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1. 发明授权

US09484702B2 System and method for agile remote generation of a broadband tunable short-pulse emission 有权
标题翻译：用于敏捷远程生成宽带可调短脉冲发射的系统和方法
公开(公告)号：US09484702B2
公开(公告)日：2016-11-01
申请号：US13428397
申请日：2012-03-23
申请人： Stéphane Payeur , Philippe Lassonde , Jean-Claude Kieffer , Francis Théberge , Marc Chàteauneuf , Jacques Dubois
发明人： Stéphane Payeur , Philippe Lassonde , Jean-Claude Kieffer , Francis Théberge , Marc Chàteauneuf , Jacques Dubois
IPC分类号： H01S3/00 , G02F1/35 , G01N21/3581
CPC分类号： H01S3/0057 , G01N21/3581 , G02F1/3511 , G02F2001/3528 , H01S3/0078 , H01S3/0092
摘要： A method comprising using a pulse shaper in the spectral domain to generate multiple-color pulses directly at the output of the laser amplifier. The delay can thus be controlled directly in the spectral domain and there is no need for an optical delay line. The method allows reducing the number of optical components and insures insensitivity to alignment, vibrations and turbulence on long distance propagation and filamentation, particularly in air. The method allows programmable and tunable interaction, since the pulse shaper is able to control the laser spectral amplitude and phase.
摘要翻译：一种方法，包括使用频谱域中的脉冲整形器直接在激光放大器的输出处产生多色脉冲。因此可以在频域中直接控制延迟，并且不需要光学延迟线。该方法允许减少光学部件的数量并且确保对长距离传播和细丝的对准，振动和湍流的不敏感性，特别是在空气中。该方法允许可编程和可调谐的相互作用，因为脉冲整形器能够控制激光的光谱振幅和相位。

2. 发明授权

US09575309B2 Telescopic control of high power laser propagation 有权
标题翻译：大功率激光传播的伸缩控制
公开(公告)号：US09575309B2
公开(公告)日：2017-02-21
申请号：US14424488
申请日：2012-09-10
申请人： Francis Théberge , Jacques Dubois , Marc Châteauneuf
发明人： Francis Théberge , Jacques Dubois , Marc Châteauneuf
IPC分类号： G02B23/02 , G01S17/88 , H02J17/00 , G02B23/06 , G02B17/06 , G02B26/06 , G02B19/00 , G01S7/481 , G02B27/10
CPC分类号： G02B23/02 , G01S7/4815 , G01S17/88 , G02B17/0621 , G02B17/0694 , G02B19/0023 , G02B19/0047 , G02B23/06 , G02B26/06 , G02B27/108 , H02J17/00 , H02J50/30
摘要： The present invention provides a reflective telescopic system, to control the generation of filamentation of ultrashort and intense laser pulses that includes: a flat mirror, an adaptive reflective mirror, a dichroic convex mirror, an off-axis parabolic mirror, and a first laser source. The convex mirror and the adaptive reflective mirror are mounted on an independent breadboard and set on a translation stage. The propagation axis of the laser beam reflected by the mirror should correspond to the off-axis of the parabolic mirror. The parabolic mirror reflects the beam at a specific angle. Finally, the propagation axis between the dichroic convex mirror and the off-axis parabolic mirror, the propagation axis between the flat mirror and the adaptive reflective mirror, and the axis of the translation stage should be substantially parallel to each other. The present invention also contemplates the boresighting of a weak laser beam from a second laser source.
摘要翻译：本发明提供了一种反射伸缩系统，用于控制超短激光脉冲的发光，其包括：平面镜，自适应反射镜，二向色凸面镜，离轴抛物面镜和第一激光源。凸面镜和自适应反射镜安装在独立的面包板上并设置在平移台上。由反射镜反射的激光束的传播轴线应对应于抛物面镜的离轴。抛物面镜以特定角度反射光束。最后，二向色凸镜和离轴抛物面镜之间的传播轴，平面镜和自适应反射镜之间的传播轴以及平移台的轴线应该基本上彼此平行。本发明还考虑了来自第二激光源的弱激光束的前视。

