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1. 发明申请

US20070064220A1 Readhead for optical inspection apparatus 有权
标题翻译：光学检测仪器的读数头
公开(公告)号：US20070064220A1
公开(公告)日：2007-03-22
申请号：US10556299
申请日：2004-06-03
申请人： Nicholas Stock , Gary Ross , David Ledden
发明人： Nicholas Stock , Gary Ross , David Ledden
IPC分类号： G01N21/47 , G01N21/64
CPC分类号： G01N21/251 , G01N21/64 , G01N21/8483
摘要： A readhead for illuminating a sample carrier and receiving light from the sample carrier, including a housing for receiving a sample carrier, an array of light sources mounted within the housing in a fixed position relative to the sample carrier, and including first and second light-emitting diodes for emitting substantially monochromatic light of a two different wavelengths, a light guide mounted in the housing between the light-emitting diodes and the sample carrier, and a light detector coupled to receive light from the sample carrier. The readhead also includes a light source for directing excitation light of a predetermined wavelength to the sample carrier, and a light filter positioned between the sample carrier and the light detector and adapted to prevent passage therethrough of the excitation light. The readhead allows both fluorescence spectroscopy and reflectance spectroscopy to be conducted on the sample carrier.
摘要翻译：一种用于照亮样品载体并从样品载体接收光的读取头，包括用于接收样品载体的壳体，安装在壳体内相对于样品载体固定位置的光源阵列，并且包括第一和第二发光层，用于发射两个不同波长的基本单色光的发光二极管，安装在发光二极管和样品载体之间的壳体中的光导，以及耦合以接收来自样品载体的光的光检测器。读取头还包括用于将预定波长的激发光引导到样品载体的光源，以及位于样品载体和光检测器之间并适于防止激发光通过的滤光器。读数头允许在样品载体上进行荧光光谱和反射光谱。

2. 发明授权

US11612689B2 Injector systems and syringe adapters for use therewith 有权
公开(公告)号：US11612689B2
公开(公告)日：2023-03-28
申请号：US17095450
申请日：2020-11-11
申请人： BAYER HEALTHCARE LLC
发明人： Molly Bingaman , Erin Novickoff , Patrick O'Rourke , Stephen Schulte
IPC分类号： A61M5/145 , A61M5/315 , A61M5/142
摘要： An adapter for releasably attaching a syringe to an injector. The adapter comprises a mounting mechanism positioned at a rear end of the adapter to mount the adapter in a desired position relative to a front wall of the injector; and a syringe carrier section adapted to seat at least a portion of the syringe. The syringe carrier section defines a first opening on a top thereof to allow placement of the syringe therein from the top and a second opening in a rear section thereof to allow the drive member of the injector to communicate forward force to the plunger. A cover portion extends over a rearward end of the first opening and has a first end configured to abut the flange of the syringe when the syringe is positioned within the syringe carrier section.

3. 发明授权

US11598664B2 Injector pressure calibration system and method 有权
公开(公告)号：US11598664B2
公开(公告)日：2023-03-07
申请号：US16621784
申请日：2018-08-28
申请人： BAYER HEALTHCARE LLC
发明人： Michael McDermott , Chelsea Marsh , Michael Spohn , William Barone , Robert Praniewicz , Edden Rabin , Corey Savannah , Vince Delbrugge
IPC分类号： G01F25/17 , A61M5/20 , F16K37/00 , G05D15/01
摘要： A calibration system for calibrating a pressure output of a fluid injector having a housing configured for connecting to the fluid injector; a drive member engagement portion configured for contacting a drive member of the fluid injector; a compressible member, which may have a known modulus of compression, connected at its proximal end to the drive member engagement portion, wherein the compressible member is compressed with movement of the drive member of the fluid injector between a first, uncompressed position and a second, at least partially compressed position of the fluid injector in a distal direction; and a sensor connected to the compressible member is described. The sensor is configured for measuring at least one of a force imparted by the drive member and a displacement of the drive member when the compressible member is in the second, at least partially compressed position. The system may generate a calibration curve for the drive member of the fluid injector and allow the generation of a fault condition. Methods for calibrating a fluid injector are also described.

4. 发明授权

US11564392B2 Methods of inactivation of viruses using n-methlyglucamide and its derivatives 有权
公开(公告)号：US11564392B2
公开(公告)日：2023-01-31
申请号：US16646600
申请日：2018-09-12
申请人： BAYER HEALTHCARE LLC
发明人： Shengjiang Liu , Allison Titong , Wensheng Wang , Nicholas Spadoni
IPC分类号： A01N37/20 , C12N7/00
摘要： This disclosure relates to methods for use in inactivating viruses. The methods of inactivating viruses with N-methylglucamides is applicable to the purification process of biologically-active drugs such as protein subunits, proteins (enzymes, factors, etc.), recombinant proteins, antibodies, vaccine or gene therapeutic products. The detergents used in this method are based on multiple N-methylglucamide homologs, consisting of a hydrophilic glucose moiety and hydrophobic fatty acid tail, linked by an amide bond. Additionally, these sugar-based detergents are nonionic by nature, which do not disrupt the drug protein, plasma biologies, non-enveloped viral vaccine or adeno associated viral particles. A method of purifying a biological product solution of interest having an unidentified enveloped virus contaminant, including incubating a biological product solution of interest with a standard solution, inactivating any potential enveloped virus contaminant present in the biological product solution of step (a), measuring the inactivated virus present in the final solution of step (b), incubating a separate biological product solution of interest with a N-methylglucamide solution, measuring the inactivated virus present in the final solution of step (d), and comparing the results of the final solutions of step (c) and step (e).

