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1. 发明授权

US10765479B2 Method for treatment of varicocele 有权
公开(公告)号：US10765479B2
公开(公告)日：2020-09-08
申请号：US15438471
申请日：2017-02-21
申请人： biolitec Unternehmensbeteiligungs II AG
发明人： Fabio Coluccia
IPC分类号： A61B6/00 , A61B18/24 , A61B8/08 , A61B6/12 , A61B18/00 , A61B90/00
摘要： A minimally invasive method for treating varices in especially sensitive areas, including pelvic varices in females, varicoceles, and also oesophageal varices is presented. The method comprises the steps of making a micro incision into the blood vessels of a patient, endoscopically inserting a catheter device into the blood vessel of a patient and advancing the distal end of the catheter to reach the varix or varices. Insertion can be made in the femoral vein and advanced using a catheter. A first localizer is placed on the distal end of said catheter to allow use of x-ray, angiography, or other imaging techniques to visualize and position the catheter. An optical fiber is then inserted into the catheter and the distal end is advanced to a predetermined point near the varix or varices. A second localizer is present on the distal end of said optical fiber to allow use of x-ray, angiography, or other imaging techniques to visualize and position the optical fiber as well. Optical fiber distal end is preferably a slim, radial 360 degree emitting fiber end. Laser energy of preferably 1470±30 nm is then transmitted to the varix to close the blood vessel. Other wavelengths with similar or greater absorption in blood/water than at 1470 nm are also effective. Imaging techniques such as angiographies may again be performed to confirm closure of the vein. The laser source linked to a radial emitting fiber allows for thermo occlusion of varicoceles using about 2-3 W of emitting power with little or no pain or discomfort for patient. The present invention is an out-patient procedure that requires no anesthesia and minimal recovery time, and does not require that any foreign objects be left in the body. This method has been shown to have a high success rate and minimum pain or side effects for the patient.

2. 发明授权

US10687894B2 Vaginal remodeling/rejuvenation device and method 有权
公开(公告)号：US10687894B2
公开(公告)日：2020-06-23
申请号：US13997554
申请日：2011-12-29
申请人： Gabriel Femopase
发明人： Gabriel Femopase
IPC分类号： A61B18/22 , A61B18/20 , A61B18/00
摘要： A device and method for treating a vagina's anatomic, functional and aesthetic conditions are disclosed. Device comprises a laser energy source which conveys laser energy through an optical fiber handpiece. A cylindrical/penis shaped device/applicator is specially designed for safe and accurate irradiation of determined parts of vaginal mucosa. Applicator has an inner hollow path through which optical fiber is inserted to irradiate interior vaginal tissue. Irradiated mucous tissue contracts, reducing vaginal radius and during penetration in sexual intercourse it embraces penis more tightly. Sensitivity is substantially improved and sexual intercourse is more pleasurable for both partners. In one embodiment, a 1470 nm diode laser source is used. In another embodiment, a vagina's outer dimensions are accurately measured and surgery is performed to achieve dimensions according to certain aesthetic and functional criteria. Minimum pain and risk of side effects are experienced with this ambulatory procedure performable in a physician's office.

3. 发明授权

US09788897B2 Method and device for underskin radiation treatment of adipose tissue 有权
公开(公告)号：US09788897B2
公开(公告)日：2017-10-17
申请号：US12987416
申请日：2011-01-10
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B18/00 , A61B18/20
CPC分类号： A61B18/22 , A61B2018/0019 , A61B2018/00994 , A61B2018/2005 , A61B2018/2272
摘要： The device for carrying out underskin radiation treatment consists of a handpiece that allows easy manipulation by physicians, with a part that can be inserted below the skin and a part that can be held and manipulated outside the body. The part inserted below the skin can be vibrated or oscillated by means of suitable transducers to aid in distributing the radiation. Simultaneously or immediately afterwards, liquefied tissue is aspirated. If convenient, fluid irrigation of the area to be treated can be done. In a preferred embodiment, handpiece consists in a hollow cannula incorporating at least one channel for suction and/or irrigation and a light guiding means in its body/wall section for the purpose of the treatment and liquefaction of adipose tissue. The device further comprises at least one radiation source, included in device part affixed to the handpiece either in a permanent or detachable manner.

