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1. 外观设计

USD689185S1 Nebulizer 有权
公开(公告)号：USD689185S1
公开(公告)日：2013-09-03
申请号：US29417297
申请日：2012-04-02
申请人： William J Flickinger , John Quackenbush
设计人： William J Flickinger , John Quackenbush
CPC分类号： A61H35/04 , A61H2201/105 , A61M11/001 , A61M11/06 , A61M15/0025 , A61M15/08

2. 发明授权

US08162921B2 Method and device for nasal irrigation and drug delivery 有权
标题翻译：用于鼻灌注和药物输送的方法和装置
公开(公告)号：US08162921B2
公开(公告)日：2012-04-24
申请号：US12633269
申请日：2009-12-08
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/02
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08
摘要： A method and device for nasal irrigation and drug delivery wherein fluid held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：一种用于鼻灌和药物输送的方法和装置，其中保持在罐中的流体经由压缩空气源雾化，以产生尺寸适于在能够支架打开鼻软组织的压力下穿透和保持在鼻腔中的颗粒将所产生的雾输送到整个鼻通道中，而不需要患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

3. 发明授权

US08146587B2 Method for nasal irrigation and drug delivery 有权
标题翻译：鼻灌和药物输送方法
公开(公告)号：US08146587B2
公开(公告)日：2012-04-03
申请号：US12787576
申请日：2010-05-26
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/00
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08 , A61M2210/0618
摘要： A method of treating neoplasms of the nasal cavity. Fluid containing corticosteroids held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：一种治疗鼻腔肿瘤的方法。保持在罐中的含有皮质类固醇的流体通过压缩空气供应被雾化，以产生尺寸适于在压力下穿透和保持在鼻腔中的颗粒，该压力能够支架打开鼻子的软组织以将所得的雾输送到整个鼻通道，无需患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

4. 发明授权

US09440020B2 Nasal irrigator 有权
标题翻译：鼻刺激器
公开(公告)号：US09440020B2
公开(公告)日：2016-09-13
申请号：US13404623
申请日：2012-02-24
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M3/02 , A61M11/00 , A61M11/02 , A61M15/08 , A61M11/06
CPC分类号： A61M3/025 , A61M3/0279 , A61M11/001 , A61M11/02 , A61M11/06 , A61M15/08 , A61M2210/0618 , Y10T29/494
摘要： A nasal nebulizer contains a main canister with at least one air exit port and an insert with at least one fluid channel. The fluid channel ends in a common bell housing above a base of the insert, which rests within the canister. The insert and the canister may form one integral unit for single usage, where a cap plugs the air exit port and the fluid channel, allowing for the transport or long-term storage of fluids within the nebulizer device. The insert may include an extension extending out to the canister and a vertical groove may extend down the fluid channel to a hole in the extension, which upon use helps create a vacuum that pulls in deflected fluid for re-use. The nebulizer may also contain a filter surrounding the tube portion near the top of the canister to catch any extraneous matter expelled from the nose during usage.
摘要翻译：鼻喷雾器包含具有至少一个空气出口的主罐和具有至少一个流体通道的插入件。流体通道在插入件的底部上方的公共钟罩中终止，其位于罐内。插入件和罐可以形成一个整体单元，用于单次使用，其中盖子堵塞空气出口和流体通道，允许在雾化器装置内输送或长期储存流体。插入件可以包括延伸到罐的延伸部分，并且垂直的沟槽可以沿着流体通道向下延伸到延伸部中的孔，在使用时，该凹槽有助于产生拉动偏转的流体以供再次使用的真空。喷雾器还可以包含围绕罐顶部的管部分的过滤器，以在使用期间捕获从鼻子排出的任何外来物质。

