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1. 发明申请

US20180238738A1 RESONANT STIMULATED RAMAN SCATTERING MICROSCOPE 审中-公开
公开(公告)号：US20180238738A1
公开(公告)日：2018-08-23
申请号：US15904089
申请日：2018-02-23
申请人： ROBERT ALFANO , LINGYAN SHI
发明人： ROBERT ALFANO , LINGYAN SHI
IPC分类号： G01J3/44 , G01J3/10 , H01S3/30 , A61K49/00
CPC分类号： G01J3/4412 , A61K49/0013 , A61K49/006 , G01J3/10 , G01J3/44 , H01S3/30
摘要： A nonlinear optical process on increasing the signal in SRS microscope by Resonant Stimulated Raman Scattering (RSRS) combines both RRS and SRS nonlinear processes, in absorber and host such a β-carotene-methanol solution, Flavins, or other key absorbers in tissues. The observed effect of enhanced RSRS in small signal gain is attributed to RR process in absorber β-carotene that transferring excess vibrations to host methanol from anharmonic vibrational interactions between the solute β-carotene in resonance with the solvent methanol vibrations. SRS microscopy signals are improved in RSRS microscope for imaging vibrational states in lipids CH2 and proteins CH3 in cancer tissues from RR in Flavins or other native chromophores in tissue and for applications in other areas of neuroscience and biomedicine, potentially enhancing signals in the RSRS microscope by 2 to 1000 times.

2. 发明授权

US09861710B1 Composite particles, methods, and in vivo diagnostic system 有权
公开(公告)号：US09861710B1
公开(公告)日：2018-01-09
申请号：US14599435
申请日：2015-01-16
申请人： Verily Life Sciences LLC
发明人： Timothy Tordella Ruckh , Kimberly Kam , Jerrod Joseph Schwartz , Vasiliki Demas , Andrew Peter Homyk
IPC分类号： A61K49/00 , B29B9/10 , A61B5/145 , A61B5/05 , B29L31/00
CPC分类号： A61K49/0054 , A61B5/05 , A61B5/145 , A61K49/0013 , B29B9/10 , B29L2031/00
摘要： A system is provided which includes the composite nanoparticles configured to bind with a target analyte, the composite nanoparticles including a polymer matrix; nanoparticles at least one type; reporter labels at least one type; and targeting entities at least one type, wherein the nanoparticles at least one type, the reporter labels at least one type and the targeting entities at least one type are encapsulated in the polymer matrix; a body-mountable device mounted on an external surface of a living body and configured to detect a target analyte binding response signal transmitted through the external surface, wherein the target analyte binding response signal is related to binding of the composite nanoparticles with one or more target analytes; and a processor configured to non-invasively detect the one or more target analytes based on the target analyte response signal. Composite nanoparticles and methods for use and for making are also provided.

3. 发明授权

US09757478B2 Mutant protease biosensors with enhanced detection characteristics 有权
公开(公告)号：US09757478B2
公开(公告)日：2017-09-12
申请号：US14990279
申请日：2016-01-07
申请人： Promega Corporation
发明人： Brock Binkowski , Braeden Butler , Lance P. Encell , Frank Fan , Brad Hook , Paul Otto , Gediminas Vidugiris , Susan Wigdal , Kristopher Zimmerman
IPC分类号： A61K49/00 , C12N9/02 , C12Q1/37 , C12Q1/66 , A01K67/027
CPC分类号： A61K49/0045 , A01K67/0275 , A61K49/0013 , C12N9/0069 , C12Q1/37 , C12Q1/66 , C12Y113/12007
摘要： A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the C-terminal portion of the thermostable luciferase to the N-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase. The linker contains a sensor region capable of interacting with a target molecule in a cell. The modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the parental circularly-permuted thermostable luciferase in the presence of the target molecule. Alternatively, the modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the modified circularly-permuted thermostable luciferase in the absence of the target molecule.

4. 发明申请

US20170058282A1 GENETICALLY ENGINEERED SENSORS FOR IN VIVO DETECTION OF BLEEDING 审中-公开
标题翻译：用于血液检测的遗传工程传感器
公开(公告)号：US20170058282A1
公开(公告)日：2017-03-02
申请号：US15205625
申请日：2016-07-08
申请人： Massachusetts Institute of Technology
发明人： Timothy Kuan-Ta Lu , Mark K. Mimee
IPC分类号： C12N15/70 , C12Q1/02 , C12Q1/68 , C12N15/63 , A61K49/00
CPC分类号： C12N15/70 , A61K35/74 , A61K49/0013 , A61K49/0017 , A61K49/0069 , C07K14/245 , C07K14/31 , C07K14/335 , C12N15/635 , C12N15/746 , C12Q1/02 , C12Q1/6897 , G01N2800/22
摘要： Provided herein are microorganisms engineered with heme-responsive transcription factors and genetic circuits. Also provided are methods for using engineered microorganisms to sense bleeding events and treat bleeding in vivo.
摘要翻译：本文提供了用血红素反应转录因子和遗传回路工程化的微生物。还提供了使用工程微生物感测出血事件和治疗体内出血的方法。

