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1. 发明授权

US11614363B2 Digital pathology color calibration and validation 有权
公开(公告)号：US11614363B2
公开(公告)日：2023-03-28
申请号：US17086099
申请日：2020-10-30
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Allen Olson
IPC分类号： G06T7/80 , G06T7/33 , G06T7/90 , G06T7/00 , G06V10/75 , G01J3/46 , G01J3/50 , G01N1/30 , G01J1/08 , G01J3/10 , G01J3/28 , G02B21/32 , G01N21/27 , G02B21/36 , G06T3/00 , G06T3/40
摘要： Color calibration for digital pathology is provided. A standard glass slide is prepared with a specimen having zero or more stains. The specimen is scanned a first time using a hyperspectral imaging system to produce a first digital image having XYZ color values. The specimen is scanned a second time using a digital pathology imaging system to produce a second digital image having RGB color values. The first and second digital images are then registered against each other to align the digital image data. Individual pixels of the first and second images may be combined in the registration process so that the first and second digital images have substantially similar pixel sizes. A lookup table is generated to associate XYZ color values to RGB color values. Once the lookup table has been generated, it can be used to present RGB color on a display using the corresponding XYZ color.

2. 发明申请

US20220163779A1 REAL-TIME FOCUSING IN LINE SCAN IMAGING 有权
公开(公告)号：US20220163779A1
公开(公告)日：2022-05-26
申请号：US17650221
申请日：2022-02-07
申请人： Leica Biosystems Imaging, Inc.
发明人： Yunlu Zou , Gregory Crandall , Allen Olson
IPC分类号： G02B21/00 , G02B21/24 , G02B21/36
摘要： Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.

3. 发明授权

US10930241B2 Color monitor settings refresh 有权
公开(公告)号：US10930241B2
公开(公告)日：2021-02-23
申请号：US16206478
申请日：2018-11-30
申请人： Leica Biosystems Imaging, Inc.
发明人： Allen Olson , Ruben Campos Zurriaga , Reiner Jung
IPC分类号： G09G5/00 , G09G5/02 , G02B21/36
摘要： Described herein are systems and methods that place a known color monitor (known by unique serial number or SKU) into a desired state for displaying digital pathology image data. Using an application programming interface, any color monitor that implements MCCS can be calibrated and characterized immediately before each display of digital pathology image data and can also be periodically reset (if needed) during display of digital pathology image data.

4. 发明授权

US10852523B2 Real-time autofocus scanning 有权
公开(公告)号：US10852523B2
公开(公告)日：2020-12-01
申请号：US16674742
申请日：2019-11-05
申请人： Leica Biosystems Imaging, Inc.
发明人： Leng-Chun Chen , Allen Olson , Yunlu Zou , Peyman Najmabadi , Greg Crandall
IPC分类号： G02B21/24 , G02B21/00 , G06T7/50 , H04N5/372
摘要： Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true-Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.

5. 发明授权

US10740896B2 Processing of histology images with a convolutional neural network to identify tumors 有权
公开(公告)号：US10740896B2
公开(公告)日：2020-08-11
申请号：US16230820
申请日：2018-12-21
申请人： Leica Biosystems Imaging, Inc.
发明人： Walter Georgescu , Allen Olson , Bharat Annaldas , Darragh Lawler , Kevin Shields , Kiran Saligrama , Mark Gregson
IPC分类号： G06T7/00 , G06K9/00 , G06N3/08 , G06N5/04 , G16H30/20 , G06N20/00 , G06K9/62 , G06K9/46
摘要： A convolutional neural network (CNN) is applied to identifying tumors in a histological image. The CNN has one channel assigned to each of a plurality of tissue classes that are to be identified, there being at least one class for each of non-tumorous and tumorous tissue types. Multi-stage convolution is performed on image patches extracted from the histological image followed by multi-stage transpose convolution to recover a layer matched in size to the input image patch. The output image patch thus has a one-to-one pixel-to-pixel correspondence with the input image patch such that each pixel in the output image patch has assigned to it one of the multiple available classes. The output image patches are then assembled into a probability map that can be co-rendered with the histological image either alongside it or over it as an overlay. The probability map can then be stored linked to the histological image.

6. 发明授权

US09366628B2 Standardizing fluorescence microscopy systems 有权
标题翻译：标准化荧光显微镜系统
公开(公告)号：US09366628B2
公开(公告)日：2016-06-14
申请号：US14586337
申请日：2014-12-30
申请人： Leica Biosystems Imaging, Inc.
发明人： Gregory Crandall , Allen Olson
IPC分类号： G01D18/00 , G01N21/64 , G06T5/00 , G06T5/40 , G01N21/27 , G02B21/36 , G06T7/00 , G01J3/44 , G01J3/02
CPC分类号： G01N21/64 , G01J3/0235 , G01J3/0264 , G01J3/027 , G01J3/4406 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/6471 , G02B21/365 , G06T5/009 , G06T5/40 , G06T7/74 , G06T7/80 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064
摘要： Systems and methods for standardizing one or more fluorescence scanning instruments to a reference system by separating the effects of drift and normalization. In an embodiment, a drift image comprising an image of a drift reference slide is captured by a system to be standardized. A drift measurement is calculated using the drift image. A first normalization image comprising an image of a normalization slide is also captured by the system to be standardized. A reference normalization image, also comprising an image of the normalization slide, is captured by a reference system. The first normalization image is compared to the reference normalization image to determine a gamma value and offset value for the system to be standardized.
摘要翻译：通过分离漂移和归一化的影响将一个或多个荧光扫描仪器标准化到参考系统的系统和方法。在一个实施例中，包括漂移参考滑块的图像的漂移图像由待标准化的系统捕获。使用漂移图像计算漂移测量。包括标准化幻灯片的图像的第一标准化图像也被要标准化的系统捕获。还包括归一化幻灯片的图像的参考归一化图像由参考系统捕获。将第一归一化图像与参考归一化图像进行比较，以确定要标准化的系统的伽马值和偏移值。

