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1. 发明申请

US20220008751A1 APPARATUS AND METHOD FOR GATING DELIVERY OF RADIATION BASED ON CAPACITIVE MONITORING OF RESPIRATORY MOTION 有权
公开(公告)号：US20220008751A1
公开(公告)日：2022-01-13
申请号：US17296758
申请日：2019-12-06
申请人： DALHOUSIE UNIVERSITY
发明人： Parisa SADEGHI , James Robar
IPC分类号： A61N5/10
摘要： An apparatus for gating delivery of radiation by a radiation delivery system to a patient is described. The apparatus includes at least one electrode positionable adjacent to but not touching a patient, at least one capacitance sensor electrically connected to the at least one electrode and configured to monitor a capacitance of the at least one electrode and generate an output signal indicative of the capacitance, and at least one processor configured to receive and process the output signal, determine a computed measure of amplitude and/or phase of respiration of the patient, and generate a gating signal for enabling or inhibiting delivery of radiation by the radiation delivery system based on the determined measure of amplitude and/or phase of respiration of the patient.

2. 发明申请

US20190127372A1 S1PR2 ANTAGONISTS AND USES THEREFOR 审中-公开
公开(公告)号：US20190127372A1
公开(公告)日：2019-05-02
申请号：US16234014
申请日：2018-12-27
申请人： DALHOUSIE UNIVERSITY
发明人： Christopher McMaster , Gordon Simms
IPC分类号： C07D471/04 , A61P3/10 , A61P15/00 , C07J31/00 , C07C317/48 , C07C229/24 , A61K31/444 , A61P27/02 , C07F9/38 , A61P25/00 , A61P11/00 , A61P9/12 , A61P19/10 , A61P9/00 , A61P25/28 , A61P9/10 , C07F9/09 , C07F9/6558
摘要： Methods and compositions are provided for the treatment of familial exudative vitreoretinopathy (FEVR) through the administration of a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) antagonist. Also provided herein are compounds which contain bioisosteric replacements of the urea group of JTE-013 and analogs thereof, and their use in treating retinopathies and diseases characterized by insufficient angiogenesis.

3. 发明授权

US09981139B2 Acoustic transmitter and implantable receiver 有权
公开(公告)号：US09981139B2
公开(公告)日：2018-05-29
申请号：US14783675
申请日：2014-05-08
申请人： Dalhousie University
发明人： Robert B. A. Adamson , Jeffrey R. Leadbetter , Jeremy A. Brown , Manohar Bance
IPC分类号： A61N1/378 , H01L41/053 , H01L41/37 , B06B1/06 , A61M1/12 , A61N1/05 , H01L41/113 , A61N1/36 , H01L41/18 , A61M5/142
CPC分类号： A61N1/3787 , A61M1/12 , A61M1/127 , A61M5/14276 , A61M2205/82 , A61M2205/8237 , A61N1/0541 , A61N1/36036 , B06B1/0633 , B06B1/0644 , H01L41/053 , H01L41/113 , H01L41/18 , H01L41/183 , H01L41/37 , H04R2225/31 , H04R2225/67
摘要： Among other things, in general, an acousto-mechanical transducer for the interconversion of electricity and acoustic waves is described. Methods are also described for the construction of such transducers.

4. 发明授权

US09949658B2 Computer-aided localization of site of origin of cardiac activation with discriminator leads 有权
公开(公告)号：US09949658B2
公开(公告)日：2018-04-24
申请号：US15492374
申请日：2017-04-20
申请人： DALHOUSIE UNIVERSITY , BIOSENSE WEBSTER (ISRAEL) LTD.
发明人： John Lewis Sapp, Jr. , Bohumil Milan Horacek , Meir Bar-Tal , Tal Haim Baron
IPC分类号： A61B5/00 , A61B5/0452 , A61B5/04 , A61B5/06 , A61B5/0408 , A61B5/0464 , A61B5/046 , A61B5/044 , A61B5/0472
CPC分类号： A61B5/04525 , A61B5/04012 , A61B5/0408 , A61B5/04085 , A61B5/044 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/061 , A61B5/7246 , A61B5/7267
摘要： A method for quantifying, during pacemapping, a comparison of a BSPM of interest to a pace site BSPM. The method may include receiving at a computing device a plurality of ECG signals from an acquisition system. The pace site BSPM may be calculated using the plurality of ECG signals. The BSPM of interest may be compared to the pace site BSPM, by: retrieving the BSPM of interest from memory accessible by the computing device and, calculating one or more comparison metrics for the BSPM of interest as compared to the pace site BSPM. An indication of similarity between the BSPM of interest and the pace site BSPM based on the comparison metric calculated may be displayed on a user interface in communication with the computing device.

