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1. 发明申请

US20200016343A1 System for Precise Injection of Nano-Formulations 审中-公开
公开(公告)号：US20200016343A1
公开(公告)日：2020-01-16
申请号：US16490592
申请日：2018-03-05
申请人： Alex HAREL , NANOMED TARGETING SYSTEMS INC
发明人： Alex HAREL
IPC分类号： A61M5/42 , A61M5/46 , A61M5/31
摘要： A system for the precise and accurate injection of therapeutic substances in a small specific site in the patient's body that includes a syringe, a miniature video camera, lighting means, control buttons, a power source, and a camera-display connecting means. The miniature video camera is positioned on the syringe and the lens of the camera is positioned on the front end of the syringe and is directed towards the needle/needle array tip area. The lighting means are positioned on the front end of the syringe and are designed to illuminate the needle tip area. The control buttons are designed to control the camera and the lighting means. The camera-display connecting means is designed to connect the camera to a display, which is designed to show the area as photographed by the camera.

2. 发明申请

US20160282600A1 REFLECTIVE TELESCOPE WITH WIDE FIELD OF VIEW 审中-公开
标题翻译：具有宽视场的反射式电缆
公开(公告)号：US20160282600A1
公开(公告)日：2016-09-29
申请号：US15081761
申请日：2016-03-25
申请人： DRS Sensors & Targeting Systems, Inc.
发明人： Harvey M. Spencer
IPC分类号： G02B23/06 , G02B17/06
CPC分类号： G02B23/06 , G02B17/0663 , G02B27/0025
摘要： Systems and methods for providing a wider FOV for a telescope system are disclosed. In one embodiment, a telescope includes a primary mirror having an orifice, where an optical path originates from an object positioned in front of the primary mirror and reflects off the primary mirror. A secondary mirror is disposed adjacent to the primary mirror, where the optical path reflects off the secondary mirror and passes through the orifice in the primary mirror. The telescope includes a set of extended field corrector optics disposed along the optical path, the extended field corrector optics positioned to reflect light incident from the secondary mirror, where the set of extended field corrector optics comprises two corrector mirrors. A tertiary mirror is disposed along the optical path and adjacent to the extended field corrector optics, the tertiary mirror positioned to reflect the light incident from the extended field corrector optics.
摘要翻译：公开了用于为望远镜系统提供更宽的FOV的系统和方法。在一个实施例中，望远镜包括具有孔口的主反射镜，其中光路源自位于主反射镜前方的物体并且从主反射镜反射出来。副反射镜邻近主反射镜设置，其中光路从副反射镜反射并穿过主镜中的孔口。望远镜包括一组沿着光路设置的扩展场校正器光学器件，扩展场校正器光学器件定位成反射从次反射镜入射的光，其中该组扩展场校正器光学器件包括两个校正器反射镜。第三反射镜沿着光路设置并且与扩展场校正器光学器件相邻，第三反射镜被定位成反射从扩展场校正器光学器件入射的光。

3. 发明申请

US20110028402A1 SUBSTANCE P-SAPORIN (SP-SAP) CONJUGATES AND METHODS OF USE 审中-公开
标题翻译：物质P-SAPORIN（SP-SAP）共混物及其使用方法
公开(公告)号：US20110028402A1
公开(公告)日：2011-02-03
申请号：US12820128
申请日：2010-06-21
申请人： Douglas A. Lappi , Ronald G. Wiley
发明人： Douglas A. Lappi , Ronald G. Wiley
IPC分类号： A61K38/16 , C07K19/00 , C12N9/96 , A61P25/00 , A61P35/00
CPC分类号： C07K7/22 , A61K38/00 , A61K47/62 , C07K14/415 , C07K2319/00
摘要： This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis.This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance 9, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject.This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expresssing neuronal cells.Lastly, this invention provides a method for treating a NK-1R-associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, in an effective amount to treat the disorder associated with the NK-1R.
摘要翻译：本发明提供了包含物质P或其类似物和抑制蛋白质合成的蛋白质如Saporin的缀合物。本发明提供减少受试者疼痛感觉的方法，其包括向受试者施用有效量的包含物质9或其类似物的缀合物的药物组合物和抑制蛋白质合成的蛋白质如Saporin，因此以减少受试者的疼痛感。本发明提供了选择性地破坏受试者中表达NK-1R的神经元细胞的方法，其包括向受试者施用有效量的包含物质P或其类似物的缀合物和抑制蛋白质合成的蛋白质如Saporin，因此以选择性地破坏NK-1R表达神经元细胞。最后，本发明提供了一种用于治疗受试者中NK-1R相关病症的方法，其包括向受试者施用一定量的包含物质P或其类似物的药物组合物和抑制蛋白质的蛋白质如Saporin 合成，以有效量治疗与NK-1R相关的病症。

