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1. 发明授权

US07684858B2 Methods and systems for placing an implanted stimulator for stimulating tissue 失效
标题翻译：放置刺激器刺激组织的方法和系统
公开(公告)号：US07684858B2
公开(公告)日：2010-03-23
申请号：US11232540
申请日：2005-09-21
申请人： Tom Xiaohai He , Todd K. Whitehurst , Alfred E. Mann , Peter K. Johnson
发明人： Tom Xiaohai He , Todd K. Whitehurst , Alfred E. Mann , Peter K. Johnson
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/37205
摘要： Systems for providing stimulation with an implantable system control unit and for optimally positioning that system control unit include a system control unit configured to provide a stimulus to a patient with a member attached to the system control unit for pulling the system control unit into position within the patient. Methods of optimally positioning the implantable system control unit within a patient such that the system control unit is proximal to target tissue that is to be stimulated by the system control unit include threading a member through a patient's body using a needle, the member passing proximal to the target tissue and being attached to the system control unit, and pulling the system control unit into place with the member.
摘要翻译：用于用可植入系统控制单元提供刺激并且用于最佳地定位该系统控制单元的系统包括系统控制单元，该系统控制单元被配置为向患者提供具有连接到系统控制单元的构件的刺激，用于将系统控制单元牵引到患者。将可植入系统控制单元最佳地定位在患者体内的方法，使得系统控制单元靠近要由系统控制单元刺激的目标组织包括使用针穿过患者身体的部件，所述构件通过近端到目标组织并附接到系统控制单元，并且将系统控制单元拉到构件的适当位置。

2. 发明申请

US20090281605A1 ENGAGEMENT TOOL FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：可植入医疗器械的辅助工具
公开(公告)号：US20090281605A1
公开(公告)日：2009-11-12
申请号：US12506890
申请日：2009-07-21
申请人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
发明人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
IPC分类号： A61N1/00
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

3. 发明授权

US08364280B2 Engagement tool for implantable medical devices 有权
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US08364280B2
公开(公告)日：2013-01-29
申请号：US12506890
申请日：2009-07-21
申请人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
发明人： Goran N. Marnfeldt , Rafael Carbunaru , Kelly H. McClure , Matthew I. Haller , Tom Xiaohai He , Todd K. Whitehurst , Meredith L. Anderson , James C. Makous , Kristen N. Jaax , Peter K. Johnson
IPC分类号： A61N1/00
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

4. 发明申请

US20120316622A1 IMPLANTABLE MICROSTIMULATORS WITH PROGRAMMABLE MULTIELECTRODE CONFIGURATION AND USES THEREOF 审中-公开
标题翻译：可编程微控制器，具有可编程多电路配置及其用途
公开(公告)号：US20120316622A1
公开(公告)日：2012-12-13
申请号：US13546873
申请日：2012-07-11
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kerry Bradley , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kerry Bradley , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Janusz A. Kuzma
IPC分类号： A61N1/36
CPC分类号： A61N1/37217 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) with programmably configurable electrodes allow, among other things, steering of the electric fields created. In addition, the microstimulators are capable of producing unidirectionally propagating action potentials (UPAPs).
摘要翻译：具有可编程可配置电极的微型可植入刺激器（即，微型激励器）除了别的以外还允许所产生的电场的转向。此外，微型激励器能够产生单向传播动作电位（UPAP）。

5. 发明授权

US07860570B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 有权
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US07860570B2
公开(公告)日：2010-12-28
申请号：US10178010
申请日：2002-06-20
申请人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
发明人： Todd K Whitehurst , Rafael Carbunaru , James P McGivern , Matthew I Haller , Tom Xiaohai He , Kerry Bradley , Janusz A Kuzma
IPC分类号： A61N1/375
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

