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    • 4. 发明授权
    • Microfiltration membranes having high pore density and mixed isotropic
and anisotropic structure
    • 具有高孔密度和混合各向同性和各向异性结构的微滤膜
    • US5906742A
    • 1999-05-25
    • US950332
    • 1997-10-14
    • I-Fan WangJerome F. DitterRick Morris
    • I-Fan WangJerome F. DitterRick Morris
    • B01D67/00B01D69/02B01D71/68B01D39/00
    • B01D71/68B01D67/0011B01D67/0013B01D69/02B01D2325/022B01D2325/36
    • The present invention relates to the field synthetic polymeric microfiltration membrane materials that are fabricated to separate liquids from solids contained therein. One aspect of the invention relates to a sulfone polymer membrane with high surface porosity (high pore density) and distinctive asymmetry that can separate solids (i.e., blood cells) from a liquid (i.e., plasma) without the need for centrifugation. The membrane is further rendered hydrophilic through co-casting the sulfone polymer (which is a hydrophobic polymer) with a hydrophilic polymer, such as polyvinylpyrrolidone. Because of these properties and the fact that it requires only a small amount of the solid containing liquid (i.e., whole blood) to be applied to the larger pore surface, the membranes of the invention are highly useful in testing devices for the quick detection of properties or components contained in liquid samples, such as diagnostic applications (i.e., the detection of physiological conditions (i.e., pregnancy, insulin levels, stomach ulcer, and the like) and infectious diseases (i.e., AIDS, hepatitis, and the like)).
    • 本发明涉及用于将液体与其中所含固体分离的现场合成聚合物微滤膜材料。 本发明的一个方面涉及具有高表面孔隙率(高孔密度)和独特的不对称性的砜聚合物膜,其可以将液体(即血浆)的固体(即血细胞)分离而不需要离心。 通过与亲水性聚合物如聚乙烯吡咯烷酮共聚合砜砜聚合物(其是疏水性聚合物),进一步使膜变得亲水。 由于这些性质和仅需要少量含有固体的液体(即全血)施加到较大孔表面的事实,本发明的膜在测试装置中非常有用,用于快速检测 液体样品中的物质或组分,如诊断应用(即检测生理条件(即怀孕,胰岛素水平,胃溃疡等)和感染性疾病(即艾滋病,肝炎等)) 。