4. 发明申请

US20100183708A1 Antigen Delivery Vectors and Constructs 有权
公开(公告)号：US20100183708A1
公开(公告)日：2010-07-22
申请号：US12700566
申请日：2010-02-04
申请人： DOMINIQUE BONNET , CARLTON B. BROWN , BERTRAND GEORGES , PHILIP J. SIZER
发明人： DOMINIQUE BONNET , CARLTON B. BROWN , BERTRAND GEORGES , PHILIP J. SIZER
IPC分类号： A61K9/127 , C12N15/63 , A61K39/12
CPC分类号： A61K47/48023 , A61K31/02 , A61K38/02 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/385 , A61K47/54 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55511 , A61K2039/5555 , A61K2039/55566 , A61K2039/60 , A61K2039/6018 , C07C19/08 , C07C57/52 , C07K2/00 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322
摘要： The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.

5. 发明申请

US20090296281A1 Bearing Assembly Having a Flex Pivot to Limit Gimbal Bearing Friction for Use in a Gimbal Servo System 审中-公开
标题翻译：具有Flex枢轴的轴承组件限制在万向节伺服系统中使用的万向节轴承摩擦
公开(公告)号：US20090296281A1
公开(公告)日：2009-12-03
申请号：US11938104
申请日：2007-11-09
申请人： Edward Bruce Baker
发明人： Edward Bruce Baker
IPC分类号： G11B5/48
CPC分类号： F16C27/04 , G01C19/02
摘要： A bearing assembly suitable for use in a gimbal servo system is provided. The bearing assembly comprises a housing, a first shaft, a bearing rotatingly coupling the first shaft to the housing such that the first shaft is adapted to rotate about an axis relative to the housing, a second shaft having a first end adapted to be coupled to a payload, and a flex pivot element pivotally coupling an end of the first shaft to a second end of the second shaft such that the second shaft is adapted to rotate relative to the first shaft via the flex pivot element. In response to a rotation of the second shaft, the flex pivot element is adapted to pivot an angle about the first shaft axis. The pivot angle reflects a displacement of the second shaft relative to the first shaft and corresponds to a friction disturbance of the bearing.
摘要翻译：提供一种适用于万向架伺服系统的轴承组件。所述轴承组件包括壳体，第一轴，旋转地将所述第一轴联接到所述壳体的轴承，使得所述第一轴适于围绕轴线相对于所述壳体旋转;第二轴，其具有适于联接到有效载荷以及将所述第一轴的端部枢转地连接到所述第二轴的第二端的挠性枢轴元件，使得所述第二轴适于经由所述挠性枢轴元件相对于所述第一轴旋转。响应于第二轴的旋转，柔性枢转元件适于围绕第一轴轴线枢转角度。枢转角反映第二轴相对于第一轴的位移，并且对应于轴承的摩擦扰动。

