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1. 发明公开

US20230414829A1 HERNIA REPAIR, BREAST RECONSTRUCTION AND SLING DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 审中-公开
公开(公告)号：US20230414829A1
公开(公告)日：2023-12-28
申请号：US18462346
申请日：2023-09-06
申请人： Tepha, Inc.
发明人： Simon F. Williams , Said Rizk , David P. Martin , Amit Ganatra
IPC分类号： A61L27/18 , A61F2/00 , A61F2/12 , A61L17/10 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/14 , A61L17/12 , A61L27/54 , D02G3/04 , D02G3/44 , A61L17/06 , C08L65/00 , C08L67/00
CPC分类号： A61L27/18 , A61F2/0045 , A61F2/0063 , A61F2/12 , A61L17/105 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/148 , A61L17/12 , A61L27/54 , D02G3/045 , D02G3/448 , D02G3/449 , A61L17/06 , C08L65/00 , C08L67/00 , A61F2002/0068 , A61F2220/0016 , A61F2240/002 , A61F2250/0067 , A61L2430/04 , A61L27/48
摘要： Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.

2. 发明申请

US20210244860A1 ARTICLES OF POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 有权
公开(公告)号：US20210244860A1
公开(公告)日：2021-08-12
申请号：US17245573
申请日：2021-04-30
申请人： Tepha, Inc.
发明人： Simon F. Williams , Said Rizk , David P. Martin , Skander Limem , Kai Guo , Amit Ganatra , German Oswaldo Hohl Lopez
IPC分类号： A61L31/06 , A61L27/56 , A61F2/00 , A61L17/10 , A61F2/12 , A61B17/86 , A61B17/80 , A61B17/72 , A61F2/30 , A61L31/14 , A61B17/04 , B29C48/05 , D01D5/08 , D04B1/22 , B29C45/00 , B33Y80/00 , B33Y10/00 , B29C70/52 , B29C48/08 , D04B1/16 , A61L27/18 , B29C48/00 , A61L27/58 , C08G63/16 , C08G63/85 , C08L67/02 , C08J5/02
摘要： Resorbable implants, coverings and receptacles comprising poly(butylene succinate) and copolymers thereof have been developed. The implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing molding, pultrusion or other melt or solvent processing method. The implants, or the fibers preset therein, may be oriented. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings, receptacles and implants described herein, may be made from meshes, webs, lattices, non-wovens, films, fibers, foams, molded, pultruded, machined and 3D printed forms.

3. 发明授权

US10227713B2 Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof 有权
公开(公告)号：US10227713B2
公开(公告)日：2019-03-12
申请号：US15368922
申请日：2016-12-05
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
IPC分类号： A61K9/00 , D01F6/62 , A61L17/10 , A61L31/06 , A61L31/14 , B29C55/00 , D01F8/14 , D01D5/08 , D02G3/04 , B29K73/00 , B29L31/00 , B29K673/00
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

4. 发明公开

US20240052528A1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
公开(公告)号：US20240052528A1
公开(公告)日：2024-02-15
申请号：US18491647
申请日：2023-10-20
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
IPC分类号： D01F6/62 , A61L17/10 , A61L31/06 , A61L31/14 , B29C55/00 , D01F8/14 , D01D5/08 , D02G3/04
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , D01F8/14 , D01D5/08 , D02G3/04 , B29K2073/00
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawirg the multifilament, yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

5. 发明授权

US11786632B2 Hernia repair, breast reconstruction and sling devices containing poly(butylene succinate) and copolymers thereof 有权
公开(公告)号：US11786632B2
公开(公告)日：2023-10-17
申请号：US16290739
申请日：2019-03-01
申请人： Tepha, Inc.
发明人： Simon F. Williams , Said Rizk , David P. Martin , Amit Ganatra
IPC分类号： A61L27/18 , A61F2/00 , A61F2/12 , A61L17/10 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/14 , A61L17/12 , A61L27/54 , D02G3/04 , D02G3/44 , A61L17/06 , C08L65/00 , C08L67/00 , A61L27/48 , A61L31/16 , A61L17/00
CPC分类号： A61L27/18 , A61F2/0045 , A61F2/0063 , A61F2/12 , A61L17/06 , A61L17/105 , A61L17/12 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/146 , A61L31/148 , C08L65/00 , C08L67/00 , D02G3/045 , D02G3/448 , D02G3/449 , A61F2002/0068 , A61F2220/0016 , A61F2240/002 , A61F2250/0067 , A61L17/005 , A61L27/48 , A61L31/16 , A61L2300/404 , A61L2300/416 , A61L2430/04 , A61L2430/34 , A61L2430/38 , D10B2331/04 , D10B2401/063 , D10B2509/04 , A61L27/18 , C08L67/04 , A61L17/105 , C08L67/04
摘要： Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.

