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1. 发明授权

US08868165B1 Use of cardiogenic impedance waveform morphology to analyze cardiac conditions and to adjust treatment therapy 有权
标题翻译：使用心源阻抗波形形态分析心脏状况并调整治疗疗法
公开(公告)号：US08868165B1
公开(公告)日：2014-10-21
申请号：US11863516
申请日：2007-09-28
申请人： Yelena Nabutovsky , Dorin Panescu , Weiqun Yang , Mihir Naware
发明人： Yelena Nabutovsky , Dorin Panescu , Weiqun Yang , Mihir Naware
IPC分类号： A61B5/053 , A61B5/04
CPC分类号： A61B5/053 , A61B5/0205 , A61B5/04 , A61B5/042 , A61B5/04525 , A61B5/0538 , A61B5/7246 , A61N1/3627 , A61N1/36521
摘要： In specific embodiments, one or more cardiogenic impedance signal template is stored, where each template has a corresponding morphology. Additionally, one or more cardiogenic impedance signal is obtained using electrodes implanted within a patient, where each signal has a corresponding morphology. The morphology of one or more obtained cardiogenic impedance signal is compared to the morphology of one or more stored template, to determine one or more metric indicative of similarity between the compared morphologies. The one or more metric indicative of similarity is used to analyze the patient's cardiac condition, to discriminate among arrhythmias and/or to adjust a cardiac pacing parameter.
摘要翻译：在具体实施例中，存储一个或多个心源阻抗信号模板，其中每个模板具有对应的形态。另外，使用植入患者体内的电极获得一个或多个心源性阻抗信号，其中每个信号具有相应的形态。将一个或多个获得的心源阻抗信号的形态与一个或多个存储的模板的形态进行比较，以确定指示比较形态之间的相似性的一个或多个度量。使用指示相似性的一个或多个度量来分析患者的心脏状况，区分心律失常和/或调整心脏起搏参数。

2. 发明授权

US08600497B1 Systems and methods to monitor and treat heart failure conditions 有权
标题翻译：监测和治疗心力衰竭病症的系统和方法
公开(公告)号：US08600497B1
公开(公告)日：2013-12-03
申请号：US11558088
申请日：2006-11-09
申请人： Weiqun Yang , Malin Ohlander , Louis Wong , Nils Holmstrom , Cem Shaquer , Euljoon Park , Dorin Panescu , Shahrooz Shahparnia , Andre Walker , Ajit Pillai , Mihir Naware
发明人： Weiqun Yang , Malin Ohlander , Louis Wong , Nils Holmstrom , Cem Shaquer , Euljoon Park , Dorin Panescu , Shahrooz Shahparnia , Andre Walker , Ajit Pillai , Mihir Naware
IPC分类号： A61B5/05 , A61N1/00
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable device monitors and treats heart failure, pulmonary edema, and hemodynamic conditions and in some cases applies therapy. In one implementation, the implantable device applies a high-frequency multi-phasic pulse waveform over multiple-vectors through tissue. The waveform has a duration less than the charging time constant of electrode-electrolyte interfaces in vivo to reduce intrusiveness while increasing sensitivity and specificity for trending parameters. The waveform can be multiplexed over multiple vectors and the results cross-correlated or subjected to probabilistic analysis or thresholding schemata to stage heart failure or pulmonary edema. In one implementation, a fractionation morphology of a sensed impedance waveform is used to trend intracardiac pressure to stage heart failure and to regulate cardiac resynchronization therapy. The waveform also provides unintrusive electrode integrity checks and 3-D impedancegrams.
摘要翻译：植入式装置监测和治疗心力衰竭，肺水肿和血液动力学状况，并且在某些情况下应用治疗。在一个实施方案中，可植入装置通过组织在多个向量上施加高频多相脉冲波形。该波形的持续时间小于体内电极 - 电解质界面的充电时间常数，以降低侵入性，同时增加趋势参数的灵敏度和特异性。波形可以在多个载体上进行复用，并且结果相互关联或进行概率分析或阈值模式以分步心脏衰竭或肺水肿。在一个实施方案中，使用感测阻抗波形的分级形态来趋向心脏内压力来分级心力衰竭并调节心脏再同步治疗。该波形还提供非侵入式电极完整性检查和3-D阻抗图。