6. 发明授权

US07622717B2 Pixel structure having an umbrella type absorber with one or more recesses or channels sized to increase radiation absorption 有权
标题翻译：像素结构具有具有一个或多个凹槽或通道的伞形吸收体，其尺寸设置成增加辐射吸收
公开(公告)号：US07622717B2
公开(公告)日：2009-11-24
申请号：US11949367
申请日：2007-12-03
申请人： George D. Skidmore , Christopher G. Howard
发明人： George D. Skidmore , Christopher G. Howard
IPC分类号： H01L31/00
CPC分类号： H01L27/14669 , G01J5/0225 , G01J5/046 , G01J5/0853 , G01J5/20 , H01L27/14601 , H01L27/14625
摘要： A pixel structure for use in an infrared imager is provided. The pixel structure includes a substrate and a bolometer. The bolometer includes a transducer that has a spaced apart relationship with respect to the substrate and has an electrical resistance that varies in response to changes in the temperature of the transducer. The bolometer also includes an absorber that has a spaced apart relationship with respect to the transducer and has a thermal connection to the transducer permitting radiation absorbed by the absorber to heat the transducer. The absorber has a top side defining a recess or channel in the absorber. The recess or channel is adapted to effect the propagation path of a portion of radiation received by the absorber such that the radiation portion is absorbed by the absorber rather than exiting the absorber. The recess or channel also decreases the thermal mass of the bolometer.
摘要翻译：提供了一种用于红外成像仪的像素结构。像素结构包括基板和测辐射热计。测辐射热计包括一个与衬底具有间隔开关系的换能器，并具有响应换能器温度变化而变化的电阻。测辐射热计还包括与换能器具有间隔开的关系的吸收器，并且具有与换能器的热连接，允许由吸收器吸收的辐射来加热换能器。吸收器具有限定吸收器中的凹部或通道的顶侧。凹部或通道适于影响由吸收体接收的辐射的一部分的传播路径，使得辐射部分被吸收体吸收而不是离开吸收体。凹槽或通道也会降低测辐射热计的热质。

7. 发明申请

US20090236525A1 Spectrally Tunable Infrared Image Sensor Having Multi-Band Stacked Detectors 有权
标题翻译：具有多波段叠层检测器的光谱可调谐红外图像传感器
公开(公告)号：US20090236525A1
公开(公告)日：2009-09-24
申请号：US12050460
申请日：2008-03-18
申请人： Pradip Mitra , James E. Robinson , John M. Dell , Charlie A. Musca , Laurie Faraone
发明人： Pradip Mitra , James E. Robinson , John M. Dell , Charlie A. Musca , Laurie Faraone
IPC分类号： G01J5/02 , G01B9/02
CPC分类号： G01J3/26 , G01J3/2823 , G01J3/36
摘要： A tunable infrared detector is provided that includes a substrate, a bottom wavelength detector formed over the substrate, a top wavelength detector formed over the first wavelength detector layer, and an interferometer filter formed over the top wavelength detector layer and the bottom wavelength detector layer. The interferometer filter is operatively configured to pass a first wavelength associated with a first portion of a predetermined band and a second wavelength associated with a second portion of the predetermined band to the top wavelength detector. The top wavelength detector is operatively configured to detect each wavelength associated with the first portion of the predetermined band and to transmit each wavelength associated with the second portion of the predetermined band to the bottom wavelength detector. The bottom wavelength detector is operatively configured to detect each wavelength associated with the second portion of the predetermined band.
摘要翻译：提供了一种可调谐红外检测器，其包括衬底，形成在衬底上的底部波长检测器，形成在第一波长检测器层上的顶部波长检测器，以及形成在顶部波长检测器层和底部波长检测器层上的干涉仪滤波器。干涉仪滤波器被可操作地配置成将与预定频带的第一部分相关联的第一波长和与预定频带的第二部分相关联的第二波长传递到顶部波长检测器。顶部波长检测器被可操作地配置为检测与预定波段的第一部分相关联的每个波长，并将与预定波段的第二部分相关联的每个波长传输到底部波长检测器。底部波长检测器可操作地配置为检测与预定波段的第二部分相关联的每个波长。