5. 发明授权

US09555156B2 Germanium-based glass polyalkenoate cement 有权
标题翻译：锗基玻璃聚烯烃水泥
公开(公告)号：US09555156B2
公开(公告)日：2017-01-31
申请号：US15136728
申请日：2016-04-22
申请人： DALHOUSIE UNIVERSITY
发明人： Victoria Dickinson , Daniel Boyd , Brett Dickey , Sharon Kehoe
IPC分类号： C08L33/08 , A61L24/12 , C03C3/253 , A61B17/58 , C03C12/00 , A61L24/00 , A61L24/02 , A61L24/04 , C03C3/062 , C03C3/078 , C03C4/00 , A61B17/70 , A61L24/06
CPC分类号： A61L24/12 , A61B17/58 , A61B17/7097 , A61L24/0089 , A61L24/02 , A61L24/046 , A61L24/06 , A61L2400/06 , A61L2430/02 , C03C3/062 , C03C3/078 , C03C3/253 , C03C4/0007 , C03C12/00 , C03C2204/00 , C08L33/08
摘要： Disclosed herein are compositions and methods for making germanium-based glass polyalkenoate cements. Also disclosed are methods for their use as bone cements for bone augmentation procedures.
摘要翻译：本文公开了用于制造锗基玻璃聚烯丙酯水泥的组合物和方法。还公开了它们用作骨增强手术的骨粘固剂的方法。

6. 发明授权

US09101649B2 Phenolic compositions derived from apple skin and uses thereof 有权
标题翻译：衍生自苹果皮肤的酚醛组合物及其用途
公开(公告)号：US09101649B2
公开(公告)日：2015-08-11
申请号：US13696872
申请日：2011-05-10
申请人： Handunkutti Pathirannehalage Vasantha Rupasinghe , George S. Robertson
发明人： Handunkutti Pathirannehalage Vasantha Rupasinghe , George S. Robertson
IPC分类号： A61K31/70 , A61K36/73 , A61K31/19 , A61K31/351 , A61K31/352 , A61K31/353 , A61K31/7034 , A61K31/7048
CPC分类号： A61K36/73 , A61K31/19 , A61K31/351 , A61K31/352 , A61K31/353 , A61K31/7034 , A61K31/7048 , A61K2300/00
摘要： Described herein are phenolic compositions derived from apple skins. In particular, described herein are flavonoid-rich fractions derived from apple skin extract. The compositions are useful in the prevention and treatment of conditions associated with oxidative stress and/or inflammation, including certain neurodegenerative diseases. Methods of producing the compositions are also described.
摘要翻译：本文描述的是衍生自苹果皮的酚类组合物。特别地，本文描述了衍生自苹果皮提取物的富含黄酮的级分。该组合物可用于预防和治疗与氧化应激和/或炎症相关的病症，包括某些神经变性疾病。还描述了制备组合物的方法。

7. 发明申请

US20140248313A1 COMBINATION ADJUVANT FORMULATION 审中-公开
标题翻译：组合辅助配方
公开(公告)号：US20140248313A1
公开(公告)日：2014-09-04
申请号：US13768694
申请日：2013-02-15
申请人： University of Saskatchewan , The University of British Columbia , Dalhousie University , International Vaccine Institute
发明人： Sylvia van den Hurk , Volker Gerdts , Andrew Potter , Lorne Babiuk , Robert Hancock , Scott Halperin , Jennifer Kovacs-Nolan , George Mutwiri , Song Lee , Mi-Na Kweon , Jason Kindrachuk , Melissa Elliott
IPC分类号： A61K39/39 , A61K45/06 , A61K47/30 , A61K39/155
CPC分类号： A61K39/39 , A61K39/099 , A61K39/12 , A61K39/155 , A61K45/06 , A61K47/30 , A61K2039/55516 , A61K2039/55561 , A61K2039/6093 , C07K7/08 , C12N2760/18534
摘要： Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.
摘要翻译：描述了增强对所选抗原的免疫应答的方法和组合物。该方法可用于治疗和预防微生物感染，例如由细菌，病毒，真菌和寄生虫引起的感染。方法和组合物包括宿主防御肽，聚磷腈和免疫刺激序列，以增强对共同施用的抗原的免疫应答。

8. 外观设计

USD692555S1 Respiratory device filter 有权
标题翻译：呼吸装置过滤器
公开(公告)号：USD692555S1
公开(公告)日：2013-10-29
申请号：US29361420
申请日：2010-05-11
申请人： Geoffrey Nicholas Maksym , Ewan Kearney MacKenzie , Christopher Gordon Estkowski , Guy Drapeau
设计人： Geoffrey Nicholas Maksym , Ewan Kearney MacKenzie , Christopher Gordon Estkowski , Guy Drapeau

