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1. 发明授权

US09366668B2 Device, array, and methods for disease detection and analysis 有权
标题翻译：用于疾病检测和分析的设备，阵列和方法
公开(公告)号：US09366668B2
公开(公告)日：2016-06-14
申请号：US14465796
申请日：2014-08-21
申请人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
发明人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
IPC分类号： G01N33/543 , B01J19/00 , C40B60/12 , B01L3/00
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00385 , B01J2219/00549 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/50273 , C40B60/12
摘要： A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
摘要翻译：提供耦合到捕获分子的装置和阵列。具体地，该装置和阵列可用于检测来自受试者的样品中生物标志物的存在和浓度。装置和阵列还可以使用用于评估样品的方法，例如用于诊断疾病的目的。该方法对于需要准确地确定受试者的疾病阶段以进行治疗决定的应用也是有利的。

2. 发明申请

US20080200342A1 Device, Array, And Methods For Disease Detection And Analysis 审中-公开
标题翻译：设备，阵列和疾病检测和分析方法
公开(公告)号：US20080200342A1
公开(公告)日：2008-08-21
申请号：US12031625
申请日：2008-02-14
申请人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
发明人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
IPC分类号： C40B30/04 , C40B60/12 , C40B30/00
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00385 , B01J2219/00549 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/50273 , C40B60/12
摘要： A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
摘要翻译：提供耦合到捕获分子的装置和阵列。具体地，该装置和阵列可用于检测来自受试者的样品中生物标志物的存在和浓度。装置和阵列还可以使用用于评估样品的方法，例如用于诊断疾病的目的。该方法对于需要准确地确定受试者的疾病阶段以进行治疗决定的应用也是有利的。

3. 发明申请

US20150087543A1 Device, Array, And Methods For Disease Detection And Analysis 有权
标题翻译：设备，阵列和疾病检测和分析方法
公开(公告)号：US20150087543A1
公开(公告)日：2015-03-26
申请号：US14465796
申请日：2014-08-21
申请人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
发明人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
IPC分类号： G01N33/543 , B01J19/00
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00385 , B01J2219/00549 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/50273 , C40B60/12
摘要： A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
摘要翻译：提供耦合到捕获分子的装置和阵列。具体地，该装置和阵列可用于检测来自受试者的样品中生物标志物的存在和浓度。装置和阵列还可以使用用于评估样品的方法，例如用于诊断疾病的目的。该方法对于需要准确地确定受试者的疾病阶段以进行治疗决定的应用也是有利的。

4. 发明授权

US08428398B2 Hand-held portable microarray reader for biodetection 有权
标题翻译：手持便携式微阵列读取器，用于生物检测
公开(公告)号：US08428398B2
公开(公告)日：2013-04-23
申请号：US12826215
申请日：2010-06-29
申请人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
发明人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
IPC分类号： G06K9/22
CPC分类号： G06K9/22 , H04N5/335
摘要： A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.
摘要翻译：用于生物检测的手持便携式微阵列读取器包括被设计为足够小以用于便携式应用的微阵列读取器。本发明包括发射激发光的大功率发光二极管，定位成接收激发光的激发滤光器，滑块，用于定位滑块以接收来自激发滤光器的激发光的滑块保持器组件，发射滤光片定位成接收来自滑块的激发光，定位成接收来自发射滤光器的激发光的透镜，以及定位成接收来自透镜的激发光的CCD照相机。