8. 发明授权

US07459730B1 Separate absorption and detection diode for VLWIR 有权
标题翻译：用于VLWIR的独立吸收和检测二极管
公开(公告)号：US07459730B1
公开(公告)日：2008-12-02
申请号：US11250162
申请日：2005-10-13
申请人： Michael A. Kinch
发明人： Michael A. Kinch
IPC分类号： H01L31/072
CPC分类号： H01L31/109
摘要： A photodiode for detection of preferably very long wavelength infrared radiation wherein low energy photons are absorbed in one region and detected in another. In one example embodiment, an absorbing P region is abutted with an N region of lower doping such that the depletion region is substantially (preferably completely) confined to the N region. The N region is also chosen with a larger bandgap than the P region, with compositional grading of a region of the N region near the P region. This compositional grading mitigates the barrier between the respective bandgaps. Under reverse bias, the barrier is substantially reduced or disappears, allowing charge carriers to move from the absorbing P region into the N region (and beyond) where they are detected. The N region bandgap is chosen to be large enough that the dark current is limited by thermal generation from the field-free p-type absorbing volume, and also large enough to eliminate tunnel currents in the wide bandgap region of the diode.
摘要翻译：用于检测优选非常长波长的红外辐射的光电二极管，其中低能光子在一个区域中被吸收并且在另一个区域中被检测。在一个示例性实施例中，吸收P区与较低掺杂的N区邻接，使得耗尽区基本上（优选完全地）限于N区。 N区域也被选择为具有比P区域更大的带隙，并且在P区域附近的N区域的区域的组成分级。这种组成分级减轻了相应带隙之间的障碍。在反向偏压下，屏障显着减少或消失，从而允许电荷载体从吸收P区域移动到检测到它们的N区域（并超出）。选择N区带隙足够大，使得暗电流受到无场p型吸收体积的热产生的限制，并且也足够大以消除二极管的宽带隙区域中的隧道电流。

9. 发明授权

US06931091B2 Gray code counter 有权
标题翻译：格雷码计数器
公开(公告)号：US06931091B2
公开(公告)日：2005-08-16
申请号：US10920477
申请日：2004-08-18
申请人： Gary L. Heimbigner
发明人： Gary L. Heimbigner
IPC分类号： H03K19/21 , H03K23/00 , H03K21/00
CPC分类号： H03K23/005 , H03K19/215
摘要： A gray code is produced from a minimum of gate logic by making available and monitoring master outputs of master-slave latch pairs, where the latch pairs are arranged to form a cascading chain of toggle flip-flop stages. The least significant bit through one less than the most significant bit in the gray code is supplied by the master latch outputs and the most significant gray code bit is supplied by the slave latch output of the last toggle stage in the chain.
摘要翻译：通过提供和监视主从锁存器对的主输出，从最小门逻辑产生灰度代码，其中锁存器对被布置成形成级联的触发器触发器级链。通过主锁存器输出提供比灰度代码中低于最高有效位的最低有效位，并且最高有效灰度位由链中最后一个切换级的从锁存器输出提供。

10. 发明授权

US6063758A Substance P-Saporin (SP-SAP) conjugates and methods of use thereof 失效
标题翻译：物质P-Saporin（SP-SAP）缀合物及其使用方法
公开(公告)号：US6063758A
公开(公告)日：2000-05-16
申请号：US890157
申请日：1997-07-09
申请人： Douglas A. Lappi , Ronald G. Wiley
发明人： Douglas A. Lappi , Ronald G. Wiley
IPC分类号： A61K38/00 , A61K47/48 , C07K7/22 , C07K14/415 , A61K38/16
CPC分类号： A61K47/48238 , C07K14/415 , C07K7/22 , A61K38/00 , C07K2319/00
摘要： This invention provides a conjugate comprising Substance P, and analogs thereof, and Saporin. This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective dose of the pharmaceutical composition of the conjugate comprising Substance P, and analogs thereof, and Saporin, so as to reduce the perception of pain by the subject. This invention provides a method of selectively destroying NK-1 receptor expressing cells in a subject comprising administering to the subject an effective dose of the conjugate comprising Substance P, and analogs thereof, and Saporin so as to selectively destroy NK-1 receptor expressing cells. Lastly, this invention provides a method for treating a NK-1 receptor associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising Substance P, and analogs thereof, and Saporin thereby treating the disorder associated with the NK-1 receptor.
摘要翻译：本发明提供包含物质P及其类似物和Saporin的缀合物。本发明提供减少受试者疼痛感觉的方法，其包括向受试者施用有效剂量的包含物质P及其类似物和Saporin的缀合物的药物组合物，以便减少疼痛的感觉学科。本发明提供了选择性地破坏受试者中NK-1受体表达细胞的方法，包括向受试者施用有效剂量的包含物质P及其类似物和皂草素的缀合物，以选择性地破坏表达NK-1的细胞。最后，本发明提供了一种治疗受试者中NK-1受体相关病症的方法，其包括向受试者施用一定量的包含物质P及其类似物的药物组合物，以及Saporin，从而治疗与NK相关的病症 -1受体。

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