5. 发明申请

US20120152238A1 Nasal Nebulizer for Transporting and Storing Fluids 有权
标题翻译：用于运输和储存液体的鼻腔喷雾器
公开(公告)号：US20120152238A1
公开(公告)日：2012-06-21
申请号：US13404623
申请日：2012-02-24
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/02 , B21D51/16 , A61M15/08
CPC分类号： A61M3/025 , A61M3/0279 , A61M11/001 , A61M11/02 , A61M11/06 , A61M15/08 , A61M2210/0618 , Y10T29/494
摘要： A nasal nebulizer contains a main canister with at least one air exit port and an insert with at least one fluid channel. The fluid channel ends in a common bell housing above a base of the insert, which rests within the canister. The insert and the canister may form one integral unit for single usage, where a cap plugs the air exit port and the fluid channel, allowing for the transport or long-term storage of fluids within the nebulizer device. The insert may include an extension extending out to the canister and a vertical groove may extend down the fluid channel to a hole in the extension, which upon use helps create a vacuum that pulls in deflected fluid for re-use. The nebulizer may also contain a filter surrounding the tube portion near the top of the canister to catch any extraneous matter expelled from the nose during usage.
摘要翻译：鼻喷雾器包含具有至少一个空气出口的主罐和具有至少一个流体通道的插入件。流体通道在插入件的底部上方的公共钟罩中终止，其位于罐内。插入件和罐可以形成一个整体单元，用于单次使用，其中盖子堵塞空气出口和流体通道，允许在雾化器装置内输送或长期储存流体。插入件可以包括延伸到罐的延伸部分，并且垂直的沟槽可以沿着流体通道向下延伸到延伸部中的孔，在使用时，该凹槽有助于产生拉动偏转的流体以供再次使用的真空。喷雾器还可以包含围绕罐顶部的管部分的过滤器，以在使用期间捕获从鼻子排出的任何外来物质。

6. 发明申请

US20110137290A1 Method and Device for Nasal Irrigation and drug delivery 有权
标题翻译：鼻灌注和药物输送的方法和装置
公开(公告)号：US20110137290A1
公开(公告)日：2011-06-09
申请号：US12633269
申请日：2009-12-08
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/02
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08
摘要： The present invention provides a method and device for nasal irrigation and drug delivery wherein fluid held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：本发明提供了一种用于鼻灌和药物输送的方法和装置，其中保持在罐中的流体经由压缩空气供应被雾化以产生尺寸适于在能够支架打开软组织的压力下穿透和保持在鼻腔中的颗粒的鼻子将所产生的雾输送到整个鼻通道中，而不需要患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

7. 发明申请

US20110132354A1 Method for Nasal Irrigation and Drug Delivery 有权
标题翻译：鼻灌注和药物输送方法
公开(公告)号：US20110132354A1
公开(公告)日：2011-06-09
申请号：US12787576
申请日：2010-05-26
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/00
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08 , A61M2210/0618
摘要： The present invention provides a method of treating neoplasms of the nasal cavity. Fluid containing corticosteroids held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：本发明提供一种治疗鼻腔肿瘤的方法。保持在罐中的含有皮质类固醇的流体通过压缩空气供应被雾化，以产生尺寸适于在压力下穿透和保持在鼻腔中的颗粒，该压力能够支架打开鼻子的软组织以将所得的雾输送到整个鼻通道，无需患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

8. 发明申请

US20090210967A1 Glutamate Receptors as Regulators of Carbon Transport, Mobilization, Distribution, Reallocation, and Partitioning in Higher Plants 审中-公开
标题翻译：谷氨酸受体作为高等植物碳转运，动员，分配，重新分配和分配的调节剂
公开(公告)号：US20090210967A1
公开(公告)日：2009-08-20
申请号：US12252573
申请日：2008-10-16
申请人： Frank J. Turano , Jiman Kang , John Quackenbush , Jason Shockey , Chen Zeng
发明人： Frank J. Turano , Jiman Kang , John Quackenbush , Jason Shockey , Chen Zeng
IPC分类号： C12N15/82 , A01H5/00 , C12N15/63
CPC分类号： C07K14/415 , C12N15/825
摘要： This invention relates to compounds for improving plant growth and characteristics, improved modified plants, processes for obtaining the same, and improved methods of obtaining plant products, and specifically those concerning AtGLR1.1.
摘要翻译：本发明涉及用于改善植物生长和特性的化合物，改进的改良植物，获得植物的方法，以及获得植物产品的改进方法，特别是有关AtGLR1.1的那些。