3. 发明授权

US08712519B1 Closed-loop adaptive adjustment of pacing therapy based on cardiogenic impedance signals detected by an implantable medical device 有权
标题翻译：基于由可植入医疗设备检测到的心源性阻抗信号的起搏治疗的闭环自适应调整
公开(公告)号：US08712519B1
公开(公告)日：2014-04-29
申请号：US11558194
申请日：2006-11-09
申请人： Dorin Panescu , Weiqun Yang , Louis Wong , Nils Holmstrom , Andre Walker
发明人： Dorin Panescu , Weiqun Yang , Louis Wong , Nils Holmstrom , Andre Walker
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/3684
摘要： Techniques are provided for controlling therapy provided by the implantable cardiac stimulation device based on cardiogenic impedance. A cardiogenic impedance signal (or intracardiac impedance signal) is an impedance signal representative of the beating of the heart of the patient in which the device is implanted. The cardiogenic impedance signal is sensed along a sensing vector passing through at least a portion of the heart so that the sensed impedance is affected by the mechanical beating of the heart along that sensing vector. Pacing therapy is automatically and adaptively adjusted based on the cardiogenic impedance signal. For example, pacing timing parameters such as the atrioventricular delay and the inter-ventricular delay may be adjusted. Preferably, the adjustments are adaptive, i.e. the adjustments are performed in a closed-loop so as to adapt the adjustments to changes in the cardiogenic impedance signal so as to optimize therapy. In one particular example, the adjustments are performed so as to reduce a degree of fractionation within a cardiogenic impedance waveform.
摘要翻译：提供技术用于基于心源性阻抗来控制由可植入心脏刺激装置提供的治疗。心源性阻抗信号（或心内阻抗信号）是表示装置植入的患者的心跳的阻抗信号。沿着通过心脏的至少一部分的感测矢量感测心源性阻抗信号，使得感测到的阻抗受到沿着该感测向量的心脏的机械跳动的影响。基于心源阻抗信号自动调整起搏治疗。例如，可以调整起搏定时参数，例如房室延迟和心室间延迟。优选地，调整是自适应的，即，在闭环中进行调整，以使调整适应于心源阻抗信号的变化，以便优化治疗。在一个具体示例中，执行调整以便降低心源阻抗波形内的分级程度。

4. 发明授权

US07736151B1 Electrical connector for a kitchen appliance 有权
标题翻译：厨房用电器连接器
公开(公告)号：US07736151B1
公开(公告)日：2010-06-15
申请号：US12407330
申请日：2009-03-19
申请人： Weiqun Yang
发明人： Weiqun Yang
IPC分类号： H01R11/30
CPC分类号： H01R13/6205
摘要： An electrical connector for a kitchen appliance includes a socket having at least one electrical contact and at least one metallic member. A plug having at least one electrical contact and a magnet which is movably positioned within the plug. A power cord is movably positioned within the plug and is operatively connected to the at least one electrical contact of the plug. An attractive force exists between the at least one metallic member and the magnet when the plug is engaged with the socket and the magnet is within a predetermined distance of the at least one metallic member. Movement of a leading end of the power cord toward a distal end of the plug moves the magnet toward the distal end of the plug to reduce a magnitude of the attractive force and permit the plug to be more easily removed from the socket.
摘要翻译：用于厨房用具的电连接器包括具有至少一个电接触件和至少一个金属构件的插座。具有至少一个电触头的插头和可移动地定位在插头内的磁体。电源线可移动地定位在插头内并且可操作地连接到插头的至少一个电触头。当插头与插座接合并且磁体在至少一个金属构件的预定距离内时，在至少一个金属构件和磁体之间存在吸引力。电源线的前端朝向插头的远端的移动使磁体朝向插头的远端移动，以减小吸引力的大小，并允许插头更容易地从插座中移除。

5. 发明授权

US5824030A Lead with inter-electrode spacing adjustment 失效
标题翻译：带电极间距调节
公开(公告)号：US5824030A
公开(公告)日：1998-10-20
申请号：US576873
申请日：1995-12-21
申请人： Weiqun Yang , Peter A. Altman
发明人： Weiqun Yang , Peter A. Altman
IPC分类号： A61N1/04 , A61N1/05
CPC分类号： A61N1/056 , A61N1/0563
摘要： A single-pass transvenous lead for atrial sensing and pacing, ventricular sensing and pacing, as well as for ventricular and atrial defibrillation. The lead optimizes the positioning of the electrodes in various patients regardless of variations in these patients' hearts, by enabling independent adjustment of the spacing between various pacing, sensing and defibrillation electrodes, before and after implantation or insertion in the heart. The lead includes an elongated lead body, an outer sheath that extends coaxially with the lead body, and two atrial windows positioned along the outer sheath, adjustable relative to a reference point such as a distal pacing tip. The outer sheath includes an atrial section that is slidably adjustable along the lead body by means of an expandable member.
摘要翻译：用于心房感应和起搏，心室感应和起搏以及心室和心房除颤的单次静脉导管。通过在植入或插入心脏之前和之后，可以独立调整各种起搏，感应和除颤电极之间的间距，从而优化各种患者的电极定位，而不管这些患者心脏的变化。引线包括细长的引线主体，与引线主体同轴延伸的外护套，以及沿着外护套定位的两个心房窗，可相对于诸如远端起搏尖端的参考点调节。外护套包括通过可膨胀构件沿引线主体可滑动地调节的心房部分。

