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    • 3. 发明申请
    • DEVICES, COMPOSITIONS AND METHODS FOR IMAGING WITH RAMAN SCATTERING
    • 用于用拉曼散射成像的装置,组合物和方法
    • US20160243261A1
    • 2016-08-25
    • US14974992
    • 2015-12-18
    • THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    • WEI MINLU WEIZHIXING CHENFANGHAO HUYIHUI SHEN
    • A61K49/00G01N33/58G01N33/569
    • G01N33/583A61K49/0013G01N33/5005G01N2021/655
    • Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
    • 公开了使用受激拉曼散射使用键合编辑的化合物对活细胞或活体进行成像的方法,系统和计算机可访问介质。 该方法包括以下步骤:将一种或多种键编辑的化合物引入活细胞或活生物体中,并用受激拉曼散射检测细胞或生物体中的振动标签。 还公开了用于检测受试者的疾病状况的方法,用于监测疾病状况的治疗的方法,用于筛选药剂的方法,使用结合编辑的化合物与受激拉曼散射组合在活细胞中追踪细胞过程的方法。 还公开了用至少一种键编辑的化合物标记靶细胞的组合物和通过受激拉曼散射来对结合编辑的化合物成像的装置。