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1. 发明申请

US20220231339A1 Non-Aqueous Electrolyte and Lithium Secondary Battery Including the Same 有权
公开(公告)号：US20220231339A1
公开(公告)日：2022-07-21
申请号：US17614041
申请日：2020-08-25
申请人： LG Energy Solution, Ltd.
发明人： Jeong Woo Oh , Hyung Tae Kim , Chul Haeng Lee
IPC分类号： H01M10/0567 , H01M10/0568 , H01M10/0569 , H01M4/525 , H01M4/38 , H01M4/134 , H01M4/131 , H01M10/052 , C07C255/03
摘要： A non-aqueous electrolyte and a lithium secondary battery including the same are disclosed herein. In some embodiments, a non-aqueous electrolyte includes an organic solvent, a lithium salt, and an additive, wherein the additive includes a compound represented by Formula I and a compound represented by Formula II wherein, in Formula I, R1 is an alkylene group having 1 to 4 carbon atoms, and wherein, in Formula II, R2, R3, and R4 are each independently a fluorine atom or a fluorine-substituted alkyl group having 1 to 10 carbon atoms.

2. 发明授权

US11130777B2 Crystalline phases of 5,6-dichloro-2-(isopropylamino)-(1-beta-L-ribofuranosyl)-1H-benzimidazole 有权
公开(公告)号：US11130777B2
公开(公告)日：2021-09-28
申请号：US16361387
申请日：2019-03-22
申请人： Takeda Pharmaceutical Company Limited
发明人： Gerard Coquerel , Guillaume Levilain , Marie-Noelle Petit , Servane Coste-Leconte
IPC分类号： C07H19/052 , A61K31/7056 , C07C31/04 , C07C31/10 , C07C43/06 , C07C69/14 , C07C255/03
摘要： The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.

3. 发明授权

US10532546B2 Composite for neutral layer 有权
公开(公告)号：US10532546B2
公开(公告)日：2020-01-14
申请号：US15578951
申请日：2016-06-07
申请人： LG Chem, Ltd.
发明人： No Jin Park , Sung Soo Yoon , Jung Keun Kim , Je Gwon Lee , Mi Sook Lee
IPC分类号： B32B27/08 , B32B27/06 , B32B27/30 , C08L53/00 , C08F212/08 , C08F220/10 , A61P35/00 , C07D215/48 , B32B3/26 , C08F8/50 , C08F226/06 , C08F299/04 , C08L53/02 , B82Y30/00 , C08F12/22 , C08F220/14 , C08F293/00 , C09D153/00 , C07D209/48 , C07D303/02 , G03F7/00 , C07C255/03 , B82Y40/00
摘要： The present application relates to a neutral layer composition. The present application can provide a neutral layer composition capable of forming a neutral layer, which can be effectively applied in the formation of a polymeric film comprising a vertically aligned self-assembled block copolymer.

4. 发明申请

US20190352326A1 CRYSTALLINE PHASES OF 5,6-DICHLORO-2-(ISOPROPYLAMINO)-(1-BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE 审中-公开
公开(公告)号：US20190352326A1
公开(公告)日：2019-11-21
申请号：US16361387
申请日：2019-03-22
申请人： Shire ViroPharma Incorporated
发明人： Gerard Coquerel , Guillaume Levilain , Marie-Noelle Petit , Servane Coste-Leconte
IPC分类号： C07H19/052 , C07C43/06 , C07C255/03 , C07C69/14 , A61K31/7056 , C07C31/10 , C07C31/04
摘要： The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.

5. 发明授权

US09181217B2 Method for producing optically active naphthalene compound 有权
标题翻译：光学活性萘化合物的制造方法
公开(公告)号：US09181217B2
公开(公告)日：2015-11-10
申请号：US14240466
申请日：2012-08-24
申请人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
发明人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
IPC分类号： C07B53/00 , C07C25/06 , C07C255/03 , C07D401/04
CPC分类号： C07D401/04 , C07B53/00 , C07C25/06 , C07C255/03
摘要： The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, Ra and Rb represent the same or different lower alkyl groups; and X1 represents a halogen atom.).
摘要翻译：本发明提供了用于制造用作皮炎等的治疗剂的光学活性萘化合物的工业上有利的方法。具体而言，本发明提供了一种光学活性萘化合物[I]的制造方法，其特征在于，在碱的存在下，使化合物[a-1]和化合物[b-1] 和由Pd化合物和叔膦配体组成的催化剂（步骤a）; 在氢供体和由钌化合物和手性配体制备的络合物的存在下，或者在光学活性的恶唑硼烷化合物（CBS催化剂）存在下，不对称地氢化化合物[c-1] 和硼氢化合物（步骤b）; 和用还原剂处理化合物[d-1]（步骤c）的步骤。（上述式中，Ra和Rb表示相同或不同的低级烷基，X1表示卤素原子。

