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1. 发明申请

US20070281003A1 Polymer-Based Films and Drug Delivery Systems Made Therefrom 审中-公开
标题翻译：基于聚合物的薄膜和药物输送系统
公开(公告)号：US20070281003A1
公开(公告)日：2007-12-06
申请号：US11674223
申请日：2007-02-13
申请人： Richard Fuisz , Joseph Fuisz , Garry Myers , Robert Yang , Pradeep Sanghvi
发明人： Richard Fuisz , Joseph Fuisz , Garry Myers , Robert Yang , Pradeep Sanghvi
IPC分类号： A61K9/70
CPC分类号： B29C39/003 , A61J3/00 , A61J2200/20 , A61K9/006 , A61K9/7007 , B29C39/14 , B29C71/02 , F26B13/104
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component which includes polyethylene oxide, optionally blended with at least one additional polymer. The films may alternatively contain a polymer component which includes polyvinyl alcohol, optionally blended with at least one additional polymer. The films also may contain a pharmaceutical and/or cosmetic active agent.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。膜包含聚合物组分，其包括聚环氧乙烷，任选地与至少一种另外的聚合物共混。膜可以备选地包含聚合物组分，其包括聚乙烯醇，任选地与至少一种另外的聚合物共混。膜也可以含有药物和/或美容活性剂。

2. 发明申请

US20080044454A1 UNIFORM FILMS FOR RAPID DISSOLVE DOSAGE FORM INCORPORATING TASTE-MASKING COMPOSITIONS 有权
标题翻译：用于快速溶解剂用量的复合膜用于吸收组合物
公开(公告)号：US20080044454A1
公开(公告)日：2008-02-21
申请号：US11775484
申请日：2007-07-10
申请人： Robert Yang , Richard Fuisz , Garry Myers , Joseph Fuisz
发明人： Robert Yang , Richard Fuisz , Garry Myers , Joseph Fuisz
IPC分类号： A61K9/70 , A61K47/30 , A61K9/00
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/14 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/7015 , A61K31/138 , A61K31/192 , A61K31/422 , A61K31/44 , A61K31/4422 , A61K31/443 , A61K31/4545 , A61K31/519 , A61K31/549 , A61K31/567 , A61K31/635 , A61K31/704 , A61K31/7048 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61K47/46 , B05D3/0254 , B29C47/0004
摘要： The present invention relates to rapid dissolve thin film drug delivery compositions for the oral administration of active components. The active components are provided as taste-masked or controlled-release coated particles uniformly distributed throughout the film composition. The compositions may be formed by wet casting methods, where the film is cast and controllably dried, or alternatively by an extrusion method.
摘要翻译：本发明涉及用于口服给药活性成分的快速溶解薄膜药物递送组合物。活性组分作为均匀分布在整个膜组合物中的掩味或控释包衣颗粒提供。组合物可以通过湿法铸造方法形成，其中膜被浇铸并可控制地干燥，或者通过挤出方法形成。

3. 发明申请

US20060147493A1 Packaging and dispensing of rapid dissolve dosage form 审中-公开
标题翻译：包装和分配快速溶解剂型
公开(公告)号：US20060147493A1
公开(公告)日：2006-07-06
申请号：US10521823
申请日：2003-07-22
申请人： Robert Yang , Richard Fuisz , Garry Myers , Joseph Fuisz
发明人： Robert Yang , Richard Fuisz , Garry Myers , Joseph Fuisz
IPC分类号： A61K47/00
CPC分类号： A61K9/7007 , A61J1/03 , A61J3/078 , A61K8/02 , A61K31/4545 , A61K2800/87 , A61Q11/00 , B65B5/06 , B65B11/50 , B65B25/06
摘要： An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.
摘要翻译：一种口服剂量递送载体，其包含包含均匀分布的活性成分的可食用膜，其中所述膜包含通过一个或多个弱化部分可释放地连接的剂量单位，其允许所述剂量单元从所述膜分离。

