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1. 发明授权

US09792555B2 Probabilistic modeling and sizing of embedded flaws in ultrasonic nondestructive inspections for fatigue damage prognostics and structural integrity assessment 有权
公开(公告)号：US09792555B2
公开(公告)日：2017-10-17
申请号：US14106919
申请日：2013-12-16
申请人： Xuefei Guan , Jingdan Zhang , Shaohua Kevin Zhou , Kai Kadau , Yan Guo , El Mahjoub Rasselkorde , Waheed A. Abbasi , Chin-Sheng Lee , Ashley L. Lewis , Steve H. Radke
发明人： Xuefei Guan , Jingdan Zhang , Shaohua Kevin Zhou , Kai Kadau , Yan Guo , El Mahjoub Rasselkorde , Waheed A. Abbasi , Chin-Sheng Lee , Ashley L. Lewis , Steve H. Radke
IPC分类号： G06N7/00 , G06F17/50 , G01N29/44
CPC分类号： G06N7/005 , G01N29/4472 , G01N2203/0066 , G01N2203/0073 , G01N2203/0214 , G01N2291/0258 , G06F17/5009
摘要： A method for probabilistic fatigue life prediction using nondestructive testing data considering uncertainties from nondestructive examination (NDE) data and fatigue model parameters. The method utilizes uncertainty quantification models for detection, sizing, fatigue model parameters and inputs. A probability of detection model is developed based on a log-linear model coupling an actual flaw size with a nondestructive examination (NDE) reported size. A distribution of the actual flaw size is derived for both NDE data without flaw indications and NDE data with flaw indications by using probabilistic modeling and Bayes theorem. A turbine rotor example with real world NDE inspection data is presented to demonstrate the overall methodology.

2. 发明申请

US20140229149A1 PROBABILISTIC MODELING AND SIZING OF EMBEDDED FLAWS IN ULTRASONIC NONDESTRUCTIVE INSPECTIONS FOR FATIGUE DAMAGE PROGNOSTICS AND STRUCTURAL INTEGRITY ASSESSMENT 有权
标题翻译：用于疲劳损伤预处理和结构完整性评估的超声波非结构检查中嵌入式液体的概率建模和尺寸
公开(公告)号：US20140229149A1
公开(公告)日：2014-08-14
申请号：US14106919
申请日：2013-12-16
申请人： Xuefei Guan , Jingdan Zhang , Shaohua Kevin Zhou , Kai Kadau , Yan Guo , El Mahjoub Rasselkorde , Waheed A. Abbasi , Chin-Sheng Lee , Ashley L. Lewis , Steve H. Radke
发明人： Xuefei Guan , Jingdan Zhang , Shaohua Kevin Zhou , Kai Kadau , Yan Guo , El Mahjoub Rasselkorde , Waheed A. Abbasi , Chin-Sheng Lee , Ashley L. Lewis , Steve H. Radke
IPC分类号： G06N7/00 , G06F17/50
CPC分类号： G06N7/005 , G01N29/4472 , G01N2203/0066 , G01N2203/0073 , G01N2203/0214 , G01N2291/0258 , G06F17/5009
摘要： A method for probabilistic fatigue life prediction using nondestructive testing data considering uncertainties from nondestructive examination (NDE) data and fatigue model parameters. The method utilizes uncertainty quantification models for detection, sizing, fatigue model parameters and inputs. A probability of detection model is developed based on a log-linear model coupling an actual flaw size with a nondestructive examination (NDE) reported size. A distribution of the actual flaw size is derived for both NDE data without flaw indications and NDE data with flaw indications by using probabilistic modeling and Bayes theorem. A turbine rotor example with real world NDE inspection data is presented to demonstrate the overall methodology.
摘要翻译：考虑非破坏性检查（NDE）数据和疲劳模型参数的不确定性，使用非破坏性测试数据的概率疲劳寿命预测方法。该方法利用不确定性量化模型进行检测，大小，疲劳模型参数和输入。基于将实际缺陷大小与非破坏性检查（NDE）报告的大小相联系的对数线性模型开发了检测概率。通过使用概率建模和贝叶斯定理，可以为无缺陷指示的NDE数据和缺陷指示的NDE数据导出实际缺陷大小的分布。提出了具有真实世界NDE检测数据的涡轮转子实例，以演示整体方法。

