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1. 发明申请

US20190235036A1 B0 SHIMMING DEVICE FOR MRI 审中-公开
公开(公告)号：US20190235036A1
公开(公告)日：2019-08-01
申请号：US16083973
申请日：2017-01-17
申请人： ETH ZURICH , UNIVERSITAET ZUERICH
发明人： David Brunner , Simon Gross , Klaas Pruessmann
IPC分类号： G01R33/3873 , G01R33/38 , G01R33/54
CPC分类号： G01R33/3873 , G01R33/3804 , G01R33/543
摘要： A magnetic resonance (MR) apparatus comprises magnet means for generating a main magnetic field in a sample region, encoding means for generating encoding magnetic fields superimposed to the main magnetic field, RF transmitter means for generating MR radiofrequency fields, driver means for operating said encoding means and RF transmitter means to generate superimposed time dependent encoding fields and radiofrequency fields according to an MR sequence for forming images or spectra; and acquisition means for acquiring an MR signal from said object. The magnet means comprise a primary magnetic field source providing a static magnetic field B0 and at least one secondary magnetic field source providing an adjustable magnetic field B′. To provide improved shimming, the secondary magnetic field source comprises at least two spatially distinct portions of a first magnetic material and of a second magnetic material, respectively, said first magnetic material having a first magnetic moment density m1 and said second magnetic material having a second magnetic moment density m2, and means for independently adjusting said second magnetic moment density m2 by variation of an external control parameter.

2. 发明申请

US20190126036A1 SYSTEM AND METHOD FOR APPLYING PULSED ELECTROMAGNETIC FIELDS 审中-公开
公开(公告)号：US20190126036A1
公开(公告)日：2019-05-02
申请号：US15571687
申请日：2016-05-05
申请人： National University of Singapore , ETH Zurich
发明人： Alfredo Franco-Obregon , Chuen Neng Lee , Wee Chuan Melvin Loh , Jürg Hans Fröhlich , Christian Beyer , Tien Min David Lai
IPC分类号： A61N1/32 , A61N2/02
摘要： Systems and methods for applying a pulsed electromagnetic fields. A system for applying a pulsed electromagnetic field (PEMF) to a cell, comprising: a sensor for obtaining a characteristic of the cell; a memory module having stored therein a plurality of characteristics and PEMF efficacy window data, each characteristic having its corresponding PEMF efficacy window data; a pulse generator coupled to a set of PEMF coils and configured to generate an output of electrical pulses to drive the set of PEMF coils; and a controller in communication with the sensor, the memory module and the pulse generator, wherein the controller is configured to: retrieve, from the memory module, the PEMF efficacy window data that corresponds to the characteristic of the cell obtained by the sensor; and control the output of the pulse generator based on the retrieved PEMF efficacy window data such that the set of PEMF coils apply a PEMF in accordance with the PEMF efficacy window data.

3. 发明申请

US20180148799A1 SCREENING ASSAY FOR IDENTIFYING miRNA-SPECIFIC DRUG COMPOUNDS 审中-公开
公开(公告)号：US20180148799A1
公开(公告)日：2018-05-31
申请号：US15316488
申请日：2015-06-02
申请人： ETH ZURICH
发明人： Yaakov Benenson , Benjamin Hafliger
IPC分类号： C12Q1/6897
CPC分类号： C12Q1/6897 , C12Q2525/207 , C12Q2545/101
摘要： The present invention relates to a method for identifying miRNA (microRNA)-modulating compounds by contacting a compound of interest with a cell comprising (i) a “miRNA-specific module” that reports specific miRNA target sequence binding by means of a first reporter product; (ii) a “non-specific RNAi module” that reports altered expression of one or more endogenous miRNAs with baseline expression levels in the cell (“non-specific miRNA markers”) by means of a second reporter product; and optionally (iii) a “gene expression module” that reports global changes in gene expression; and subsequent detection of changes in reporter product expression. The advantage of this method is that non-specific miRNA- and/or RNAi-effects of the compound of interest are detected and false positive results due to the structural similarity of different miRNAs and the commonly shared maturation pathway for most miRNAs are substantially reduced over conventional miRNA screening assays.

