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    • 1. 发明申请
    • Double balanced mixer
    • 双平衡搅拌机
    • US20110312295A1
    • 2011-12-22
    • US13134968
    • 2011-06-22
    • Xin JiangMichael Koechlin
    • Xin JiangMichael Koechlin
    • H04B1/26
    • H03D7/1441H03D7/1408H03D7/1458H03D2200/0013H03D2200/0023H03H7/42
    • An improved double balanced mixer is provided which in one embodiment includes a first balun for receiving a first single input and providing a first balanced output having two ports, a second balun for receiving a second single input and providing a second balanced output having two ports, and a balanced mixer core responsive to the first and second balanced outputs to provide a mixed signal from the first and second single inputs. The first balun includes an RC network coupled between at least one of the ports of the first balanced output and one of ground and a common mode node of the first balun to improve the linearity of the double balanced mixer.
    • 提供了一种改进的双平衡混频器,其在一个实施例中包括用于接收第一单个输入并提供具有两个端口的第一平衡输出的第一平衡 - 不平衡变换器,用于接收第二单个输入并提供具有两个端口的第二平衡输出的第二平衡 - 以及响应于第一和第二平衡输出的平衡混频器核心,以提供来自第一和第二单个输入的混合信号。 第一平衡 - 不平衡变压器包括耦合在第一平衡输出的至少一个端口和地之一的第一平衡 - 不平衡变换器的共模模式节点之间的RC网络,以改善双平衡混频器的线性度。
    • 2. 发明授权
    • Double balanced mixer
    • 双平衡搅拌机
    • US08498604B2
    • 2013-07-30
    • US13134968
    • 2011-06-22
    • Xin JiangMichael Koechlin
    • Xin JiangMichael Koechlin
    • H04B1/26H03D7/14
    • H03D7/1441H03D7/1408H03D7/1458H03D2200/0013H03D2200/0023H03H7/42
    • An improved double balanced mixer is provided which in one embodiment includes a first balun for receiving a first single input and providing a first balanced output having two ports, a second balun for receiving a second single input and providing a second balanced output having two ports, and a balanced mixer core responsive to the first and second balanced outputs to provide a mixed signal from the first and second single inputs. The first balun includes an RC network coupled between at least one of the ports of the first balanced output and one of ground and a common mode node of the first balun to improve the linearity of the double balanced mixer.
    • 提供了一种改进的双平衡混频器,其在一个实施例中包括用于接收第一单个输入并提供具有两个端口的第一平衡输出的第一平衡 - 不平衡变换器,用于接收第二单个输入并提供具有两个端口的第二平衡输出的第二平衡 - 以及响应于第一和第二平衡输出的平衡混频器核心,以提供来自第一和第二单个输入的混合信号。 第一平衡 - 不平衡变压器包括耦合在第一平衡输出的至少一个端口和地之一的第一平衡 - 不平衡变换器的共模模式节点之间的RC网络,以改善双平衡混频器的线性度。
    • 4. 发明授权
    • Generation of vascularized human heart tissue and uses thereof
    • 血管化人心脏组织的产生及其用途
    • US08765117B2
    • 2014-07-01
    • US13375402
    • 2010-06-10
    • Kenneth R. ChienLei BuXin JiangKathy Oi Lan LuiJolanta Chmielowiec
    • Kenneth R. ChienLei BuXin JiangKathy Oi Lan LuiJolanta Chmielowiec
    • A01N63/00G01N33/53
    • C12N5/0662A61K35/12C12N5/0657C12N2501/15C12N2501/165C12N2501/415C12N2506/02
    • The present invention relates to the generation of vascularized human heart tissue from human primordial Islet1-positive (ISL1+) progenitors, and more particularly the generation of vascularized human heart tissue from human primordial Islet1+ cardiovascular stem cells which are positive for markers ISL1+/NKX2.5−/KDR−. One aspect of the invention relates to isolation of human ISL1+ primordial cells from human pluripotent cells, such as human ES cells or other human pluripotent stem cell sources, wherein the human ISL1+ primordial cells can differentiate into three different lineages; cardiomyocyte lineages, endothelial lineages and smooth muscle lineages. Another aspect relates to use and implantation of the human primordial ISL1+ progenitors into an animal model to generate human vascularized heart tissue, and more particularly, the production of an in vivo humanized model of vascular disease. One embodiment relates to the use of an in vivo humanized model of vascular disease as an assay, for example to assess drug toxicity and/or identify agents which increase and decrease coronary blood flow to the human vascularized heart tissue. Another embodiment relates to the therapeutic use of human primordial ISL1+ progenitors, for example, in one embodiment the invention provides methods for the treatment cardiovascular disorders and/or congenital heart disease in a subject comprising transplanting into subjects vascularized human heart tissue generated from human ISL1+ progenitors.