6. 发明申请

US20210186702A1 RESORBABLE IMPLANTS FOR RECONSTRUCTION OF BONE DEFECTS 有权
公开(公告)号：US20210186702A1
公开(公告)日：2021-06-24
申请号：US17116940
申请日：2020-12-09
申请人： Tepha, Inc.
发明人： Kemal Sariibrahimoglu , Skander LIMEM , Amit Ganatra , Said Rizk , Simon F. Williams
IPC分类号： A61F2/28 , A61L27/18 , A61L27/58 , C08K3/34
摘要： Devices to repair bone defects prevent the formation of depressions and palpable tissue at bone repair sites. The devices can be used to repair burr holes in the cranium, providing an improved cosmetic result that reduces or eliminates functional handicaps that can result from combing and hairdressing. The devices are secured in bone defects with filament elements, by expanding the device inside the bone defect, or by gluing. Tissue in-growth into the device regenerates bone at the defect site, and prevents the formation of depressions or palpable tissue. The devices preferably comprise a ceramic and poly-4-hydroxybutyrate or copolymer thereof, or a ceramic and poly(butylene succinate) or copolymer thereof.

7. 发明申请

US20170081784A1 METHODS OF ORIENTING MULTIFILAMENT YARN AND MONOFILAMENTS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开
公开(公告)号：US20170081784A1
公开(公告)日：2017-03-23
申请号：US15368922
申请日：2016-12-05
申请人： Tepha, Inc.
发明人： Amit Ganatra , Fabio Felix , Bhavin Shah , Matthew Bernasconi , Said Rizk , David P. Martin , Simon F. Williams
IPC分类号： D01F6/62 , A61L31/06 , B29C55/00 , D02G3/04 , D01D5/08 , A61L17/10 , A61L31/14
CPC分类号： D01F6/625 , A61L17/105 , A61L31/06 , A61L31/148 , B29C55/005 , B29K2073/00 , B29K2673/00 , B29L2031/731 , D01D5/08 , D01F8/14 , D02G3/04 , D10B2331/04 , D10B2331/041 , D10B2401/063 , D10B2509/04 , D10B2509/08
摘要： Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

8. 发明申请

US20150313700A1 THREE-DIMENSIONAL RESORBABLE IMPLANTS FOR TISSUE REINFORCEMENT AND HERNIA REPAIR 审中-公开
标题翻译：用于组织加固和HERNIA修复的三维可折叠植入物
公开(公告)号：US20150313700A1
公开(公告)日：2015-11-05
申请号：US14687435
申请日：2015-04-15
申请人： Tepha, Inc.
发明人： Said Rizk , Amit Ganatra , Antonio Fosco , David P. Martin , Simon F. Williams
IPC分类号： A61F2/00
CPC分类号： A61F2/0063 , A61F2230/0093 , A61F2240/004
摘要： Resorbable three-dimensional implants that can be temporarily deformed, implanted by minimally invasive means, and resume their original shape in vivo, have been developed. These implants are particularly suitable for use in minimally invasive procedures for tissue reinforcement, repair of hernias, and applications where it is desirable for the implant to contour in vivo to an anatomical shape, such as the inguinofemoral region. In the preferred embodiment, the implants are made from meshes of poly-4-hydroxybutyrate monofilament that have reinforced outlying borders that allow the meshes to form three-dimensional shapes that can be temporarily deformed. These implants can resume three-dimensional shapes after being temporarily deformed that contour to the host's tissue or an anatomical shape, for example, in the repair of a hernia, and particularly a hernia in the inguinofemoral region. The implants can contour to the host's tissue for example, of the inguinofemoral region, without the implants wrinkling, bunching or folding.
摘要翻译：已经开发了可以暂时变形，通过微创手段植入并在体内恢复其原始形状的可再吸收的三维植入物。这些植入物特别适用于用于组织加强，疝修补的微创手术，以及其中期望植入物在体内轮廓到解剖学形状（例如腹股沟区域）的应用。在优选实施例中，植入物由聚-4-羟基丁酸酯单丝的网格制成，其具有增强的外围边界，允许网格形成可暂时变形的三维形状。这些植入物可以在将轮廓暂时变形成主体的组织或解剖形状之后恢复三维形状，例如修复疝气，特别是在腹股沟区域中的疝。植入物可以轮廓到宿主的组织，例如，腹股沟区域，而没有植入物起皱，聚束或折叠。

