每个信号分成多个信号并分别对多个信号中的每个信号进行滤波; （iii）接收多个AIS信号并将它们与不同的相位和振幅组合以产生多个组合的AIS信号; 以及（iv）从所接收的AIS信号中去除提取出的消息段，并重新处理修改后的AIS信号。

2. 发明申请

US20110075602A1 SYSTEMS AND METHODS FOR DECODING AUTOMATIC IDENTIFICATION SYSTEM SIGNALS 有权
标题翻译：用于解码自动识别系统信号的系统和方法
公开(公告)号：US20110075602A1
公开(公告)日：2011-03-31
申请号：US12567104
申请日：2009-09-25
申请人： Robert Peach , Weiguo Chen
发明人： Robert Peach , Weiguo Chen
IPC分类号： H04J3/08
CPC分类号： G01S13/9307 , G01S1/68 , G01S5/0018 , G08G3/00 , H04B7/18513
摘要： A method of extracting automatic identification system (AIS) message segments from AIS signals received by a satellite. The method includes: (a) receiving AIS signals from satellite antennas; (b) generating multiple versions of the AIS signals; (c) extracting message segments contained within each of the AIS signals using one or more AIS receivers; (d) sorting the message segments by time; and (e) deleting any duplicate message segments. Multiple versions of the AIS signals may be generated by one or more of the following methods: (i) processing the AIS signals multiple times, each time with different AIS receiver parameter settings; (ii) splitting each signal into multiple signals and filtering each of the multiple signals separately; (iii) receiving multiple AIS signals and combining them with different phases and amplitudes to produce a plurality of combined AIS signals; and (iv) removing extracted message segments from the received AIS signals and reprocessing the modified AIS signals.
摘要翻译：一种从卫星接收的AIS信号中提取自动识别系统（AIS）消息段的方法。该方法包括：（a）从卫星天线接收AIS信号; （b）产生AIS信号的多个版本; （c）使用一个或多个AIS接收机提取包含在每个AIS信号内的消息段; （d）按时间对消息片段进行排序; 和（e）删除任何重复的消息段。可以通过以下一种或多种方法产生AIS信号的多个版本：（i）每次使用不同的AIS接收机参数设置多次处理AIS信号; （ii）将每个信号分成多个信号并分别对多个信号中的每个信号进行滤波; （iii）接收多个AIS信号并将它们与不同的相位和振幅组合以产生多个组合的AIS信号; 以及（iv）从所接收的AIS信号中去除提取出的消息段，并重新处理修改后的AIS信号。

3. 发明申请

US20070071674A1 Polynucleotides encoding novel isoforms of IGSF9 审中-公开
标题翻译：编码IGSF9新型同工型的多核苷酸
公开(公告)号：US20070071674A1
公开(公告)日：2007-03-29
申请号：US11488161
申请日：2006-07-18
申请人： Karen McLachlan , Scott Glaser , Robert Peach , Tony Rowe
发明人： Karen McLachlan , Scott Glaser , Robert Peach , Tony Rowe
IPC分类号： A61K51/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82
CPC分类号： C07K14/70503 , A61K51/1027 , A61K51/1045 , C07K14/47 , C07K16/2803 , C07K16/30 , C07K2319/30
摘要： Human IGSF9 and LIV-1 polypeptides and DNA (RNA) encoding such polypeptides are disclosed. The disclosed polypeptides and/or polynucleotide are particularly useful generating antibodies, both modified and native, which bind IGSF9 or LIV-1. Also disclosed are pharmaceutical compositions and vaccines comprising the antibodies, polypeptides and polynucleotides of the invention. Also disclosed are methods for utilizing such polypeptides for identifying ligands, antagonists and agonists to said polypeptides. Finally, methods comprising the above-mentioned compositions are disclosed for the treatment, diagnosis, and/or prognosis of neoplastic disorders.
摘要翻译：公开了人IGSF9和LIV-1多肽和编码这种多肽的DNA（RNA）。公开的多肽和/或多核苷酸是特别有用的，其产生结合IGSF9或LIV-1的经修饰和天然的抗体。还公开了包含本发明的抗体，多肽和多核苷酸的药物组合物和疫苗。还公开了利用这些多肽鉴定所述多肽的配体，拮抗剂和激动剂的方法。最后，公开了包含上述组合物的方法用于肿瘤性疾病的治疗，诊断和/或预后。