4. 发明申请

US20070190157A1 Film lined packaging and method of making same 审中-公开
标题翻译：薄膜衬里包装及其制作方法
公开(公告)号：US20070190157A1
公开(公告)日：2007-08-16
申请号：US11655376
申请日：2007-01-19
申请人： Pradeep Sanghvi , Garry Myers , Joseph Fuisz , Richard Fuisz
发明人： Pradeep Sanghvi , Garry Myers , Joseph Fuisz , Richard Fuisz
IPC分类号： A61K9/14
CPC分类号： A61K9/009 , A23G3/56 , A23P10/30 , A24B13/00 , A61K9/0056 , A61K9/7007 , B65D65/46 , B65D85/808
摘要： The present invention relates to packaging in the form of a pouch, which may contain active substances, such as food products, pharmaceutical agents, nutraceuticals and cosmetic agents, or the like. More specifically, in some embodiments, the present invention provides a pouch, which includes at least one porous substrate encompassing a closed volume and at least one water-soluble film at least partially covering the at least one porous substrate. The pouch may contain an active substance within the closed volume, as well as an active substance in the water-soluble film. The present invention also relates to methods of making and using the pouches.
摘要翻译：本发明涉及袋子形式的包装，其可以含有活性物质，如食品，药剂，保健品和化妆品等。更具体地，在一些实施方案中，本发明提供了一种袋，其包括至少一个包含闭合体积的多孔基材和至少部分地覆盖至少一种多孔基材的至少一种水溶性薄膜。该袋可以在封闭体积内含有活性物质，以及水溶性膜中的活性物质。本发明还涉及制造和使用袋的方法。

5. 发明申请

US20060039958A1 Multi-layer films having uniform content 审中-公开
标题翻译：具有均匀含量的多层膜
公开(公告)号：US20060039958A1
公开(公告)日：2006-02-23
申请号：US11237525
申请日：2005-09-28
申请人： Richard Fuisz , Joseph Fuisz , Garry Myers
发明人： Richard Fuisz , Joseph Fuisz , Garry Myers
IPC分类号： A61K9/70 , B29C59/00
CPC分类号： A61K9/7007 , A23F5/36 , A23L2/395 , A23L23/10 , A23L27/72 , A23L33/40 , A23P20/20 , A61K8/0208 , A61K8/0216 , A61K8/0233 , A61K8/34 , A61K8/347 , A61K8/37 , A61K8/498 , A61K8/73 , A61K8/731 , A61K8/8176 , A61K8/86 , A61K8/891 , A61K9/006 , A61K9/7015 , A61K31/192 , A61K31/4545 , A61K47/26 , A61K47/34 , A61K47/38 , A61K2800/592 , A61K2800/594 , A61K2800/92 , A61Q11/00 , A61Q19/00 , C08J5/18 , C08J2371/02 , F26B13/104
摘要： The present invention relates to edible multi-layer films that dissolve in water. In particular, the edible multi-layer films have a first water-soluble film layer and one or more additional water-soluble film layers in at least partial face-to-face engagement with the first film layer. The film layers include a polymer composition which contains polyethylene oxide alone or in combination with at least one water-soluble polymer. The edible multi-layer films may include pockets defined between the layers that house an active component. Upon addition of water, the multi-layer film dissolves, thereby releasing the active component into the water.
摘要翻译：本发明涉及溶于水的可食用多层膜。特别地，可食用的多层膜具有与第一膜层至少部分面对面接合的第一水溶性薄膜层和一个或多个附加的水溶性薄膜层。膜层包括单独包含聚环氧乙烷或与至少一种水溶性聚合物组合的聚合物组合物。可食用的多层膜可以包括限定在容纳活性成分的层之间的袋。加入水后，多层膜溶解，从而将活性成分释放到水中。

6. 发明申请

US20050184427A1 Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom 审中-公开
标题翻译：具有非自聚集均匀异质性的薄膜和由其制成的药物递送系统
公开(公告)号：US20050184427A1
公开(公告)日：2005-08-25
申请号：US11092217
申请日：2005-03-29
申请人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
发明人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
IPC分类号： A61K9/00 , A61K9/16 , A61K9/70 , A61K45/00 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61P1/04 , A61P11/10 , A61P11/14 , A61P25/04 , A61P25/16 , A61P29/00 , A61P31/04 , A61P37/08 , B29C67/20
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7015 , A61K31/192 , A61K31/422 , A61K31/435 , A61K31/4525 , A61K31/4545 , A61K31/80 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61K47/44 , A61K47/46 , C08J5/18
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。理想地，膜在水中分解，并且可以通过受控的干燥过程或保持膜所需均匀性的其它方法形成。

