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1. 发明申请

US20200368425A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20200368425A1
公开(公告)日：2020-11-26
申请号：US16986544
申请日：2020-08-06
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/145 , A61M5/172 , A61M5/20 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , A61M5/142
摘要： The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

2. 发明授权

US10463847B2 Infusion set 有权
公开(公告)号：US10463847B2
公开(公告)日：2019-11-05
申请号：US14737204
申请日：2015-06-11
申请人： STEADYMED LTD.
发明人： Assaf Shaked , Inna Dekel , Jonathan Guillaume Jamin , Stephen Edward Augustyn , Stewart Maddison Fox , Peter Noymer
IPC分类号： A61M39/12 , A61M5/168 , A61M5/14 , A61M5/145 , A61M39/08 , A61M5/36 , A61M5/50 , A61M39/10
摘要： An exemplary infusion set includes a tubing, a first connector, and a second connector. The first connector connects a first terminus of the tubing to an exit port of an infusion pump, providing fluid communication between fluid being conveyed by the infusion pump and the tubing. The second connector connects a second terminus of the tubing to a delivery module, providing fluid communication between the tubing and the delivery module. Full engagement of the first connector and the exit port of the infusion pump actuates operation of the infusion pump.

3. 发明授权

US08834454B2 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US08834454B2
公开(公告)日：2014-09-16
申请号：US12299602
申请日：2007-05-06
申请人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61K9/22 , A61M5/20 , A61M5/145 , A61M5/142 , A61M5/172
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14276 , A61M5/1452 , A61M5/14586 , A61M5/172 , A61M5/1723 , A61M5/2046 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/35 , A61M2205/8206 , A61M2230/201 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , H01M2220/30
摘要： The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.
摘要翻译：本申请提供了一种药物递送装置，其包括药物储存室16，其包含与药物施用装置18流体连接的待递送物质，以及电控电池单元10，其包括至少一个位移产生电池单元 19通过联接装置14耦合到药物储存室16，该布置使得从电池单元10获得的位移被耦合装置14输送到药物储存室16，使得物质从药物储存器中排出腔室16朝向药物管理装置18。

4. 发明授权

US07524304B2 Drug infusion device 有权
标题翻译：药物输液装置
公开(公告)号：US07524304B2
公开(公告)日：2009-04-28
申请号：US10544167
申请日：2004-02-02
申请人： Amir Genosar
发明人： Amir Genosar
IPC分类号： A61M5/20
CPC分类号： A61M5/1454 , A61M5/14248 , A61M5/16804 , A61M2005/14204 , A61M2005/14513
摘要： The invention provides a drug delivery infusion device comprising an injection means (18) in fluid connection with a drug reservoir chamber (12) and pressure-generation means (10) coupled to both the drug reservoir (12) and to a liquid-filled control chamber (13), wherein the coupling is such that the liquid-filled control chamber (13) serves to constrain the motion of the pressure-generation means (10), thereby controlling the drug infusion rate, wherein the liquid-filled control chamber (13) is associated with means for controlled depletion of the liquid therein whereby depletion of the volume of liquid in the control chamber enables the pressure-generation means to drive the drug in the reservoir chamber therefrom for infusion thereof.
摘要翻译：本发明提供了一种药物递送输注装置，其包括与药物储存室（12）流体连接的注射装置（18）和联接到药物储存器（12）两者的压力产生装置（10）和与液体填充控制腔室（13），其中联接器使得充满液体的控制室（13）用于约束压力产生装置（10）的运动，从而控制药物输注速率，其中充满液体的控制室 13）与其中的液体的可控耗尽的装置相关联，由此在控制室中的液体体积的减少使得压力产生装置能够驱动储存室中的药物用于其输注。

5. 发明申请

US20210128823A1 SELECTIVELY MECHANICALLY ACTIVATABLE PREFILLED INFUSION-PUMP DEVICES 有权
公开(公告)号：US20210128823A1
公开(公告)日：2021-05-06
申请号：US16638840
申请日：2018-08-02
申请人： SteadyMed, Ltd.
发明人： Assaf Shaked , Avi Azoulay , Maya Gartenberg
IPC分类号： A61M5/145 , A61M5/158 , A61M5/142
摘要： This invention provides a prefilled selectively activatable body-worn infusion-pump assembly for rapid delivery of large volumes or highly viscous volume comprising a housing; a pre-filled aseptically-sealed flexible drug reservoir-containing assembly; a conjoined, coordinately controlled and perpendicularly arranged cannulated needle dispensing and needle insertion assembly operationally connected to and in fluid connection with the pre-filled aseptically-sealed drug reservoir-containing assembly, wherein the cannulated needle dispensing assembly projects generally perpendicularly to a generally planar surface of the housing, promotes insertion of the cannulated needle in skin of a subject and promotes retraction of the needle within the cannulated needle dispensing assembly thereafter, and wherein the needle insertion assembly projects generally in a parallel orientation to a generally planar surface of the housing, which projection initiates opening a fluid path with the pre-filled aseptically-sealed drug reservoir-containing assembly; an engine assembly contained in the housing operationally connected to the pre-filled aseptically-sealed flexible drug reservoir-containing assembly promoting release of a drug contained therein, wherein the engine assembly comprises: a motor; a worm gear, operationally connected to the motor; a lifting gear, operationally connected to the worm gear; a piston operationally connected to the lifting gear; and a chassis fitted with an attachment promoting a floating connection thereto with the worm gear; wherein the worm gear and motor are mounted radially with respect to the chassis; a printed circuit board (PCB) assembly, which mechanically supports, electrically connects and controls the function of at least the engine assembly; and a single step activator that when engaged simultaneously promotes activation of the needle insertion assembly opening a fluid path with the pre-filled aseptically-sealed drug reservoir-containing assembly; activation of the engine assembly; and activation of the cannulated needle dispensing assembly inserting in a skin of a subject.