5. 发明申请

US20160376629A1 Use of Bacterial Beta-Lactamase for In Vitro Diagnostics and In Vivo Imaging, Diagnostics and Therapeutics 审中-公开
标题翻译：使用细菌β-内酰胺酶进行体外诊断和体内成像，诊断和治疗
公开(公告)号：US20160376629A1
公开(公告)日：2016-12-29
申请号：US15262374
申请日：2016-09-12
申请人： Jeffrey D. Cirillo , Jianghong Rao
发明人： Jeffrey D. Cirillo , Jianghong Rao
IPC分类号： C12Q1/18 , G01N21/64 , G01N21/78
CPC分类号： C12Q1/18 , A61K49/0013 , A61K49/0021 , A61K49/0028 , A61K49/0032 , A61K49/0041 , A61K49/0052 , C09B57/02 , C12Q1/04 , C12Q1/34 , C12Q1/66 , G01N21/6408 , G01N21/6428 , G01N21/78 , G01N2021/6417 , G01N2201/061 , G01N2333/986
摘要： Provided herein provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product. Also provided is an in vitro method to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility.
摘要翻译：本文提供了一种用于监测病原细菌的药物敏感性的测定系统，其包括致病细菌的β-内酰胺酶的着色产生底物，用于可见地检测其底物上的β-内酰胺酶的产物和读数器配置为量化可见检测到的产品。还提供了一种体外方法来确定对具有β-内酰胺酶活性的致病细菌例如致病分枝杆菌有效的药物的易感性。在β-内酰胺酶底物的存在下，将激发波长输送到从具有病原菌感染的受试者获得的生物样品。在受试者的β-内酰胺酶的产物的发射波长处的信号强度，例如荧光，发光或比色信号与药物敏感性相关。

6. 发明授权

US09482513B2 Apparatus and methods for optical coherence tomography and two-photon luminescence imaging 有权
标题翻译：用于光学相干断层扫描和双光子发光成像的装置和方法
公开(公告)号：US09482513B2
公开(公告)日：2016-11-01
申请号：US14212756
申请日：2014-03-14
申请人： RESEARCH DEVELOPMENT FOUNDATION
发明人： Marc Feldman , Thomas Milner , Tianyi Wang , Jennifer Phipps
IPC分类号： G01B9/02 , A61B5/00
CPC分类号： G01B9/0203 , A61B1/24 , A61B5/0035 , A61B5/0066 , A61B5/0071 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/7425 , A61B2562/0233 , A61B2576/00 , A61K49/0013 , G01B9/02007 , G01B9/02014 , G01B9/02091 , G01B2290/70 , G02B21/0076 , G02B21/16 , G02B23/24 , G02B23/2484
摘要： Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (OCT-TPL) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.
摘要翻译：本公开的示例性实施例包括组合的基于导管的光学相干断层扫描双光子发光（OCT-TPL）成像系统。示例性实施方案还包括在体内具有高空间分辨率的薄盖纤维状细胞中检测并进一步表征细胞组分（例如，巨噬细胞，胶原/弹性蛋白纤维，脂滴）的分布的方法。

7. 发明申请

US20150252259A1 ENHANCING UPCONVERSION LUMINESCENCE IN RARE-EARTH DOPED PARTICLES 审中-公开
标题翻译：增加稀土掺杂颗粒中的UPCONVERSION LUMINESCENCE
公开(公告)号：US20150252259A1
公开(公告)日：2015-09-10
申请号：US14427693
申请日：2013-09-17
申请人： Macquarie University
发明人： Dayong Jin , Jiangbo Zhao
IPC分类号： C09K11/77
CPC分类号： A61K49/0013 , A61K49/0058 , A61K49/0093 , B41M3/144 , B42D25/29 , B42D2035/34 , C09D11/30 , C09D11/50 , C09K11/025 , C09K11/7773 , G02F2/02
摘要： Disclosed is a method for enhancing upconversion luminescence of rare-earth doped particles comprising a host material, an enriched concentration of activator (emitter) and a sufficient concentration level of sensitiser, the method comprising subjecting the particles to increased irradiance. The increased irradiance is higher than presently used relatively low irradiance levels. Enhancing upconversion luminescence involves enhancing luminescence intensity, brightness and/or upconversion efficiency. Particles are preferably subjected to an irradiance power density sufficient to overcome or reverse concentration quenching. The activator preferably has an intermediate meta stable energy level which accepts resonance energy from the sensitiser excited state level. In another form, particles are designed to minimize or exclude quenchers from the upconversion system between sensitizer and activator, such as the core-shell particles wherein the core comprises the host material, sensitiser and the activator, and the shell comprises a material which prevents, retards or inhibits surface quenching.
摘要翻译：公开了一种用于增强包含主体材料，富集浓度的活化剂（发射体）和足够浓度的敏化剂的稀土掺杂颗粒的转换发光的方法，所述方法包括使颗粒经受增加的辐照度。增加的辐照度高于目前使用的相对低的辐照度水平。增强上变频发光涉及提高发光强度，亮度和/或上转换效率。颗粒优选经受足以克服或反向浓缩猝灭的辐照功率密度。优选地，活化剂具有从敏化剂激发态水平接受共振能的中间元稳定能级。在另一种形式中，颗粒被设计成使敏化剂和活化剂之间的上转换系统中的猝灭剂最小化或排除，例如核 - 壳颗粒，其中芯包含主体材料，敏化剂和活化剂，并且壳包含防止，延缓或抑制表面淬火。

