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1. 发明申请

US20150118179A1 BIOCIDAL COMPOUNDS AND METHODS FOR USING SAME 审中-公开
标题翻译：生物化合物及其使用方法
公开(公告)号：US20150118179A1
公开(公告)日：2015-04-30
申请号：US14398926
申请日：2013-05-16
申请人： UNIVERSITY OF MANITOBA
发明人： Song Liu
IPC分类号： A01N43/50 , A01N43/647 , C07F9/6506 , C07D233/72 , C07D401/12
CPC分类号： C07D403/12 , A01N33/12 , A01N35/02 , A01N43/50 , A01N43/647 , C07D233/72 , C07D233/82 , C07D401/12 , C07D403/14 , C07F9/6506 , Y10T442/30 , Y10T442/40 , Y10T442/60 , A01N59/00
摘要： Biocidally active cationic analogs of N-halamine having two biocidally active groups covalently bonded together in a single molecule and having general Formula (I). Compounds of Formula (I), and precursors thereof, can be in solution form immobilized onto a substrate via physical coating or covalent chemical bonding to functionalize surfaces or added into materials as additives so as to render them biocidal. The biocidal solutions and substrates comprising the compounds or precursors of the present invention can then be used to inactivate pathogenic microorganisms. N-halamine-L-QUAT (I) wherein: the N-halamine may be a cyclic or acyclic N-halamine; L is C1-C6 alkyl, cyclic aromatic or non-aromatic ring, ether, ketone or any other organic linking structures, and QUAT has general formula (II):
摘要翻译：具有两个生物活性基团的N-卤代胺的生物活性阳离子类似物在单个分子中共价键合在一起并具有通式（I）。式（I）化合物及其前体可以是通过物理涂层或共价化学键固定在基底上的溶液形式，以将表面官能化或添加到材料中作为添加剂，以使其具有杀生物活性。包含本发明化合物或前体的杀生物溶液和底物可用于灭活病原微生物。 N-卤胺-L-QUAT（I）其中：N-卤胺可以是环状或非环状N-卤胺; L是C1-C6烷基，环状芳族或非芳族环，醚，酮或任何其他有机连接结构，QUAT具有通式（II）：

2. 发明申请

US20210236427A1 Development of Lipid Matrix Granules with Incorporation of Polysaccharides for Effective Delivery of an Antimicrobial Essential Oil 有权
公开(公告)号：US20210236427A1
公开(公告)日：2021-08-05
申请号：US17052022
申请日：2019-05-06
申请人： University of Manitoba
发明人： Chengbo Yang , Song Liu , Martin Nyachoti
IPC分类号： A61K9/16 , A61K31/05 , A23K20/163 , A23K20/158
摘要： Antibiotics have long been used at sub-therapeutic levels to control incidences of post-weaning diarrhea and to improve growth performance in pigs. However, the current trend world-wide is to eliminate the use of in-feed antibiotics due to increased public concerns over the spread of antibiotic resistance in bacterial pathogens, which poses a threat to public health. Alternatives to in-feed antibiotics are needed. Thymol essential oil exhibits strong in vitro antibacterial activity; however; direct inclusion of essential oils to pig feeds has limited efficacy due to their high volatility, low stability during feed processing, interactions with other feed components and poor availability in lower gut. To solve these problems, we developed lipid matrix beads using thymol and a fatty acid with incorporation of 2% polysaccharides via a melt-granulation technique. Laurie acid was identified as a suitable carrier for thymol. In vitro release of thymol from lipid matrix granules was determined using simulated salivary fluid (SSF), simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively. The lipid matrix granules with 2% polysaccharides exhibited a slow release rate (%) of essential oil and fatty acid in SSF (21.2±2.3; 36±1.1), SGF (73.7±6.9; 54.8±1.7) and SIF (99.1±1.2; 99.1±0.6), respectively. However, the lipid matrix granules without polysaccharides had quick release (%) of essential oil and fatty acid from the SSF (79.9±11.8; 84.9±9.4), SGF (92.5±3.5; 75.8±5.9) and SIF (93.3±9.4; 93.3±4.6), respectively.