6. 发明授权

US06934584B1 Enhanced power efficiency in implantable cardiac stimulation devices 有权
标题翻译：在植入式心脏刺激装置中提高功率效率
公开(公告)号：US06934584B1
公开(公告)日：2005-08-23
申请号：US10113706
申请日：2002-03-27
申请人： Louis Wong , Weiqun Yang
发明人： Louis Wong , Weiqun Yang
IPC分类号： A61N1/365 , A61N1/37 , A61N1/39
CPC分类号： A61N1/37 , A61N1/3981
摘要： Pacing pulse power efficiency is increased in an implantable cardiac stimulation device. The invention includes a cardiac function sensor for sensing cardiac functions. A controller is coupled to the sensor for determining a required cardiac pacing pulse voltage level. A determining means is coupled to the controller for determining a desired battery voltage multiplication factor as a function of the required pacing pulse voltage level. A setting means is coupled to the determining means for setting a battery voltage multiplier to multiply the battery voltage to a level as close as possible to the required pacing pulse voltage level.
摘要翻译：可植入心脏刺激装置中起搏脉冲功率效率增加。本发明包括用于感测心脏功能的心脏功能传感器。控制器耦合到传感器以确定所需的心脏起搏脉冲电压电平。确定装置耦合到控制器，用于根据所需的起搏脉冲电压电平确定期望的电池电压倍增因子。一个设置装置耦合到确定装置，用于设置电池电压倍增器以将电池电压乘以尽可能接近所需的起搏脉冲电压电平的电平。

7. 发明授权

US06931280B1 Apparatus and method for bi-ventricular pacing and sensing in an implantable device 失效
标题翻译：用于可植入装置中的双心室起搏和感测的装置和方法
公开(公告)号：US06931280B1
公开(公告)日：2005-08-16
申请号：US10074403
申请日：2002-02-11
申请人： Weiqun Yang
发明人： Weiqun Yang
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3684
摘要： An apparatus and method for pacing and sensing the right side as well as the left side of the heart (bi-ventricular pacing and sensing). The bi-ventricular pacing and sensing is accomplished by introducing an additional dedicated pacing and sensing path for the left ventricle of the heart. Two additional terminals are added to the pacing and sensing path for the left ventricle to enable pacing and sensing in the left ventricle of the heart. In addition, switches are added to the pacing path for the left ventricle of the heart. The switches are controlled by a programmable controller and allow the selection of the desired ventricle(s) in which pacing is to occur.
摘要翻译：用于起搏和感测心脏右侧和左侧的装置和方法（双心室起搏和感测）。通过为心脏的左心室引入额外的专用起搏和感测路径来实现双心室起搏和感测。将两个额外的终端添加到左心室的起搏和感测路径中，以使心脏左心室起搏和感测。此外，开关被添加到心脏左心室的起搏路径。开关由可编程控制器控制，并允许选择起搏发生的所需心室。

8. 发明申请

US20110202105A1 BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS 有权
标题翻译：用于可植入器件应用的BIOELECTRIC BATTERY
公开(公告)号：US20110202105A1
公开(公告)日：2011-08-18
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , H01M8/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

9. 发明授权

US08709631B1 Bioelectric battery for implantable device applications 有权
标题翻译：用于植入式设备应用的生物电池
公开(公告)号：US08709631B1
公开(公告)日：2014-04-29
申请号：US11737307
申请日：2007-04-19
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： H01M4/00 , H01M8/16
CPC分类号： A61N1/362 , A61N1/378 , H01M4/466 , H01M4/92 , H01M12/06 , H01M2220/30 , Y02E60/50
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

10. 发明授权

US08574737B2 Bioelectric battery for implantable device applications 有权
标题翻译：用于植入式设备应用的生物电池
公开(公告)号：US08574737B2
公开(公告)日：2013-11-05
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： H01M4/00 , H01M8/16 , H01M4/02 , H01M2/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

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