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1. 发明申请

US20140243501A1 HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS 有权
标题翻译：组胺脱乙酰酶抑制剂及其合成方法及其在制药中的应用
公开(公告)号：US20140243501A1
公开(公告)日：2014-08-28
申请号：US13980308
申请日：2012-02-23
申请人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
发明人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
IPC分类号： C07K5/097
CPC分类号： C07K5/0821 , A61K38/06 , C07F7/10 , C07F7/1804 , Y02A50/411
摘要： The invention provides histone deacetylase (HDAC) inhibitors shown as Formula I, where R1 to R8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of HDAC.
摘要翻译：本发明提供如式I所示的组蛋白脱乙酰酶（HDAC）抑制剂，其中R1至R8如说明书中所定义。本发明还提供了这些化合物的合成方法和这些化合物在制备用于预防或治疗与HDAC失调相关的哺乳动物疾病的药物中的应用。

2. 发明授权

US08933195B2 Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments 有权
标题翻译：组蛋白脱乙酰酶抑制剂及其合成方法及其在药物制造中的应用
公开(公告)号：US08933195B2
公开(公告)日：2015-01-13
申请号：US13980308
申请日：2012-02-23
申请人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
发明人： Sheng Jiang , Shang Li , Zhiyi Yao , Yiwu Yao , Feng Zhang , Yang Chao , Hai Ye , Min Chen
IPC分类号： C07K5/097 , C07F7/10 , C07F7/18 , A61K38/06
CPC分类号： C07K5/0821 , A61K38/06 , C07F7/10 , C07F7/1804 , Y02A50/411
摘要： The invention provides histone deacetylase (HDAC) inhibitors shown as Formula I, where R1 to R8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of HDAC.
摘要翻译：本发明提供如式I所示的组蛋白脱乙酰酶（HDAC）抑制剂，其中R1至R8如说明书中所定义。本发明还提供了这些化合物的合成方法和这些化合物在制备用于预防或治疗与HDAC失调相关的哺乳动物疾病的药物中的应用。

3. 发明授权

US06960475B2 Composition and process for indicating the presence of soluble fluoride ion in oral care compositions and method of making the same 失效
标题翻译：用于表示口腔护理组合物中可溶性氟离子的存在的组成和方法及其制备方法
公开(公告)号：US06960475B2
公开(公告)日：2005-11-01
申请号：US10188613
申请日：2002-07-03
申请人： Junjian Ling , Hai Ye , Christopher David Buckley
发明人： Junjian Ling , Hai Ye , Christopher David Buckley
IPC分类号： A61K8/21 , A61Q11/00 , A61K7/18 , G01N33/00
CPC分类号： A61Q11/00 , A61K8/21 , Y10T436/19
摘要： Disclosed is a process for indicating the presence of soluble fluoride ions in oral care compositions comprising making a signal solution and then bringing the signal solution into contact with an oral care composition and a color change occurs if an effective amount of soluble fluoride ion is present in the oral care composition. Further disclosed are test compositions for use in such process.
摘要翻译：公开了一种用于指示口腔护理组合物中可溶性氟离子存在的方法，包括制备信号溶液，然后使信号溶液与口腔护理组合物接触，并且如果有效量的可溶性氟离子存在于口腔护理组合物。还公开了用于这种方法的试验组合物。