3. 发明申请

US20130143963A1 SULFORAPHANE STABILIZATION 有权
标题翻译：硫磺稳定性
公开(公告)号：US20130143963A1
公开(公告)日：2013-06-06
申请号：US13811619
申请日：2011-07-19
申请人： Jacques Dubois , Alfred Marchal , Damien Lacroix , Jérôme Cabou
发明人： Jacques Dubois , Alfred Marchal , Damien Lacroix , Jérôme Cabou
IPC分类号： A61K47/34 , A61K47/14 , A61K47/24 , A61K47/22
CPC分类号： A61K47/34 , A61K9/1075 , A61K47/14 , A61K47/22 , A61K47/24
摘要： A stable galenic composition of a compound of general formula (I) wherein R1 and R2 both represent independently of each other an alkyl, aryl, arylalkyl group, optionally substituted with one or more linear or branched groups, optionally bearing one or more heteroatoms, comprising said compound of formula I in an amount ranging from 0.01 to 15% by weight based on the total weight of the final composition; at least one anhydrous ester, the main chain and/or optionally the branched chains of which are free from free and/or reactive groups or functions, in an amount ranging from 0.1 to 99.9% by weight based on the total weight of the cosmetically and pharmaceutically acceptable composition; and optionally a cosmetically and pharmaceutically acceptable excipient for completing the 100% of the total weight of the composition.
摘要翻译：通式（I）的化合物的稳定的盖仑组合物，其中R 1和R 2彼此独立地表示任选地被一个或多个具有一个或多个杂原子的一个或多个直链或支链基团取代的烷基，芳基，芳烷基，其包含所述式I化合物的量为基于最终组合物总重量的0.01至15重量％; 至少一种无水酯，主链和/或任选的支链没有游离和/或反应性基团或官能，其量为0.1至99.9重量％，基于化妆品和/ 药学上可接受的组合物; 和任选的美容和药学上可接受的赋形剂，用于完成组合物总重量的100％。

4. 发明授权

US6054138A Stabilized pseudo-emulsions and their preparation process 失效
标题翻译：稳定的假乳剂及其制备方法
公开(公告)号：US6054138A
公开(公告)日：2000-04-25
申请号：US952647
申请日：1997-11-21
申请人： Marie-Therese Trebosc , Jacques Dubois
发明人： Marie-Therese Trebosc , Jacques Dubois
IPC分类号： A61K8/00 , A61K8/06 , A61K8/29 , A61K8/30 , A61K8/31 , A61K8/34 , A61K8/37 , A61K8/41 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/97 , A61K9/06 , A61K9/107 , A61K47/36 , A61Q1/02 , A61Q1/14 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61K7/00 , A61K7/42 , A61K31/74 , A61K47/00
CPC分类号： A61K8/06 , A61K9/06 , A61K9/107 , A61Q17/00 , A61Q19/00 , A61Q17/04 , A61Q19/005 , A61Q19/007 , Y10S514/844 , Y10S514/937
摘要： The present invention relates to a pharmaceutical and/or cosmetic composition in the form of a stabilized pseudoemulsion, characterized in that it is essentially comprised of (1) at least one aqueous phase containing a single gelifying agent selected from the group comprising polyoses, such as gelose, the xanthane gums, cellulose, alginates, semisynthetic derivatives of cellulose, and acrylic polymers such as Synthalen.RTM.; (2) at least one lipidic phase containing at least one consistency factor, with a ratio consistency factor/total lipidic phase between about 0.06 and 0.18, and in that said composition is free of surfactants. It also relates to a process for preparing such composition.
摘要翻译： PCT No.PCT / FR96 / 00756 Sec。 371日期：1997年11月21日 102（e）1997年11月21日日期PCT提交1996年5月21日PCT公布。 WO96 / 37180 PCT出版物日本1996年11月28日本发明涉及稳定的假乳剂形式的药物和/或化妆品组合物，其特征在于其基本上由（1）至少一种含有单一凝胶剂的水相，所述单一凝胶剂选自包括多糖，例如粗糖，黄原胶，纤维素，藻酸盐，纤维素的半合成衍生物和丙烯酸聚合物如Synthalen TM; （2）至少一种含有至少一种稠度因子的脂质相，其比例稠度因子/总脂质相在约0.06至0.18之间，并且所述组合物不含表面活性剂。它还涉及制备这种组合物的方法。