6. 发明授权

US10750987B2 Drug delivery device with electrically controlled volume changing means 有权
公开(公告)号：US10750987B2
公开(公告)日：2020-08-25
申请号：US15634880
申请日：2017-06-27
申请人： SteadyMed Ltd.
发明人： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC分类号： H01M2/02 , A61B5/157 , A61M5/145 , A61B5/15 , A61M5/142
摘要： Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

7. 发明授权

US10737017B2 Drug delivery device 有权
公开(公告)号：US10737017B2
公开(公告)日：2020-08-11
申请号：US15972322
申请日：2018-05-07
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/145 , A61M5/142 , A61M5/20 , A61M5/172 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42
摘要： The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

8. 发明申请

US20170340647A1 Preservative-free Treprostinil Formulations and Methods and Devices for Use with Same 审中-公开
公开(公告)号：US20170340647A1
公开(公告)日：2017-11-30
申请号：US15528452
申请日：2015-11-15
申请人： SteadyMed Ltd.
发明人： Jonathan Rigby , Peter Noymer , Robert Zwolinski
IPC分类号： A61K31/5575 , C07C39/17 , A61K9/00 , A61M5/142 , C07C405/00 , C07C59/72
CPC分类号： A61K31/5575 , A61K9/0019 , A61M5/14248 , C07C39/17 , C07C59/72 , C07C405/0075
摘要： This invention provides for a unit dosage form of treprostinil at a dosage of between 0.1 mg/mL and 25 mg/mL in a sterile fluid composition formulated for subcutaneous or intravenous injection, which composition does not comprise an antimicrobial preservative. Selectively activatable patch-pump assemblies comprising a sealed prefilled drug-reservoir containing the unit dosage form is described as are methods for reducing pain at a site of subcutaneous or intravenous infusion of treprostinil in a subject in need thereof, and methods of reducing irritation, inflammation or a combination thereof at a site of subcutaneous or intravenous infusion of treprostinil in a subject in need thereof. The invention also provides a method of treating pulmonary hypertension, and methods for treating, or reducing the severity or reducing the pathogenesis of Pulmonary arterial hypertension (PAH) in a subject making use of the compositions as herein described.

9. 发明授权

US09687186B2 Drug delivery device 有权
公开(公告)号：US09687186B2
公开(公告)日：2017-06-27
申请号：US13956965
申请日：2013-08-01
申请人： SteadyMed Ltd.
发明人： Jonathan Goldstein , Niles Fleischer , Nir Rotem , Lior Bar-Gat , Vladimir Piskosh
IPC分类号： A61K9/22 , A61B5/157 , A61B5/15 , A61M5/145 , A61M5/142
CPC分类号： A61B5/157 , A61B5/15003 , A61B5/150992 , A61M5/1452 , A61M5/14526 , A61M2005/14204
摘要： Embodiments of the present invention provide drug-delivery devices comprising a drug reservoir chamber containing a substance to be delivered, in fluid connection with a drug administration means, and at least one displacement-generating battery cell coupled to said drug reservoir chamber by a coupling means, the at least one displacement-generating battery cell comprising an element that changes shape as a result of discharge of the battery cell so as to cause a displacement within the battery unit, the arrangement being such that the displacement derived from said battery unit is conveyed by said coupling means to cause displacement of at least a portion of a wall of said drug reservoir chamber reducing the volume of said drug reservoir chamber such that said substance is expelled from said drug reservoir chamber towards said drug administration means upon discharge, thereby being a self-powered drug delivery device.

10. 发明申请

US20090093772A1 Drug Delivery Device with Electrically Controlled Volume Changing Means 有权
标题翻译：具有电控体积变化手段的药物输送装置
公开(公告)号：US20090093772A1
公开(公告)日：2009-04-09
申请号：US11996468
申请日：2006-07-03
申请人： Amir Genosar , Jonathan Goldstein
发明人： Amir Genosar , Jonathan Goldstein
IPC分类号： A61M5/142
CPC分类号： A61M5/14244 , A61B5/01 , A61B5/14532 , A61B5/4839 , A61M5/14526 , A61M5/1454 , A61M5/14566 , A61M5/14593 , A61M5/1723 , A61M2005/14252 , A61M2005/14513 , A61M2230/201
摘要： The present invention provides a drug delivery device comprising a drug reservoir chamber (15) containing a substance (16) to be delivered in fluid connection with a drug administration means (17) and (18), and a hydraulic control chamber (9) containing an electrically controlled, non-gassing, volume changing means (13), a coupling means (14) coupling said hydraulic control chamber (9) to said drug chamber (15), the arrangement being such that a change in the electrical control means (11) causes a change in the volume of the volume changing means (13), the volume change being conveyed by the coupling means (14) to the drug chamber (15) such that the substance (16) is expelled from the drug chamber (15) towards the drug administration means (17) and (18).
摘要翻译：本发明提供了一种药物输送装置，其包括药物储存室（15），其包含与药物施用装置（17）和（18）流体连接地输送的物质（16），以及液压控制室（9），其包含电控制的非气体体积变化装置（13），将所述液压控制室（9）联接到所述药物室（15）的联接装置（14），所述装置使得电气控制装置 11）引起体积变化装置（13）的体积变化，体积变化由联接装置（14）输送到药物室（15），使得物质（16）从药物室排出 15）朝向药物施用装置（17）和（18）。

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