4. 发明申请

US20230086782A1 BASE EDITOR LACKING HNH AND USE THEREOF 有权
公开(公告)号：US20230086782A1
公开(公告)日：2023-03-23
申请号：US17795316
申请日：2021-01-20
申请人： ETH Zurich
发明人： Gerald SCHWANK , Lukas VILLIGER
IPC分类号： C12N15/90 , C12N15/11 , C12N9/22 , C12N9/78 , C12N15/62
摘要： The present invention relates to a chimeric enzyme comprising a CRISPR class 2 type II enzyme backbone, wherein the HNH domain in the backbone has been replaced, essentially, by a peptide or protein domain having catalytic activity on a single stranded polynucleotide.

5. 发明申请

US20230083353A1 SIMULTANEOUS DISTILLATION AND ALLOYING 有权
公开(公告)号：US20230083353A1
公开(公告)日：2023-03-16
申请号：US17800392
申请日：2021-02-11
申请人： ETH ZURICH
发明人： Christian WEGMANN , Joerg LOEFFLER , Urs GONZENBACH , Leopold BERGER , Philip STURZENEGGER
IPC分类号： B01D3/10 , C22B9/02 , C22B9/00 , C22B9/04
摘要： A device for producing a target material from starting material comprises a chamber, at least one trough, at least a first heating element being configured to heat the chamber such that starting material is vaporized, and at least one collecting vessel being configured to receive a condensate that will constitute the target material. The device optionally comprises at least a first source of negative pressure or at least a first supply device being in connection with the chamber being configured to evacuate the chamber or to supply an inert gas to the chamber. The device further comprises at least one condensation device, wherein said condensation device is configured to condensate the vaporized starting material, whereby the condensate is formed, and/or at least a first gate device being in connection with the chamber such, that the starting material is introducible into the chamber via said first gate device.

6. 发明申请

US20230063565A1 A COMPUTER-IMPLEMENTED METHOD FOR IDENTIFYING AND LOCALIZING RADIATION EVENTS AND A PIXILATED RADIATION DETECTOR FOR CARRYING OUT THE METHOD 有权
公开(公告)号：US20230063565A1
公开(公告)日：2023-03-02
申请号：US17797316
申请日：2021-02-03
申请人： ETH Zurich
发明人： Max Ludwig AHNEN , Jannis Nikolaus Rudolf FISCHER
IPC分类号： G01T1/20 , A61B6/00
摘要： A computer-implemented method (200) of radiation events localizations is indicated for a pixelated radiation detector (10) having a scintillator array (24) of scintillator array elements (26) arranged in an (m)×(n) array, and an optical sensor array (28) of optical sensors (30) arranged in a (q)×(z) array and coupled to the scintillator array (24) in light sharing mode. The method includes the steps of sampling (72) spatial intensity distributions of scintillation photons emitted by the scintillator array (24) in response to multiple incident radiation events; performing a clustering analysis (76) based on the sampled spatial intensity distributions, to obtain clusters (84) of radiation events attributed to scintillator array elements (26), wherein the dimension of the sampled spatial intensity distributions correspond to the (q)×(z) dimensions of the optical sensor array (28), and determining the localization of the radiation events based on the clustering analysis (76).

7. 发明授权

US11591071B2 Controlled flight of a multicopter experiencing a failure affecting an effector 有权
公开(公告)号：US11591071B2
公开(公告)日：2023-02-28
申请号：US17195744
申请日：2021-03-09
申请人： ETH Zurich
发明人： Mark W. Mueller , Sergei Lupashin , Raffaello D'Andrea , Markus Waibel
IPC分类号： G05D1/00 , G05D1/08 , G05D3/00 , G06F7/00 , B64C13/24 , B64C27/20 , B64C39/02 , B64C27/08 , B64D45/00 , B64C27/32
摘要： According to a first aspect of the invention, there is provided a method for operating a multicopter experiencing a failure during flight, the multicopter comprising a body, and at least four effectors attached to the body, each operable to produce both a torque and a thrust force which can cause the multicopter to fly when not experiencing said failure. The method may comprise the step of identifying a failure wherein the failure affects the torque and/or thrust force produced by an effector, and in response to identifying a failure carrying out the following steps, (1) computing an estimate of the orientation of a primary axis of said body with respect to a predefined reference frame, wherein said primary axis is an axis about which said multicopter rotates when flying, (2) computing an estimate of the angular velocity of said multicopter, (3) controlling one or more of said at least four effectors based on said estimate of the orientation of the primary axis of said body with respect to said predefined reference frame and said estimate of the angular velocity of the multicopter. The step of controlling one or more of said at least four effectors may be performed such that (a) said one or more effectors collectively produce a torque along said primary axis and a torque perpendicular to said primary axis, wherein (i) the torque along said primary axis causes said multicopter to rotate about said primary axis, and (ii) the torque perpendicular to said primary axis causes said multicopter to move such that the orientation of said primary axis converges to a target orientation with respect to said predefined reference frame, and (b) such that said one or more effectors individually produce a thrust force along said primary axis.