5. 发明申请

US20110188782A1 Hand-Held Portable Microarray Reader For Biodetection 有权
标题翻译：手持式便携式微阵列读取器，用于生物检测
公开(公告)号：US20110188782A1
公开(公告)日：2011-08-04
申请号：US12826215
申请日：2010-06-29
申请人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
发明人： Deanna Lynn Thompson , Matthew A. Coleman , Stephen M. Lane , Dennis L. Matthews , Joanna Albala , Sebastian Wachsmann-Hogiu
IPC分类号： G06K9/22 , H04N5/335
CPC分类号： G06K9/22 , H04N5/335
摘要： A hand-held portable microarray reader for biodetection includes a microarray reader engineered to be small enough for portable applications. The invention includes a high-powered light-emitting diode that emits excitation light, an excitation filter positioned to receive the excitation light, a slide, a slide holder assembly for positioning the slide to receive the excitation light from the excitation filter, an emission filter positioned to receive the excitation light from the slide, a lens positioned to receive the excitation light from the emission filter, and a CCD camera positioned to receive the excitation light from the lens.
摘要翻译：用于生物检测的手持便携式微阵列读取器包括被设计为足够小以用于便携式应用的微阵列读取器。本发明包括发射激发光的大功率发光二极管，定位成接收激发光的激发滤光器，滑块，用于定位滑块以接收来自激发滤光器的激发光的滑块保持器组件，发射滤光片定位成接收来自滑块的激发光，定位成接收来自发射滤光器的激发光的透镜，以及定位成接收来自透镜的激发光的CCD照相机。

6. 发明授权

US06233479B1 Microwave hematoma detector 有权
标题翻译：微波血肿检测仪
公开(公告)号：US06233479B1
公开(公告)日：2001-05-15
申请号：US09153642
申请日：1998-09-15
申请人： Waleed S. Haddad , James E. Trebes , Dennis L. Matthews
发明人： Waleed S. Haddad , James E. Trebes , Dennis L. Matthews
IPC分类号： A61B505
CPC分类号： A61B5/0507 , A61B5/05 , G01V3/12
摘要： The Microwave Hematoma Detector is a non-invasive device designed to detect and localize blood pooling and clots near the outer surface of the body. While being geared towards finding sub-dural and epi-dural hematomas, the device can be used to detect blood pooling anywhere near the surface of the body. Modified versions of the device can also detect pneumothorax, organ hemorrhage, atherosclerotic plaque in the carotid arteries, evaluate perfusion (blood flow) at or near the body surface, body tissue damage at or near the surface (especially for burn assessment) and be used in a number of NDE applications. The device is based on low power pulsed microwave technology combined with a specialized antenna, signal processing/recognition algorithms and a disposable cap worn by the patient which will facilitate accurate mapping of the brain and proper function of the instrument. The invention may be used for rapid, non-invasive detection of sub-dural or epi-dural hematoma in human or animal patients, detection of hemorrhage within approximately 5 cm of the outer surface anywhere on a patient's body.
摘要翻译：微波血肿检测器是一种非侵入性装置，用于检测和定位身体外表面附近的血液汇集和凝块。在用于寻找硬脑膜下和硬膜外血肿的同时，该装置可用于检测身体表面附近任何地方的血液汇集。装置的修改版本还可以检测颈动脉中的气胸，器官出血，动脉粥样硬化斑块，评估身体表面处或附近的灌注（血流），表面处或附近的身体组织损伤（特别是对于烧伤评估），并使用在一些NDE应用中。该设备基于低功率脉冲微波技术，结合专用天线，信号处理/识别算法和患者佩戴的一次性盖帽，这将有助于大脑的准确映射和仪器的正常功能。本发明可用于人或动物患者中的硬脑膜下或硬膜外血肿的快速，非侵入性检测，在患者身体任何地方的外表面的约5cm内检测出血。

