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    • 3. 发明授权
    • Method for reducing image artifacts produced by a CMOS camera
    • 降低CMOS相机产生的图像伪影的方法
    • US09373158B2
    • 2016-06-21
    • US13813197
    • 2011-07-19
    • Pavel A. FomitchovWitold BulaCarlos ZarateYang Zhang
    • Pavel A. FomitchovWitold BulaCarlos ZarateYang Zhang
    • G06K9/00G06T5/00H04N1/409H04N5/357
    • G06T5/00G06T5/005H04N1/409H04N5/357
    • The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.
    • 本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。 用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。 优选地,该方法还包括校正随机列偏移和增益。 可选地,该方法还包括限制缺陷像素和/或减去暗电流。 当单色图像是荧光图像时,该方法还包括压缩CMOS相机噪声的步骤。 还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统,以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。
    • 4. 发明申请
    • METHOD FOR REDUCING IMAGE ARTIFACTS PRODUCED BY A CMOS CAMERA
    • 降低由CMOS相机产生的图像制品的方法
    • US20130129212A1
    • 2013-05-23
    • US13813197
    • 2011-07-19
    • Pavel A. FomitchovWitold BulaCarlos ZarateYang Zhang
    • Pavel A. FomitchovWitold BulaCarlos ZarateYang Zhang
    • G06T5/00
    • G06T5/00G06T5/005H04N1/409H04N5/357
    • The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.
    • 本发明涉及一种用于减少用作线共焦荧光成像仪的光学检测器的CMOS相机的图像伪影的系统和方法。 用于减少单色图像中的图像伪像的方法包括减去RGB信道偏移不匹配; 并校正每行的随机行偏移量。 优选地,该方法还包括校正随机列偏移和增益。 可选地,该方法还包括限制缺陷像素和/或减去暗电流。 当单色图像是荧光图像时,该方法还包括压缩CMOS相机噪声的步骤。 还提供了一种用于减少来自CMOS照相机的单色图像中的图像伪影的系统,以及用于基于CMOS照相机的线共聚焦荧光显微镜的图像伪像减少系统。
    • 5. 发明申请
    • MICROSCOPY SYSTEM AND METHOD FOR BIOLOGICAL IMAGING
    • 用于生物成像的微观系统和方法
    • US20140140595A1
    • 2014-05-22
    • US14129640
    • 2012-06-27
    • Pavel A. FomitchovWitold Bula
    • Pavel A. FomitchovWitold Bula
    • G02B21/36G06T7/00
    • G02B21/365G01N21/6458G02B21/0076G02B21/008G02B21/16G06T7/0012
    • Microscopy system for biological imaging, comprising an image quality monitoring system for monitoring image quality of an image of a biological sample comprising a biological object selection means arranged to let a user of the system to select one or more Biological Reference Objects (BRO) in the image of the biological sample, and an image quality evaluation means arranged to compare the signal level of image pixels of the one or more BROs with an image background signal level to calculate one or more image quality parameters for the image of the biological sample. The system is arranged to present the image quality parameters to the user as an indication of the image quality specific for the BRO(s).
    • 用于生物成像的显微镜系统,包括用于监测生物样品的图像的图像质量的图像质量监测系统,所述图像质量监测系统包括生物物体选择装置,所述生物物体选择装置被布置为使得所述系统的用户选择所述生物样本中的一个或多个生物参考对象 图像质量评估装置,其被布置为将一个或多个BRO的图像像素的信号电平与图像背景信号电平进行比较,以计算生物样本的图像的一个或多个图像质量参数。 系统被布置为向用户呈现图像质量参数作为对BRO特有的图像质量的指示。