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1. 发明授权

US11604200B2 Power off delay system and method 有权
公开(公告)号：US11604200B2
公开(公告)日：2023-03-14
申请号：US17813877
申请日：2022-07-20
申请人： Leica Biosystems Imaging, Inc.
发明人： Nicholas Newberg , Benjamin Siehl , Markus Wittmann , Markus Sharpe
IPC分类号： G01N35/00 , G01N35/04 , G02B21/26 , G02B21/34 , H02J9/06
摘要： A power off delay system and method is configured to delay termination of electrical power to a digital pathology device in a power off condition. If the apparatus includes a UPS, the power off delay system and method delays termination of electrical power when a power switch is turned off and when a catastrophic power failure occurs. During the delay of the termination of electrical power, the digital pathology device is configured to control the scanning stage system and the glass slide conveyor system and the slide rack conveyor system to place each of these systems into a known state and position all glass slides into a known position prior to the termination of electrical power to the digital pathology device. This allows the digital pathology device to resume normal operation upon power up.

2. 发明授权

US11454781B2 Real-time autofocus focusing algorithm 有权
公开(公告)号：US11454781B2
公开(公告)日：2022-09-27
申请号：US17085962
申请日：2020-10-30
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Allen Olson , Kiran Saligrama , Yunlu Zou , Peyman Najmabadi
IPC分类号： G02B7/38 , G02B21/02 , G02B21/26 , G02B7/09 , G02B21/36 , H04N5/232
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.

3. 发明申请

US20220277440A1 USER-ASSISTED ITERATION OF CELL IMAGE SEGMENTATION 有权
公开(公告)号：US20220277440A1
公开(公告)日：2022-09-01
申请号：US17634212
申请日：2020-09-02
申请人： Leica Biosystems Imaging, Inc.
发明人： Carlos Luna , Caitriona Lyons
IPC分类号： G06T7/00 , G06T7/11
摘要： A segmentation of cell image data obtains cell segmentation data for the nuclei, cytoplasm and cell membranes, which are displayed on an image pane. A data pane is also displayed which contains a table with rows specific to cells and columns specific to cell attributes. In an editing session, a user can select cells for deletion either from the data pane or the image pane. Responsive to a selection via the data pane, the image pane is updated and responsive to a selection via the image pane, the data pane is updated. At any time, the user can command a re-segmentation taking account of the edits, which starts from a version of the previous nuclear segmentation data which has been edited to remove data relating to cells selected for deletion and then from that determines the cytoplasm and cell membrane segmentation data.

4. 发明申请

US20220196686A1 SLIDE INVENTORY AND REINSERTION SYSTEM 有权
公开(公告)号：US20220196686A1
公开(公告)日：2022-06-23
申请号：US17572595
申请日：2022-01-10
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Nicholas Newberg , Prentash Djelosevic , Aaron Stearrett , Peyman Najmabadi
IPC分类号： G01N35/00 , G01V8/12 , G01N21/84
摘要： A slide rack inventory and reinsertion system for use with a digital slide scanning apparatus is provided that determines, prior to scanning of glass slides in a slide rack, a status of each slot in the slide rack as properly occupied, improperly occupied, or empty. The system also determines whether a slide that has been removed from the slide rack for processing has been properly reinserted into the slide rack.

5. 发明申请

US20220076410A1 COMPUTER SUPPORTED REVIEW OF TUMORS IN HISTOLOGY IMAGES AND POST OPERATIVE TUMOR MARGIN ASSESSMENT 有权
公开(公告)号：US20220076410A1
公开(公告)日：2022-03-10
申请号：US17415396
申请日：2020-05-29
申请人： Leica Biosystems Imaging, Inc.
发明人： Walter Georgescu
IPC分类号： G06T7/00 , G06K9/00 , G06K9/62 , G16H30/40 , G06N3/08
摘要： A computer apparatus and method for identifying and visualizing tumors in a histological image and measuring a tumor margin are provided. A CNN is used to classify pixels in the image according to whether they are determined to relate to non-tumorous tissue, or one or more classes for tumorous tissue. Segmentation is carried out based on the CNN results to generate a mask that marks areas occupied by individual tumors. Summary statistics for each tumor are computed and supplied to a filter which edits the segmentation mask by filtering out tumors deemed to be insignificant. Optionally, the tumors that pass the filter may be ranked according to the summary statistics, for example in order of clinical relevance or by a sensible order of review for a pathologist. A visualization application can then display the histological image having regard to the segmentation mask, summary statistics and/or ranking. Tumor masses extracted by resection are painted with an ink to highlight its surface region. The CNN is trained to distinguish ink and no-ink tissue as well as tumor and no-tumor tissue. The CNN is applied to the histological image to generate an output image whose pixels are assigned to the tissue classes. Tumor margin status of the tissue section is determined by the presence or absence of tumor-and-ink classified pixels. Tumor margin involvement and tumor margin distance are determined by computing additional parameters based on classification-specified inter-pixel distance parameters.