7. 发明授权

US06575965B1 Medical devices utilizing optical fibers for simultaneous power, communications and control 有权
标题翻译：利用光纤同时进行电力，通信和控制的医疗设备
公开(公告)号：US06575965B1
公开(公告)日：2003-06-10
申请号：US09713988
申请日：2000-11-16
申请人： Joseph P. Fitch , Dennis L. Matthews , Karla G. Hagans , Abraham P. Lee , Peter Krulevitch , William J. Benett , Robert E. Clough , Luiz B. DaSilva , Peter M. Celliers
发明人： Joseph P. Fitch , Dennis L. Matthews , Karla G. Hagans , Abraham P. Lee , Peter Krulevitch , William J. Benett , Robert E. Clough , Luiz B. DaSilva , Peter M. Celliers
IPC分类号： A61B1822
CPC分类号： A61B17/12022 , A61B5/0084 , A61B17/1214 , A61B17/29 , A61B2017/00292 , A61B2017/00345 , A61B2017/12072 , A61B2017/12077 , A61B2017/2926
摘要： A medical device is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a proximal end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a proximal end for external coupling of laser light energy. A laser-light-to-mechanical-power converter is connected to receive light from the distal end of the fiber optic cable and may include a photo-voltaic cell and an electromechanical motor or a heat-sensitive photo-thermal material. An electronic sensor is connected to receive electrical power from said distal end of the fiberoptic cable and is connected to provide signal information about a particular physical environment and communicated externally through the fiberoptic cable to the proximal end thereof. A mechanical sensor is attached to the distal end of the fiberoptic cable and connected to provide light signal information about a particular physical environment and communicated externally through the fiberoptic cable.
摘要翻译：医疗装置构造成具有导管的基本形式，其具有用于插入体内和在体内操作的远端，并且近端为使用者提供控制体内远端的操作。光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的光，并且可以包括光电池和机电马达或热敏光热材料。电子传感器被连接以从光纤电缆的所述远端接收电力，并且被连接以提供关于特定物理环境的信号信息，并且通过光纤电缆向外传播到其近端。机械传感器连接到光纤电缆的远端并被连接以提供关于特定物理环境的光信号信息，并通过光纤电缆在外部通信。

8. 发明授权

US5722989A Microminiaturized minimally invasive intravascular micro-mechanical systems powered and controlled via fiber-optic cable 失效
标题翻译：通过光纤电缆供电和控制的微小型微创血管内微机械系统
公开(公告)号：US5722989A
公开(公告)日：1998-03-03
申请号：US812142
申请日：1997-03-06
申请人： Joseph P. Fitch , Karla Hagans , Robert Clough , Dennis L. Matthews , Abraham P. Lee , Peter A. Krulevitch , William J. Benett , Luiz Da Silva , Peter M. Celliers
发明人： Joseph P. Fitch , Karla Hagans , Robert Clough , Dennis L. Matthews , Abraham P. Lee , Peter A. Krulevitch , William J. Benett , Luiz Da Silva , Peter M. Celliers
IPC分类号： B25J15/08 , A61B17/00 , A61B17/12 , A61B17/28 , A61B19/00 , B81B3/00
CPC分类号： A61B17/1214 , A61B17/12022 , A61B17/29 , A61B2017/00292 , A61B2017/00345 , A61B2017/00398 , A61B2017/1205 , A61B2017/12068 , A61B2017/12077 , A61B2017/12081 , A61B2017/2926
摘要： A micro-mechanical system for medical procedures is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a near end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a near end for external coupling of laser light energy. A microgripper is attached to the distal end of the catheter and providing for the gripping or releasing of an object within the body. A laser-light-to-mechanical-power converter is connected to receive laser light from the distal end of the fiberoptic cable and connected to mechanically actuate the microgripper.
摘要翻译：用于医疗程序的微机械系统以导管的基本形式构造，其具有用于插入身体内部和在身体内操作的远端，并且近端提供用户以控制身体内的远端的操纵。光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。微型抓爪附接到导管的远端，并提供用于在体内夹持或释放物体。连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的激光并连接到机械致动微型抓爪。

