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1. 发明申请

US20140179553A1 MERCURY METHYLATION GENES IN BACTERIA AND ARCHAEA 审中-公开
标题翻译：细菌和细菌中的甲基化甲基化
公开(公告)号：US20140179553A1
公开(公告)日：2014-06-26
申请号：US14132906
申请日：2013-12-18
申请人： UT-Battelle, LLC
发明人： Jerry M. Parks , Alexander Johs
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/142
摘要： Two genes required for this mercury methylation have been identified in bacteria and archaea. These genes are the hgcA gene and hgcB, a corrinoid protein that facilitates methyl group transfer to Hg, and a corrinoid protein-associated ferredoxin with two [4Fe-4S] binding motifs involved in generating cob(I)almin, respectively. The invention provides nucleic acid probes and primers for detecting methylmercury and or for assessing mercury methylation potential in environmental, clinical and other samples. The invention also provides antibodies against these proteins, antibodies against these proteins, methods of using the antibodies and methods of biocatalysis.
摘要翻译：这种汞甲基化所需的两个基因已被鉴定在细菌和古细菌中。这些基因是hgcA基因，hgcB是促进甲基转移到Hg的类胡萝卜素蛋白质，以及分别涉及产生cob（I）almin的两个[4Fe-4S]结合基序的类角蛋白相关铁氧还蛋白。本发明提供用于检测甲基汞和/或用于评估环境，临床和其他样品中的汞甲基化潜力的核酸探针和引物。本发明还提供针对这些蛋白质的抗体，针对这些蛋白质的抗体，使用抗体的方法和生物催化方法。

2. 发明申请

US20230102656A1 COVALENT INHIBITORS OF CORONAVIRUS PAPAIN-LIKE PROTEASE 有权
公开(公告)号：US20230102656A1
公开(公告)日：2023-03-30
申请号：US17896182
申请日：2022-08-26
申请人： UT-Battelle, LLC
发明人： Brian Sanders , Stephanie S. Galanie , Jerry M. Parks
IPC分类号： C07C243/28 , A61P31/14 , C07C255/03
摘要： A compound having the following structure: wherein: R1 is a linker having the formula —(CH2)n-L1-, wherein L1 contains 1-6 carbon atoms and at least one —NH— linkage and at least one oxygen-containing or sulfur-containing linkage, and n is an integer of 0-3; R2 is a group having the formula —C(Y)-E, wherein Y is O or S, and E is a hydrocarbon group and either: (i) at least one carbon-carbon or carbon-nitrogen unsaturated bond or (ii) at least one alkyl halide group; R3 is selected from H, NR′2, NHC(O)R′, and —(CH2)p-T, wherein T contains at least one —NH— linkage; Ra, Rb, Rc, Rd, Re, and Rf are independently selected from of H, hydrocarbon groups containing 1-3 carbon atoms, fluorine atom, and chlorine atom; X is N or CR9, wherein R9 is selected from H, hydrocarbon groups containing 1-3 carbon atoms, fluorine atom, and chlorine atom; and pharmaceutically acceptable salts thereof.

3. 发明授权

US10036072B2 Mercury methylation genes in bacteria and archaea 有权
公开(公告)号：US10036072B2
公开(公告)日：2018-07-31
申请号：US14132906
申请日：2013-12-18
申请人： UT-Battelle, LLC
发明人： Jerry M. Parks , Alexander Johs
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/689
CPC分类号： C12Q1/689 , C12Q2600/142
摘要： Two genes required for this mercury methylation have been identified in bacteria and archaea. These genes are the hgcA gene and hgcB, a corrinoid protein that facilitates methyl group transfer to Hg, and a corrinoid protein-associated ferredoxin with two [4Fe-4S] binding motifs involved in generating cob(I)almin, respectively. The invention provides nucleic acid probes and primers for detecting methylmercury and or for assessing mercury methylation potential in environmental, clinical and other samples. The invention also provides antibodies against these proteins, antibodies against these proteins, methods of using the antibodies and methods of biocatalysis.

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