5. 发明授权

US5280167A Very high angular resolution laser beam rider detector having a gated image intensifier and a video camera 失效
标题翻译：具有门控图像增强器和摄像机的非常高的角度分辨率激光束骑士检测器
公开(公告)号：US5280167A
公开(公告)日：1994-01-18
申请号：US4073
申请日：1993-01-13
申请人： Jacques Dubois
发明人： Jacques Dubois
IPC分类号： G01S3/784 , G01S3/785 , G01S7/02 , G01S7/483 , G01S7/495 , H01J40/14
CPC分类号： G01S3/784 , G01S3/785 , G01S7/483 , G01S7/495 , G01S7/4804
摘要： A laser warning receiver (LWR) having an ability to not only detect a low power level laser source, such as a pulse train emitted by a laser beam rider, but to also provide a high angular resolution in determining the angle of arrival of that pulse train. The receiver includes a lens/filter arrangement for a large area photodetector to detect an incoming signal from an emitting source and a high gain amplifier to amplify the signal which is then applied to a synchronization generator that generates a digital pulse train with pulses corresponding to peaks in the incoming signal. The digital pulse train is applied to a code breaker where the code is analyzed and a further code is generated anticipating the arrival of further pulses in order to verify the code. That further code is applied to a time gate generator which generate a code, synchronized with the incoming signal, that controls the high voltage of a gated image intensifier which is coupled to a video camera. Gating of the image intensifier is synchronized, as a result, with coded emissions from the source so that a video image from the camera can be displayed on a monitor and more easily differentiated from the background. The width of pulses generated by the time gate generator, the video camera, gain of the gated image intensifier, gain of the gated image intensifier and an auto-iris zoom lens coupled to the image intensifier are all under the control of a video processor.
摘要翻译：具有能够不仅检测由激光束骑手发射的脉冲串的低功率电平激光源的能力的激光警告接收器（LWR），而且在确定该脉冲的到达角度时也提供高角度分辨率培养。接收机包括用于大面积光电检测器的透镜/滤光器装置，用于检测来自发射源的输入信号和高增益放大器以放大信号，然后将其施加到同步发生器，该同步发生器产生具有对应于峰值的脉冲的数字脉冲串在输入信号中。将数字脉冲串应用于代码分析器的代码断路器，并且产生另外的代码以预测进一步的脉冲的到达以验证代码。该另外的代码被应用于时间门发生器，其产生与输入信号同步的代码，该代码控制耦合到摄像机的门控图像增强器的高电压。因此，图像增强器的门控与来自源的编码的发射同步，使得来自摄像机的视频图像可以显示在监视器上并且更容易与背景区分开。由时间门发生器产生的脉冲宽度，摄像机，门控图像增强器的增益，门控图像增强器的增益以及耦合到图像增强器的自动光圈变焦镜头都处于视频处理器的控制之下。

6. 发明申请

US20130053347A1 PRO-DRUGS OF AMARYLLIDACEAE ISOCARBOSTYRIL PRODUCTS AND THEIR USE AGAINST BRAIN TUMORS 审中-公开
标题翻译：阿奇霉素异烟肼产品的副作用及其对脑肿瘤的使用
公开(公告)号：US20130053347A1
公开(公告)日：2013-02-28
申请号：US13695609
申请日：2010-05-03
申请人： Veronique Mathieu , Gwendoline Van Goietsenoven , Jacques Dubois , Florence Lefranc-Kiss , Laurent Ingrassia , Robert Kiss
发明人： Veronique Mathieu , Gwendoline Van Goietsenoven , Jacques Dubois , Florence Lefranc-Kiss , Laurent Ingrassia , Robert Kiss
IPC分类号： C07F9/6574 , G01N33/566 , A61P35/00 , A61K31/675
CPC分类号： C07D491/056
摘要： The present invention relates to the biology and mechanism of action of the naturally occurring compound Narciclasine, especially as an anti-cancer agent for brain tumors. The invention provides new insights on the target molecule of Amaryllidaceae isocarbostyril derivatives as for example Narciclasine and provides new prodrugs of these Amaryllidceae isocabostyril constituents for treating cancer, specifically cancers or tumors located in the brain.
摘要翻译：本发明涉及天然存在的化合物Narciclasine的生物学和作用机理，特别是作为脑肿瘤的抗癌剂。本发明提供了关于芳香樟科异卡泊霉素衍生物如Narciclasine的靶分子的新见解，并提供了这些用于治疗癌症，特别是位于脑中的癌症或肿瘤的这些芳樟脑异卡培司他尔的新前药。

7. 发明申请

US20110280940A1 Di-Vanilloyl And Tri-Vanilloyl Derivatives For Use In Anti-Cancer Therapy 审中-公开
标题翻译：用于抗癌治疗的二 - 香草酰和三 - 糠醛衍生物
公开(公告)号：US20110280940A1
公开(公告)日：2011-11-17
申请号：US12998410
申请日：2009-10-13
申请人： Robert Kiss , Jacques Dubois , Jean Neve , Delphine Lamoral-Theys , Francois Dufrasne , Laurent Pottier
发明人： Robert Kiss , Jacques Dubois , Jean Neve , Delphine Lamoral-Theys , Francois Dufrasne , Laurent Pottier
IPC分类号： A61K31/235 , A61K9/36 , C12Q1/48 , A61P25/00 , C07C69/84 , A61P35/00 , A61P25/28 , A61P25/16 , C07C69/92 , C07C69/76
CPC分类号： A61K31/166 , A61K31/235 , C07C69/88 , C07C69/92 , C07C235/42 , C07C2601/14
摘要： The invention relates to the medical field, more precisely in the field of anti-cancer treatment and treatment of Alzheimer's disease, Parkinson's disease or Pick's disease or for ameliorating symptoms of Down syndrome, providing newly synthesised multi-vanilloyl derivative compounds and their use in the treatment of said disorders.
摘要翻译：本发明涉及医学领域，更准确地说在阿尔茨海默氏病，帕金森病或皮克病的抗癌治疗和治疗领域，或用于改善唐氏综合征的症状，提供新合成的多香草衍生物化合物及其在治疗所述疾病。