6. 发明申请

US20210368087A1 CAMERA EXPOSURE CONTROL WHEN ACQUIRING FLUORESCENT IN SITU HYBRIDIZATION IMAGES 有权
公开(公告)号：US20210368087A1
公开(公告)日：2021-11-25
申请号：US17281534
申请日：2019-10-23
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Karl RATCLIFF
IPC分类号： H04N5/235 , G06T7/00 , G06T5/20
摘要： A fluorescence in situ hybridization, FISH, image acquisition apparatus and a method for controlling a FISH image acquisition apparatus. A FISH probe image is acquired (S24, S44). Image processing using morphological operations is applied to identify areas of interest around locations of elevated image intensity. From this, a mask is generated (S22, S42) which filters out all but the areas of interest. The mask is applied to determine image intensity in the areas of interest. If the image intensity does not have a desired value (S26), indicating incorrect exposure of the image, then the method is repeated with one or more different exposures until an adequately exposed FISH probe image is obtained (S29, S47, S48). The correct exposure is determined either empirically by iteratively applying stepwise increases (S28), or analytically by applying a formula (S46).

7. 发明授权

US11106726B2 Systems and methods for an image repository for pathology 有权
公开(公告)号：US11106726B2
公开(公告)日：2021-08-31
申请号：US16902086
申请日：2020-06-15
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Ole Eichhorn , Dirk Soenksen
IPC分类号： G06F16/58 , G06F16/54 , G06Q10/10 , G06Q30/06 , G16H30/20 , G16H30/40 , G16H70/00 , G06Q20/14 , G16Z99/00
摘要： Systems and methods for managing an image repository for pathology. In an embodiment, a search request is received. One or more digital slide images are identified from an image repository based on the search request. A user is provided access to the identified digital slide images. In addition, each of a plurality of collections of digital slide images are associated with a search rating, and a value for each of the plurality of collections is computed based on the associated search rating and a size of the collection.

8. 发明申请

US20210048606A1 REAL-TIME AUTOFOCUS FOCUSING ALGORITHM 有权
公开(公告)号：US20210048606A1
公开(公告)日：2021-02-18
申请号：US17085962
申请日：2020-10-30
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Allen OLSON , Kiran SALIGRAMA , Yunlu ZOU , Peyman NAJMABADI
IPC分类号： G02B7/38 , G02B21/02 , G02B21/26 , G02B7/09 , G02B21/36
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.

9. 发明授权

US10823936B2 Real-time autofocus focusing algorithm 有权
公开(公告)号：US10823936B2
公开(公告)日：2020-11-03
申请号：US16601355
申请日：2019-10-14
申请人： Leica Biosystems Imaging, Inc.
发明人： Allen Olson , Kiran Saligrama , Yunlu Zou , Peyman Najmabadi
IPC分类号： G02B7/38 , G02B21/02 , G02B21/26 , G02B7/09 , G02B21/36 , H04N5/232
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.

10. 发明授权

US10732394B2 Managing plural scanning devices in a high-throughput laboratory environment 有权
公开(公告)号：US10732394B2
公开(公告)日：2020-08-04
申请号：US16205011
申请日：2018-11-29
申请人： Leica Biosystems Imaging, Inc.
发明人： Timothy Dailey , Aaron Stearrett
IPC分类号： G06F15/16 , G02B21/00 , G06F9/4401 , G01N35/00
摘要： Systems and methods for managing a plurality of scanning devices in a high-throughput laboratory environment. Each of the scanning devices is configured for a remote boot operation from an administrative server that is communicatively coupled with the plurality of scanning devices via a local network. The remote boot replaces the complete operational firmware of a scanning device. The scanning devices are each configured to periodically provide operational information to the administrative server for centralized storage. The centralized storage of operational information for each of the plurality of scanning devices, coupled with the ability of the administrative server to initiate a reboot of any scanning device and thereby update the complete operational firmware of the scanning device, allows for centralized administration of multiple scanning devices that facilitates configuration, support, image data storage, and/or communication with outside servers.

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