3. 发明申请

US20170275302A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL 审中-公开
公开(公告)号：US20170275302A1
公开(公告)日：2017-09-28
申请号：US15505266
申请日：2015-10-09
申请人： Alexander PASTERNAK , Barbara PIO , Harry R. CHOBANIAN , Zhi-Cai SHI , Shuzhi DONG , Yan GUO , Shawn P. WALSH , Zhiqiang GUO , Ronald D. FERGUSON , Brian CATO , Merck Sharp & Dohme Corp.
发明人： Alexander Pasternak , Barbara Pio , Harry Chobanian , Zhi-Cai Shi , Shuzhi Dong , Yan Guo , Shawn P. Walsh , Zhiqiang Guo , Ronald D. Ferguson II , Brian Cato
IPC分类号： C07D519/00 , A61K31/4985 , C07D471/10 , A61K31/435 , C07D498/10 , A61K31/519 , A61K31/437 , A61K31/4365 , A61K31/4375 , A61K31/4355 , A61K45/06 , A61K31/5025
CPC分类号： C07D519/00 , A61K31/401 , A61K31/407 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/4422 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/55 , A61K45/06 , C07D471/10 , C07D498/10 , A61K2300/00
摘要： The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

4. 发明授权

US08670741B2 Mixer with high second-order and third-order intercept point 失效
标题翻译：混合器具有高二阶和三阶截点
公开(公告)号：US08670741B2
公开(公告)日：2014-03-11
申请号：US13333925
申请日：2011-12-21
申请人： Yan Guo , Patrick T. Clancy , Peter J. Mares
发明人： Yan Guo , Patrick T. Clancy , Peter J. Mares
IPC分类号： H04B1/26
CPC分类号： H03D7/1466 , H03D7/1441 , H03D2200/0023
摘要： Embodiments of apparatuses, systems and methods relating to a mixer having high second- and third-order intercept points are disclosed. Other embodiments may be described and claimed.
摘要翻译：公开了与具有高二级和三级截距点的混合器相关的装置，系统和方法的实施例。可以描述和要求保护其他实施例。

5. 发明申请

US20130165061A1 MIXER WITH HIGH SECOND-ORDER AND THIRD-ORDER INTERCEPT POINT 失效
标题翻译：具有高二级和三级中间点的混合器
公开(公告)号：US20130165061A1
公开(公告)日：2013-06-27
申请号：US13333925
申请日：2011-12-21
申请人： Yan Guo , Patrick T. Clancy , Peter J. Mares
发明人： Yan Guo , Patrick T. Clancy , Peter J. Mares
IPC分类号： H04B1/04 , G06G7/12 , H04B1/06
CPC分类号： H03D7/1466 , H03D7/1441 , H03D2200/0023
摘要： Embodiments of apparatuses, systems and methods relating to a mixer having high second- and third-order intercept points are disclosed. Other embodiments may be described and claimed.
摘要翻译：公开了与具有高二级和三级截距点的混合器相关的装置，系统和方法的实施例。可以描述和要求保护其他实施例。

6. 发明授权

US08465297B2 Self referencing pin 有权
标题翻译：自引脚
公开(公告)号：US08465297B2
公开(公告)日：2013-06-18
申请号：US12890646
申请日：2010-09-25
申请人： Bin Zou , Yan Guo , Robert L. Sankman , Jiangqi He
发明人： Bin Zou , Yan Guo , Robert L. Sankman , Jiangqi He
IPC分类号： H01R12/00
CPC分类号： H01R43/16 , H01L23/49811 , H01L2924/0002 , H01R12/57 , H01R2103/00 , H05K1/0219 , H05K1/0231 , H05K1/0242 , H05K1/0251 , H05K1/113 , H05K2201/09336 , H05K2201/09663 , H05K2201/1031 , Y02P70/611 , Y10T29/49204 , H01L2924/00
摘要： Methods and apparatus relating to self-referencing pins are described. In one embodiment, a pin electrically couples a first agent to a second agent. The pin includes two or more portions that are at least partially separated by an insulator, e.g., to improve crosstalk performance. Other embodiments are also disclosed and claimed.
摘要翻译：描述与自引用引脚相关的方法和装置。在一个实施例中，引脚将第一试剂电耦合到第二试剂。该销包括至少部分地被绝缘体隔开的两个或多个部分，例如，以提高串扰性能。还公开并要求保护其他实施例。

