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1. 发明授权

US08741611B2 Methods for improving malic acid production in filamentous fungi 失效
公开(公告)号：US08741611B2
公开(公告)日：2014-06-03
申请号：US12870523
申请日：2010-08-27
申请人： Stephen Brown , Sheryl Luttringer , Debbie Yaver , Alan Berry
发明人： Stephen Brown , Sheryl Luttringer , Debbie Yaver , Alan Berry
IPC分类号： C12P7/46 , C12N1/00
CPC分类号： C12P7/46 , C07K14/38 , C12N15/80
摘要： The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants.

2. 发明授权

US08497103B2 Methods for C4-dicarboxylic acid production in filamentous fungi 失效
标题翻译：丝状真菌中C4-二羧酸生产方法
公开(公告)号：US08497103B2
公开(公告)日：2013-07-30
申请号：US13165719
申请日：2011-06-21
申请人： Sheryl Luttringer , Debbie Yaver
发明人： Sheryl Luttringer , Debbie Yaver
IPC分类号： C12N1/15 , C12P7/46
CPC分类号： C12P7/46 , C07K14/38
摘要： The present invention relates to methods of producing C4-dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4-dicarboxylic acid transporter; and (b) recovering the C4-dicarboxylic acid. The present invention also relates to methods for increasing C4-dicarboxylic acid production, as well as host cells comprising the polynucleotides.
摘要翻译：本发明涉及生产C4-二羧酸如苹果酸的方法，其包括：（a）培养包含编码C4-二羧酸转运蛋白的多核苷酸的宿主细胞; 和（b）回收C4-二羧酸。本发明还涉及增加C4-二羧酸产生的方法以及包含多核苷酸的宿主细胞。

3. 发明授权

US09284588B2 Promoters for expressing genes in a fungal cell 有权
标题翻译：在真菌细胞中表达基因的启动子
公开(公告)号：US09284588B2
公开(公告)日：2016-03-15
申请号：US13885145
申请日：2011-12-15
申请人： Sandra Merino , Debbie Yaver
发明人： Sandra Merino , Debbie Yaver
IPC分类号： C12P21/00 , C12N9/08 , C12N15/80
CPC分类号： C12N15/80 , C12N9/0065 , C12P21/00
摘要： The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides.
摘要翻译：本发明涉及分离的启动子和构建体，载体和包含与编码多肽的多核苷酸可操作地连接的此类启动子的真菌宿主细胞。本发明还涉及生产这种多肽的方法。

4. 发明申请

US20140212977A1 Methods For Producing Multiple Recombinant Polypeptides In A Filamentous Fungal Host Cell 有权
标题翻译：在丝状真菌宿主细胞中产生多种重组多肽的方法
公开(公告)号：US20140212977A1
公开(公告)日：2014-07-31
申请号：US14238691
申请日：2012-08-23
申请人： Debbie Yaver , Qiming Jin
发明人： Debbie Yaver , Qiming Jin
IPC分类号： C12N15/87 , C12N9/42 , C12N15/80
CPC分类号： C12N9/2437 , C12N9/2402 , C12N15/80 , C12N15/87 , C12Y302/01091 , C12Y302/0115
摘要： The present invention relates to methods for constructing a filamentous fungal strain for production of multiple recombinant polypeptides having biological activity. The present invention also relates to methods for producing multiple recombinant polypeptides having biological activity in a filamentous fungal strain. The present invention also relates to filamentous fungal strains expressing multiple recombinant polypeptides having biological activity.
摘要翻译：本发明涉及构建用于生产具有生物活性的多重重组多肽的丝状真菌菌株的方法。本发明还涉及在丝状真菌菌株中生产具有生物活性的多重重组多肽的方法。本发明还涉及表达具有生物活性的多种重组多肽的丝状真菌菌株。

5. 发明授权

US08604181B2 Promoter variants for expressing genes in a fungal cell 有权
标题翻译：用于在真菌细胞中表达基因的启动子变体
公开(公告)号：US08604181B2
公开(公告)日：2013-12-10
申请号：US13424018
申请日：2012-03-19
申请人： Debbie Yaver , Peter Nham
发明人： Debbie Yaver , Peter Nham
IPC分类号： C07H21/04 , C12N15/63 , C12N15/00
CPC分类号： C12N15/80 , C12N9/0044 , C12N9/20 , C12N9/58 , C12N9/93 , C12N15/113 , C12P1/02 , C12P21/00 , C12Y107/01003 , C12Y301/01003 , C12Y304/21004 , C12Y603/04002
摘要： The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic acid sequence comprising a promoter variant selected from the group consisting of SEQ ID NOs: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, and 12; and a subsequence thereof; and hybrid and tandem promoters thereof; and (b) isolating the biological substance from the cultivation medium. The present invention also relates to the isolated promoter variants and to constructs, vectors, and fungal host cells comprising the promoter variants operably linked to nucleic acid sequences encoding biological substances.
摘要翻译：本发明涉及生物体的制造方法，其特征在于，包括：（a）在有助于生物生物的培养基中培养真菌宿主细胞，其中所述真菌宿主细胞可操作地包含编码生物物质的第一核酸序列与包含选自SEQ ID NO：2,3,4,5,6,7,8,9,10,11和12的启动子变体的第二核酸序列连接; 及其后果; 及其杂交和串联启动子; 和（b）从培养基中分离生物物质。本发明还涉及分离的启动子变体和构建体，载体和真菌宿主细胞，其包含可操作地连接于编码生物物质的核酸序列的启动子变体。