4. 发明授权

US07048911B2 Unit dose oral treatment products, kits and methods 有权
标题翻译：单位剂量口服治疗产品，试剂盒和方法
公开(公告)号：US07048911B2
公开(公告)日：2006-05-23
申请号：US10412085
申请日：2003-04-11
申请人： Stuart Reginald Cashman , Gaelle Moneuze , Jennifer Claire Morton , Hai Ye
发明人： Stuart Reginald Cashman , Gaelle Moneuze , Jennifer Claire Morton , Hai Ye
IPC分类号： A61K7/16 , A61K7/20 , A61B19/02 , A61B17/06
CPC分类号： A61K8/35 , A61K8/22 , A61Q11/00
摘要： The present invention provides a unit dose treatment product comprising: a) a sealed disposable package comprising a laminate wherein the laminate comprises; i) an aluminium barrier layer; and ii) a polymer contact layer selected from polypropylene, polyamide and nylon 12; b) a liquid treatment product contained within the package, wherein the liquid treatment product comprises: i) a film-forming polymer; ii) an organic solvent for the film-forming polymer having a boiling point of less than 150° C. and a solubility parameter of less than 22 (MPa)0.5; and iii) an active agent; wherein the polymer contact layer of the laminate is in contact with the liquid treatment product. Kits comprising the unit dose treatment products and methods of treating the tissues of the oral cavity employing the unit dose treatment products are also provided. The products, kits and methods herein provide for convenient oral treatments, especially tooth whitening treatments using an extended regimen.
摘要翻译：本发明提供一种单位剂量处理产品，其包括：a）密封的一次性包装，其包含层压体，其中所述层压体包含; i）铝阻挡层; 和ii）选自聚丙烯，聚酰胺和尼龙12的聚合物接触层; b）包含在包装内的液体处理产品，其中所述液体处理产品包括：i）成膜聚合物; ii）沸点低于150℃，溶解度参数小于22（MPa）<0.5的成膜聚合物的有机溶剂; 和iii）活性剂; 其中层压体的聚合物接触层与液体处理产物接触。还提供了包含单位剂量治疗产品和使用单位剂量治疗产品治疗口腔组织的方法的试剂盒。本文的产品，试剂盒和方法提供方便的口服治疗，特别是使用延长方案的牙齿美白治疗。

5. 发明申请

US20050088815A1 Hard disk mounting assembly 失效
标题翻译：硬盘安装组件
公开(公告)号：US20050088815A1
公开(公告)日：2005-04-28
申请号：US10948553
申请日：2004-09-22
申请人： Yun Chen , Hai Ye , Zhou Xu
发明人： Yun Chen , Hai Ye , Zhou Xu
IPC分类号： G06F1/00 , G11B33/12 , H05K7/00 , H05K7/18
CPC分类号： G11B33/124
摘要： A hard disk mounting assembly includes a chassis (10), a first cage (20) mounted to the chassis, a hard disk drive(40) (HDD) and a second cage (60). The HDD defines a plurality of fixing openings (42). The first cage includes a plurality of mounting pillars (28) resilient connected with the cage and received in the fixing openings of the HDD at one end portion. The first cage further defines a pair of engaging apertures (34) at opposite sides thereof. The second cage has a base (62) and two connecting arms (68) depending from the base. the base forms a plurality of elastic fingers (66). The first cage is mounted to the chassis and the HDD is received in the first cage, the second cage hitches the first cage by the connecting arms with the elastic fingers pressing the HDD, thereby mounting the HDD to the chassis.
摘要翻译：硬盘安装组件包括底盘（10），安装到底盘的第一保持架（20），硬盘驱动器（40）（HDD）和第二保持架（60）。 HDD限定多个固定开口（42）。第一保持架包括与保持架弹性连接的多个安装柱（28），并被容纳在HDD的一端部的固定开口中。第一笼还在其相对侧限定一对接合孔（34）。第二保持架具有底座（62）和从基座悬挂的两个连接臂（68）。基部形成多个弹性指状物（66）。第一保持架安装在底盘上，HDD被容纳在第一保持架中，第二笼通过连接臂与弹性指状物按压HDD连接，从而将HDD安装在底盘上。