4. 发明申请

US20220380388A1 Application of Boron Dipyrromethene Derivatives in Anti-Tumor and Anti-Bacterial Therapy 有权
公开(公告)号：US20220380388A1
公开(公告)日：2022-12-01
申请号：US17774662
申请日：2020-11-05
申请人： biolitec Unternehmensbeteiligungs II AG
发明人： Benjamin Florian Hohlfeld , Arno Wiehe , Burkhard Gitter , Dorika Steen , Gerhard Wieland , Volker Albrecht
IPC分类号： C07F5/02 , A61K41/00 , A61K47/64 , A61K31/69 , A61P35/00
摘要： Biologically active compounds and their methods of preparation are provided that may be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, otorhinolaryngology disorders, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Embodiments also include methods to synthesize boron dipyrromethene complex structures incorporating a substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetrafluorophenyldipyrrin) unit or a substituted 3-nitrophenyl-dipyrromethene (3-nitrophenyl-dipyrrin) unit. Amphiphilic compounds with increased anti-tumour and anti-bacterial efficacy are also provided. Specifically, this is achieved by substitution with bromine atoms and sugar moieties.

5. 发明授权

US10085802B2 Endoluminal laser ablation device and method for treating veins 有权
公开(公告)号：US10085802B2
公开(公告)日：2018-10-02
申请号：US12731525
申请日：2010-03-25
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/20 , A61B18/24 , A61B17/22 , A61B18/22
摘要： An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Additional embodiments include spacing/centering mechanisms to keep emitting end radially equidistant from vein walls. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

6. 发明授权

US10781227B2 Application of metal complexes in anti-tumor and anti-bacterial therapy 有权
公开(公告)号：US10781227B2
公开(公告)日：2020-09-22
申请号：US16266509
申请日：2019-02-04
申请人： biolitec Unternehmensbeteiligungs II AG
发明人： Claudia S. Gutsche , Arno Wiehe , Benjamin F. Hohlfeld , Burkhard Gitter , Volker Albrecht
IPC分类号： C07F15/00 , C07F15/06 , C07F15/02 , C07F15/04 , C07F1/08 , C07F3/06 , C07F5/00 , C07F19/00 , A61K47/64 , A61K41/00 , A61P35/00 , A61P31/04 , A61P19/02 , C07F1/00 , A61K49/00 , C07F3/00 , A61K31/555
摘要： The present invention provides biologically active compounds and methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of non-tumorous indications such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders. As the compounds exhibit also toxicity against targets (tumor cells, bacteria, inflammation-related cells) without light these biologically active compounds may also be used for the light-independent treatment of such indications. Preferred embodiments of the present invention consist of methods to synthesize metal or half-metal complex structures incorporating one or more substituted 2,3,5,6-tetrafluorophenyl-dipyrromethene (2,3,5,6-tetrafluorophenyldipyrrin) units. These dipyrromethenes (dipyrrins) can carry a variety of different substituents in the 4-position enabling a fine tuning of their biological or amphiphilic/hydrophilic properties. Another object of the present invention is to provide amphiphilic compounds with a higher membrane affinity and increased efficacy.

7. 发明授权

US10709896B2 System and method for treating hemorrhoids 有权
公开(公告)号：US10709896B2
公开(公告)日：2020-07-14
申请号：US12976484
申请日：2010-12-22
申请人： Wolfgang Neuberger , Endrick Groenhoff
发明人： Wolfgang Neuberger , Endrick Groenhoff
IPC分类号： A61N5/06 , A61B8/12 , A61N5/067 , A61B8/00
摘要： System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