8. 发明申请

US20100074851A1 COSMETIC OR PHARMACEUTICAL COMPOSITION CONTAINING HYALURONIC ACID 审中-公开
标题翻译：含有羟丙酸的化妆品或药物组合物
公开(公告)号：US20100074851A1
公开(公告)日：2010-03-25
申请号：US12375857
申请日：2007-08-01
申请人： Jacques Dubois , Alfred Marchal
发明人： Jacques Dubois , Alfred Marchal
IPC分类号： A61K31/728 , A61K8/73 , A61P17/00 , A61P17/02 , A61P17/10 , A61Q19/08 , A61Q17/04
CPC分类号： A61K8/735 , A61K8/416 , A61K8/84 , A61Q19/001 , A61Q19/08
摘要： A cosmetic or pharmaceutical composition includes particles of hyaluronic acid having a molecular weight between 20000 Da and 3000000 Da, combined with a polyamine.
摘要翻译：化妆品或药物组合物包括分子量在20000Da和3000000Da之间的透明质酸颗粒，与多胺组合。

9. 发明申请

US20060049299A1 Beam laser atmospheric scattering trajectory guidance 失效
公开(公告)号：US20060049299A1
公开(公告)日：2006-03-09
申请号：US10933527
申请日：2004-09-03
申请人： Jacques Dubois , Jean Fortin
发明人： Jacques Dubois , Jean Fortin
IPC分类号： F41G7/24 , F41G7/00
CPC分类号： F41G7/26
摘要： A guidance system for a missile utilitizes a laser beam source at a missile launch pad to generate a laser beam that is directed towards a target. A sensor on the body of a spinning missile detects radiation scattered from the laser beam, the sensor looking sideways and backward at an angle to the missile's longitudinal axis. Signals generated by that sensor are applied to a missile's guidance system's processing electronics that then determines the distance from the missile to the beam from the width of the signal generated by the sensor due to detecting scattered radiation from that laser beam. Once the distance between the missile and the beam is determined, the missile's guidance system corrects the missile's trajectory to maintain its position at a predetermined distance from the beam.

10. 发明授权

US5604695A Analog high resolution laser irradiation detector (HARLID) 失效
标题翻译：模拟高分辨率激光照射检测器（HARLID）
公开(公告)号：US5604695A
公开(公告)日：1997-02-18
申请号：US462065
申请日：1995-06-05
申请人： Andre Cantin , Maurice Gravel , Jacques Dubois
发明人： Andre Cantin , Maurice Gravel , Jacques Dubois
IPC分类号： G01S3/783 , G01S3/784 , G01S7/48 , G01J1/00 , G01B11/26
CPC分类号： G01S3/7835 , G01S3/784 , G01S7/4804
摘要： An opto-electronic device for detecting a beam of radiation and determining the angle-of-arrival of that beam with a high degree of angular resolution. The device has a linear array of radiation detectors arranged in a plane with a shadow mask located at a predetermined height h above and parallel to that plane wherein the shadow mask has a plurality of transparent apertures separated by opaque areas. Each radiation detector in the array comprises at least one pair of individual detector elements and apertures of the shadow mask, which apertures have the same width as the detector elements, are centred directly above the area between adjacent detector elements. Signals generated by corresponding detector elements in each radiation detector are supplied, in parallel, to one channel providing a number of output channels which correspond to the number of individual detector elements in each radiation detector. The angle-of-arrival of a radiation beam emitted by a source and traversing the apertures can then be determined by output signals from the channels. This radiation beam detecting device is particularly designed for use in Laser Warning Receivers which detect, identify and locate laser sources associated with laser guided weapons.
摘要翻译：一种用于检测辐射束并以高度角度分辨率确定该光束的到达角度的光电装置。该装置具有布置在平面中的辐射检测器的线性阵列，其中荫罩位于预定高度h并且平行于该平面，其中荫罩具有由不透明区域分开的多个透明孔。阵列中的每个辐射检测器包括至少一对单独的检测器元件和荫罩的孔，这些孔具有与检测器元件相同的宽度，它们位于相邻检测器元件之间的区域的正上方。由每个辐射检测器中的相应检测器元件产生的信号并联地提供给一个通道，其提供与每个辐射检测器中的各个检测器元件的数量相对应的多个输出通道。然后可以通过来自通道的输出信号确定由源发射并穿过孔的辐射束的到达角度。该辐射束检测装置特别设计用于检测，识别和定位与激光制导武器相关的激光源的激光警报接收器。

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