8. 发明申请

US20150224211A1 LEUKOCYTES AS DELIVERY CELLS FOR IMAGING AND DISEASE THERAPY 审中-公开
标题翻译：作为成像和疾病治疗的递送细胞的白细胞介素
公开(公告)号：US20150224211A1
公开(公告)日：2015-08-13
申请号：US14694511
申请日：2015-04-23
申请人： Deryl L. Troyer , Stefan H. Bossmann
发明人： Deryl L. Troyer , Stefan H. Bossmann , Hongwang Wang , Matthew T. Basel , Tej B. Shrestha , Sebastian Wendel
IPC分类号： A61K49/00 , A61K9/127 , A61K47/46 , A61K41/00 , A61K31/65
CPC分类号： A61K49/0013 , A61K9/1271 , A61K31/65 , A61K41/0061 , A61K47/46 , A61K49/0021 , A61K49/0041 , A61K49/0084 , Y02A50/473
摘要： Theranostic methods are described herein, which are useful in diagnosing and/or treating infection, inflammation, and/or cancer. The methods utilize naturally-occurring leukocytes for in situ photodynamic therapy and imaging, and for the delivery of targeted therapies to the infection, inflammation, and/or cancer.
摘要翻译：治疗方法在本文中描述，其可用于诊断和/或治疗感染，炎症和/或癌症。该方法利用天然存在的白细胞用于原位光动力治疗和成像，并且用于将感染，炎症和/或癌症的靶向治疗递送。

9. 发明申请

US20150139911A1 PREVENTION OF MYOCARDIAL INFARCTION INDUCED VENTRICULAR EXPANSION AND REMODELING 审中-公开
标题翻译：预防心肌梗塞引起的心室扩张和重建
公开(公告)号：US20150139911A1
公开(公告)日：2015-05-21
申请号：US14560588
申请日：2014-12-04
申请人： Cormend Technologies, LLC
发明人： William P. Santamore , Jeanne M. Lesniak
IPC分类号： A61K9/14 , A61K47/42 , A61K49/04 , A61K47/02 , A61K49/00
CPC分类号： A61K38/1841 , A61B17/00234 , A61B17/00491 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/3468 , A61B18/1815 , A61B2017/00243 , A61B2017/00247 , A61B2017/00862 , A61B2017/0404 , A61B2017/0412 , A61B2017/0422 , A61B2017/0427 , A61B2017/0437 , A61B2017/044 , A61B2017/0443 , A61B2017/0464 , A61B2017/048 , A61B2017/0641 , A61B2017/0647 , A61B2017/0649 , A61B2018/00392 , A61F2/2451 , A61F2/2493 , A61F2002/249 , A61K9/0024 , A61K9/14 , A61K47/02 , A61K47/42 , A61K49/0013 , A61K49/04 , A61M25/09 , Y10S623/904
摘要： A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.
摘要翻译：用于在具有病理状态的心脏的局部区域中直接治疗心肌组织的方法。该方法包括鉴定心肌的靶区域，并且直接且基本上只施加至目标区域的心肌组织的至少一部分。施加的材料导致物理地改变所述组织的机械性能，包括刚度。公开了实施该方法的各种装置和方式，用于加强，约束和约束心肌组织用于治疗包括心肌梗死或二尖瓣反流的病症。

10. 发明授权

US08909326B2 Method and apparatus for 3-D imaging of internal light sources 有权
标题翻译：内部光源3-D成像的方法和装置
公开(公告)号：US08909326B2
公开(公告)日：2014-12-09
申请号：US12947794
申请日：2010-11-16
申请人： Daniel G. Stearns , Bradley W. Rice , Michael D. Cable
发明人： Daniel G. Stearns , Bradley W. Rice , Michael D. Cable
IPC分类号： H04N13/02 , G01B11/24 , G01N21/76 , A61K49/00 , G01N21/64 , G01B11/25 , G01B9/02
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
摘要翻译：本发明提供用于获得样品（例如哺乳动物）内的一个或多个光源的三维（3D）表示的系统和方法。哺乳动物组织是一种混浊的培养基，这意味着光子在通过组织传播时被吸收和分散。在与吸收相比散射大的情况下，例如通过组织的红色至近红外光，通过扩散理论描述样品内的光的传输。使用成像数据和计算机实现的光子扩散模型，本发明的实施例产生样品内的光源的3D表示，例如这种光源的3D位置，尺寸和亮度。

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