7. 发明申请

US20100083092A1 Dynamic Schema Creation 有权
标题翻译：动态模式创建
公开(公告)号：US20100083092A1
公开(公告)日：2010-04-01
申请号：US12241720
申请日：2008-09-30
申请人： Geoff Schuller , Yan Guo
发明人： Geoff Schuller , Yan Guo
IPC分类号： G06F17/24 , G06F17/30
CPC分类号： G06F17/246 , G06F17/30292 , Y10S707/99942
摘要： In a database application executing on a computer system, a database table view is represented by a structured object located on a storage device coupled to the computer system. Responsive to a user pasting content (e.g., spreadsheet data) onto the view of the table, the database application determines if the content to be pasted extends beyond the number of rows (records in a database) or columns (database fields) currently displayed in the table view. If the content extends beyond the number of rows or columns currently displayed, the database application automatically adds one or more records or fields to the structured object on the storage device, and updates the table view to display one or more rows or columns corresponding to the records or fields added to the structured object.
摘要翻译：在计算机系统上执行的数据库应用程序中，数据库表视图由位于耦合到计算机系统的存储设备上的结构化对象表示。响应于将内容（例如，电子表格数据）粘贴到表的视图上的用户，数据库应用程序确定要粘贴的内容是否超出当前显示的行数（数据库中的记录）或列（数据库字段）表视图。如果内容超出当前显示的行数或列数，则数据库应用程序会自动将一个或多个记录或字段添加到存储设备上的结构化对象，并更新表视图以显示一个或多个对应于添加到结构化对象的记录或字段。

8. 发明申请

US20060276490A1 Thiopyrimidine and isothiazolopyrimidine Kinase Inhibitors 审中-公开
标题翻译：硫嘧啶和异噻唑嘧啶激酶抑制剂
公开(公告)号：US20060276490A1
公开(公告)日：2006-12-07
申请号：US11464961
申请日：2006-08-16
申请人： Michael Michaelides , Lee Arnold , Michael Curtin , Yujia Dai , Steven Davidsen , Robin Frey , Yan Guo , Zhiqin Ji , Neil Wishart
发明人： Michael Michaelides , Lee Arnold , Michael Curtin , Yujia Dai , Steven Davidsen , Robin Frey , Yan Guo , Zhiqin Ji , Neil Wishart
IPC分类号： A61K31/519 , C07D498/02
CPC分类号： C07D495/04 , C07D513/04
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：具有该式的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

9. 外观设计

USD936454S1 Door lock 有权
公开(公告)号：USD936454S1
公开(公告)日：2021-11-23
申请号：US29634641
申请日：2018-01-23
申请人： Yan Guo
设计人： Yan Guo

10. 发明授权

US08153626B2 Substituted diazepine sulfonamides as bombesin receptor subtype-3 modulators 有权
标题翻译：取代的二氮杂类磺酰胺作为铃蟾肽受体亚型-3调节剂
公开(公告)号：US08153626B2
公开(公告)日：2012-04-10
申请号：US12517836
申请日：2007-12-07
申请人： Robert K. Baker , Linda L. Chang , Marc Chioda , Harry R. Chobanian , Ying-Duo Gao , Yan Guo , Linus S. Lin , Ping Liu , Ravi P. Nargund , Kathleen M. Rupprecht , Shouwu Miao
发明人： Robert K. Baker , Linda L. Chang , Marc Chioda , Harry R. Chobanian , Ying-Duo Gao , Yan Guo , Linus S. Lin , Ping Liu , Ravi P. Nargund , Kathleen M. Rupprecht , Shouwu Miao
IPC分类号： A01N43/62 , A61K31/55 , C07D491/00 , C07D513/00 , C07D515/00 , C07D243/10 , C07D487/12
CPC分类号： C07D471/04 , C07D471/14
摘要： Certain novel substituted diazepine sulfonamides are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.
摘要翻译：某些新型取代的二氮杂类磺酰胺是人类bombesin受体的配体，特别是人类bombesin受体亚型-3（BRS-3）的选择性配体。因此，它们可用于治疗，控制或预防对调节BRS-3的疾病和病症，例如肥胖症和糖尿病。

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