9. 发明申请

US20070194792A1 NON-METALLIC FLOW-THROUGH ELECTRODELESS CONDUCTIVITY SENSOR WITH LEAK AND TEMPERATURE DETECTION 有权
标题翻译：具有漏电和温度检测的非金属流通电导率传感器
公开(公告)号：US20070194792A1
公开(公告)日：2007-08-23
申请号：US11650154
申请日：2007-01-05
申请人： John Quackenbush , Michael Bower , Stephen Talutis , Donald McKinlay , Daniel Tower
发明人： John Quackenbush , Michael Bower , Stephen Talutis , Donald McKinlay , Daniel Tower
IPC分类号： G01N27/02
CPC分类号： G01N27/023
摘要： A non metallic flow through electrodeless conductivity sensor is provided with a conduit having primary and secondary process fluid flow paths to form a fluid loop. At least one drive and one sense toroid surround the conduit on the fluid loop. Voltage supplied to the drive toroid induces a current in the sense toroid via the fluid loop to eliminate any need for metallic electrodes in contact with the process fluid. At least one additional drive and/or sense toroid is disposed on the fluid loop to enhance induction. Optionally one or more sense coils are disposed about the conduit outside of the fluid loop to cancel out stray electrical noise. An optional conductor disposed along the conduit detects any fluid leakage through changes in resistance thereof. A temperature detector is supported within an electrically non-conductive holder extending into the fluid flow path, so that the detector is free from physical contact with the fluid. An optional enclosure is provided with ports to enable a user to purge any gas permeating the conduit walls.
摘要翻译：通过无电极电导率传感器的非金属流提供有具有初级和次级过程流体流动路径以形成流体回路的导管。至少一个驱动器和一个感测环绕环绕流体回路上的导管。提供给驱动环形电极的电压通过流体回路在一定程度上引起电流，以消除与工艺流体接触的金属电极的任何需要。至少一个额外的驱动和/或感测环形线圈设置在流体回路上以增强感应。可选地，一个或多个感测线圈布置在流体回路外部的导管周围以消除杂散的电噪声。沿着管道设置的可选导体通过其电阻的变化来检测任何流体泄漏。温度检测器被支撑在延伸到流体流动路径内的非导电保持器内，使得检测器没有与流体的物理接触。可选的外壳提供有端口，以使用户能够清除渗透导管壁的任何气体。

10. 发明授权

US09179961B2 Methods and apparatus for deploying sheet-like materials 有权
标题翻译：用于部署片状材料的方法和装置
公开(公告)号：US09179961B2
公开(公告)日：2015-11-10
申请号：US12794673
申请日：2010-06-04
申请人： Charles L. Euteneuer , Rebecca McCarville , Duane Frion , Nathaniel Zenz-Olson , Diane M. Feehan , John Quackenbush
发明人： Charles L. Euteneuer , Rebecca McCarville , Duane Frion , Nathaniel Zenz-Olson , Diane M. Feehan , John Quackenbush
IPC分类号： A61B17/88 , A61F2/08 , A61B17/064 , A61B17/068 , A61F2/00 , A61B17/30
CPC分类号： A61B17/8872 , A61B17/0642 , A61B17/0682 , A61B17/88 , A61B2017/303 , A61F2/0063 , A61F2/08 , A61F2/0811 , A61F2002/0072
摘要： Implant delivery systems for delivering sheet-like implants include a delivery shaft, an implant expander, a sheath, and a sheet-like implant. In some embodiments, the delivery shaft has a proximal end and a distal end. The implant expander is mounted to the distal end of the delivery shaft. The implant expander includes a central portion and a plurality of leg portions radiating from the central portion. The implant expander is evertable between an unstressed configuration in which a distal surface of the implant expander defines a concave surface, and a first compact configuration in which the distal surface of the implant expander defines a convex surface. The implant expander has a first lateral extent when the implant expander is free to assume the unstressed configuration. The sheath defines a lumen having a lumen diameter. At least a portion of the delivery shaft is slidably disposed in the lumen. The lumen diameter is smaller than the first lateral extent of the implant expander so that the sheath holds the implant expander in the first compact configuration when slidably disposed therein. The sheet-like implant overlays at least a portion of the distal surface of the implant expander with portions of the sheet-like implant extending between the leg portions of the implant expander and the sheath. Methods of treating a rotator cuff of a shoulder are also disclosed.
摘要翻译：用于递送片状植入物的植入物递送系统包括输送轴，植入物扩张器，护套和片状植入物。在一些实施例中，输送轴具有近端和远端。植入物扩张器安装到输送轴的远端。植入物扩张器包括从中心部分辐射的中心部分和多个腿部。植入物扩张器可以在其中植入物扩张器的远端表面限定凹表面的无应力构型和其中植入物扩张器的远侧表面限定凸表面的第一紧凑构型之间是可转换的。当植入物扩张器自由地呈现不受应力的构型时，植入物扩张器具有第一横向范围。护套限定具有内腔直径的内腔。输送轴的至少一部分可滑动地设置在内腔中。管腔直径小于植入物扩张器的第一横向范围，使得当可滑动地设置在其中时，护套将植入物扩张器保持在第一紧凑构型中。片状植入物覆盖植入物扩张器的远端表面的至少一部分，其中片状植入物的部分在植入物扩张器的腿部和护套之间延伸。还公开了治疗肩肩的肩袖的方法。

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