9. 发明授权

US11844879B2 Articles of poly(butylene succinate) and copolymers thereof 有权
公开(公告)号：US11844879B2
公开(公告)日：2023-12-19
申请号：US17245573
申请日：2021-04-30
申请人： Tepha, Inc.
发明人： Simon F. Williams , Said Rizk , David P. Martin , Skander Limem , Kai Guo , Amit Ganatra , German Oswaldo Hohl Lopez
IPC分类号： A61L31/06 , A61L27/56 , A61F2/00 , A61L17/10 , A61F2/12 , A61B17/86 , A61B17/80 , A61B17/72 , A61F2/30 , A61L31/14 , A61B17/04 , B29C48/05 , D01D5/08 , D04B1/22 , B29C45/00 , B33Y80/00 , B33Y10/00 , B29C70/52 , B29C48/08 , D04B1/16 , A61L27/18 , B29C48/00 , A61L27/58 , C08G63/16 , C08G63/85 , C08L67/02 , C08J5/02 , A61B17/00 , B29L31/00 , B29K67/00 , B29K105/00
CPC分类号： A61L31/06 , A61B17/0401 , A61B17/72 , A61B17/80 , A61B17/8095 , A61B17/866 , A61F2/0063 , A61F2/12 , A61F2/30756 , A61L17/105 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/146 , B29C45/0001 , B29C48/022 , B29C48/05 , B29C48/08 , B29C70/52 , B33Y10/00 , B33Y80/00 , C08G63/16 , C08G63/85 , C08J5/02 , C08L67/02 , D01D5/08 , D01D5/082 , D04B1/16 , D04B1/22 , A61B2017/00526 , A61F2240/001 , A61L2430/02 , A61L2430/04 , A61L2430/06 , A61L2430/10 , A61L2430/34 , B29K2067/00 , B29K2105/0085 , B29L2031/7532 , B29L2031/7546 , C08J2367/02 , D10B2331/04 , D10B2509/04
摘要： Resorbable implants, coverings and receptacles comprising poly(butylene succinate) and copolymers thereof have been developed. The implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing molding, pultrusion or other melt or solvent processing method. The implants, or the fibers preset therein, may be oriented. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings, receptacles and implants described herein, may be made from meshes, webs, lattices, non-wovens, films, fibers, foams, molded, pultruded, machined and 3D printed forms.

10. 发明授权

US11040170B2 Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof 有权
公开(公告)号：US11040170B2
公开(公告)日：2021-06-22
申请号：US15983773
申请日：2018-05-18
申请人： Tepha, Inc.
发明人： Amit Ganatra , Said Rizk
IPC分类号： A61M25/00 , A61N5/10 , C08J5/00 , A61L29/06 , A61L29/16 , A61L29/18 , A61L29/04 , A61L29/02 , B29C48/09 , B29C48/00 , B29C48/88 , B29B13/06 , B29C48/80 , B29C55/24 , A61L31/16 , B29C48/92 , B29C48/10 , B29C48/90 , A61L31/06 , B29B13/04 , A61L29/14 , A61L31/14 , A61L31/18 , B29K67/00 , B29L31/00 , A61M25/01
摘要： Methods have been discovered that make it possible to continuously extrude tubes of P4HB and copolymers thereof. These methods allow tubes of P4HB and copolymers thereof to be produced without radial deformation of the tubes despite the slow crystallization of the polymer and copolymers. The methods can produce tubes of P4HB and copolymers thereof with tightly defined outside and inside diameters which are required for medical application. These tubes are produced by radial expansion at temperatures above the melting temperature of P4HB and copolymers thereof, and using low tube cooling temperatures and prolonged cooling times. The tubes made from P4HB and copolymers thereof are flexible, and can be prepared with high elongation to break values.

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