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1. 发明申请

US20140154677A1 CELL ANALYSIS APPARATUS AND CELL ANALYSIS METHOD 审中-公开
标题翻译：细胞分析装置和细胞分析方法
公开(公告)号：US20140154677A1
公开(公告)日：2014-06-05
申请号：US14164773
申请日：2014-01-27
申请人： Sysmex Corporation
发明人： Masaki ISHISAKA , Kazuki KISHI , Masakazu FUKUDA
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N15/147 , G01N2015/0092 , G01N2015/1497
摘要： A cell analysis apparatus that can accurately distinguish between an aggregating cell and a non-aggregating cell is provided. The cell analysis apparatus (10) includes: an optical detection section (3) for flowing a measurement sample obtained from a biological sample and a pigment into a flow cell (51), irradiating the measurement sample flowing in the flow cell (51) with laser beam and detecting fluorescence from the measurement sample; a signal processing circuit (4) for acquiring, based on a fluorescence signal outputted from the detection section (3), a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal; and a system control section (13) for distinguishing between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value reflecting the height of the waveform of the fluorescence signal and the value reflecting the length of the ridge line of the waveform of the fluorescence signal obtained by the signal processing circuit (4).
摘要翻译：提供了可以精确地区分聚集单元和非聚集单元的单元分析设备。细胞分析装置（10）包括：光检测部（3），用于将从生物样品和颜料获得的测定样品流入流动池（51），向流动池（51）中流动的测定样品照射激光束和检测来自测量样品的荧光; 信号处理电路（4），用于基于从检测部（3）输出的荧光信号，获取反映信号的波形的高度的值和反映该信号的波形的脊线的长度的值信号; 以及系统控制部（13），用于基于反映荧光信号的波形的高度的值和反映荧光信号的长度的值来区分由多个单元的聚集形成的聚集单元和非聚集单元由信号处理电路（4）获得的荧光信号波形的脊线。

2. 发明申请

US20230055601A1 URINE ANALYSIS SYSTEM, IMAGE CAPTURING APPARATUS, URINE ANALYSIS METHOD 有权
公开(公告)号：US20230055601A1
公开(公告)日：2023-02-23
申请号：US18047682
申请日：2022-10-19
申请人： SYSMEX CORPORATION
发明人： Masakazu FUKUDA , Masamichi TANAKA , Yousuke TANAKA
IPC分类号： G06V20/69 , G01N33/493 , G01N33/52 , G01N21/78 , G01N15/14 , G01N33/483 , G01N1/14 , G01N21/64 , G01N33/487
摘要： A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.

3. 发明申请

US20170322159A1 CELL ANALYSIS APPARATUS AND CELL ANALYSIS METHOD 审中-公开
公开(公告)号：US20170322159A1
公开(公告)日：2017-11-09
申请号：US15650105
申请日：2017-07-14
申请人： Sysmex Corporation
发明人： Masaki ISHISAKA , Kazuki KISHI , Masakazu FUKUDA
IPC分类号： G01N21/64 , G01N15/14 , G01N15/00
CPC分类号： G01N21/6486 , G01N15/147 , G01N2015/0092 , G01N2015/1497
摘要： A cell analyzing method includes measuring cells that are nuclear stained, by a cytometric device, to obtain a histogram of a parameter of a fluorescence signal, where the parameter indicates an amount of DNA in a nucleus of a cell. A number of cells that are distributed in an area where the parameter of the fluorescence signal is larger than normal cells are obtained by a computer having at least one processor. The possibility of cancer is determined based on the obtained number of cells and the histogram.