3. 发明授权

US11059790B2 Compounds, polymers and coating formulations that comprise at least one N-halamine precursor, a cationic center and a coating incorporation group 有权
公开(公告)号：US11059790B2
公开(公告)日：2021-07-13
申请号：US15768824
申请日：2016-10-14
申请人： UNIVERSITY OF MANITOBA
发明人： Zachary J. Wolff , Sadegh Ghanbar , Dominic Tessier , Chenxi Ning , Jonathan van Leeuwen , Marcelo Dubiel , Gurmeet Singh Bindra , Song Liu
IPC分类号： C07D233/76 , C07D211/46 , C09D5/14 , C08K5/3435 , C08K5/3445 , C07D211/58 , C07D233/74 , A01N43/40 , A01N43/50 , C07D233/78 , C08K5/19 , C08K5/00
摘要： The present disclosure relates to a compound that has biocidal activity or is a precursor of a compound with biocidal activity. The compound comprises an N-halamine precursor, at least one quaternary ammonium and at least one coating-incorporation group (CIG). In some embodiments of the present disclosure, the compound may be incorporated into a coating formulation. The coating formulation comprises the compound and at least one further component. In some embodiments of the present disclosure, the CIG reacts with the further component of the coating formulation to incorporate the compound into the coating formulation. In some embodiments, the coating formulation comprises a polymer. In some embodiments, the CIG of the compound reacts with the further component to incorporate the compound into the polymer of the coating formulation. The coating formulation may be used to coat a substrate. The coated substrate may demonstrate biocidal activity or the potential for increased biocidal activity.

4. 发明授权

US10975260B2 Monomers, polymers and coating formulations that comprise at least one N-halamine precursor, a cationic center and a coating incorporation group 有权
公开(公告)号：US10975260B2
公开(公告)日：2021-04-13
申请号：US15775816
申请日：2016-11-10
申请人： University of Manitoba
发明人： Song Liu , Rajbir Kaur , Zachary J. Wolff , Gurmeet Singh Bindra
IPC分类号： C09D201/02 , C09D201/04 , C09D5/14 , C09D133/24 , C09D7/63 , C08K5/3415 , C08K5/34
摘要： A modified surface with at least one cationic center and at least one compound. The surface can be modified by various methods. The result of these methods is that the cationic center and the compound are connected to the modified surface. The cationic center and the compound are connected to the modified surface so that both of the cationic center and the compound are available upon the modified surface to react with other chemicals or microorganisms that come into contact with or near to the modified surface. The availability of the cationic center and the compound cause the modified surface to have a functionality that it would not otherwise have. The number of molecules of the cationic center relative to the number of molecules of the at least one compound may influence the functionality of the modified surface.

5. 发明授权

US10973775B2 Antibacterial nanofiber 有权
公开(公告)号：US10973775B2
公开(公告)日：2021-04-13
申请号：US16138577
申请日：2018-09-21
申请人： UNIVERSITY OF MANITOBA
发明人： Song Liu , Sarvesh Logsetty
IPC分类号： A61K9/70 , D01D5/00 , A61L15/24 , A61P17/02 , A61P31/04 , A61F13/00 , A61L15/26 , A61K47/32 , A61K47/34 , A61K9/00 , A61L15/46 , D01F1/10 , D01F8/14 , D01F8/10 , B82Y30/00
摘要： Bacteria-responsive core-shell nanofibers and a process for the preparation thereof are described. The nanofibers release of an antibacterial agent in response to the presence of bacteria. The core of the nanofiber comprises a biocompatible polymer together with an antibacterial agent such as a quaternary ammonium compound, for example benzyl dimethyl tetradecyl ammonium chloride (BTAC). Surrounding the core is shell comprised of a bacterially degradable polymer, which is susceptible to break-down by bacterial enzymes such as lipase, or to acidic pH conditions. The shell may comprise, for example, polycaprolactone (PCL) and poly(ethylene succinate) (PES). The nanofibers may be incorporated into wound dressings.

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