    • 本发明涉及从人原始Islet1阳性(ISL1 +)祖细胞产生血管化人心脏组织,更具体地说,从人原代Islet1 +心血管干细胞产生血管化人心脏组织,其对于标志物ISL1 + / NKX2.5是阳性的 - / KDR-。 本发明的一个方面涉及从人多能细胞例如人ES细胞或其他人多能干细胞来源分离人ISL1 +原始细胞,其中人ISL1 +原始细胞可分化成三种不同谱系; 心肌细胞谱系,内皮谱系和平滑肌谱系。 另一方面涉及将人原始ISL1 +祖细胞用于和植入动物模型中以产生人血管化的心脏组织,更具体地,涉及血管疾病的体内人源化模型的产生。 一个实施方案涉及血管疾病的体内人源化模型的用途作为测定,例如用于评估药物毒性和/或鉴定增加和减少冠心病血液流向人血管化心脏组织的药剂。 另一个实施方案涉及人原始ISL1 +祖细胞的治疗用途,例如,在一个实施方案中,本发明提供了治疗受试者心血管疾病和/或先天性心脏病的方法,所述方法包括移植入受试者从人ISL1 +祖细胞产生的血管化人心脏组织 。
    • 6. 发明申请
    • Screening Methods Involving the Detection of Short-Lived Proteins
    • 涉及短寿命蛋白检测的筛选方法
    • US20120046200A1
    • 2012-02-23
    • US13288772
    • 2011-11-03
    • Xianqiang LiXin Jiang
    • Xianqiang LiXin Jiang
    • C40B30/00C40B30/10
    • C40B30/04C12Q1/6897G01N33/6845
    • A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived from a sample of cells, the sequence from the cDNA library varying within the cell library; contacting the library of cells with a plurality of agents which may affect protein degradation rates; for each agent, selecting cells in the library which express short-lived proteins based on whether the cells have different reporter signal intensities than other cells in the library, the difference being indicative of the selected cells expressing shorter lived fusion proteins than the fusion proteins expressed by the other cells in the library; and characterizing the fusion proteins expressed by the selected cells for each agent.
    • 提供了用于筛选影响蛋白质降解速率的试剂的方法,所述方法包括:获取细胞文库,表达包含报道蛋白的融合蛋白的细胞和由源自下列样品的cDNA文库的序列编码的蛋白质: 细胞,来自cDNA文库的序列在细胞文库内变化; 使细胞库与可能影响蛋白质降解速率的多种试剂接触; 对于每个试剂,基于细胞是否具有与文库中的其他细胞不同的报道信号强度来选择表达短寿命蛋白质的文库中的细胞,所述差异表示选择的表达比所表达的融合蛋白更短的生物融合蛋白的细胞 由图书馆内的其他细胞; 并表征由所选细胞表达的每种试剂的融合蛋白。
    • 10. 发明申请
    • Hybrid marchand/back-wave balun and double balanced mixer using same
    • 混合动力/逆波平衡 - 不平衡转换器和双平衡混频器使用相同
    • US20100231316A1
    • 2010-09-16
    • US12381465
    • 2009-03-12
    • Xin Jiang
    • Xin Jiang
    • H03H7/42H01P5/10
    • H03H7/42H03D7/1408H03D2200/0013H03D2200/0023H03D2200/0074
    • A hybrid Marchand/back-wave balun includes a first pair of coupled sections having a first primary section and first secondary section; a second pair of coupled sections having a second primary section and second secondary section; a first reactance interconnecting the first and second primary sections and a second reactance interconnecting the first and second secondary sections; one of the reactances being open at high frequency and shorted at low frequency, the other reactance being shorted at high frequency and open at low frequency for selectively providing low frequency Marchand/high frequency back-wave function and high frequency Marchand/low frequency back-wave function; and a double balanced mixer using same.
    • 混合Marchand /逆波平衡 - 不平衡变压器包括具有第一初级部分和第一次级部分的第一对耦合部分; 第二对耦合部分,具有第二初级部分和第二次级部分; 互连第一和第二初级部分的第一电抗和互连第一和第二次级部分的第二电抗; 其中一个电抗器在高频下开路,低频短路,另一个电抗在高频下短路,低频开路,选择性地提供低频三角和高频反波功能,高频率三通/低频背波功能, 波函数; 和使用它的双平衡混合器。