4. 发明申请

US20180017480A1 URINE ANALYSIS SYSTEM, IMAGE CAPTURING APPARATUS, URINE ANALYSIS METHOD 审中-公开
公开(公告)号：US20180017480A1
公开(公告)日：2018-01-18
申请号：US15715190
申请日：2017-09-26
申请人： SYSMEX CORPORATION
发明人： Masakazu FUKUDA , Masamichi TANAKA , Yousuke TANAKA
IPC分类号： G01N15/14 , G01N21/64 , G01N33/487 , G01N33/493 , G01N1/14 , G01N15/10 , G01N15/00
CPC分类号： G01N15/1463 , G01N1/14 , G01N15/14 , G01N15/1436 , G01N15/1459 , G01N21/6428 , G01N21/78 , G01N33/483 , G01N33/48792 , G01N33/493 , G01N33/52 , G01N2015/0065 , G01N2015/1006 , G01N2021/6439 , G01N2201/068
摘要： A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.

5. 发明申请

US20140242633A1 URINE SAMPLE ANALYZER AND SAMPLE ANALYZING METHOD 有权
标题翻译：尿样分析仪和样品分析方法
公开(公告)号：US20140242633A1
公开(公告)日：2014-08-28
申请号：US14193015
申请日：2014-02-28
申请人： Sysmex Corporation
发明人： Masakazu FUKUDA , Masamichi TANAKA
IPC分类号： G01N33/50 , G01N33/80 , C12Q1/06
CPC分类号： G01N33/5094 , C12Q1/06 , G01N15/1425 , G01N33/493 , G01N33/80
摘要： A urine analyzer capable of operating in a urine measurement mode and a body fluid measurement mode, the urine analyzer includes a specimen preparing section configured to prepare a measurement specimen and a detecting section configured to derive signals of particles in the measurement specimen supplied from the specimen preparing section. A computer and a memory including programs on a computer-readable medium that enable the computer to execute operations to control the specimen preparing section and the detecting section in the urine measurement mode and in the body fluid measurement mode.
摘要翻译：一种能够在尿液测量模式和体液测量模式下操作的尿液分析器，所述尿液分析仪包括：样本制备部，其被配置为制备测量样本;以及检测部，其被配置为从所述样本提供的所述测量样本中导出粒子的信号准备部分。一种包括计算机可读介质上的程序的计算机和存储器，其使得计算机能够执行在尿液测量模式和体液测量模式中控制样本制备部分和检测部分的操作。

6. 发明申请

US20180356330A1 BIOLOGICAL SAMPLE IMAGING DEVICE AND BIOLOGICAL SAMPLE IMAGING METHOD 审中-公开
公开(公告)号：US20180356330A1
公开(公告)日：2018-12-13
申请号：US16040868
申请日：2018-07-20
申请人： SYSMEX CORPORATION
发明人： Masakazu FUKUDA , Toshikuni SUGANUMA , Kazuhiro KANOU , Yanyan LIU
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/00 , G01N33/493 , G01N35/08 , G01N2015/1409 , H04N5/225
摘要： Provided is a biological sample imaging device and a biological sample imaging method that are capable of disposing a sufficient number of large-sized particles in a biological sample so as to be moderately dispersed within an imaging range. The biological sample imaging method includes: a first step of introducing a biological sample containing particles into a liquid flow channel; a second step of causing the biological sample introduced into the liquid flow channel to flow in a forward direction; a third step of causing the biological sample to flow in a reverse direction after the second step; and an imaging step of taking, in an imaging cell, images of the particles contained in the biological sample that remains in the liquid flow channel after the third step.

7. 发明申请

US20170285000A1 CELL IMAGING DEVICE, CELL IMAGING METHOD, AND SAMPLE CELL 审中-公开
公开(公告)号：US20170285000A1
公开(公告)日：2017-10-05
申请号：US15628188
申请日：2017-06-20
申请人： Sysmex Corporation
发明人： Masakazu FUKUDA , Masamichi TANAKA , Yanyan LIU , Ryosuke FUJII , Takumi INUTSUKA , Tomoyuki TSUKAHARA
IPC分类号： G01N33/50 , G01N33/483 , C12Q1/68
摘要： Provided are a cell imaging device and a cell imaging method that can shorten the time period of taking images of cells in a liquid sample, compared with conventional techniques. This cell imaging device introduces a urine sample containing cells into an internal space of a sample cell, moves at least one of the sample cell and an objective lens in a second direction while at least one of the sample cell and the objective lens is moved in a first direction, the second direction being different from the first direction, and takes, at a plurality of imaging positions, images of cells contained in the urine sample by means of an imaging unit.