4. 发明申请

US20050214313A1 Soluble CTLA4 mutant molecules and uses thereof 有权
标题翻译：可溶性CTLA4突变体分子及其用途
公开(公告)号：US20050214313A1
公开(公告)日：2005-09-29
申请号：US10980742
申请日：2004-11-03
申请人： Robert Peach , Joseph Naemura , Peter Linsley , Jurgen Bajorath
发明人： Robert Peach , Joseph Naemura , Peter Linsley , Jurgen Bajorath
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , C07H21/04 , C07K14/705 , C07K14/74 , C12N5/0783 , C12N15/09
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/1774 , A61K39/39 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/70521 , C07K2319/30 , C12N5/0636 , C12N2501/51
摘要： The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non-mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.
摘要翻译：本发明提供与野生型CTLA4或非突变型CTLA4Ig相比，其结合比CD80和/或CD86抗原更高亲合力的可溶性CTLA4突变体分子。可溶性CTLA4分子具有包含CTLA4细胞外结构域的第一个氨基酸序列，其中S25-R33区域和M97-G107区域内的某些氨基酸残基被突变。本发明的突变分子还可以包括增加突变分子的溶解度的第二个氨基酸序列。

5. 发明授权

US06300775B1 Scattering parameter calibration system and method 有权
标题翻译：散射参数校准系统及方法
公开(公告)号：US06300775B1
公开(公告)日：2001-10-09
申请号：US09241704
申请日：1999-02-02
申请人： Robert Peach , Nicholas Svensson , Thai Vo
发明人： Robert Peach , Nicholas Svensson , Thai Vo
IPC分类号： G01R2728
CPC分类号： G01R27/28 , G01R35/00
摘要： A system and method of calibrating an S parameter measurement instrument (such as a vector network analyzer) in which the number of calibrations required to fully characterize the error model of an n-port system is n/2 calibrations for an even number of ports and (n+1)/2 calibrations for an odd number of ports. Each test port in the system is involved in at least one full calibration, thus n/2 test paths are fully calibrated. For each measured test path, the error terms of the applicable error model are calculated. These error terms are then decoupled from the associated test path into error parameters that are localized to the individual test ports of the test path. Having localized the error parameters, the error model for each test port can then be treated independently from the other test ports. The error terms for the test paths that are not calibrated are then constructed using the localized error parameters for the individual test ports.
摘要翻译：校准S参数测量仪器（如矢量网络分析仪）的系统和方法，其中完全表征n端口系统的误差模型所需的校准次数为偶数个端口的n / 2校准，（n + 1）/ 2个校准。系统中的每个测试端口都参与至少一次完全校准，因此n / 2个测试路径被完全校准。对于每个测量的测试路径，计算适用误差模型的误差项。然后将这些误差项从相关联的测试路径解耦到被定位到测试路径的各个测试端口的错误参数。本地化了错误参数后，可以独立于其他测试端口对每个测试端口的错误模型进行处理。然后使用各个测试端口的本地化错误参数构建未校准的测试路径的误差项。

6. 发明申请

US20060140937A1 B7-related nucleic acids and polypeptides useful for immunomodulation 有权
公开(公告)号：US20060140937A1
公开(公告)日：2006-06-29
申请号：US11355735
申请日：2006-02-16
申请人： Glen Mikesell , Han Chang , Joshua Finger , Guchen Yang , Robert Peach
发明人： Glen Mikesell , Han Chang , Joshua Finger , Guchen Yang , Robert Peach
IPC分类号： C12Q1/70 , C12Q1/68 , C07H21/02 , A61K39/395 , A61K39/42 , C07K14/16 , C07K14/705
CPC分类号： C07K14/70532 , A61K38/00 , C07K16/2827 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

7. 发明申请

US20050239700A1 Treatment of cancer using antibodies to LRRC15 审中-公开
标题翻译：使用LRRC15抗体治疗癌症
公开(公告)号：US20050239700A1
公开(公告)日：2005-10-27
申请号：US10963987
申请日：2004-10-14
申请人： William Kloetzer , Karen McLachlan , Michael La Barre , Jonathon Fitchett , Robert Peach , Bill Shestowsky , Scott Glaser
发明人： William Kloetzer , Karen McLachlan , Michael La Barre , Jonathon Fitchett , Robert Peach , Bill Shestowsky , Scott Glaser
IPC分类号： A61K38/17 , A61K39/395 , A61K48/00 , C07K16/30 , C12N20060101
CPC分类号： C07K16/30 , C07K2319/30
摘要： The present invention is directed to novel methods of treating or diagnosing a hyperproliferative disease or disorder in an patient, where the methods include administrating to the patient a binding molecule which binds to a cell surface-expressed glycoprotein expressed predominantly in tumor or tumor-associated cells. In particular, the therapeutic and diagnostic methods of the present invention include the use of a binding molecule, for example an antibody or immunospecific fragment thereof, which specifically binds to the human LRRC15 protein. The present invention further provides a method of isolating and identifying cell surface expressed glycoproteins expressed in tumor or tumor associated tissues, where the method includes isolating desired glycoproteins via their affinity for specific lectins.
摘要翻译：本发明涉及治疗或诊断患者过度增殖性疾病或病症的新方法，其中所述方法包括向患者施用结合分子，其结合主要在肿瘤或肿瘤相关细胞中表达的细胞表达的糖蛋白。特别地，本发明的治疗和诊断方法包括使用与人LRRC15蛋白特异性结合的结合分子，例如抗体或其免疫特异性片段。本发明还提供了分离和鉴定在肿瘤或肿瘤相关组织中表达的细胞表面表达的糖蛋白的方法，其中所述方法包括通过其对特异性凝集素的亲和力分离所需的糖蛋白。