7. 发明授权

US09019546B2 Image processing of digital slide images based on a macro 有权
标题翻译：基于宏的数字幻灯片图像的图像处理
公开(公告)号：US09019546B2
公开(公告)日：2015-04-28
申请号：US14310117
申请日：2014-06-20
申请人： Leica Biosystems Imaging, Inc.
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K15/00 , G06K9/46 , G06T1/00 , G06F3/12
CPC分类号： G06K9/46 , G06T1/00
摘要： Method, systems, and media for processing a digital slide image. In an embodiment, an identification of a macro, representing a plurality of algorithms, and an identification of digital slide image(s) are received over a network. Parameter data is obtained for the identified macro, and the digital slide image(s) are retrieved. The plurality of algorithms represented by the identified macro are executed on the digital slide image(s) according to the parameter data.
摘要翻译：用于处理数字幻灯片图像的方法，系统和媒体。在一个实施例中，通过网络接收表示多个算法的宏的标识和数字幻灯片图像的标识。获得用于所识别的宏的参数数据，并且检索数字幻灯片图像。由所识别的宏表示的多个算法根据参数数据在数字幻灯片图像上执行。

8. 发明授权

US11385713B2 Eye-tracking image viewer for digital pathology 有权
公开(公告)号：US11385713B2
公开(公告)日：2022-07-12
申请号：US17281907
申请日：2019-12-19
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Allen Olson , Kiran Saligrama
IPC分类号： G06F3/01 , G16H40/67 , G16H30/20 , G06F3/0485 , G16H50/20
摘要： Image viewing in digital pathology using eye-tracking. In an embodiment, a position of a user's gaze on a graphical user interface, comprising at least a portion of a digital slide image within a macro view, is repeatedly detected based on an output from an eye-tracking device. After detecting a change of the user's gaze from a first position to a second position on the graphical user interface, a view of the digital slide image within the macro view is automatically panned based on the second position, so as to move a position on the digital slide image that corresponds to the second position on the graphical user interface toward a center of the macro view.

9. 发明授权

US10459193B2 Real-time autofocus focusing algorithm 有权
公开(公告)号：US10459193B2
公开(公告)日：2019-10-29
申请号：US16147448
申请日：2018-09-28
申请人： Leica Biosystems Imaging, Inc.
发明人： Allen Olson , Kiran Saligrama , Yunlu Zou , Peyman Najmabadi
IPC分类号： G02B7/38 , G02B21/02 , G02B21/26 , G02B7/09 , G02B21/36 , H04N5/232
摘要： A digital scanning apparatus is provided that includes imaging and focusing sensors and a processor to analyze the image data captured by the imaging and focusing sensors and adjust the focus of the scanning apparatus in real time during a scanning operation. The individual pixels of the imaging sensor are all in the same image plane with respect to the optical path of the digital scanning apparatus. The individual pixels of the focusing sensor are each in a different image plane with respect to the optical path, and one pixel of the focusing sensor is on the same image plane as the image sensor. The processor analyzes image data from the imaging sensor and the focusing sensor and determines a distance and direction to adjust the relative position of an objective lens and a stage of the digital scanning apparatus to achieve optimal focus during the scanning operation.

10. 发明申请

US20150130920A1 REAL-TIME FOCUSING IN LINE SCAN IMAGING 有权
标题翻译：实时聚焦在线扫描成像
公开(公告)号：US20150130920A1
公开(公告)日：2015-05-14
申请号：US14398443
申请日：2013-03-13
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： Yunlu Zou , Greg J. Crandall , Allen Olson
IPC分类号： G02B21/00 , G02B21/36
CPC分类号： G02B21/006 , G02B21/245 , G02B21/361 , G02B21/365
摘要： Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.
摘要翻译：使用成像线传感器和聚焦线传感器捕获幻灯片的数字图像的系统和方法。在一个实施例中，分束器光学耦合到物镜并且被配置为通过物镜接收样品的一部分的一个或多个图像。分束器同时将一个或多个图像的第一部分提供给聚焦传感器，并将一个或多个图像的第二部分提供给成像传感器。处理器控制舞台和/或物镜，使得一个或多个图像的每个部分在被成像传感器接收之前由聚焦传感器接收。以这种方式，可以在使用成像传感器捕获样本的一部分的图像之前，使用从聚焦传感器接收的数据来控制物镜的焦点。

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