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1. 发明申请

US20060121607A1 Compositions and methods for neural differentiation of embryonic stem cells 审中-公开
标题翻译：胚胎干细胞神经分化的组成和方法
公开(公告)号：US20060121607A1
公开(公告)日：2006-06-08
申请号：US10524157
申请日：2003-08-08
申请人： Thomas Schulz , Steven Stice , Brian Condie , Bruce Davidson
发明人： Thomas Schulz , Steven Stice , Brian Condie , Bruce Davidson
IPC分类号： C12N5/08
CPC分类号： C12N5/0618 , A61K35/12 , C12N5/0619 , C12N2500/32 , C12N2500/90 , C12N2501/115 , C12N2501/91 , C12N2502/13 , C12N2506/02
摘要： The present invention provides compositions and methods for human neural cell production. More particularly, the present invention provides cellular differentiation methods employing an essentially serum free MEDII conditioned medium for the generation of human neural cells from pluripotent and multipotent human stem cells.
摘要翻译：本发明提供了人神经细胞产生的组合物和方法。更具体地，本发明提供了使用基本上无血清的MEDII条件培养基用于从多能和多能人干细胞产生人神经细胞的细胞分化方法。

2. 发明申请

US20070204351A1 Direct differentiation of cardiomyocytes from human embryonic stem cells 审中-公开
标题翻译：心肌细胞与人胚胎干细胞的直接分化
公开(公告)号：US20070204351A1
公开(公告)日：2007-08-30
申请号：US11644790
申请日：2006-12-22
申请人： Bruce Davidson , Ralph Graichen , Robert Zweigerdt , Xu Xuiqin , Christine Mummery , William Sun
发明人： Bruce Davidson , Ralph Graichen , Robert Zweigerdt , Xu Xuiqin , Christine Mummery , William Sun
IPC分类号： A01K67/027 , C12N5/08 , C12N5/06
CPC分类号： C12N5/0657 , A61K35/12 , C12N5/0043 , C12N2500/25 , C12N2500/99 , C12N2501/02 , C12N2501/105 , C12N2501/115 , C12N2501/125 , C12N2501/155 , C12N2501/33 , C12N2501/999 , C12N2502/13 , C12N2502/30 , C12N2506/02 , C12N2510/00 , G01N33/502 , G01N33/5061
摘要： The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided.
摘要翻译：本发明涉及诱导干细胞分化为心肌细胞和诸如前列腺素的因素，或与其它因素组合，包括选自包括转铁蛋白和硒的必需矿物质，选自包括p38MAPK抑制剂在内的小分子作为SB203580和FGF，IGF和BMP家族的蛋白生长因子，例如但不限于IGF1，FGF2，BMP2，BMP4和BMP6。和影响心肌细胞分化过程的胰岛素。还提供了适合于诱导心肌细胞从干细胞分化的培养基，其中培养基含有这些因子。还提供了通过移植中的定向分化和心脏化合物筛选产生的心肌细胞和心脏祖细胞的使用。

3. 发明申请

US20050244964A1 Production of neural progenitor cells 审中-公开
标题翻译：神经祖细胞的生产
公开(公告)号：US20050244964A1
公开(公告)日：2005-11-03
申请号：US10514094
申请日：2003-05-09
申请人： Bruce Davidson
发明人： Bruce Davidson
IPC分类号： A61K35/12 , C12N5/0793 , C12N5/0797 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0619 , C12N2500/90 , C12N2501/115 , C12N2506/02 , C12N2506/03
摘要： A method of producing neural progenitor cells and/or neuronal cells which method includes providing a source of pluripotent cells; a cell aggregate-inducing culture medium; and a neural inducing supplement; culturing the pluripotent cells in the cell aggregate-inducing culture medium, in the presence of the neural inducing supplement, for a period sufficient to permit cell aggregates or embryoid bodies (EB's) to form, wherein the EB's include neural progenitor cells; and culturing the cell aggregates including neural progenitor cells for a period sufficient to permit neuronal differentiation.
摘要翻译：一种产生神经祖细胞和/或神经细胞的方法，所述方法包括提供多能细胞来源; 细胞聚集诱导培养基; 和神经诱导补体; 在所述神经诱导性补充剂的存在下培养所述细胞聚集体诱导培养基中的多能细胞足以允许形成细胞聚集体或胚状体（EB）的时间，其中所述EB包括神经祖细胞; 并培养包括神经祖细胞的细胞聚集体足以允许神经元分化的时间。