9. 发明授权

US5720894A Ultrashort pulse high repetition rate laser system for biological tissue processing 失效
标题翻译：超短脉冲高重复率激光系统用于材料加工
公开(公告)号：US5720894A
公开(公告)日：1998-02-24
申请号：US584522
申请日：1996-01-11
申请人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
发明人： Joseph Neev , Luiz B. Da Silva , Dennis L. Matthews , Michael E. Glinsky , Brent C. Stuart , Michael D. Perry , Michael D. Feit , Alexander M. Rubenchik
IPC分类号： A61B18/20 , A61B18/26 , A61C3/02 , A61N5/06 , B23K26/03 , B23K26/06 , B23K26/18 , B23K26/36 , B23K26/40 , C06B21/00 , B44C1/22
CPC分类号： B23K26/0665 , A61B18/20 , A61B18/26 , A61C1/0046 , B23K26/032 , B23K26/0624 , B23K26/0643 , B23K26/0648 , B23K26/18 , B23K26/40 , B23K26/402 , C06B21/0033 , A61B2018/00636 , B23K2203/05 , B23K2203/10 , B23K2203/30
摘要： A method and apparatus is disclosed for fast, efficient, precise and damage-free biological tissue removal using an ultrashort pulse duration laser system operating at high pulse repetition rates. The duration of each laser pulse is on the order of about 1 fs to less than 50 ps such that energy deposition is localized in a small depth and occurs before significant hydrodynamic motion and thermal conduction, leading to collateral damage, can take place. The depth of material removed per pulse is on the order of about 1 micrometer, and the minimal thermal and mechanical effects associated with this ablation method allows for high repetition rate operation, in the region 10 to over 1000 Hertz, which, in turn, achieves high material removal rates. The input laser energy per ablated volume of tissue is small, and the energy density required to ablate material decreases with decreasing pulse width. The ablation threshold and ablation rate are only weakly dependent on tissue type and condition, allowing for maximum flexibility of use in various biological tissue removal applications. The use of a chirped-pulse amplified Titanium-doped sapphire laser is disclosed as the source in one embodiment.
摘要翻译：公开了使用以高脉冲重复率操作的超短脉冲持续时间激光系统来快速，有效，精确和无损伤的生物组织去除的方法和装置。每个激光脉冲的持续时间约为1fs至小于50ps，使得能量沉积位于较小的深度并发生在显着的水动力运动和热传导之间，导致附带损伤。每个脉冲去除的材料的深度约为1微米，并且与该消融方法相关的最小的热和机械效应允许在10至超过1000赫兹的区域中的高重复率操作，这进而达到高材料去除率。每个消融体积的组织的输入激光能量很小，消融材料所需的能量密度随着脉冲宽度的减小而减小。消融阈值和消融率只是弱取决于组织类型和条件，允许在各种生物组织去除应用中使用的最大灵活性。在一个实施例中公开了使用啁啾脉冲放大钛掺杂蓝宝石激光器作为源。

10. 发明授权

US4731786A Method and apparatus for producing durationally short ultraviolet or X-ray laser pulses 失效
标题翻译：用于生产持续短时紫外线或X射线激光脉冲的方法和装置
公开(公告)号：US4731786A
公开(公告)日：1988-03-15
申请号：US46020
申请日：1987-05-05
申请人： Brian J. MacGowan , Dennis L. Matthews , James E. Trebes
发明人： Brian J. MacGowan , Dennis L. Matthews , James E. Trebes
IPC分类号： G21K1/04 , H01S4/00 , H05G2/00 , H05H1/22 , H01S3/30
CPC分类号： H05G2/003 , G21B1/23 , H01S4/00 , H05G2/008
摘要： A method and apparatus is disclosed for producing ultraviolet or X-ray laser pulses of short duration (32). An ultraviolet or X-ray laser pulse of long duration (12) is progressively refracted, across the surface of an opaque barrier (28), by a streaming plasma (22) that is produced by illuminating a solid target (16, 18) with a pulse of conventional line focused high power laser radiation (20). The short pulse of ultraviolet or X-ray laser radiation (32), which may be amplified to high power (40, 42), is separated out by passage through a slit aperture (30) in the opaque barrier (28).
摘要翻译：公开了用于产生短持续时间（32）的紫外或X射线激光脉冲的方法和装置。长时间（12）的紫外线或X射线激光脉冲通过通过用固体靶（16,18）照射而产生的流动等离子体（22）逐渐折射穿过不透明屏障（28）的表面，传统的线路聚焦高功率激光辐射的脉冲（20）。通过穿过不透光屏障（28）中的狭缝孔（30）将紫外线或X射线激光辐射（32）的短脉冲放大到高功率（40,42）。

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