8. 发明授权

US11539516B2 Encoding and decoding information in synthetic DNA with cryptographic keys generated based on polymorphic features of nucleic acids 有权
公开(公告)号：US11539516B2
公开(公告)日：2022-12-27
申请号：US16757847
申请日：2018-09-25
申请人： ETH ZURICH
发明人： Robert N. Grass , Wendelin Jan Stark
IPC分类号： H04L29/06 , G06F21/00 , H04L9/08 , G16B20/20 , G16B30/00 , H04L9/06 , H04L9/30
摘要： The invention is notably directed to a method for encoding information. This method first comprises generating an encryption key according to polymorphic features of nucleic acids from one or more entities. Next, information is encrypted based on the generated key. Finally, the encrypted information is encoded into synthetic DNA. Another aspect concerns a method for retrieving information. Consistently with the above encoding scheme, synthetic DNA in provided, which encodes encrypted information. Such information is read by sequencing the synthetic DNA and by decrypting the information read using a decryption key. The latter is generated according to polymorphic features of nucleic acids from one or more entities (e.g., from the legitimate individual(s) requesting access to information). Thus, the encoded information cannot be interpreted unless a suitable decryption key is available. The invention is further directed to related DNA samples and systems, including DNA vaults.

9. 发明申请

US20220389659A1 MICROFIBRILLATED CELLULOSE-LOADED FOAM, METHOD OF PRODUCING SUCH FOAM AND USE OF SUCH A FOAM 有权
公开(公告)号：US20220389659A1
公开(公告)日：2022-12-08
申请号：US17771233
申请日：2020-10-16
申请人： Weidmann Holding AG , ETH Zurich
发明人： Erich Josef WINDHAB , Judith WEMMER , Stefan TRUNIGER , Nadine PENEDER
IPC分类号： D21H11/18 , D21H21/56 , C08J9/30 , C08J9/00
摘要： A microfibrillated cellulose-loaded foam is indicated, comprising microfibrillated cellulose, at least one thickening agent and/or at least one adhesive biopolymer. Furthermore, a method for producing such a microfibrillated cellulose-loaded foam and a use of such a foam are provided.

10. 发明授权

US11472102B2 Core-shell nozzle for three-dimensional printing and method of use 有权
公开(公告)号：US11472102B2
公开(公告)日：2022-10-18
申请号：US16467412
申请日：2017-12-05
申请人： President and Fellows of Harvard College , ETH Zurich (Swiss Federal Institute of Technology)
发明人： Jennifer A. Lewis , Jochen Mueller , Jordan R. Raney , Kristina Shea
IPC分类号： B29C64/209 , B33Y10/00 , B33Y30/00 , B29C64/118 , B33Y70/00 , B29C64/106 , B33Y80/00
摘要： In one aspect, the present disclosure provides a nozzle for 3-D printing. The nozzle may include a first nozzle tip defining a first outlet, where the first nozzle tip includes a first channel extending therethrough. The nozzle may further include a second nozzle tip defining a second outlet, where the second nozzle tip includes a second channel extending therethrough, and where the first channel surrounds the second outlet. The second nozzle tip may be retracted longitudinally with respect to the first nozzle tip such that the second outlet of the second nozzle tip is located in the first channel.

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