4. 发明申请

US20070289457A1 METHODS OF FORMING IMAGES ON AN OUTER SURFACE OF A GOLF BAG 有权
标题翻译：在高尔夫球包外表面上形成图像的方法
公开(公告)号：US20070289457A1
公开(公告)日：2007-12-20
申请号：US11846937
申请日：2007-08-29
申请人： Bruce Davidson
发明人： Bruce Davidson
IPC分类号： B41C1/06
CPC分类号： A63B55/00 , B41J3/4073 , B41M7/0072 , G09F23/00 , G09F23/0066
摘要： Methods of forming images on an outer surface of a golf bag are provided. A method can include the step of obtaining a photographic-type image to be formed onto a substantially flat side outer surface portion of a golf bag having a main bag body including an open end, a closed end, a club chamber positioned between the open and closed ends, and the substantially flat side outer surface portion. The method can also include controlling image production by sending the photographic-type image to a printer and activating at least one printer motor to form the photographic-type image onto the flat side outer surface portion of the golf bag, and printing the photographic-type image onto the substantially flat side outer surface portion of the golf bag so that the photographic-type image is readily visible and substantially permanently affixed.
摘要翻译：提供了在高尔夫球袋的外表面上形成图像的方法。一种方法可以包括获得要形成在高尔夫球袋的基本平坦的侧表面部分上的照相型图像的步骤，该高尔夫球袋具有包括开口端，封闭端，位于开口和闭合端部和大致平坦的侧面外表面部分。该方法还可以包括通过将照相型图像发送到打印机并激活至少一个打印机电机以在高尔夫球袋的平坦侧外表面部分上形成照相型图像来控制图像生成，并且将照相型图像到高尔夫球袋的基本上平坦的侧表面部分上，使得照相型图像容易可见并且基本上永久地固定。

5. 发明申请

US20070062384A1 Golf bag having image thereon, systems and methods of forming same, and methods of using golf bag 有权
标题翻译：具有图像的高尔夫球袋，其形成方法及其制造方法以及使用高尔夫球袋的方法
公开(公告)号：US20070062384A1
公开(公告)日：2007-03-22
申请号：US11603369
申请日：2006-11-22
申请人： Bruce Davidson
发明人： Bruce Davidson
IPC分类号： B41F17/00
CPC分类号： A63B55/00 , B41J3/4073 , B41M7/0072 , G09F23/00 , G09F23/0066
摘要： A golf bag system, a golf bag having an image positioned thereon, and methods of forming and using the golf bag are provided. The system preferably includes a golf bag having a main bag body including an open end, a closed end, a club chamber positioned between the open and closed ends, an outer surface portion, and an image thereon positioned on the outer surface portion. The system can also include a memory having an image stored thereon, a controller to obtain the image and control printing, and a printing device. A method of forming images on a golf bag can include obtaining an image to be formed onto the golf bag and forming the image onto the golf bag. A method of using a golf bag having images thereon can include examining the golf bag, physically comparing an image on the golf bag with a known image associated with the alleged golf bag owner, determining ownership, and issuing the golf bag to the determined owner.
摘要翻译：提供一种高尔夫球袋系统，具有定位在其上的图像的高尔夫球袋，以及形成和使用高尔夫球袋的方法。该系统优选地包括高尔夫球袋，该高尔夫球袋具有包括开口端，封闭端，位于打开和关闭端之间的球杆室，外表面部分和位于外表面部分上的图像的主体。该系统还可以包括具有存储在其上的图像的存储器，用于获得图像和控制打印的控制器以及打印装置。在高尔夫球袋上形成图像的方法可以包括获得要形成在高尔夫球袋上的图像并将图像形成在高尔夫球袋上。使用其上具有图像的高尔夫球袋的方法可以包括检查高尔夫球袋，将高尔夫球袋上的图像与所声称的高尔夫球袋所有者相关联的已知图像物理地比较，确定所有权，以及向所确定的所有者发行高尔夫球袋。

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