6. 再颁专利

USRE45325E1 Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring 有权
公开(公告)号：USRE45325E1
公开(公告)日：2015-01-06
申请号：US14080414
申请日：2013-11-14
申请人： Reata Pharmaceuticals, Inc.
发明人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
IPC分类号： A61K31/277 , C07C255/03 , C07D223/14 , C07D285/12 , C07D271/10 , C07D313/06 , C07D257/04
CPC分类号： C07D261/20 , C07C69/757 , C07D207/27 , C07D413/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

7. 发明申请

US20130064871A1 COMPOSITION COMPRISING A DIBENZOYLMETHANE SCREENING AGENT AND A MEROCYANINE DICYANO OR CYANOACETATE DERIVATIVE; METHOD FOR THE PHOTOSTABILIZATION OF THE DIBENZOYLMETHANE SCREENING AGENT 有权
公开(公告)号：US20130064871A1
公开(公告)日：2013-03-14
申请号：US13634176
申请日：2011-03-07
申请人： Herve Richard , Benoit Muller
发明人： Herve Richard , Benoit Muller
IPC分类号： A61K8/41 , A61K8/06 , A61Q17/04 , C07D211/44 , C07D241/04 , A61K8/02 , C07C255/03
CPC分类号： C07D211/14 , A61K8/35 , A61K8/41 , A61K8/44 , A61K2800/52 , A61Q17/04 , C07C45/86 , C07C255/30 , C07C2601/14 , C07D211/46 , C07C49/84
摘要： The present invention relates to a cosmetic composition comprising the combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one specific merocyanine dicyano or cyanoacetate derivative. It also relates to a method for the photostabilization, with regard to radiation, of at least one screening agent of the dibenzoylmethane derivative type by an effective amount of at least one specific merocyanine dicyano or cyanoacetate derivative.

8. 发明授权

US08106230B2 Succinic acid diester derivative, process for production thereof, and use of the derivative in the production of pharmaceutical preparation 有权
标题翻译：琥珀酸二酯衍生物，其制备方法，以及衍生物在制备药物中的用途
公开(公告)号：US08106230B2
公开(公告)日：2012-01-31
申请号：US12310524
申请日：2007-08-30
申请人： Takashi Inagaki , Yoshikazu Yamakawa
发明人： Takashi Inagaki , Yoshikazu Yamakawa
IPC分类号： C07C255/03 , C07C299/04
CPC分类号： C07D207/416 , C07B53/00 , C07C269/06 , C07C271/22 , C07C2601/14
摘要： The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic acid diester of the formula (2): wherein R1 is an amino group protected with a group removed by hydrogenolysis or a tert-butoxycarbonylamino group and R2 is an ethyl group optionally substituted with one or two methyl group(s) at α-position, provided that R2 is not a tert-butyl group when R1 is a tert-butoxycarbonylamino group; with alkali metal alkoxide and the compound (3) can be an important intermediate for production of ranirestat.
摘要翻译：本发明提供了制备光学活性琥珀酰亚胺衍生物的方法，该衍生物是生产ranirestat的关键中间体。通过处理式（2）的琥珀酸二酯的衍生物容易地制备化合物（3）：其中R1是被氢解除去的基团保护的氨基或叔丁氧基羰基氨基，R2是任选取代的乙基在α位具有一个或两个甲基，条件是当R 1是叔丁氧基羰基氨基时，R 2不是叔丁基; 与碱金属醇盐和化合物（3）可以作为生产ranirestat的重要中间体。

9. 发明授权

US07863327B2 Therapeutic compounds and methods of use 有权
公开(公告)号：US07863327B2
公开(公告)日：2011-01-04
申请号：US11121316
申请日：2005-05-03
申请人： Gordon W. Gribble , Tadashi Honda , Michael B. Sporn , Nanjoo Suh
发明人： Gordon W. Gribble , Tadashi Honda , Michael B. Sporn , Nanjoo Suh
IPC分类号： A61K31/275 , A61K31/35 , C07C255/03
CPC分类号： C07C255/47 , A61K31/19 , A61K31/275 , A61K31/277 , A61K31/35
摘要： Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.

10. 发明申请

US20100022640A1 ESTERS OF 2-PHENYLALKANENITRILES AND ANTIFUNGAL COMPOSITIONS CONTAINING THEM 失效
标题翻译：二苯并呋喃基酯和含有它们的抗真菌组合物
公开(公告)号：US20100022640A1
公开(公告)日：2010-01-28
申请号：US12448192
申请日：2007-12-10
申请人： Donald Wesley Stoutamire
发明人： Donald Wesley Stoutamire
IPC分类号： A61K31/275 , C07C255/03 , A01P3/00
CPC分类号： C07C255/38 , A01N37/34
摘要： Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations.
摘要翻译： 2-苯基亚烷基腈如3-乙酰氧基-2-（2-氯-5-（二氟甲氧基）苯基）丙腈和3-乙酰氧基-2-（4-氯苯基）丙腈的酯和含有这些酯的组合物可用作杀菌剂浓度非常低。

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