6. 再颁专利

USRE42126E1 Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip 失效
标题翻译：包含有机硅氧烷树脂的口腔护理组合物的递送系统使用可移除的背衬条
公开(公告)号：USRE42126E1
公开(公告)日：2011-02-08
申请号：US10927655
申请日：2000-06-30
申请人： Hai Ye , Christopher David Buckley , Jiang Yue
发明人： Hai Ye , Christopher David Buckley , Jiang Yue
IPC分类号： A61K8/00 , A61K8/18 , A61K8/02 , A61K9/70 , A01N25/34 , A61F13/00 , A61L15/16
CPC分类号： A61Q11/00 , A61C19/063 , A61K6/0067 , A61K6/0094 , A61K8/0208 , A61K8/19 , A61K8/20 , A61K8/22 , A61K8/25 , A61K8/26 , A61K8/31 , A61K8/35 , A61K8/37 , A61K8/416 , A61K8/70 , A61K8/891 , A61K9/006 , A61K9/7015 , A61K6/0017 , C08L83/04
摘要： Disclosed is a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a theology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed. Further disclosed are such delivery systems in which the oral care composition further comprises fluid diorganopolysiloxane-based polymers; such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers. Still further disclosed are methods of using the delivery systems.
摘要翻译：公开了一种用于将口腔护理物质递送到口腔的递送系统，所述递送系统包括：（a）具有足够柔性的可移除背衬条，以便当将递送系统放置在其上时容易地与口腔表面吻合; 口腔护理组合物包含：（i）有机硅氧烷树脂;和（b）应用于所述材料带的口腔护理组合物，使得当将所述递送系统置于所述口腔表面上时，所述口腔护理组合物接触口腔表面，（ii）神学改良剂; 和（iii）至少一种口腔护理物质; 其中所述口腔护理组合物在所述背衬带去除之后保留在所述口腔表面上。进一步公开的是这样的递送系统，其中口腔护理组合物还包含流体二有机聚硅氧烷基聚合物; 这样的组合物还可以包含用于增溶有机硅氧烷树脂和流体二有机聚硅氧烷基聚合物的载体。还公开了使用递送系统的方法。

7. 发明申请

US20080045554A1 PURINONE DERIVATIVES AS HM74A AGONISTS 有权
标题翻译：嘌呤衍生物作为HM74A激动剂
公开(公告)号：US20080045554A1
公开(公告)日：2008-02-21
申请号：US11766981
申请日：2007-06-22
申请人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Ye , Brian Metcalf
发明人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Ye , Brian Metcalf
IPC分类号： A61K31/495 , A61P3/00 , C07D239/00
CPC分类号： C07D487/14
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要翻译：本发明涉及作为HM74a受体的激动剂的嘌呤酮衍生物。还提供了使用本文化合物及其药学上可接受的盐来治疗疾病的组合物和方法。

8. 发明授权

US06649147B1 Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip 有权
标题翻译：包含有机硅氧烷树脂的口腔护理组合物的递送系统使用可移除的背衬条
公开(公告)号：US06649147B1
公开(公告)日：2003-11-18
申请号：US10019032
申请日：2002-03-20
申请人： Hai Ye , Christopher David Buckley , Jiang Yue
发明人： Hai Ye , Christopher David Buckley , Jiang Yue
IPC分类号： A61K716
CPC分类号： A61Q11/00 , A61C19/063 , A61K8/0208 , A61K8/19 , A61K8/20 , A61K8/22 , A61K8/25 , A61K8/26 , A61K8/31 , A61K8/35 , A61K8/37 , A61K8/416 , A61K8/70 , A61K8/891 , A61K9/006 , A61K9/7015
摘要： Disclosed is a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a theology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed. Further disclosed are such delivery systems in which the oral care composition further comprises fluid diorganopolysiloxane-based polymers; such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers. Still further disclosed are methods of using the delivery systems.
摘要翻译：公开了一种用于将口腔护理物质递送到口腔的递送系统，所述递送系统包括：（a）具有足够柔性的可移除背衬条，以便当将递送系统放置在其上时容易地与口腔表面吻合; 口腔护理组合物包含：（i）有机硅氧烷树脂;和（b）应用于所述材料带的口腔护理组合物，使得当将所述递送系统置于所述口腔表面上时，所述口腔护理组合物接触口腔表面，（ii）神学改良剂; 和（iii）至少一种口腔护理物质; 其中所述口腔护理组合物在所述背衬带去除之后保留在所述口腔表面上。进一步公开的是这样的递送系统，其中口腔护理组合物还包含流体二有机聚硅氧烷基聚合物; 这样的组合物还可以包含用于增溶有机硅氧烷树脂和流体二有机聚硅氧烷基聚合物的载体。还公开了使用递送系统的方法。

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