7. 发明申请

US20070069416A1 Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom 审中-公开
标题翻译：具有非自聚集均匀异质性的薄膜和由其制成的药物递送系统
公开(公告)号：US20070069416A1
公开(公告)日：2007-03-29
申请号：US11473356
申请日：2006-06-22
申请人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
发明人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
IPC分类号： B29C37/00 , B29D7/00
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7015 , A61K31/192 , A61K31/422 , A61K31/435 , A61K31/4525 , A61K31/4545 , A61K31/80 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61K47/44 , A61K47/46 , C08J5/18
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。理想地，膜在水中分解，并且可以通过受控的干燥过程或保持膜所需均匀性的其它方法形成。

8. 发明申请

US20050037055A1 Polyethylene oxide-based films and drug delivery systems made therefrom 有权
标题翻译：聚环氧乙烷基薄膜和药物输送系统
公开(公告)号：US20050037055A1
公开(公告)日：2005-02-17
申请号：US10856176
申请日：2004-05-28
申请人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
发明人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
IPC分类号： A23L27/10 , A61K9/00 , A61K9/70 , F26B13/20 , B29C47/00
CPC分类号： A61K8/731 , A61K8/0216 , A61K8/86 , A61K9/006 , A61K9/7007 , A61K9/7015 , A61K2800/92 , A61Q11/00 , C08J5/18 , C08J2371/02 , F26B13/104
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。膜包含聚合物组分，其包括任选地与亲水性纤维素聚合物共混的聚环氧乙烷。期望地，膜还含有药物和/或化妆品活性剂，其每单位面积膜的活性剂药物和/或美容活性剂的变化不超过10％。

9. 发明申请

US20070154527A1 Topical film compositions for delivery of actives 审中-公开
标题翻译：用于递送活性物质的局部膜组合物
公开(公告)号：US20070154527A1
公开(公告)日：2007-07-05
申请号：US11634280
申请日：2006-12-05
申请人： Garry Myers , Richard Fuisz
发明人： Garry Myers , Richard Fuisz
IPC分类号： A61F13/00 , A61K8/00 , A61K8/19 , A61K31/74 , B29C37/00 , B29D7/00 , A61K9/70
CPC分类号： A61K9/7007 , A61K8/0208 , A61K8/0216 , A61K8/731 , A61K8/86 , A61K31/74 , A61K47/10 , A61K47/38 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q9/02 , A61Q15/00 , A61Q17/005 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B29C41/28 , B29K2001/00 , B29K2001/12 , B29K2003/00 , B29K2005/00
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain a topical active agent.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。期望地，膜含有局部活性剂。

10. 发明申请

US20080004812A1 Bodily fluid analyzer, and system including same and method for programming same 失效
标题翻译：体液分析仪，以及包括相同的系统和编程方法
公开(公告)号：US20080004812A1
公开(公告)日：2008-01-03
申请号：US11790131
申请日：2007-04-24
申请人： Richard Fuisz , Joseph Fuisz
发明人： Richard Fuisz , Joseph Fuisz
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/4839 , G06F19/00 , G06F19/3456 , G16H40/63 , Y10T436/115831
摘要： A bodily fluid analyzer, system and method for programming the same includes a sensor for sensing at least one analyte in a patient; a display; a data reader unit for reading information from a data storage unit that contains stored information concerning a particular drug being taken by or course of treatment for the patient; and a processor for setting the at least one threshold value for at least one analyte to be sensed by the sensing unit based on the information read by the data reader from the data storage unit, for processing the information concerning the analyte and for sending the processed information to the display, wherein the threshold value is associated with the particular drug taken by or course of treatment for the patient, the threshold value being one beyond which the display will display an alert.
摘要翻译：用于对其进行编程的体液分析仪，系统和方法包括用于感测患者中的至少一种分析物的传感器; 一个显示器用于从数据存储单元读取信息的数据读取器单元，该数据存储单元包含关于患者正在服用的特定药物或治疗过程的存储信息; 以及处理器，用于基于由数据读取器从数据存储单元读取的信息，设置感测单元要感测的至少一个分析物的至少一个阈值，以处理关于被分析物的信息，并且用于发送处理过的信息到显示器，其中所述阈值与所述患者采取的特定药物或治疗过程相关联，所述阈值是显示器将显示警报之外的阈值。

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