8. 发明授权

US10422487B2 Fiber optic light source 有权
公开(公告)号：US10422487B2
公开(公告)日：2019-09-24
申请号：US15670067
申请日：2017-08-07
申请人： biolitec unternehmensbeteiligungs II AG
发明人： Wolfgang Neuberger , Alexey Solomatin
IPC分类号： F21K9/64 , F21V8/00 , G02B6/02 , G02B6/42 , H04B10/114 , H04B10/116 , H01S3/067 , G02B27/09
摘要： A fiber optic light source in which input light with short and narrow band wavelength is converted/transformed into multi-band visible white light with high intensity output power is provided. The new light source comprises at least one homogenizing light guide element, and at least one photoluminescence element. It may also comprise at least one input element and an optical fiber. All or some of the elements may be integrated into an optical waveguide. In some embodiments, the at least one input element increases light transfer efficiency from a ray source to the at least one homogenizing light guide element component of the fiber optic light source. The at least one photoluminescence element can be a point or an extended form like a line or surface. The fiber optic light source output beam may also contain the input ray wavelength, which in turn can be from a fiber optic laser. In operation, an input ray travels through at least one homogenizing light guide element and irradiates at least one photoluminescence element present in preselected positions of the device to cause large area or spacious illumination at a desired target. This source can be an information source to communicate information through light modulation not noticeable to the naked human eye. Information is sent from the optical light source to information receivers, technical devices like smart phones, TV-Displays, or other devices, which could replace the common use of LAN or WLAN networks. Here a known luminescent detector can be used to efficiently collect the information in its optical form and to lead it to a suitable photo detector. This enables free-space optical light information transfer especially in areas where traditional infrastructure using transmitting fibers is difficult to establish.

9. 发明授权

US09724069B2 Tissue resection under image guidance/control 有权
公开(公告)号：US09724069B2
公开(公告)日：2017-08-08
申请号：US12976337
申请日：2010-12-22
申请人： Wolfgang Neuberger , Manfred Kistner
发明人： Wolfgang Neuberger , Manfred Kistner
IPC分类号： A61B5/05 , A61B8/08 , A61N5/06 , A61B8/12 , A61B18/24 , A61B18/00 , A61B18/18 , A61B90/00
CPC分类号： A61B8/0841 , A61B8/12 , A61B18/24 , A61B2018/00547 , A61B2018/1807 , A61B2090/3762 , A61B2090/3764 , A61B2090/3784 , A61N5/0601
摘要： An improved method and device for accurate, efficient surgical procedures are disclosed. The disclosed system consists in simultaneously using an elongated member that conveys energy to a treatment site and imaging means to control position of the elongated member and monitor treatment progress in real-time. In a preferred embodiment, for BPH, a twister fiber with a fused cap is used and ultrasound image guidance is obtained using a rectal probe. The method consists in placing an ultrasound rectal probe, fixed by mechanical means, and an optical fiber inserted into urethra. Initial positioning of probe is done under endoscopic/ultrasound control. The twister fiber probe operates in contact-mode. Treatment is monitored, real-time, by the ultrasound device. Additional imaging technologies include Positron Emission Tomography (PET), Computed Tomography (CT) or Optical Coherence Tomography. Other applications include the removal of tumorous (hyperplasic) tissue. Sources include lasers, higher power LEDs or bright lamps and photodynamic therapy.

10. 发明申请

US20230086322A1 STRUCTURED SILICA CLAD SILICA OPTICAL FIBERS 有权
公开(公告)号：US20230086322A1
公开(公告)日：2023-03-23
申请号：US17802495
申请日：2021-02-25
申请人： Biolitec Unternehmensbeteiligungs II AG
发明人： Bolesh J. Skutnik , Wolfgang Neuberger , Andrey B. Grischenko
IPC分类号： H01S3/067 , H01S3/17 , C03B37/027
摘要： A new type of all-silica optical fiber is described; a Structured Silica Clad Silica (SSCS) optical fiber, whose cladding is structured to provide mode mixing within the core; and/or to have an average effective refractive index. Its cross-section is essentially symmetrical, it can be used, among other objects, to provide flatter, more speckle-free outputs from fiber lasers, or other limited mode photonic sources. Building the new fiber structure around a rare earth doped laser core provides a better fiber laser/amplifier for cladding pumping. The structured silica cladding contains paired layers, in which a down doped silica layer is followed by a layer of pure, or lesser down-doped, or even up-dope silica, and die number of paired layers is, typically, from 5 to about 25, and, generally, within the paired layers the ratio of thickness of the higher RI layer of silicate the down-doped silica is very broad, lying between about 0.0625 to about 16, depending on the intended use of the SSCS fibers. In some versions, the main core material can be up-doped silica with pure silica or down-doped silica as the primary second component.

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