6. 发明授权

US06582441B1 Surgical insertion tool 有权
标题翻译：手术插入工具
公开(公告)号：US06582441B1
公开(公告)日：2003-06-24
申请号：US09761934
申请日：2001-01-17
申请人： Tom Xiaohai He , James P. McGivern , Todd K. Whitehurst
发明人： Tom Xiaohai He , James P. McGivern , Todd K. Whitehurst
IPC分类号： A61B1900
CPC分类号： A61N1/05 , A61N1/0551
摘要： A tool is provided for facilitating determining a proper location for an implantable device or medication, and for then delivering the implant to the precise location determined with the tool. To determine the target location, the tool may include a component for testing target locations, such as a stimulating probe for simulating a miniature implantable stimulator. In one embodiment, the tool is used to test a miniature implantable stimulator prior to depositing the implant precisely at the target location. The components of the tool are configured to maintain the implant at the target location while the tool is withdrawn. In one embodiment, a push rod assembly of the tool keeps the implant in position while it retracts the implant holder from around the implant. The ergonomic and light-weight tool leads to reduced surgical time, number and size of incisions, risk of infection, and likelihood of error.
摘要翻译：提供了一种用于便于确定可植入装置或药物的适当位置的工具，然后将植入物递送到由工具确定的精确位置。为了确定目标位置，该工具可以包括用于测试目标位置的部件，例如用于模拟微型可植入刺激器的刺激探针。在一个实施例中，该工具用于在将植入物精确地放置在目标位置之前测试微型可植入刺激器。该工具的组件被配置为在撤回工具时将植入物保持在目标位置。在一个实施例中，该工具的推杆组件将植入物保持在适当位置，同时使植入物保持器从植入物周围缩回。符合人体工程学和轻量级工具可减少手术时间，切口数量和大小，感染风险和误差的可能性。

7. 发明授权

US08712547B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US08712547B2
公开(公告)日：2014-04-29
申请号：US13036278
申请日：2011-02-28
申请人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K. Whitehurst , James P. McGivern , Rafael Carbunaru , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/372
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： An implantable stimulation device includes a device body; at least one set of partitioned electrodes disposed on a portion of the device body and configured and arranged for application of electrical stimulation to adjacent tissue; and insulating material separating the partitioned electrodes from each other. Each set of partitioned electrodes includes a plurality of partitioned electrodes disposed around a circumference of the device body. The implantable stimulation device can be configured and arranged so that each of the partitioned electrodes is independently programmable.
摘要翻译：可植入刺激装置包括装置主体; 至少一组分隔电极，其设置在所述装置主体的一部分上，并被配置和布置成用于对相邻组织施加电刺激; 以及将分隔电极彼此分离的绝缘材料。每组分隔电极包括围绕装置主体的圆周设置的多个分隔电极。可植入式刺激装置可以被配置和布置成使得每个分隔电极可独立编程。

8. 发明授权

US08548604B2 Implantable microstimulators and methods for unidirectional propagation of action potentials 失效
标题翻译：可植入的微型激励器和动作电位单向传播的方法
公开(公告)号：US08548604B2
公开(公告)日：2013-10-01
申请号：US12960722
申请日：2010-12-06
申请人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Kerry Bradley , Janusz A. Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/37252 , A61N1/05 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37217 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) are capable of producing unidirectionally propagating action potentials (UPAPs). The methods and configurations described may, for instance, arrest action potentials traveling in one direction, arrest action potentials of small diameters nerve fibers, arrest action potentials of large diameter nerve fibers. These methods and systems may limit side effects of bidirectional and/or less targeted stimulation.
摘要翻译：微型植入式刺激器（即微型刺激器）能够产生单向传播动作电位（UPAP）。所描述的方法和结构可以例如阻止在一个方向上行进的动作电位，阻止小直径神经纤维的动作电位，阻止大直径神经纤维的动作电位。这些方法和系统可以限制双向和/或较少靶向刺激的副作用。

9. 发明授权

US07203548B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US07203548B2
公开(公告)日：2007-04-10
申请号：US10176743
申请日：2002-06-20
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

10. 发明授权

US09409028B2 Implantable microstimulators with programmable multielectrode configuration and uses thereof 有权
标题翻译：具有可编程多电极配置的可植入微型激励器及其用途
公开(公告)号：US09409028B2
公开(公告)日：2016-08-09
申请号：US13546873
申请日：2012-07-11
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kerry Bradley , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Janusz A. Kuzma
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kerry Bradley , James P. McGivern , Matthew I. Haller , Tom Xiaohai He , Janusz A. Kuzma
IPC分类号： A61N1/372 , A61N1/05 , A61N1/36
CPC分类号： A61N1/37217 , A61N1/0556 , A61N1/36071 , A61N1/37205 , A61N1/37288
摘要： Miniature implantable stimulators (i.e., microstimulators) with programmably configurable electrodes allow, among other things, steering of the electric fields created. In addition, the microstimulators are capable of producing unidirectionally propagating action potentials (UPAPs).
摘要翻译：具有可编程可配置电极的微型可植入刺激器（即，微型激励器）除了别的以外还允许所产生的电场的转向。此外，微型激励器能够产生单向传播动作电位（UPAP）。

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