5. 发明授权

US11547793B2 Fluid injector with syringe engagement mechanism 有权
公开(公告)号：US11547793B2
公开(公告)日：2023-01-10
申请号：US16341285
申请日：2017-10-16
申请人： BAYER HEALTHCARE LLC
发明人： Kevin Cowan , Michael Spohn , Barry Tucker , James Dedig , Gregory Johnston , Michael McDermott , David Berry , Adam Steege , Keith Lipford , Chet Larrow , Mariano Mumpower , Danica Gordon
IPC分类号： A61M5/145 , A61M5/00 , A61M5/142 , A61M5/24
摘要： An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

6. 发明授权

US11529427B2 Gene editing for hemophilia A with improved factor VIII expression 有权
公开(公告)号：US11529427B2
公开(公告)日：2022-12-20
申请号：US16849796
申请日：2020-04-15
申请人： CRISPR THERAPEUTICS AG , BAYER HEALTHCARE LLC
发明人： Alan Richard Brooks
IPC分类号： C07H21/04 , A61K48/00 , C12N15/113
摘要： Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.

7. 发明申请

US20220375586A1 SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR SMART FLUID INJECTOR PERFORMANCE MONITORING 有权
公开(公告)号：US20220375586A1
公开(公告)日：2022-11-24
申请号：US17770696
申请日：2020-11-19
申请人： BAYER HEALTHCARE LLC
发明人： MICHAEL MCDERMOTT , SAMANTHA PARKER , ROBERT PRANIEWICZ , TYLER SKIRBLE , UTE MCDERMOTT
IPC分类号： G16H40/40 , A61M5/145 , G16H40/63
摘要： A method, system, and computer program product are disclosed for performance monitoring of a smart fluid injector system having at least one sensor configured for detecting operation data. The operation data includes one or more operation parameters associated with at least one of: one or more drive components of the fluid injector system and at least one disposable component configured for use with the fluid injector system. The fluid injector system further includes a control device having at least one processor programmed or configured to: receive the operation data, and determine a component status for at least one of: the drive component(s), the disposable component(s), and administration line(s) by comparing the received operation data with stored operation data. The component status includes one or more predictions of an operation failure or a misuse of at least one of: the drive component(s), the disposable component(s), and administration line(s).

8. 发明申请

US20220339297A1 HUMAN GENE THERAPY METHODS FOR HEMOPHILIA A 有权
公开(公告)号：US20220339297A1
公开(公告)日：2022-10-27
申请号：US17725086
申请日：2022-04-20
申请人： Bayer HealthCare LLC
发明人： Nicole Schmidt , Inge Ivens , Anita Shah , Konstantina Vanevski
IPC分类号： A61K48/00 , A61K38/37 , A61K9/00 , A61P7/04 , C12N15/861
摘要： Methods and materials for effective dosages of AAV gene therapy for the treatment and prophylaxis of hemophilia A.

9. 发明申请

US20220288322A1 Syringe Plunger With Dynamic Seal 有权
公开(公告)号：US20220288322A1
公开(公告)日：2022-09-15
申请号：US17830604
申请日：2022-06-02
申请人： Bayer Healthcare LLC
发明人： Michael Swantner , Michael McDermott
IPC分类号： A61M5/315
摘要： A plunger, a syringe, system, and a method for increasing a seal between a sidewall of a plunger and a sidewall of a syringe are disclosed. The plunger includes a support ring and a cover disposed over and coupled to the support ring. A cavity defining a predetermined volume is defined between the support ring and the cover. The syringe includes a barrel defining an inner wall and the plunger inserted therein.

10. 发明授权

US11419977B2 Self-orienting syringe and syringe interface 有权
公开(公告)号：US11419977B2
公开(公告)日：2022-08-23
申请号：US16369267
申请日：2019-03-29
申请人： BAYER HEALTHCARE LLC
发明人： Kevin Cowan , Arthur Uber, III , Michael Spohn , Barry Tucker , Edward Rhinehart
IPC分类号： A61M5/145 , A61M5/00 , A61M5/14
摘要： A medical injector including at least one syringe port for engaging at least one syringe and having a locking mechanism. The locking mechanism enables the syringe to self-align with the syringe port for locking engagement upon insertion of the syringe into the syringe port and to axially eject the syringe from the port upon rotational disengagement of the syringe from the port.

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