8. 发明授权

US09015567B2 Methods and systems for consistency checking and anomaly detection in automatic identification system signal data 有权
标题翻译：自动识别系统信号数据一致性检查和异常检测的方法和系统
公开(公告)号：US09015567B2
公开(公告)日：2015-04-21
申请号：US13445552
申请日：2012-04-12
申请人： Robert Peach
发明人： Robert Peach
IPC分类号： G06F11/00 , G08C25/00 , H03M13/00 , H04L1/00 , G06F11/07 , H04B7/185
CPC分类号： G06F11/0751 , H04B7/18513
摘要： Methods and systems for validating positions reported in AIS message signals by fitting suitably chosen functions to signal characteristic data, such as timing and Doppler shift data, derived from a plurality of AIS message signals. Ships whose reported positions deviate from the fitted function may be flagged as suspect.
摘要翻译：通过拟合适当选择的功能来信号从多个AIS消息信号导出的诸如定时和多普勒频移数据的特征数据来验证AIS消息信号中报告的位置的方法和系统。报告的位置偏离拟合功能的船舶可能被标记为可疑。

9. 发明申请

US20110268229A1 SYSTEM AND METHOD FOR DECODING AUTOMATIC IDENTIFICATION SYSTEM SIGNALS 有权
标题翻译：用于解码自动识别系统信号的系统和方法
公开(公告)号：US20110268229A1
公开(公告)日：2011-11-03
申请号：US12915699
申请日：2010-10-29
申请人： Robert Peach
发明人： Robert Peach
IPC分类号： H04L27/22
CPC分类号： G08G3/02 , H04B7/18513
摘要： Various embodiments are described herein for a system and method of detecting Automatic Identification System (AIS) signals in space and decoding these signals. In one aspect, a system for performing this function is described which includes a receiver configured to receive the plurality of AIS signals and pre-process the plurality of AIS signals to produce digital input data, and a processing unit configured to process the digital input data to identify one or more candidate AIS message signals based on Doppler offsets associated with the digital input data, determine corresponding Doppler offset estimates and time estimates of the one or more candidate AIS message signals, decode the one or more candidate AIS message signals to obtain corresponding message segments and validate the decoded message segments for proper AIS formatting.
摘要翻译：这里描述了用于检测空间中的自动识别系统（AIS）信号并对这些信号进行解码的系统和方法的各种实施例。一方面，描述了一种用于执行该功能的系统，其包括被配置为接收多个AIS信号并预处理多个AIS信号以产生数字输入数据的接收器，以及处理单元，被配置为处理数字输入数据基于与数字输入数据相关联的多普勒偏移来识别一个或多个候选AIS消息信号，确定一个或多个候选AIS消息信号的相应多普勒偏移估计和时间估计，对一个或多个候选AIS消息信号进行解码以获得对应的消息段并验证解码的消息段以获得正确的AIS格式。

10. 发明申请

US20110244501A1 CANCER STEM CELLS 审中-公开
标题翻译：癌细胞
公开(公告)号：US20110244501A1
公开(公告)日：2011-10-06
申请号：US12375657
申请日：2007-08-02
申请人： Petter Chu , Robert Peach
发明人： Petter Chu , Robert Peach
IPC分类号： C12Q1/02 , C12N5/095 , C12N13/00
CPC分类号： G01N33/5011 , C12N5/068 , C12N5/0695 , G01N33/574 , G01N2333/70585 , G01N2500/04 , G01N2500/10
摘要： Cancer stem cell populations characterized by expression of CD44hi, ABCG2, β-catenin, CD117, CD133, ALDH, VLA-2, CD166, CD201, IGFR, and/or EGF1R, and methods of isolating and using the same.
摘要翻译：以CD44hi，ABCG2，b-cadherin，CD117，CD133，ALDH，VLA-2，CD166，CD201，IGFR和/或EGF1R的表达为特征的癌症干细胞群，以及分离和使用它们的方法。

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