9. 发明授权

US07796243B2 Detection and monitoring of changes in mineralized tissues or calcified deposits by optical coherence tomography and Raman spectroscopy 有权
标题翻译：通过光学相干断层扫描和拉曼光谱法检测和监测矿化组织或钙化沉积物的变化
公开(公告)号：US07796243B2
公开(公告)日：2010-09-14
申请号：US11148422
申请日：2005-06-09
申请人： Lin-P'ing Choo-Smith , Alex C. T. Ko , Mark Hewko , Lorenzo Leonardi , Blaine Cleghorn , Cecilia Dong
发明人： Lin-P'ing Choo-Smith , Alex C. T. Ko , Mark Hewko , Lorenzo Leonardi , Blaine Cleghorn , Cecilia Dong
IPC分类号： G01N21/00
CPC分类号： A61B5/0066 , A61B5/0088
摘要： Early dental caries detection is carried out by a method that combines optical coherence tomography (OCT) and Raman spectroscopy to provide morphological information and biochemical specificity for detecting and characterizing incipient carious lesions found in extracted human teeth. OCT imaging of tooth samples demonstrated increased light back-scattering intensity at sites of carious lesions as compared to the sound enamel. Raman microspectroscopy and fibre-optic based Raman spectroscopy are used to characterize the caries further by detecting demineralization-induced alterations of enamel crystallite morphology and/or orientation. OCT imaging is useful for screening carious sites and determining lesion depth, with Raman spectroscopy providing biochemical confirmation of caries. The combination is incorporated into a common probe operable without movement to scan the tooth surface and to provide an output for the dentist.
摘要翻译：早期龋齿检测是通过光学相干断层扫描（OCT）和拉曼光谱相结合的方法进行的，以提供形态信息和生物化学特异性，用于检测和表征提取的人牙齿中发现的初期龋病。与搪瓷相比，牙齿样品的OCT成像显示龋损灶部位的光背散射强度增加。拉曼显微光谱和基于光纤的拉曼光谱法用于通过检测软化诱导的釉质微晶形态和/或取向的改变来进一步表征龋齿。 OCT成像可用于筛选龋齿位点和确定病变深度，拉曼光谱提供龋齿的生化确认。该组合被并入通用探针中，其可操作而不移动以扫描牙齿表面并为牙医提供输出。

10. 发明授权

US5985592A Uses for pentoxifylline or functional derivatives/metabolites thereof 失效
标题翻译：用于己酮可可碱或其功能衍生物/代谢物
公开(公告)号：US5985592A
公开(公告)日：1999-11-16
申请号：US870096
申请日：1997-06-05
申请人： Theresa C. Peterson
发明人： Theresa C. Peterson
IPC分类号： A61K31/00 , A61K31/522 , A61K38/00 , A61K45/06 , C12N15/113 , G01N33/68 , C12Q1/02 , C12Q1/00 , C12Q1/50 , G01N33/53
CPC分类号： C12N15/1135 , A61K31/00 , A61K31/522 , A61K45/06 , G01N33/6887 , A61K38/00 , C12N2310/315 , G01N2333/49 , G01N2333/52 , G01N2333/78 , G01N2500/00 , Y10S435/975
摘要： In accordance with the present invention, it has been discovered that monocyte conditioned medium (MCM) obtained from patients with liver disease stimulates the proliferation of fibroblasts. Platelet derived growth factor (PDGF) has also been found to stimulate fibroproliferation of fibroblasts, and to be at least partially responsible for the fibroproliferative effect of the MCM. Further in accordance with the present invention, the effect of MCM and PDGF on the expression of c-fos and c-jun has been investigated, because c-fos and c-jun form AP-1 complexes which can stimulate genes involved in proliferation. It has recently been reported that pentoxifylline inhibits platelet derived growth factor-stimulated proliferation. The mechanism of this action of pentoxifylline is unclear. Thus, in the course of the work undertaken as part of the present invention, studies were conducted to determine whether pentoxifylline altered the expression of c-fos and c-jun. While PDGF was found to induce the expression of both c-fos and c-jun, pentoxifylline was found to effectively reduce the effect of PDGF-induced c-jun gene expression, without altering c-fos gene expression. These results suggest that pentoxifylline inhibits PDGF stimulated proliferation by decreasing c-jun expression. These results further suggest a variety of diseases and/or conditions which may also be successfully treated with pentoxifylline.
摘要翻译：根据本发明，已经发现从肝病患者获得的单核细胞条件培养基（MCM）刺激成纤维细胞的增殖。还发现血小板衍生生长因子（PDGF）刺激成纤维细胞的纤维增生，并且至少部分地负责MCM的纤维增生作用。此外，根据本发明，已经研究了MCM和PDGF对c-fos和c-jun表达的影响，因为c-fos和c-jun形成可以刺激涉及增殖的基因的AP-1复合物。最近报道己酮可可碱抑制血小板衍生生长因子刺激的增殖。己酮可可碱的这种作用的机制尚不清楚。因此，在作为本发明的一部分进行的工作中，进行了研究以确定己酮可可碱是否改变了c-fos和c-jun的表达。当发现PDGF诱导c-fos和c-jun两者的表达时，发现己酮可可碱有效地降低PDGF诱导的c-jun基因表达的作用，而不改变c-fos基因表达。这些结果表明己酮可可碱通过降低c-jun表达来抑制PDGF刺激的增殖。这些结果进一步表明也可以用己酮可可碱成功治疗的各种疾病和/或病症。

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