8. 发明申请

US20150000428A1 SAMPLE PROCESSING APPARATUS AND AN ERROR DETECTING METHOD FOR SAMPLE PROCESSING APPARATUS 有权
标题翻译：样品加工设备和样品加工设备的错误检测方法
公开(公告)号：US20150000428A1
公开(公告)日：2015-01-01
申请号：US14315997
申请日：2014-06-26
申请人： Sysmex Corporation
发明人： Masakazu FUKUDA , Masamichi TANAKA
IPC分类号： G01N1/14 , G01V3/00
CPC分类号： G01N35/1009
摘要： A sample processing apparatus comprises an aspirating member which comprises a pump at one side and which is configured to aspirate a sample from the other side, a sensor which is configured to sense the presence or absence of a liquid at a predetermined position of the aspirating member, and a controller which is programmed to execute operations. The operations comprise controlling the aspirating member to aspirate a sample, obtaining a first sensing result by the sensor when the aspirating member aspirates a sample, controlling the aspirating member to aspirate air after aspirating a sample, obtaining a second sensing result by the sensor when the aspirating member aspirates air, and detecting an error in the aspirating operation, based on the first sensing result and the second sensing result.
摘要翻译：一种样品处理装置，包括：抽吸构件，其包括在一侧的泵，其构造成从另一侧抽吸样品;传感器，被配置为感测在吸气构件的预定位置处液体的存在或不存在以及被编程为执行操作的控制器。操作包括控制抽吸构件抽吸样品，当抽吸构件抽吸样品时获得传感器的第一感测结果，在抽吸样品之后控制吸气构件抽吸空气，当传感器吸入样品时获得第二感测结果抽吸构件基于第一感测结果和第二感测结果抽吸空气，并检测抽吸操作中的误差。

9. 发明申请

US20200158624A1 URINE ANALYSIS SYSTEM, IMAGE CAPTURING APPARATUS, URINE ANALYSIS METHOD 审中-公开
公开(公告)号：US20200158624A1
公开(公告)日：2020-05-21
申请号：US16752716
申请日：2020-01-27
申请人： SYSMEX CORPORATION
发明人： Masakazu FUKUDA , Masamichi TANAKA , Yousuke TANAKA
IPC分类号： G01N15/14 , G01N33/487 , G01N21/64 , G01N1/14 , G01N33/493 , G01N33/483 , G01N21/78 , G01N33/52
摘要： A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.

10. 发明申请

US20180348200A1 URINE ANALYZER AND URINALYSIS METHOD 审中-公开
公开(公告)号：US20180348200A1
公开(公告)日：2018-12-06
申请号：US15992500
申请日：2018-05-30
申请人： SYSMEX CORPORATION
发明人： Shota TATEYAMA , Masakazu FUKUDA , Mitsumasa SAKAMOTO
IPC分类号： G01N33/493 , G01N33/92
CPC分类号： G01N33/493 , G01N15/14 , G01N15/1434 , G01N15/1459 , G01N21/95623 , G01N33/92 , G01N2015/0065 , G01N2035/00465
摘要： The urine analyzer 10 includes a sample preparation unit 30 for mixing a urine sample with a hemolytic agent to prepare a measurement sample, a flow cell 41 for flowing a measurement sample, a light source 42 for irradiating light on the measurement sample flowing through the flow cell 41, a light receiving unit 50 for receiving scattered light given off from the measurement sample by irradiation of light and outputting a scattered light signal, and an analysis unit 12 for detecting fat particles in the measurement sample by using a parameter reflecting the intensity of the scattered light signal output by the light receiving unit 50, and a parameter reflecting the width of the scattered light signal.

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