6. 发明申请

US20120192316A1 POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
公开(公告)号：US20120192316A1
公开(公告)日：2012-07-26
申请号：US13440626
申请日：2012-04-05
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
IPC分类号： A01H5/00 , C07H21/04 , C12N15/63 , C12N9/20 , C12N5/10
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

7. 发明授权

US07955830B2 Polypeptides having lipase activity and polynucleotides encoding same 有权
标题翻译：具有脂肪酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US07955830B2
公开(公告)日：2011-06-07
申请号：US12944557
申请日：2010-11-11
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
IPC分类号： C11D3/386 , C07K1/00 , C12N9/10
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有脂肪酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

8. 发明授权

US07662602B2 Polypeptides having lipase activity and polynucleotides encoding same 有权
公开(公告)号：US07662602B2
公开(公告)日：2010-02-16
申请号：US11255553
申请日：2005-10-21
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
IPC分类号： C12N9/10 , C07K1/00
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

9. 发明申请

US20090253171A1 Methods For Producing Secreted Polypeptides Having Biological Activity 失效
标题翻译：用于生产具有生物活性的分泌多肽的方法
公开(公告)号：US20090253171A1
公开(公告)日：2009-10-08
申请号：US12373470
申请日：2007-07-13
申请人： Debbie Yaver , Mads Eskelund Bjornvad
发明人： Debbie Yaver , Mads Eskelund Bjornvad
IPC分类号： C12P21/02 , C12N9/20 , C12N15/11
CPC分类号： C12P21/02 , C07K14/37 , C07K2319/02 , C12N9/20 , C12N15/625 , C12N15/81 , C12Y301/01003
摘要： The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.
摘要翻译：本发明涉及生产具有生物活性的多肽的方法，其包括：（a）在有助于产生多肽的培养基中培养真菌宿主细胞，其中真菌宿主细胞包含编码多肽的第一多核苷酸，其可操作地连接到编码变体信号肽或变体前肽的第二个多核苷酸; 和（b）从培养基中分离具有生物活性的分泌多肽。

10. 发明申请

US20090137474A1 USE OF POLYPEPTIDES HAVING ANTIMICROBIAL ACTIVITY 失效
标题翻译：使用具有抗微生物活性的多肽
公开(公告)号：US20090137474A1
公开(公告)日：2009-05-28
申请号：US12282429
申请日：2007-03-20
申请人： Erik Gormsen , Debbie Yaver
发明人： Erik Gormsen , Debbie Yaver
IPC分类号： A61K38/16 , A61L2/18 , C11D7/42
CPC分类号： A61K38/164 , A01N37/46 , A01N63/02 , A61L2/16 , C11D3/3719 , C11D3/38 , C11D3/48
摘要： The present invention relates to the use of polypeptides related to a Bacillus licheniformis polypeptide (amino acids 1-85 of SEQ ID NO: 2) as antimicrobial agents, for example in pharmaceutical applications, including veterinary applications, as well as for preservation, cleaning and disinfection of various surfaces, objects and substances. The polypeptides may in particular be used to treat textiles or laundry, e.g., in detergents, for reducing microbes on textile or laundry, and/or for odor reduction. The invention also relates to use of Bacillus strains producing these polypeptides as antimicrobial agents. Examples of microorganism inhibited by Lento are Gram positive bacterial strains, such as Bacillus cereus, and various species of Corynebacterium, Enterococcus, Micrococcus, Streptococcus, and Staphylococcus.
摘要翻译：本发明涉及与地衣芽孢杆菌多肽（SEQ ID NO：2的氨基酸1-85）相关的多肽作为抗微生物剂的用途，例如在药物应用中，包括兽医应用，以及用于保存，清洁和消毒各种表面，物体和物质。多肽可特别用于处理纺织品或衣物，例如在洗涤剂中，用于还原织物或衣物上的微生物和/或降低气味。本发明还涉及产生这些多肽的芽孢杆菌菌株作为抗微生物剂的用途。由Lento抑制的微生物的实例是革兰氏阳性细菌菌株，如蜡状芽孢杆菌，以及各种棒状杆菌，肠球菌，微球菌，链球菌和葡萄球菌。

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